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All Journal HAYATI Journal of Biosciences INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Science and Applicative Technology Acta Pharmaciae Indonesia : Acta Pharm Indo JFL : Jurnal Farmasi Lampung Jurnal Kreativitas PKM Stannum : Jurnal Sains dan Terapan Kimia Jurnal Pengabdian Dharma Wacana Mejuajua Jurnal Vokasi Kesehatan Indonesian Journal of Chemical Science Indonesian Journal of Jamu
Syaikhul Aziz
Program Studi Farmasi, Fakultas Sains, Institut Teknologi Sumatera, Lampung, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Science and Applicative Technology

 1 
Penambatan molekul senyawa turunan orizanol terhadap enzim 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reduktase Syaikhul Aziz; Nur Adliani; Sukrasno Sukrasno
Journal of Science and Applicative Technology Vol 4 No 1 (2020): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.567 KB) | DOI: 10.35472/jsat.v4i1.191

Abstract

Oryzanol has been reported to reduce serum total cholesterol (hypolipidemic agent) by inhibiting HMG-CoA reductase, an enzyme responsible for the metabolic pathway that produces cholesterol and isoprenoid. The purpose of this experiment is to determine the inhibition activity of oryzanol derivatives on HMG-CoA reductase by molecular docking. Four structure of oryzanol derivatives, Lanosteryl-ferulate, Brassicasteryl-ferulate, Lupeol-ferulate, and Cholesteryl-ferulate were used as ligands for molecular docking. The HMG-CoA reductase structure was obtained from protein data bank and the study was performed using AutoDock Tools as a molecular docking software. All oryzanol derivatives show binding affinity against HMG-CoA reductase. Lupeol-ferulate was predicted to be the best inhibitory activity against HMG-CoA reductase because of molecular docking.
Quantitative Profiling of Total Flavonoid Content in Cassava Leaf (Manihot esculenta Crantz) Varieties and Isolation of Flavonoid Compounds from a High-Flavonoid Variety Aziz, Syaikhul; Siringoringo, Vinta Marito; Mulyani, Isna; Ngatinem
Journal of Science and Applicative Technology Vol. 9 No. 1 (2025): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v9i1.2190

Abstract

Cassava (Manihot esculenta Crantz) is widely utilized across Indonesia as both a staple food and a traditional medicinal resource, and its leaves are known to contain bioactive secondary metabolites such as flavonoids. This study aimed to quantify the total flavonoid content in several cassava leaf varieties and to isolate a flavonoid compound from the variety with the highest flavonoid content. Total flavonoid content was determined using UV-Visible spectrophotometry. The isolation of flavonoid compounds was carried out using vacuum liquid chromatography (VLC) and column chromatography (CC), with thin-layer chromatography (TLC) employed to monitor the separation results. The total flavonoid content of the Gajah, UJ-3 (Thailand), UJ-5 (Katsesart), Cimanggu dan Kaspro varieties were found to be 1.029 ± 0.003 mgQE/g, 0.746 ± 0.006 mgQE/g, 0.970 ± 0.009 mgQE/g, 0.936 ± 0.004 mgQE/g and 1.220 ± 0.003 mgQE/g, respectively. The Kaspro variety exhibited the highest flavonoid content. Isolation and characterization of the flavonoid from Kaspro leaves yielded a yellowish powder with absorption maxima at 269 nm (Band II) and 334 nm (Band I). Further analysis using shift reagents identified the isolated compound as apigenin, a member of the flavone group.
Analysis Interaction of Nicotinamide and Ascorbic Acid and Its Derivatives as Active Substances in Skin Lightening Cosmetic Products Hidayati, Pratiwi Al Fitri; Auli, Winni Nur; Aziz, Syaikhul; Zaqia, Lulu; Liswatini, Putri
Journal of Science and Applicative Technology Vol. 9 No. 2 (2025): Journal of Science and Applicative Technology December Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v9i2.2154

Abstract

Ascorbic acid and its derivatives with nicotinamide are often used as skin lightening, anti-aging, and anti-pigmentation agents. Combining these two active substances may increase the risk of instability due to degradation. This research was conducted to determine the effect of nicotinamide concentration on the degradation process of ascorbic acid and its derivatives, and to determine the degradation products formed using liquid chromatography-mass spectrometry (LC-MS). The study was conducted by combining nicotinamide concentrations ranging from 5 to 15 micrograms per milliliter with incubation times of 1, 2, 3, and 24 hours to react with ascorbic acid and its derivatives. The spectral shape and maximum wavelength were analyzed using a UV-Vis spectrophotometer. Samples that showed changes in chemical structure were subsequently analyzed by LC-MS to identify degradation products. The results showed that only the combination of ascorbic acid and nicotinamide shifted the maximum wavelength and generated a new peak at 310 nm after 24 hours of incubation. Nicotinamide can accelerate the degradation process of ascorbic acid. The LC-MS analysis results show that the degradation products formed from the combination of ascorbic acid and nicotinamide samples are dehydroascorbic acid and 3-hydroxy-2-pyrone. These findings highlight the importance of incorporating stabilizing agents into cosmetic formulations containing unstable active ingredients, such as ascorbic acid, to ensure product stability during storage and use.
Co-Authors Abdul Muhyi Akbar Dana Alya Pinahayu Sakanthi Arif Azhari Azrifitria, Azrifitria Budipramana, Krisyanti Chairul . Cresentia Aurora Mizuki Damayanti Abdul Karim, Dewi Dana, Akbar Debora Silalahi Elfahmi Elfahmi, Elfahmi Evanggeulista, Arnanda Fajar Fauzi, Muh Fauziyya, Riri Firly Shalsha Billa Frangky Sangande Hamdiyah Fuola Zeri Hasibuan Hidayati, Pratiwi Al Fitri Isna Mulyani Jannah, Aryn Fatkhul Kartika Sari Ramadhani, Untia Liswatini, Putri Maulidia Rahayyu, Annisa Meiriska Maharani Surya Nugroho Mendrofa, Alexander Yoel Harazachi Muhammad F. Agustiawan Muhammad Raffi Zakaria Muhammad Yogi Saputra Muhyi, Abdul Murni Sari Nadiah, Syaadatun Ngatinem Nur Adliani Nurnahari, Naura Rahmat Kurniawan Refsya Azanti Putri Rissyelly Rissyelly Rizki Nisfi Ramdhini Rizki Nisfi Ramdhini Salim, Prayoga Drajat Pangestu Salsa Nabila Ahlika Ulya Sekarsari Yusuf, Mubarika Sena Maulana Shindy Martha Rahayu Siringoringo, Vinta Marito Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Tantri Liris Nareswari Welldone Sartika Winda Septiani Winda Septiani Winni Nur Auli Yodha, Agung Wibawa Mahatva Zaqia, Lulu