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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Jurnal Kesehatan Jurnal Biomedika dan Kesehatan Cermin Dunia Kedokteran Jurnal Neuroanestesi Indonesia Buletin Kedokteran dan Kesehatan Prima
Bangun, Chrismas Gideon
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Antidiabetic potential of andaliman: Histopathological and glycemic improvements in diabetic rats Simbolon, Boyke Marthin; Lina, Juliana; Saragih, Ayu Theresia; Bangun, Chrismas Gideon; Nasution, Muhammad Fauzi; Rosari, Anita; Dewani, Yunita; Syahputra, Imam; Silalahi, Todung Donald Aposan
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7891

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and pancreatic dysfunction, particularly involving the Islets of Langerhans. Andaliman (Zanthoxylum acanthopodium) is a plant rich in flavonoids and antioxidants, which are believed to have antidiabetic effects. This study aimed to evaluate the effectiveness of the ethanol extract of Andaliman fruit on pancreatic histopathology in alloxan-induced diabetic rats. Methods: This study employed a true experimental design with a pre-test and post-test control group structure. Twenty-four male Wistar rats were randomly assigned to six groups: a normal control, a positive control (metformin 9 mg/kg), a diabetic control (alloxan 90 mg/kg), and three treatment groups induced with alloxan followed by administration of Andaliman extract at doses of 150, 250, and 350 mg/kg body weight, respectively. Treatments were administered for 14 days, after which blood glucose analysis (pre- and post-treatment) and pancreatic histopathological assessments were performed. Results: Statistical analysis revealed a significant reduction in blood glucose levels following treatment (p = 0.001). Histopathological examination showed that Andaliman extract ameliorated alloxan-induced damage to the Islets of Langerhans. The 350 mg/kg body weight dose resulted in the most pronounced tissue regeneration compared to the other treatment groups. Conclusion: The ethanol extract of Andaliman fruit effectively improves pancreatic histopathology and lowers blood glucose levels in diabetic rats.
Co-Authors Bangun, Primta Chiuman, Linda Dewani, Yunita Dewi Yulianti Bisri Eri Surahman Ginting, Chrismis Novalinda Hamdi, Tasrif Harahap, Juliandi Irina, Rr. Sinta Lina, Juliana Lubis, Andriamuri Prima Lubis, Andriamuri Primaputra Nasution, Atika Rimalda Nasution, Muhammad Fauzi Ramud, Samawi Husein Rosari, Anita Rose Mafiana Saleh, Siti Chasnak Saragih, Ayu Theresia SATRIYAS ILYAS Sibarani, Nicholas Hamonangan Simamora, Veronica Simbolon, Boyke Marthin Syafruddin Gaus Syahputra, Imam Todung Donald Aposan Silalahi Umar, Nazaruddin Venawati, Feni vera vera, vera Yunanda, Yuki Yutu Solihat