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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Masyarakat Jurnal Kesehatan Andalas GIZI INDONESIA Journal Of Holistic Nursing Science Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) South East Asia Nursing Research Ina Kidney Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Pena Medika : Jurnal Kesehatan
Shofa Chasani
Nefrologi-Hipertensi Division, Master Program of Biomedical Science, Medical Faculty of UNDIP
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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High Ultrafiltration Increasing Intradialytic Blood Pressure on Hemodialysis Patients Armiyati, Yunie; Hadisaputro, Suharyo; Chasani, Shofa; Sujianto, Untung
South East Asia Nursing Research Vol 3, No 1 (2021)
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/seanr.3.1.2021.8-15

Abstract

The increase in blood pressure when the patient is undergoing hemodialysis is experienced by patients with intradialytic hypertension. This condition can be very dangerous for the patient, must be prevented and needs to be controlled. Prevention can be done by controlling variables that can affect intradialytic blood pressure, including ultrafiltration during hemodialysis. This study aims to analyze the relationship between ultrafiltration (ultrafiltration goal, ultrafiltration rate) and intradialytic blood pressure. This research was a descriptive-analytic study with a cross-sectional design, with 112 samples at two centres of dialysis in Semarang. Data were analyzed using the Spearman Rho. The finding obtained showed that ultrafiltration goal (UFG) and ultrafiltration rate (UFR) correlated with intradialytic blood pressure (systolic, diastolic and mean arterial pressure). The magnitude of UFG an associated with increase in intradialytic systolic (p=0,024; r=0,213), increase in intradialytic diastolic (p=0,007; r=0,252) and increase in mean arterial pressure (p=0,016; r=0,227). High UFR is associated with with increase in intradialytic systolic (p=0,037; r=0,211), increase in intradialytic diastolic (p=0,001; r=0,320) and increase in mean arterial pressure (p=0,034; r=0,200). Determination of ultrafiltration during hemodialysis must be done carefully and precisely to prevent an increase in intradialytic blood pressure.
PEMBERIAN PROBIOTIK TERHADAP PENINGKATAN KADAR KALSIUM DARAH PADA PASIEN PENYAKIT GINJAL KRONIK TERMINAL Maryusman, Taufik; Sulchan, M; Chasani, Shofa
GIZI INDONESIA Vol 41, No 1 (2018): Maret 2018
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v41i1.238

Abstract

Patients with Terminal Chronic Renal Disease (ESRD) generally have impaired metabolism of minerals such as calcium. Probiotics can increase the balance of gastrointestinal microflora. Suplementation probiotics may increase levels of calcium. The aim of this study was to analyze the effect of probiotics on the increase of calcium levels. This study used a true experiment research using a randomized pre-post test control group design involving 24 subjects divided into 2 groups at random. The treatment group was given lactobacillus probiotics  (4.0x109CFU) each day in capsul, while the control group was given standard treatment. Statistical analyzes applied paired t-test and independent t-test. Data regarding characteristics of subject were collected using a structured questionnaire. Calcium levels measured by CPO methods and It conducted before intervension and after the intervention. Calcium levels in the treatment group increased at 0.9 g / dl, or higher than in the control group 0.7 g / dl. The treatment group showed a significant increase of calcium level (p = 0.02). But, this increases did not make a significant difference between the 2 groups. Giving of probiotics increases blood calcium levels even in a small level, therefore it is beneficial to be given to patients with ESRD.ABSTRAK Penderita Penyakit Ginjal Kronik (PGK) terminal pada umumnya mengalami gangguan metabolisme mineral seperti kalsium. Probiotik mampu meningkatkan keseimbangan mikroflora saluran pencernaan. Suplementasi probiotik mampu meningkatkan kadar kalsium. Tujuan penelitian ini adalah menganalisis pengaruh pemberian probiotik terhadap kadar kalsium darah pada pasien PGK terminal. Penelitian ini merupakan penelitian true experiment dengan rancangan randomized pre-post test control group design yang melibatkan 24 subjek yang dibagi menjadi 2 kelompok secara acak. Kelompok perlakuan  diberikan probiotik lactobacillus (4.0x109CFU) per hari dalam bentuk kapsul, sedangkan kelompok kontrol diberikan pengobatan standar. Pengumpulan data penelitian meliputi karakteristik subjek yang dilakukan dengan wawancara menggunakan kuesioner. Data kalsium darah diperoleh dari hasil pemeriksaan dengan metode OCP. Analisis statistik yang dilakukan adalah uji paired t-tes dan independent t-test. Kadar kalsium pada kelompok perlakuan meningkat 0,9 g/dl, atau lebih tinggi dibandingkan pada kelompok kontrol 0,7 g/dl. Kelompok perlakuan menunjukan peningkatan kadar kalsium secara bermakna (p=0,02).  Namun kenaikan ini tidak memberikan perbedaan yang bermakna antara dua kelompok (p= 0,21) Pemberian probiotik meningkatkan kadar kalsium darah walapun tidak banyak, sehingga bermanfaat untuk diberikan kepada pasien PGK terminal.  Kata kunci: probiotik lactobacillus, kadar kalsium, PGK terminal
DIFFERENCE IN THE LEVELS OF FERRITIN, HEMOGLOBIN, AND ERYTHROCYTE COUNT OF STAGE 5 CHRONIC KIDNEY DISEASE PATIENTS AFTER ONE, THREE AND SIX MONTHS OF HEMODIALYSIS Wibowo, Subur; Chasani, Shofa; Wibowo, Joko Wahyu; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (722.769 KB)

