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Association of rs235768 A>T polymorphism of the bone morphogenetic protein 2 gene on non-syndromic orofacial cleft in an Indonesian population Kiranahayu, Rarasih; Suhartono, Antonius Winoto; Sulistyani, Lilies Dwi; Latief, Benny Sjariefsjah; Auerkari, Elza Ibrahim
Padjadjaran Journal of Dentistry Vol 32, No 2 (2020): July 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no2.23917

Abstract

Introduction: Orofacial cleft is one of the many congenital malformations that often occur in human, leaving it at the fourth level of the most common orofacial birth defect findings. The incident rate is one in 700-1000 deliveries, where without therapeutic and surgical interventions, children with an orofacial cleft may have problems with speech, nutrition intake, and growth. Bone morphogenetic protein 2 (BMP-2) gene play essential roles in the migration and proliferation of neural crest cell of the early head formation and regulate mineralised tissues such as maxillary, mandible, palate and teeth. This study was aimed to analyse the BMP-2 polymorphism and its potential association with orofacial cleft in an Indonesian population. Methods: Cross-sectional study was conducted towards 128 samples, 32 samples of orofacial cleft patients and 96 samples of control. Extracted genotype and allele was determined with PCR-RFLP method using stored DNA samples from 32 orofacial cleft patients, and 96 healthy control. Results: The TT genotype was showing the p-value = 0.001, OR = 2.43% in orofacial samples (71.4%), which was significantly higher than in control groups (28.6%). The allele distribution was also considered statistically significant (p = 0.036, OR =1.89%. Conclusion: There is a significant association of rs235768 A>T polymorphism of the BMP-2 gene on non-syndromic orofacial cleft patients in Indonesia.
Identification of Forensic Odontology in Investigation Case of Human Skeletal Findings: Case Report Kaurow, Farah Primadani; Soedarsono, Nurtami; Auerkari, Elza Ibrahim
Journal La Medihealtico Vol. 6 No. 4 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i4.2379

Abstract

The objective of forensic identification is to assist investigators in identifying an individual's identity, Through the identification process in forensic odontology, we can obtain information related to a person's identity such as race, gender, age and oral habits. This case report discusses the identification of skeletal found by residents in a garbage dump. This discovery was reported to the police in charge for further investigation. These skeletals were identified by a joint team, consist of forensic pathologist and forensic odontologist. In this case, we conclude the skeletals was human skeletals, mongoloid male with estimation of age between 30-50 years old.
The role of forensic odontology in the identification of a mutilation victim: A case report Yatma, Debby; Auerkari, Elza Ibrahim; Yuniastuti, Mindya; Soedarsono, Nurtami; Suhartono, Antonius Winoto; Kaurow, Farah P.; Pasaribu, Roben Suhadi; Auerkari, Pertti
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p409-414

Abstract

Background: Forensic odontology is an invaluable resource for human identification. An individual’s bones and teeth may be the only remnants of their identity in certain situations where soft tissue has been lost, carbonized, or destroyed for any other reason. The body’s hardest and best-protected structures are found in teeth, and these have individual characteristics and are resistant to factors such as temperature and chemistry. When antemortem dental records are not available for comparison, dental profiling is performed. Purpose: This case study highlights the importance of teeth in the identification process and their usefulness in estimating biological profile factors such as sex, age, and population affinity. Case: The case of an unidentified woman who was found in a house in a severely decomposed, skeletonized state is presented. The unidentified body was sent to the Forensic Medicine Installation of Bhayangkara Level I Hospital to determine the cause of death and for dental identification. Case management: The body was suspected to be a victim of mutilation. Shovel shapes observed on the lingual surface of the lateral upper incisor and tori palatini are the most outstanding diagnostic features in Mongoloid populations. The specific mesiodistal crown width and mandibular canine index revealed female traits. Using the Lamendin method, the age was estimated to be 52–58 years old. Conclusion: A forensic odontologist can identify individuals by comparing antemortem and postmortem dental data. They can also provide age estimation, sex, and population affinity determination by analyzing teeth.
Human Beta-defensin-1 and Periodontal Disease: The Past, Present, and Future Sulijaya, Benso; Masulili, Sri Lelyati C; Auerkari, Elza Ibrahim
Journal of Indonesian Dental Association Vol 4 No 1 (2021): April
Publisher : Indonesian Dental Association

