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All Journal Jurnal Kedokteran Syiah Kuala Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Majalah Obstetri dan Ginekologi Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Jurnal ABM Mengabdi Jurnal Ilmiah Kesehatan (JIKA) Jurnal Widya Medika
ManikRetno Wahyunitisari
Departement Of Medical Microbiology, Faculty Of Medicine, Airlangga University/Dr. Soetomo General Hospital Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Bacterial and Antibiogram Profile of Urinary Tract Infection Patients in a Tertiary Hospital, Surabaya, Indonesia Mahrumi Dewi Tri Utami; Manik Retno Wahyunitisari; Nunuk Mardiana; Rebekah Juniati Setiabudi
Folia Medica Indonesiana Vol. 58 No. 3 (2022): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1180.165 KB) | DOI: 10.20473/fmi.v58i3.33186

Abstract

Highlights: Most urinary tract infections are caused by Gram-negative bacteria with E. coli being the most common bacteria. Antibiotics with the highest susceptibility for Gram-negative bacteria were ertapenem, meropenem, amikacin, and imipenem. Antibiotics with the highest susceptibility for Gram-positive bacteria mainly were susceptible to chloramphenicol,streptomycin, vancomycin, rifampin, tigecycline,  teicoplanin, and ampicillin.   Abstract: Urinary tract infection (UTI) is one of the most common bacterial infections. Inappropriate antibiotic use for UTI treatment may lead to antibiotic resistance. This study aimed to provide an updated bacterial and antibiogram profile from urine specimens of patients diagnosed with UTI. This study was a retrospective study using urine culture and antibiotic susceptibility test results obtained from Clinical Microbiology Laboratory in a tertiary general hospital in Surabaya, Indonesia for a two-month period patients. Most aged more than and/or equal to 59 years, in both sexes. Gram-negative bacteria, particularly , was being the most between June to July 2019. There were 215 patients with significant urine culture results of 54.4% from Escherichia coli female bacteria were carbapenem antibiotics and amikacin, while teicoplanin and vancomycin were some antibiotics susceptible to gramcommon bacteria that caused UTI, followed by K. pneumoniae. Some antibiotics with the highest susceptibility to gram-negative positive bacteria. This study result indicated that there was an urge to conduct local antibiogram profile investigation due to the low susceptibilities shown in recent empirical therapy recommendations, such as trimethoprim sulfamethoxazole, fluoroquinolone, nitrofurantoin, and fosfomycin.
The role of adequate vitamin D levels in the menstrual cycle of reproductive-age women Ahila Meliana; Hana Salsabila; Bendix Samarta Witarto; Manik Retno Wahyunitisari
Majalah Obstetri & Ginekologi Vol. 30 No. 3 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V30I32022.154-160

Abstract

HIGHLIGHTS 1. This study reviews the effect of adequate levels of serum vitamin D on menstrual cycle2. Vitamin D affects the length and regularity of menstrual cycle3. Women with vitamin D insufficiency typically report irregular and prolonged menstrual periods than women with adequate vitamin D levels.   ABSTRACT Objective: This study investigated the role of adequate vitamin D levels in the menstrual cycle of reproductive-age women. Materials and Methods: We systematically searched using certain key words in PubMed and ScienceDirect for English articles, full articles, published between August 2013 - August 2022 that evaluated the effect of vitamin D levels on the menstrual cycle of women in reproductive age. The results were analyzed qualitatively. Results: Eight studies from 653 recorded articles were eligible for review. Decreased vitamin D levels can cause menstrual cycle irregularities, which are related to a decrease in the hormone estradiol, affecting the menstrual cycle. In addition, lower levels of vitamin D lead to longer menstrual cycles. Conclusion: Vitamin D is vital in the menstrual cycle because it influences the frequency and duration of menstruation.
The Frequency of Multidrug-Resistant Tuberculosis Patient who have History of Tuberculosis, HIV, and Diabetes Mellitus at Dr. Soetomo General Academic Hospital Marsha Zahrani; Rebekah J. Setiabudi; Helmia Hasan; Manik Retno Wahyunitisari
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42603