Abstract

INTRODUCTION: 77,892 chronic kidney disease patients in Indonesia undergo hemodialysis in 2017. However, the effects of period of undergoing hemodialysis on hemoglobin level, erythrocyte count, and ferritin level are still unclear.OBJECTIVE: This research aims at examining the effects of period of undergoing hemodialysis on the levels of ferritin, hemoglobin, and erythrocyte count of stage 5 of chronic kidney disease patients.METHODS: In the analytical observational research with a cross sectional design, 30 men meet the inclusion criteria and are randomly divided into 3 groups: one month group (1M-G), three months group (3M-G), and six months group (6M-G). Each of the research objects has undergone hemodialysis for one, three and six months. The levels of ferritin, hemoglobin, and erythrocyte count are analyzed with an immunoflourescence method.RESULTS: The Post Hoc LSD analysis states that the ferritin levels of 3M-G (718±63.61) and 6M-G (947±66.22) are significantly higher than that of 1M-G (383.77), p< 0.01. The ferritin level of 6M-G is significantly higher than that of 3M-G, p<0.01. The hemoglobin levels and erythrocyte counts between 1M-G (9.45±0.84) & (3.26±0.55), 3M-G (9.10±1.22) & (3.21±0.50) and 6M-G (8.35±1.21) & (2.92±0.40) are insignificant, p>0.05.CONCLUSION: After undergoing hemodialysis for three and six months, the ferritin levels improve significantly compared to that of one month of hemodialysis, and there is no significant difference in hemoglobin levels and erythrocyte counts.
Sudden Blindness as Post-Hemodialysis Complication Experienced by Patients at The End-Stage of Kidney Disease: a Case Report Perdhana, Langgeng; Chasani, Shofa; Martiningsih, Wahju Ratna; Yekti, Murwani; Arinawati, Arinawati
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 12, No 2 (2021): December 2021
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.895 KB) | DOI: 10.30659/sainsmed.v12i2.15636

