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All Journal World Chemical Engineering Journal Pendas : Jurnah Ilmiah Pendidikan Dasar Avicenna : Journal of Health Research Jurnal Inovasi, Evaluasi dan Pengembangan Pembelajaran (JIEPP) Elementary School: Jurnal Pendidikan dan Pembelajaran ke-SD-an YASIN: Jurnal Pendidikan dan Sosial Budaya Jurnal Ekonomi Bisnis Manajemen dan Akuntansi (Jebisma)
Hidayati, Anisa
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Humanities Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Mathematics Nursing Public Health Social Sciences Other

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Journal : World Chemical Engineering Journal

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In Silico Study and Bioactivity of Flavonoid Extract Syzygium polyanthum (Wight) Walp. Leaves Against Salmonella typhi Rochmat, Agus; Hidayati, Anisa; Mujijah, Mujijah; suhaedah, suhaedah
World Chemical Engineering Journal VOLUME 4 NO. 2 DECEMBER 2020
Publisher : Chemical Engineering Department, Engineering Faculty, Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62870/wcej.v4i2.10593

Abstract

Salmonella typhi bacteria cause complications of bleeding in the intestine or intestinal perforation. However, Salmonella typhi bacteria will become resistant to chloramphenicol due to the formation of plasmids that produce the chloramphenicol acetyl transferase (CAT) enzyme which works to activate chloramphenicol. So, the search for active groups of natural compounds which are expected to have the work of deactivating the CAT enzyme. One of them is a flavonoid compound. The flavonoid group is widely used as an antimicrobial. This research was aimed at the extraction of bay leaf flavonoids. The presence of flavonoids was proven by phytochemical tests, namely a yellow color change with a slightly acidic amyl alcohol solvent - Mg metal and strengthened by the scanning results of the maximum wavelength on the band 1 407 nm and band 2 338 nm which is a special feature of flavonoid backbone. The results of GC-MS analysis obtained 4 flavonoid compounds from bay leaf extract which have an abundance above 1% and qualification above 90%: 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, alpha- tocopherol, beta-tocopherol, and pyragallol. The correlation between the results of the inhibitory test against Salmonella typhi at a concentration of 100 ppm with the results of docking tocopherol - 3CLA receptors which have an affinity bond energy / ∆Gbinding = 7.40 kcal / mol, indicates that the bay leaf flavonoid extract can inhibit the formation of chloramphenicol acetyl transferase (CAT).
Co-Authors Adi Saputro, Endri Aditya, Mifta Ahmad Zamani, Ahmad Akhmad Azmiardi Anasulfalah, Hakim Aprilia, Rara Nasywa Aqsyari, Rizki Ardia Pramesti, Risa Auraldi Nansurya, Alga Baehaqi Daryanto Daryanto DEWI FITRIA, DEWI Dewi Lieskusumastuti, Anita Dina Irawati Dwi Lestari Eri Pramuja, Wanda Ernawati, Heni Fauziah, Sobrini Febri Susanti, Rinandita Fitriani, Lisna Annisa Hanif, Ihsan Hanifah, Lilik Hasanah, Puji Isratul Ihdina Fityatal Hasanah, Yesi Ika Yuli Ayuningrum Indah Wulandari, Dwi Indarto Indarto Ismail, Aem Isratulhasanah, Puji Iswahyuni, Sri Joko Triwibowo, Joko Joko Yulianto, Dwi Karmadi, Karmadi Khansa Azizah, Fara Kuntari, Saras Lita Maratul Munawar, Siti Maria, Fanny Lusce Masykur, Muhammad Miranda Juandrina, Shella Mirsanti, Faradilla MUHAMMAD SHOLEH Mujijah, Mujijah Noerlita Ningrum, Andriani Novitasari, Meliana Nur Fauziah, Ani Nur Rokhmatun, Puji Nurhayati, Isnani Nurrahmah, Silva Nurrochim, Nurrochim Pradana Putri, Anggie Pradana, Anggie Puji Lestari, Apriliani Puspitasary, Kiki Rahma Widyaningrum, Nova Rasyid Ridha, Achmad Rejo, Rejo Reza Kurnia, Febria Rizkia, Nadila Putri Rochmat, Agus Rofiudin, Mohammad Rohmi, Rohmi Sabngatun, Sabngatun Sayekti Heni Sunaryanti, Sri Sembiring, Armanta Setiawan Manurung, Budi Setyorini, Catur Sindi Wardani, Galuh Sirait, Lidia Thimora Siti Maesaroh Siti Marwiyah Solly Aryza Suciyati Suciyati, Suciyati Suhaedah Suhaedah, Suhaedah Syafitri, Syarifah Syafriel, Muhammad Syauqi Mubarok, Ahmad Tri Atmojo, Joko Tri Darmayanti, Aquartuti Tri Handayani, Rina Tri Yuniarti, Tri Verasita, Prissy Widiyanto, Aris