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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia Biomedika Indonesian Journal of Cancer MNJ (Malang Neurology Journal) Smart Medical Journal Indonesian Journal of Medicine SEMAR JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Magna Neurologica Plexus Medical Journal
Rivan Danuaji
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Association between vaspin rs2236242 gene polymorphism and atherosclerosis in ischemic stroke patients with diabetes mellitus in the Indonesian population Danuaji, Rivan; Suroto; Purwanto, Bambang; Indarto, Dono; Muhammad, Faizal; Mirawati, Diah Kurnia; Widyaningsih, Vitri; Soetrisno; Subandi; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Ristinawati, Ira; Tejomukti, Teddy; Tedjo, Raden Andi Ario
Medical Journal of Indonesia Vol. 33 No. 4 (2024): December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247566

Abstract

BACKGROUND Stroke is the third leading cause of morbidity and second in mortality worldwide. Diabetes mellitus (DM) is a risk factor for stroke. Vaspin and single nucleotide polymorphism (SNP) rs2236242 involved DM pathogenesis. This study aimed to explore the correlation between SNP rs2236242, serum vaspin levels, and atherosclerosis in patients with ischemic stroke and DM. METHODS This study was conducted in Dr. Moewardi Hospital from 2022 to 2023. The case group included patients with ischemic stroke and DM, while the controls were those with ischemic stroke only. Tetra-primer amplification refractory mutation system-polymerase chain reaction was used to determine the genotypes. RESULTS There were 31 cases and 33 control. SNP rs2236242 showed that odds ratio (OR) (95% confidence interval [CI]) for AA-TT was 0.273 (0.241–0.305) and for TA-TT was 0.315 (0.298–0.341). The OR (95% CI) for allele A to T was 0.789 (0.373−1.669). The mean (standard deviation) serum vaspin level in the case group compared to the control was 1,570 (2,108) ng/ml versus 1,630 (1,428) ng/ml (p = 0.064). Higher vaspin levels were found in T allele of the TT (1,523 [2,269] ng/ml, p = 0.021) and TA (1,760 [1,349] ng/ml, p = 0.004) genotype groups than the A allele of the AA genotype group (0.914 [0.329] ng/ml). CONCLUSIONS Vaspin gene polymorphism AA genotype or A allele significantly reduces vaspin levels in patients with ischemic stroke with DM.
Convalescent Plasma Treatment for Moderate to Critical Ill COVID-19 Patients – A Safe but Futile Treatment: A Non-Randomized Comparative Study Aphridasari, Jatu; Soetjahjo, Bintang; Joko, Agus; Sidharta, Rina; Harsini, Harsini; Arifin, Arifin; Permana, Septian Adi; Saraswati, Kunti; Adhiputri, Artrien; Marwanta, Sri; Laqif, Abdurahman; Danuaji, Rivan
Indonesian Journal of Medicine Vol. 8 No. 4 (2023)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.4.620

Abstract

Background: In a number of cases of viral infection, convalescent plasma therapy has been effective. Reportedly, the use of convalescent plasma as a therapy for COVID-19 patients with severe and life-threatening disorders is beneficial at this time. This study aims to assess the effectiveness and safety of convalescent plasma transfusions in hospitalized COVID-19 patients. Subjects and Method: This was a clinical trial employing a non-randomized comparative study. A historical control group (21 samples) and convalescent plasma transfusions (21 samples) was selected consecutively from hospitalized COVID-19 patients between May 6th, 2020, and May 6th, 2021 at Dr. Moewardi General Hospital. We assessed and quantified viral clearance in the laboratory. Statistical analysis is performed in SPSS version 20.0. Results: Plasma was taken from fifteen convalescent donors. In the plasma convalescent treatment group, there was a statistically significant difference between outcome and severity degree (p = 0.005). In addition, there was a substantial discrepancy between the result group and the control group (p 0.005). Significant differences in post-treatment NLR between the control and treatment groups (p 0.005). In addition, there were statistically significant differences between the control and treatment groups in post-treatment hsCRP levels (p 0.005). In addition, there were statistically significant differences (p 0.005) between all groups' inflammatory markers and outcomes. Conclusion: Using convalescent plasma to treat patients with COVID-19 is a rather safe practice. Our analysis demonstrated that the administration of convalescent plasma did not enhance survival or clinical outcomes for COVID-19 patients with moderate to severe disease. Keywords: COVID-19, convalescent therapy, critical ill
Combination of stem cell and repetitive transcranial magnetic stimulation in acute ischaemic stroke as a promising treatment: A case report Danuaji, Rivan; Hambarsari, Yetty; Hamidi, Baarid Luqman; Hutabarat, Ervina Arta Jayanti; Tedjo, Raden Andi Ario; Fairuzya, Azmi Farah; Savitri, Martha Oktavia Dewi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art15