Abstract

Introduction: Hemodialysis is the most preferred Renal Replacement Therapy (RRT) options for End-Stage Kidney Disease (ESKD) patients. Although it is safe and beneficial for patients, several complications may occur during hemodialysis process. One complication that is rarely found in the hemodialysis process is visual impairment. Visual impairment or even sudden blindness occured during or within 24 hours post hemodialysis. Objective: To describe the occurring sudden blindness as a rare complication in patients undergoing hemodialysis and its etiology.Brief Case: 19 years old man with ESKD undergoing hemodialysis for 1 month with a complaint of sudden blindness in both eyes occurring <24 hours post hemodialysis.Discussion: Fast and precise efforts are needed to diagnose the etiology of blindness, so that prevention and appropriate treatment can be immediately taken. Multidisciplinary teamwork is needed to diagnose the etiology of visual impairment.Conclusion: Sudden blindness in this case may be caused by the 3rd degree hypertensive retinopathy caused by malignant hypertension and Posterior Reversible Encephalopathy Syndrome (PRES)
Purslane (Portulaca oleracea) Ethanol Extract decreases hs-CRP levels and Total Score of Renal Tubular Degeneration in Rat Model of Gentamicine-Induced Renal Damage Saptaningtyas, Ragil; Chasani, Shofa; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2020): December 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (998.233 KB) | DOI: 10.30659/sainsmed.v11i2.4092

Abstract

Introduction: Injection of intraperitoneal gentamicin at a dose of 60 mg/kg BW intra-peritoneal in rats for 7 days has been shown to trigger renal tubular degeneration and increase in high sensitivity C-reactive protein (hs-CRP) level. The use of purslane (Portulaca oleracea) to reduce hs-CRP levels and total score of renal tubular degeneration has not been reported.Objective: to determine the effect of purslane ethanol extract on hs-CRP levels and renal tubular degeneration score in gentamicin induced-renal damage in rats.Methods: This was a study using posttest only control group design. Twentyfive male Wistar rats aged 8-12 weeks, weighed 150-200 grams were allocated into 5 groups: normal (Nor-G), without treatment; negative (Neg-G), gentamicin (60 mg/kg BW), intraperitoneally; P-200; P-300 ; P-400 (gentamicin plus purslane extract at a dose of 200, 300, and 400 respectively) for 7 days. The hs-CRP was evaluated using the ELISA method. Total score of renal tubular degeneration was evaluated using modified score of Sarjadi.Results: there was a significant difference in mean hsCRP level and total score of renal tubular degeneration between groups (p <0.05). Posthoc analysis showed that hsCRP level and total score group of P-200, P-300 and P-400 were significantly lower than those of Neg-G, p <0.05. Meanwhile, the levels of hsCRP and total score of renal tubular degeneration in P-200, P-300, P-400, and Nor-G groups were not significantly different (p> 0.05).Conclusion: the administration of purslane ethanol extract at doses of 200, 300, and 400 mg/kg BW for 7 days improve hs-CRP level and total score of tubular degeneration similar to normal. 
Vitamin D Insufficiency with Elevated ADMA and hs-CRP: A Single-center Study of Chronic Kidney Disease Patients Undergoing Hemodialysis Lusito, Lusito; Lestariningsih, Lestariningsih; Partiningrum, Dwi Lestari; Chasani, Shofa; Arwanto, Arwedi; Nurani, Ayudyah; Makarim, Fadhli Rizal
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.134

Abstract

Background: Vitamin D deficiency is a common issue among patients with chronic kidney disease (CKD) due to its ability to convert vitamin D into the active form of calcitriol, which is crucial for controlling cell inflammation. Low vitamin D levels are associated with increased inflammation and higher levels of biomarkers such as c-reactive protein and asymmetric dimethylarginine as an endogenous inhibitor of nitric oxide synthase. Those two combined become a specific marker for cardiovascular diseases, which become one of the common causes of CKD mortality. Objective: This study examines the correlation between vitamin D insufficiency, elevated high-sensitivity c-reactive protein, and asymmetric dimethylarginine in CKD patients receiving hemodialysis. Methods: This study used a cross-sectional design of CKD patients receiving hemodialysis in Dr. Kariadi Central General Hospital, Semarang, Indonesia, in November 2021. Thirty-six patients were randomly enrolled after meeting inclusion and exclusion criteria. Primary outcomes of Vitamin D, hs-CRP, and ADMA were measured from patients’ blood after hemodialysis. A statistical analysis of Pearson's correlation was used for primary outcomes. Results: No significant difference was found in the patient's baseline characteristics. A significant correlation between vitamin D and ADMA has been found; however, no correlation between vitamin D and hs-CRP has been found Conclusion: Vitamin D deficiency is correlated with elevated ADMA, indicative of endothelial dysfunction.
Factors Contributing to Intradialytic Hypertension in Hemodialysis Patients Armiyati, Yunie; Hadisaputro, Suharyo; Chasani, Shofa; Sujianto, Untung
South East Asia Nursing Research Vol 3, No 2 (2021)
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/seanr.3.2.2021.73-80