Abstract

Introduction: The main causes of MDR TB include interperson transmission and TB treatment failure. In addition to TB, HIV and diabetes mellitus may raise the risk of TB MDR. To determine the TB MDR risk factors, it's critical to understand the prevalence of TB MDR patients with TB, HIV, and diabetes mellitus histories.Methods: This study is an observational descriptive study with a retrospective design. The sample for this study was all patients from the TB and MDR-TB polyclinic at Dr. Soetomo General Academic Hospital, Surabaya, in January 2020–December 2020 who met the inclusion criteria. The data obtained were analyzed descriptively.Results: There were 72 patients who met the criteria: there were 26 patients who have a history of TB, 15 patients who only have a history of diabetes mellitus, 2 patients who only have a history of HIV, 27 patients who have a history of TB with diabetes mellitus, and 2 patients who have a history of TB with HIV.Conclusion: The data could support the theory of an association between MDR-TB with TB, HIV, and diabetes mellitus and increase the awareness of primary MDR TB cases with history of HIV and diabetes mellitus.
IN VITRO ANTIBACTERIAL ACTIVITY OF EUCALYPTUS (Melaleuca leucadendra) OIL AGAINST METHICILLIN-RESISTANT Staphylococcus aureus (MRSA) Constantia Lidwina Targanski; Wiwin Retnowati; Mohammad Fathul Qorib; Manik Retno Wahyunitisari; Wilda Mahdani
Majalah Biomorfologi Vol. 33 No. 2 (2023): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v33i2.2023.59-67

Abstract

Highlights The use of eucalyptus oil is natural and risk-free. It has a lengthy history of use as a traditional medicine in Asia, including Indonesia. It has been demonstrated that eucalyptus oil possesses antibacterial activity against MRSA, and this activity was controlled by the oil's concentration. Abstract Background: Eucalyptus (Melaleuca leucadendra) oil is used by Indonesians as an herbal medicine. Eucalyptus containing 1,8-cineol at 72.30% is expected to be used as an antibacterial.  Objective: The study aimed to assess the antibacterial activity of eucalyptus oil against Methicillin-resistant Staphylococcus aureus (MRSA) bacteria in vitro. Material and Method: The materials used were eucalyptus oil (M. leucadendra) in various concentrations with ethyl acetate as solvent. The research method used was the agar-well diffusion assay. The MRSA was suspended to 0.5 McFarland turbidity. The MRSA suspension was thoroughly swabbed onto the surface of the Mueller-Hinton agar plate. The wells were made with a diameter of 0.6 mm on Muller-Hinton agar aseptically and 100 µl of eucalyptus oil was put into the well using a micropipette and incubated for 24 hours at 37°C. The diameter of the inhibition zone was measured with a caliper. Statistical analysis using the SPSS software edition 23. Result: Eucalyptus oil solution starting from a concentration of 10% to 100% had an antibacterial response, which could be seen by the formation of a bacterial inhibition zone around the eucalyptus oil (M. leucadendra) wells. The inhibition ability of eucalyptus oil against MRSA bacteria was greatest at a concentration of 90% with an inhibition zone of 31.26 mm. It was found that the concentration of eucalyptus oil affected the diameter of the bacterial inhibition area. Conclusion: Eucalyptus oil has been shown to have antibacterial activity against MRSA and was influenced by the concentration of the oil.
Analysis of Neutrophil, Leukocyte, Lymphocyte, and NLR Cell Profiles in Patients Diagnosed with Chronic Gastritis Affected by Helicobacter pylori and Non-Helicobacter pylori Infection at Dr. Soetomo Hospital in Surabaya, Indonesia Nahdah Aulia Aziz; Manik Retno Wahyunitisari; Imam Susilo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.21260