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Abstract

Human beta-defensin-1 (HBD-1), a peptide released by the immune system, has been investigated for its association with periodontal disease. Several studies have found positive findings of its expression related to disease progression, whereas others have reported some tendencies. This review highlights studies associated with HBD-1 and periodontal disease in both primary and clinical investigations, as well as the underlying mechanism and discusses further research possibilities for HBD-1. HBD-1 acts as an innate immune apparatus and mediating the adaptive immune system; therefore, its role in the pathogenesis of a periodontal disease is indisputable. HBD-1 is mainly expressed in the oral stratified epithelium and sulcular epithelium, where the barrier junction properties (e.g., E-cadherin and β-catenin in the adherent junction) of the gingival epithelial cells serve as the first line of defense against periodontal infection. The HBD-1-reinforced epithelium therefore provides both a mechanical and a chemical barrier action. Critical issues that arise in the gingival epithelium can therefore be alleviated by modulation of HBD-1 production to enhance its protective function. The antimicrobial, anti-inflammatory, and wound healing properties of HBD-1 support its use as a promising clinical treatment strategy.
Radiographic Techniques For Estimating Dental Age: A Comparative Study Khan, Muhammad Salman; Auerkari, Elza Ibrahim; Suhartono, Antonius Winoto
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.574

Abstract

The determination of dental age using radiographic techniques has become a crucial method in forensic dentistry for estimating the chronological age of individuals, particularly in cases involving children and adolescents. This study aims to compare various radiographic techniques in estimating dental age based on tooth development. A comparative research method was employed, analyzing radiographic data from individuals aged 6 to 18 years. The data were collected using two primary techniques: panoramic and intraoral periapical, and analyzed using well-established methods such as the Demirjian and Nolla methods. The results showed that the Demirjian method had a higher accuracy rate compared to other methods, particularly in age estimation for individuals under 12 years old. The discussion highlights that differences in accuracy between techniques are due to better visualization of dental anatomical structures in some techniques. The conclusion of this study is that radiographic methods, especially the panoramic technique and the Demirjian method, are optimal choices for dental age estimation with high accuracy.  
Collaboration between forensic odontology and forensic pathology is crucial in Disaster Victim Identification Salman Khan, Muhammad; Suhartono, Antonius Winoto; Auerkari, Elza Ibrahim
Eduvest - Journal of Universal Studies Vol. 4 No. 7 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i7.1231

Abstract

While forensic pathologists have always played a pivotal role in victim identification after mass casualties, new developments in forensic methods have given forensic anthropologists more agency in positively identifying individuals who were previously unidentifiable.This review aims to contribute to the refinement of diagnostic tools, ensure optimal utilization of remnants and information available, and emphasize the contributions of forensic pathologists and forensic odontologist to victim identification and the importance of forensic pathologists and forensic odontologist in the criminal justice system. Considering the Interpol DVI Guide's emphasis on fingerprints, dental examinations, and DNA as primary identifiers, the forensic pathologist's role as the leader of a multidisciplinary team of experts in a disaster situation has taken on new significance. This is due to the forensic pathologist's and forensic odontologist training and experience leading similar teams during routine operations at a forensics institute. This thorough examination highlights the utmost significance of the job carried out by forensic pathologists and forensic odontologist. They play an important role in the judicial process by providing expert views in criminal investigations. Their expertise ensures accurate identification of victims and provides critical evidence that is necessary for holding offenders responsible. Their contributions are fundamental to the administration of justice, highlighting the great importance of their function in the overall structure of the criminal judicial system.