Abstract

Intradialytic hypertension (IDH) is the most common complication of hemodialysis patients in Indonesia. It must be controlled, to maintain the patient's quality of life and prevent worsening conditions. Some factors affecting IDH include predialysis fluid overload characterized by excessive interdialytic weight gain (IDWG), low adherence to fluid restriction and increased ultrafiltration during haemodialysis. The study aims to identify contributing factors of IDH. A case-control design was used in this study. A purposive sampling technique was used to recruit 92 samples at two centres of dialysis in Semarang, which was divided into case group (n=46) and control group (n=46). Data were analyzed using the Chi-square test by calculating Odds Ratios (OR). The finding showed that excessive IDWG (p=0,000, OR=16.95, 95% CI:5,56-51,65), low fluid adherence (p=0,001, OR=4,41, 95% CI:1,82-10,68) and excessive ultrafiltration (p=0,000, OR = 29,52, 95% CI:9,23-94,46) showed significant result. However, the incidence of IDH was not correlated with sex, age and length of haemodialysis. A greater increase in interdialytic weight requires lower fluid and higher ultrafiltration factors must be controlled precisely because those are considered as the risk factors for the high incidence of IDH. Excessive ultrafiltration is the most dominant risk factor in the high incidence of IDH.
Faktor Risiko Penyakit Ginjal Kronik Stadium Terminal Pada Penderita Hipertensi Stadium 1-2 Ikawati, Kartika; Chasani, Shofa
Pena Medika Jurnal Kesehatan Vol 7, No 2 (2017): PENA MEDIKA JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v7i2.706

Abstract

Background : End Stage Renal Disease (ESRD) has been a health problem because the incidence to increase with high mortality. Risk faktors of ESRD of  stage 1-2 hypertention in during 5-10 years have not been studied.  Risk faktors of ESRD ware associated with behaviors and comorbidity diseases in hypertension patientsMethod : This study applied an analytical observational method with a case control study design. The study used 64 respondents as sampels , divided into; 32  as case samples and 32 as control samples with consecutive sampling. Independent variabels in this study ware behavior, history of diabetes mellitus, hyper total cholesterol and  hyper uric acid.  Data were collected by interview and medical record. These data were subject to analyses using univariat, bivariate, and multivariate testsResults : Risk faktors of ESRD of stage 1-2 hypertention in during 5-10 as  followings: type-2 diabetes mellitus (OR=39 ; 95% CI=5.435-73.531; P=0.000), not regularly taking anti-hypertensive drugs  (OR=14; 95%CI=2.117-92.170; P=0.006) and  hyper total cholesterol (OR=13; 95% CI=2.136-81.025; P=0.005).  .Conclusion : Risk factors for ESRD in hypertension patients were; type-2 diabetes mellitus, not regularly taking anti-hypertensive drugs and hyper total cholesterol.  To prevent the progression of hypertension into ESRD, strived not to suffered type 2 diabetes mellitus, taking anti-hypertensive medication regulary and control of  total cholesterol   Keywords :  Risk Faktors, End Stage Renal Disease, Hypertension
Depresi sebagai Prediksi Kematian dalam 1 Tahun pada Pasien Hemodialisis Perdhana, Langgeng; Chasani, Shofa; Nuraini, Siti
Andalas Journal of Health Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1808