Abstract

Stroke is a major contributor to long-term disability and its incidence continues to rise annually. This case report aimed to explore the promising benefits of combining stem cell therapy with repetitive transcranial magnetic stimulation (rTMS) in managing acute ischaemic stroke patients. A 62-year-old male presented with left-sided hemiparesis and hemineglect, as well as a cognitive disturbance in the attention domain. His medical history included uncontrolled hypertension over decades and diabetes mellitus for five years. A non-contrast head computed tomography (CT) scan revealed infarction in the right middle cerebral artery (MCA), with an initial National Institutes of Health Stroke Scale (NIHSS) of 13 upon admission to the Emergency Room. The infection and tumour markers were conducted to confirm no contraindication in this patient receiving stem cell therapy. Following the acute phase, the patient underwent a comprehensive treatment regimen involving both stem cell therapy and serial rTMS. Clinical assessments included NIHSS, Barthel Index, and Fugl-Meyer Assesement to evaluate neurological deficits. Additionally, the Montreal Cognitive Assessment-Indonesian version (MoCA-INA) assessment, electroencephalography examination and motor threshold were conducted. The results of this case report revealed noteworthy improvements in NIHSS, motoric strength, and cognitive function post-treatment. In this case report, improvement in clinical outcomes was obtained in the form of motor strength and higher cortical function. Stem cell therapy combined with rTMS has good potential in treating various neuroregenerative and rehabilitative aspects in ischaemic stroke patients.
Cell Based Treatment for Spinocerebellar Ataxia: A Clinical Case Report Damar Dyah Mentari; Rivan Danuaji
Magna Neurologica Vol. 4 No. 1 (2026): January
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v4i1.2412

Abstract

Background: Spinocerebellar ataxia (SCA) is a dominant and monogenic central nervous system disorder, characterized by progressive motor disorders affecting coordination, balance, speech, and ADL. The prevalence is 2.7 out of 100,000 people. Currently, cell-based therapy is being developed for clinical improvement in SCA. Case: A 48-year-old woman with weakness in both legs and arms, difficulty walking, dysmetria, and dysarthria since 2015. Examination of SARA scoring is severe ataxia, EMG showed polyradiculopathy, muscle denervation, and suspicion of posterior ramus lesions; complete blood laboratory and tumor markers were routine. MRI brain contrast and whole spine contrast radiology imaging were also performed. Clinical improvement was achieved in 2016 following stem cell injection in Thailand (dose and type of cells unknown). However, clinical worsening occurred from 2020 to 2024. The patient received Umbilical Cord Mesenchymal Stem Cells (MSC) in October 2024, administered intrathecally at a dose of 20 million cells. Discussion: The first injection showed significant clinical improvement. The second injection showed no clinical improvement, but no worsening of symptoms was found. The difference in results may be due to variations in the route of administration, cell type, cell quality, and the dose administered. Conclusion: The administration of umbilical cord mesenchymal stem cells (UC-MSCs) in SCA is considered safe, with minimal complications, and can suppress disease progression, although it does not produce clinical improvement.
Hubungan Antara Tipe Sepeda Motor dengan Nyeri Punggung Bawah di Wilayah Surakarta dan Sekitarnya Rakha Zidane Muhammad; Rivan Danuaji; Yetty Hambarsari; Rieva Ermawan
Plexus Medical Journal Vol. 4 No. 6 (2025): Desember
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v4i6.2365

Abstract

Latar Belakang: Penggunaan sepeda motor sebagai moda transportasi memiliki banyak kelebihan, seperti fleksibel untuk jarak dekat maupun jauh, praktis dan mudah dibawa untuk sehari-hari, serta perawatan yang relatif mudah dan terjangkau. Namun, penggunaan sepeda motor sebagai moda transportasi memiliki resiko menimbulkan LBP. Dilansir dari studi di tahun 2023, ditemukan 43,8% dari pengendara motor yang berpartisipasi di studi tersebut mengidap low back pain. Ini dipengaruhi beberapa faktor resiko seperti postur tubuh, usia, indeks massa tubuh, durasi, dan rute berkendara. Penelitian bertujuan untuk menganalisa hubungan tipe sepeda motor dengan nyeri punggung bawah. Metode: Bentuk penelitian ini merupakan observasional analitik dengan menggunakan desain studi belah lintang (cross-sectional). Penelitian dilakukan di wilayah Surakarta dengan Google Form yang berisi pertanyaan mengenai data individu dan kuesioner terkait LBP. Hasil: Data dari penelitian menunjukkan pengaruh faktor individu dari pengendara motor terhadap keluhan LBP. Pengaruh faktor individu berdasarkan signifikansi adalah sebagai berikut: jenis kelamin, usia, indeks massa tubuh, rute berkendara, durasi berkendara, waktu istirahat ketika berkendara, dan postur berkendara.  
Intracranial and Extracranial Vertebrobasilar Artery Stenosis Patient Profile in Dr. Moewardi General Hospital Subandi, Subandi; Suroto, Suroto; Mirawati, Diah Kurnia; Danuaji, Rivan; Budianto, Pepi; Hambarsari, Yetty; Hamidi, Baarid Luqman; Prabaningtyas, Hanindia Riani; Hutabarat, Ervina Arta Jayanti; Tejomukti, Teddy; Ristinawati, Ira; Tedjo, Raden Andi Ario; Pretikasari, Zefania Yonisa; Hafizhan, Muhammad; Putra, Stefanus Erdana
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.71299

