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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Sains dan Teknologi Farmasi INDONESIAN JOURNAL OF PHARMACY Jurnal Kesehatan Medika Saintika JOPS (Journal Of Pharmacy and Science) JSFK (Jurnal Sains Farmasi & Klinis) SCIENTIA JOURNAL Buletin Ilmiah Nagari Membangun JFIOnline Majalah Kedokteran Andalas YARSI Medical Journal JURNAL FARMASIMED (JFM) Menara Ilmu Indonesian Journal of Global Health research Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Pharmaceutical Sciences and Research (PSR)

Almahdy A

Fakultas Farmasi Universitas Andalas

Author-ID : 216731

Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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ISOLASI SENYAWA SITOTOKSIK TERHADAP SEL KANKER PAYUDARA DARI KULIT BATANG Garcinia griffithii T. Anders Wahyuni, Fatma Sri; Lusianti, Mittha; Almahdy, .; Dachriyanus, .
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 4 (2009)
Publisher : Indonesian Research Gateway

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A cytotoxic compound was isolated from n-hexane the stem bark of Garcinia griffithii T. Anders. (Guttiferae) as colourless needles from which melted at 242-243oC. Based on spectroscopies data of this compound was identified as isoxanthocymol. Cytotoxic assay using Microculture Tetrazolium (MTT) assay showed that isoxanthocymol was active against breast cancer cell line MCF-7, with IC50 value 35,46 μg/ml. ABSTRAK Telah diisolasi senyawa sitotoksik dari kulit batang Garcinia griffithii T. Anders. (Guttiferae). Senyawa diisolasi dari fraksi n-heksana berupa amorf tidak berwarna dengan jarak leleh 242-2430C. Dari data spektroskopi massa, 1H-RMI, 13C-RMI, diketahui bahwa senyawa tersebut adalah isoxanthocymol. Pengujian aktifitas sitotoksik isoxanthocymol dilakukan dengan metode Microculture Tetrazolium (MTT) terhadap sel kanker payudara MCF-7, dan memperlihatkan aktifitas dengan nilai IC50 sebesar 35,46 μg/ml.

Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 2 (2016)
Publisher : Indonesian Research Gateway

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Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then two– third of fetuses were immersed in alizarin red solution and the remainingin Bouin’s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.

Uji Efek Sitotoksik Ekstrak Etanol Daun Asam Kandis pada Mencit Putih Betina dengan Metode Penetapan Mironukleus Wahyuni, Fatma Sri; Afrina, Uci; A, Almahdy
Jurnal Farmasi Indonesia Vol 6, No 2 (2012)
Publisher : Jurnal Farmasi Indonesia

The cytotoxic effect of ethanolic extract of the leaf of Garcinia cowa Roxb had been studied b bone marrow micronucleus test. Fourty five female mice were clasified into five groups: negative control, positive control, 30 mg/kgBW extract, 100 mg/kgBW extract, and 300 mg/kgBW extract. Each group was divided into three groups based on the duration of treatment. The mice were induced with 50 mg/kgBW cyclophosphamide intraperitoneally. After 30 hours, the extract were administered orally into the treatment groups for the duration of 3,7, and 15 days. After treatment, the mice were sacrified to obtain their femur marrow. The parameter investigated was the number of micronucleus. It was shown that the extract at does of 30, 100 and 300 mg/kgBW decreased the percentage of micronucleus cells significantly compared with positive control (p<0,05). The highest decrease of micronuclei cells was showed by the dose of 100 mg/kgBW.Keywords : cytotoxic effect, Garcinia cowa Roxb, bone marrow micronucleus test.AbstrakTelah dilakukan penelitian tentang efek sitotoksik dari ekstrak etanol daun asam kandis (Garcinia cowa Roxb) dengan Metoda Penetapan Mikrinukleus. Sebanyak 45 ekor mencit putih betina, dibagi menjadi lima kelompok yaitu kontrol negatif, kontrol positif, 30 mg/kgBB), 100mg/kgBB, dan 300 mg/kgBB. Tiap-tiap kelompok dibagi lagi menjadi tiga kelompok berdasarkan lama pemberian sediaan uji. Mencit diinduksi dengan siklofosfamida 50 mg/kgBB secara intraperitoneal. Setelah 30 jam, kelompok uji diberikan ekstrak uji secara oral selama 3,7 dan 15 hari. Setalah perlakuan, mencit dikorbankan dan diambil sumsum tulang femurnya. Parameter yang diamati adalah persentase jumlah sel mikronuklei. Hasil penelitian menunjukkan sediaan uji pada dosis 30, 100 dan 300 mg/kkBB mampu menurunkan persentase jumlah sel mikronuklei secara signifikan dibandingkan kontrol positif (P<0,05). Penurunan persentase sel mikronuklei paling besar diberikan oleh sediaan uji dosis 100 mg/kgBB.Kata kunci : Efek sitotoksik, Garcinia cowa Roxb, metode penetapan mikronukleus.

Evaluasi Efek Teratogen Ekstrak Terpurifikasi yang Diisolasi dari Fraksi Etil Asetat Daun Surian (Toona sureni (Blume) Merr) Suharti, Suharti; Yosmar, Rahmi; Fitriani, Ade; Almahdy, Almahdy
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Evaluation of teratogenic effects of purified extract isolated fromethyl acetate fractionation of surian leaves (Toona sureni (Blume) Merr.) onwhite female fetus mice has been carried out. The extract was given to miceorally in solution at doses of 5, 10, and 20 mg/kg BW on 6th until 15th day ofpregnancy. On 18th day of pregnancy, laparatomy was performed, then twoâ?? third of fetuses were immersed in alizarin red solution and the remainingin Bouinâ??s solution. The analyzed parameters were the weight of pregnantmice, the number of fetuses, the weight of fetuses, skeletal malformation andmorphology. The result showed that malformations were not shown in dose of 5mg/kg BW, but in dose of 10 mg/kg BW from one mice found one fetus causedlate growth and death. While on dose 20 mg/kg BW, one mice was not death.

Co-Authors Ade Fitriani, Ade Adek Zamrud Adnan Afrina, Uci Ahsol Hasyim Al-Khansaa, Syawwal Andini, Airiza Fitri Andre, Boy Armenia, Armenia Armenia, Armenia Armi Djamain Arriva, Dzaskia Biomechy Oktomalioputri, Biomechy Boy Andre Dachriyanus Dafiriani, Putri Dafriani, Putri Deddi Prima Putra Desmini, Yuliya Dini Qurrata Ayuni Dwisari Dillasamola eliza arman, eliza Elvionita, Cindy Esi Afriyanti Fatma Sri Wahyuni Hansen Nasif Jayawarsa, A.A. Ketut Kurniasi, Fitra Lailaturrahmi Lailaturrahmi Lailaturrahmi, Lailaturrahmi Lusianti, Mittha Mardinus, Mardinus Marina Yandri Muchtar, M. Husni Najmiatul Fitria Noni Zakiah Noverial, Noverial Nurhasanah Nurhasanah Prabandasari, Gustia Indah Prima Putra, Deddi Primadhini, Tessa Amanda Putri, Biomechy Oktomalio Rahmi Yosmar Raihana, Nadia Sahputra, Roni Eka Sari, Azzahra Ayu Sari, Novita Purnama Sari, Yelly Oktavia Skunda Diliarosta Syed Wasif Gillani Varizal, Hagi Verawati Verawati Yohannes Alen

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