Abstract

Depression is a mental disorder that is often found in hemodialysis patients. Depression had bad effects on patients. The study that determines the relationship between depression and all-cause mortality risk in hemodialysis patients is debatable. Objectives: To determine the role of depression as a predictor factor of all-cause mortality within one year in hemodialysis patients. Methods: This cohort study was conducted from February to August 2020 at the hemodialysis unit of Roemani Muhammadiyah Hospital, Semarang. The inclusion criteria were undergoing hemodialysis ≥3 months, hemodialysis frequency twice a week, being willing to participate in this study, being able to communicate well, and there was no history of previous mental disorders. Meanwhile, those whose data were incomplete, transferred to another hemodialysis unit, HBSAg +, and had other stressors unrelated to hemodialysis or Chronic Kidney Disease (CKD) were excluded from this study. Depression was assessed using the Beck Depression Inventory-II questionnaire. The collected data was then analyzed using Kaplan Meier and Cox regression. Results: From 82 respondents, 20 (24,4%) respondents categorized into depression group and 62 (75,6%) respondents into non depression group. Cox Regression analysis showed that depression plays a role as a predictor factor of all-cause mortality within one year in hemodialysis patients (p value=0,007, and Hazard ratio=3,587). Conclusion: Depression plays a role as a predictor factor of all causes of mortality within one year in hemodialysis patients.Keywords: depression, hemodialysis, mortality, end-stage renal disease
Association Between Intradialysis Hypotension and Interdialytic Weight Gain in Deceased Hemodialysis Patients at Banyumas Regional General Hospital Poernomo, Gigih Rahmandanu; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa; Alatas, Haidar
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2025): Volume 2 No. 1, April 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i1.178

Abstract

Background: Intradialytic hypotension (IDH) occurs in 5-40 percent of chronic kidney disease (CKD) with hemodialysis patients, it is associated with increased cardiovascular events and mortality. High Interdialytic Weight Gain (IDWG) requires higher ultrafiltration, increases the incidence of IDH, associated with a worse prognosis, patients with a history of diabetes are at higher risk. Objective: This study aimed to assess the association between IDWG and the occurrence of IDH in deceased patients undergoing hemodialysis, with a particular focus on the differences between diabetic and non-diabetic patients Methods: A retrospective study was conducted for one year at Banyumas Regional General Hospital, involving deceased hemodialysis patients. IDWG was calculated as the average of the last three hemodialysis sessions. Patients were further categorized based on their history of diabetes. Results: Among 37 deceased hemodialysis patients, 56.8% experienced IDH, including 50% of those with diabetes mellitus. IDWG was normally distributed (p = 0.283) and showed a weak but statistically significant correlation with IDH (r = 0.333, p = 0.044). Logistic regression indicated that each 1% increase in IDWG was associated with an 8% increase in the predicted probability of IDH. Diabetic status did not significantly modify this association (p = 0.772). Conclusion: Higher IDWG was associated with increased incidence of IDH in deceased hemodialysis patients, independent of diabetic status.
Co-Authors - Anggorowati Alatas, Haidar Ari Yulistianingsih Arinawati, Arinawati Arwanto, Arwedi Dwi Lestari Partiningrum Eka Sakti Wahyuningtyas Himawan, Fatchurozak Ikawati, Kartika Joko Wahyu Wibowo Lestariningsih Lestariningsih Lusito, Lusito Makarim, Fadhli Rizal Mohammad Sulchan Nurani, Ayudyah Oktaviarini, Eka Perdhana, Langgeng Poernomo, Gigih Rahmandanu Ragil Saptaningtyas, Ragil Rosiah, Rosiah Rudy Handoyo, Rudy Siti Nuraini Suharyo Hadisaputro Sulchan, M Sulchan, M Tanti Ajoe Kesoema, Tanti Ajoe Taufik Maryusman Taufiqurrachman Nasihun Untung Sujianto Wahju Ratna Martiningsih Wahyu Hidayati wibowo, subur Winarto, Dedi Yekti, Murwani Yunie Armiyati