Abstract

Helicobacter pylori (HP) is a prevalent cause of bacterial infections, particularly chronic gastritis in the human body. The diagnosis of gastritis relied on gastric biopsy examination, where inflammation is characterized by an increase in various inflammatory cells, including macrophage, neutrophil, lymphocyte, or plasma cells. Therefore, this research aimed to determine the profiles of neutrophil, leukocyte, lymphocyte, and neutrophil lymphocyte ratio (NLR) in chronic gastritis patients, distinguishing between those with Helicobacter pylori and non-Helicobacter pylori infection at Dr. Soetomo Hospital in Surabaya. This research adopted a retrospective method, using medical records for chronic gastritis patients at Dr. Soetomo Hospital between 2018 and 2022. The variables analyzed included Helicobacter pylori infections and values of neutrophil, leukocyte, lymphocyte, and NLR cells. The obtained data were subjected to analysis using descriptive statistics. The results showed that the majority of participants were females (61.9%), senior high school graduates (52.38%), and aged 45-59 (pre-elderly) (32.14%). In non-Helicobacter pylori group, the average values of neutrophil, leukocyte, lymphocyte, and NLR cells were 62.29 (SD = 12.17), 8.155 (SD = 4.02), 29.165 (SD = 12.31), and 3.68 (SD=4.865), respectively. In conclusion, females showed a propensity for chronic gastritis with Helicobacter pylori. It was observed that non-Helicobacter pylori chronic gastritis tended to have elevated neutrophil and leukocyte values. Meanwhile, Helicobacter pylori-related chronic gastritis tended to show increased lymphocyte and NLR values due to systemic inflammation. Helicobacter pylori was associated with conditions such as iron deficiency anemia, cardiovascular disease, diabetes, thyroid disease, and malnutrition.
Progress In Knowledge Of Microscopic Tuberculosis Diagnosis Laboratory Training Participants Silvia Sutandhio; Ni Made Mertaniasih; Eko Budi Koendhori; Deby Kusumaningrum; Titiek Sulistyowati; Lindawati Alimsardjono; Pepy Dwi Endraswari; Manik Retno Wahyunitisari; Rebekah Juniati Setiabudi
JURNAL WIDYA MEDIKA Vol. 5 No. 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i2.2202

Abstract

Indonesia is the second highest tuberculosis (TB)-burden country in the world. TB affects men and women in productive ages. Early and accurate diagnosis of TB is crucial in TB management because it allows prompt treatment with appropriate regimen. Sputum smear microscopy is the most common method used in resource-limited laboratories. The aim of this study is to assess whether adult learning method with student-centered approach can improve knowledge in laboratory techniques in microscopic TB diagnosis. It was a quasi experimental research with one group pretest and posttest design. Pretest was conducted before the training started. During the training, participants attended lectures, discussion sessions, and hands-on laboratory activities. After training, participants were asked to respond to posttest. There were 33 participants of this training (n=33). Paired t-test analysis showed significant difference between pretest and posttest scores (p=6.5x10-9). Variance between pretest scores was 4.00 and variance between posttest scores were 1.34. Pearson correlation coefficient was 0.45. Regardless their level of knowledge before training, participants could achieve relatively equivalent results after training. Significant difference between pre- and post-training test scores indicated that the learning method was effective and the training could improve participants knowledge in laboratory techniques in microscopic TB diagnosis.
Ence Of ESBL Bacteria In Baby Box Handle At Dr. Soetomo Hospital Manik Retno Wahyunitisari; Martono Tri Utomo; Nicholas Fernando Purnomo
JURNAL WIDYA MEDIKA Vol. 6 No. 2 (2020): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v6i2.2789

