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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kesehatan Masyarakat Jurnal Kesehatan Andalas GIZI INDONESIA Journal Of Holistic Nursing Science Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) South East Asia Nursing Research Ina Kidney Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Pena Medika : Jurnal Kesehatan
Shofa Chasani
Nefrologi-Hipertensi Division, Master Program of Biomedical Science, Medical Faculty of UNDIP
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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The Effect of Hemodialysis Adequacy on Inflammatory Status in Stage 5 Chronic Kidney Disease Patients Winarto, Dedi; Partiningrum, Dwi Lestari; Lestariningsih, Lestariningsih; Nurani, Ayudyah; Arwanto, Arwedi; Chasani, Shofa
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2025): Volume 2 No. 2, August 2025
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v2i2.183

Abstract

Background: Chronic Kidney Disease (CKD) is a critical global health issue, particularly Stage 5 CKD, where kidney function is severely impaired. Hemodialysis, essential for managing such patients, aims to remove waste and excess fluids. Chronic inflammation, common among CKD5-HD patients, heightens cardiovascular risks and worsens quality of life. Hemodialysis adequacy, measured by the Kt/V ratio, plays a vital role in outcomes, yet its relationship with inflammatory markers, such as Hs-CRP, albumin, and TIBC, remains unclear. Objective: This study aimed to evaluate the relationship between hemodialysis adequacy, as reflected by Kt/V values, and inflammatory markers such as c-reactive protein (CRP), albumin, and total iron binding capacity (TIBC) in CKD stage 5 patients undergoing hemodialysis, providing insights into optimizing dialysis protocols to mitigate inflammation. Methods: A cross-sectional study of 45 CKD5-HD patients assessed Kt/V values and inflammatory markers (Hs-CRP, albumin, TIBC). Data were analyzed using Shapiro-Wilk, Independent t-tests, or Mann-Whitney U tests based on data distribution. Results: The mean Kt/V value was 1.31 ± 0.21. Lower Kt/V values were significantly associated with elevated Hs-CRP levels (p = 0.018). No significant differences in Kt/V values were observed concerning albumin (p = 0.546) or TIBC (p = 0.523). Correlations between Hs-CRP and albumin or TIBC were non-significant (p = 1.000). Conclusion: Adequate hemodialysis, reflected in optimal Kt/V values, is crucial for reducing systemic inflammation marked by Hs-CRP. Albumin and TIBC levels showed no significant association, underscoring the multifactorial nature of inflammation in CKD5 patients.
Co-Authors - Anggorowati Alatas, Haidar Ari Yulistianingsih Arinawati, Arinawati Arwanto, Arwedi Dwi Lestari Partiningrum Eka Sakti Wahyuningtyas Himawan, Fatchurozak Joko Wahyu Wibowo Kartika Ikawati Lestariningsih Lestariningsih Lusito, Lusito Makarim, Fadhli Rizal Mohammad Sulchan Nurani, Ayudyah Oktaviarini, Eka Perdhana, Langgeng Poernomo, Gigih Rahmandanu Ragil Saptaningtyas, Ragil Rosiah, Rosiah Rudy Handoyo, Rudy Siti Nuraini Suharyo Hadisaputro Sulchan, M Sulchan, M Tanti Ajoe Kesoema, Tanti Ajoe Taufik Maryusman Taufiqurrachman Nasihun Untung Sujianto Wahju Ratna Martiningsih Wahyu Hidayati wibowo, subur Winarto, Dedi Yekti, Murwani Yunie Armiyati