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Journal : Journal of Multidisciplinary Applied Natural Science

Phytochemical Profiling, Antibacterial Properties and Toxicity of Amla Fruit Tea (Phyllanthus emblica L.): An In Vitro and In Silico Study Cahyaningrum, Putu Lakustini; Sudaryati, Ni Luh Gede; Bogoriani, Ni Wayan; Asih, Ida Ayu Raka Astiti; Adnyana, I Made Dwi Mertha; Jenar, Putut Dewantha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.284

Abstract

Antimicrobial resistance represents a critical global health challenge, necessitating the exploration of alternative therapeutic agents. This study investigated the antimicrobial potential of amla fruit tea (Phyllanthus emblica L.) through comprehensive phytochemical characterization, antibacterial assessment, and computational modeling to identify potential mechanisms of action. LC-HRMS analysis was employed for phytochemical profiling, antibacterial activity was evaluated via disk diffusion method against Staphylococcus aureus and Escherichia coli, and molecular docking studies were conducted against tyrosyl-tRNA synthetase and FimH adhesin proteins. Analysis identified 89 bioactive compounds, with oxidized hydroxytetrahydrofuranyl acetate, L-α-palmitin, and ellagic acid predominating. Antibacterial activity against S. aureus and E. coli was evaluated via the disk diffusion method, revealing that moderate inhibition increased at higher concentrations (25%) and with extended exposure, with E. coli exhibiting greater susceptibility than S. aureus. Molecular docking studies against tyrosyl-tRNA synthetase (S. aureus) and FimH adhesin protein (E. coli) identified the W-18 benzenesulfonamide derivative as the most promising compound, which demonstrated strong binding affinities of -11.01 and -7.48 kcal/mol, respectively. While all five principal compounds met Lipinski's drug-likeness criteria, toxicological assessment revealed varying safety profiles, with two compounds classified as "possibly hazardous" and two as "toxic when swallowed." These findings suggest that amla fruit tea has antibacterial properties through two mechanisms: disruption of protein synthesis and bacterial adhesion. However, its efficacy remains considerably lower than that of conventional antibiotics, suggesting potential applications as complementary therapy rather than antibiotic replacement.
Co-Authors A.A.A. Sauca Sunia Widyantari Adnyana , I Made Dwi Mertha Anak Agung Ayu Sauca Sunia Widyantari Anak Agung Komang Suardana Anak Agung Putu Agung Mediastari Armita, Pande Made Nova Astuti, Ni Made Widi da Cruz , Zito Viegas Dwinka Syafira Eljatin Farachatus Salwa Salsabila Azhari Gusti Ayu Putu Wahyu Purnama Dewi Handayani, Ni Made I Ketut Suada I Made Agus Gelgel Wirasuta I Made Damriyasa I Made Sumarya I Nyoman Arsana I Nyoman Arsana I Nyoman Arsana, I Nyoman I P. Sudiartawan I Putu Sudiarta I Putu Sudiartawan I W BUDIARSA SUYASA I Wayan Kasa I Wayan Martadi Santika I Wayan Masa Tenaya, I Wayan Masa I Wayan Suarda I Wayan Wahyudi, I Wayan I. A. R. Astiti Asih Ida Ayu Pasti Apsari Ida Bagus Putra Suta Ida Bagus Wiryanatha Kadek Karang Agustina N. W. Bogoriani Ni Kadek Warditiani Ni Ketut Ayu Juliasih Ni Ketut Ayu Juliasih Ni Ketut Ayu Juliasih Ni Luh Inten Mitadewi Wulandari Ni Luh Nyoman Vivi Tri Handayani Ni Made Listya Ari Ni Made Riris Divayani Aristyantari Ni Made Riris Divayani Aristyantari Ni Made Widiastuti Ni Nyoman Triyani Ni Wayan Ariska Yustina Ni Wayan Korniasih Ni Wayan Susilawati Noor, Thalia Anggrea Pande Made Nova Armita Putu Alit Wardana Putu Lakustini Cahyaningrum Putut Dewantha Jenar Raza, Syed Meesam Ronald Pratama Adiwinoto Suardana, A.A Komang Sudiartawan, I Putu Sumarya, I Made Suparmi Suparmi Suta, Ida Bagus Putra TRI KOMALA SARI Wayan Suryana Widayantari, Anak Agung Ayu Sauca Sunia Widyantari, Anak Agung Ayu Sauca Sunia Wyasena, Pande Nyoman Tri Saguna