Abstract

Health Associated Infection (HAI) in neonates can increase neonatal infection risk, which is a fairly frequent cause of neonatal death. Microorganisms that are quite often found to contaminate include gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae. Gram-negative bacteria are also quite often found to have resistance to antibiotic therapy that is usually given, especially actlactam, and will increase the degree of disease to mortality, this bacterium is called ESBL. The study was conducted to determine the level of ESBL bacterial contamination in health facilities at Dr. Soetomo general hospital. Swabs are taken and biochemical tests were done to identify pathogen species. These isolates were also tested for ESBL production by the double-disc synergy test (DDST). There were 30 samples that contaminate the handle of the baby box, 2 of which (6.67%) tested positive for ESBL. With good hand hygiene, the use of disinfectants in medical devices, floors, walls, and doors, maintenance and replacement of tap water filters, and regular monitoring can reduce the number of bacterial contamination.
Antibacterial Effect of 96% Ethanol Extract of Papaya Seeds (Carica papaya L.) on the Growth of Staphylococcus aureus and Klebsiella pneumoniae causing Pneumonia Fernanda Toriq Ainur Rochman; Eko Budi Koendhori; Dewi Ratna Sari; Manik Retno Wahyunitisari; Nasicha, Arifatun
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.95-102

Abstract

Highlights Papaya seeds are a natural and traditionally used remedy in Indonesia, known for their safety and medicinal properties. The 96% ethanol extract of papaya seeds exhibits antibacterial activity against Staphylococcus aureus and Klebsiella pneumoniae.   ABSTRACT Background: Pneumonia is an infectious disease with the highest childhood mortality rate worldwide, commonly caused by Staphylococcus aureus and Klebsiella pneumoniae, which have developed resistance to antibacterial agents. Papaya seeds have traditionally been used in Indonesian medicine due to their bioactive compounds, which are expected to exhibit antibacterial properties. Objective: To analyze the antibacterial effect of 96% ethanol extract of papaya seeds against S. aureus and K. pneumoniae in vitro. Material and Method: This study employed a true experimental design with a posttest-only control group. Ethanol extracts of papaya seeds at concentrations of 10%, 30%, and 50% were tested using the well diffusion method. Erythromycin and chloramphenicol were used as positive controls, and 70% alcohol served as the negative control. Inhibition zone diameters were analyzed using SPSS version 29 with the non-parametric Kruskal-Wallis and Mann-Whitney tests. Results: The ethanol extract of papaya seeds inhibited the growth of S. aureus starting at a concentration of 10%, with the largest inhibition zone observed at 50%. Against K. pneumoniae, the extract demonstrated the lowest effective inhibitory concentration at 30%, which also produced the largest inhibition zone. However, the extract was less effective than the antibiotics used. Conclusion: The ethanol extract of papaya seeds exhibits antibacterial activity against both S. aureus and K. pneumoniae, with a more pronounced effect on S. aureus.
Co-Authors Agung Dwi Wahyu Widodo Ahila Meliana Alimsardjono, Lindawati Anindita Rehana BaiqIsti Hijriani Bendix Samarta Witarto Constantia Lidwina Targanski Deby Kusumaningrum Dewi Ratna Sari Dwiyanti Puspitasari, Dwiyanti Eko Budi Koendhori, Eko Budi Evy Ervianti Faisal Yusuf Ashari Fernanda Toriq Ainur Rochman Hana Salsabila Hasan, Helmia Ida Fitriawati Imam Susilo Ivan Sofian Wibowo Linda Astari, Linda Mahrumi Dewi Tri Utami Marani Bafianti Suwito Marsha Zahrani Martono Tri Utomo Mohammad Fathul Qorib Nahdah Aulia Aziz Nasicha, Arifatun Ni Made Mertaniasih Ni Putu Anggita Medyantari Nicholas Fernando Purnomo Nunuk Mardiana, Nunuk Pepy Dwi Endraswari, Pepy Dwi Rebekah Setiabudi, Rebekah Risky Vitria Prasetyo Rochmanti, Maftuchah Rochmanti S. Soedarsono Selvia Yuliani Dwi Ratih Sanggarwati Setio Harsono Silvia Sutandhio Sri Umijati Sulistiawati Sulistiawati Titiek Sulistyowati Tuksin Jearanaiwitayakul Umiastuti, Pirlina Utami Meilanie Putri Wilda Mahdani Wiwin Retnowati