Abstract

Introduction: Vertebrobasilar artery stenosis can be extracranial or intracranial, and accounts for up to 20% of posterior circulation ischemic strokes. The gold standard for diagnosing is Digital Subtraction Angiography (DSA), an invasive diagnostic method by injecting a contrast agent into the blood vessels leading to the brain through a catheter. This study aims to determine the profile of patients with intracranial and extracranial vertebrobasilar artery stenosis who underwent DSA procedures.Methods: This descriptive research was conducted in RSUD Dr. Moewardi in patients who underwent DSA procedures for the period January 2020 to March 2022 and found vertebrobasilar artery stenosis. The study samples were grouped based on the location of the stenosis; intracranial and extracranial. The data collected included age, gender, symptoms, risk factors, degree of stenosis, and angiographic findings.Results: Of 42 subjects, 33 (78.6%) patients were male. There are 23 (54.8%) patients with intracranial vertebrobasilar stenosis and 19 (45.2%) patients in extracranial. The main symptoms included hemiparesis, vertigo, hemiesthesia, loss of consiciousness, aphasia, dysartria, and dysphagia. The risk factors were 36 (85.7%) patients with hypertension, 18 (42.9%) patients with diabetes mellitus, 18 (42.9%) patients with a history of smoking, and 13 (31%) patients with hyperlipidemia. A total of 8 patients underwent stenting/angioplasty.Conclusion: The prevalence of vertebrobasilar artery stenosis increases with age, most commonly occurring at the age of 50-59 years..The most common risk factor for vertebrobasilar artery stenosis is hypertension. Management recommendations include a combination of antiplatelet and endovascular therapy.
Pelatihan Pengisian Mini Mental State Examination (MMSE) dan Eight-item Informant Interview to Differentiate Aging and Dementia (AD8) untuk Deteksi Dini Demensia Alzheimer bagi Tenaga Kesehatan di Fasilitas Kesehatan Tingkat Pertama Ristinawati, Ira; Mirawati, Diah Kurnia; Subandi, Subandi; Danuaji, Rivan; Budianto, Pepi; Prabaningtyas, Hanindia Riani; Tedjo, Raden Andi Ario; Putra, Stefanus Erdana; Hafizhan, Muhammad
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 11, No 2 (2022): November
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v11i2.66400

Abstract

Kegiatan ini bertujuan untuk  untuk meningkatkan pengetahuan dan kesadaran para tenaga kesehatan di fasilitas kesehatan tingkat pertama (FKTP) tentang pentingnya cara pengisian kedua instrumen tersebut dalam rangka deteksi dini demensia Alzheimer. Kegiatan ini juga bertujuan mengarahkan para tenaga kesehatan di FKTP untuk melakukan skrining pada pasien yang memiliki faktor risiko mengalami demensia Alzheimer sehingga tatalaksana dini yang lebih baik dapat diterapkan pada penderita demensia Alzheimer yang tentunya dapat meningkatkan kualitas hidup pasien tersebut. Target yang dicapai adalah peningkatan pemahaman dan informasi terkait cara pengisian MMSE dan AD8 dan manfaat skrining demensia Alzheimer. Metode pelaksanaan kegiatan pemberdayaan dan pengabdian masyarakat pada mitra berupa pemetaan demografi tenaga kesehatan FKTP potensial yang dilanjutkan dengan koordinasi dan kolaborasi dengan bagian Diklit RSUD Dr. Moewardi Surakarta untuk promosi dan pelaksanaan pelatihan daring. Selanjutnya, peneliti melakukan pelatihan dengan cara menjelaskan cara pengisian MMSE dan AD8 serta manfaat skrining demensia Alzheimer, simulasi interaktif cara pengisian MMSE dan AD8 dengan probandus, diskusi dan tanya jawab, serta evaluasi. Hasil pengabdian ini menunjukkan bahwa para tenaga kesehatan memiliki pemahaman yang meningkat dibandingkan sebelum pelatihan tentang cara dan manfaat pengisian MMSE dan AD8 dalam skrining demensia Alzheimer, sehingga meningkatkan kesadaran para tenaga kesehatan di FKTP akan dampak buruk peningkatan kejadian demensia Alzheimer yang dapat timbul akibat keterlambatan diagnosis. Kata kunci: demensia Alzheimer; pelatihan; tenaga kesehatan; MMSE; AD8
Efektifitas Penyuluhan Epilepsi Terhadap Tingkat Pengetahuan Kader PMR SMA/SMK Surakarta Tentang Penyakit Epilepsi dan Penanganan Kedaruratan pada Kasus Kejang Mirawati, Diah Kurnia; Budianto, Pepi; Prabaningtyas, Hanindia Riani; Subandi, Subandi; Danuaji, Rivan; Ristinawati, Ira; Ario Tedjo, Raden Andi; Wijnaputri, Ginong Pratidina; Hapsari, Dhiandra Dwi
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 14, No 1 (2025): Mei
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v14i1.94925

Abstract

 Epilepsi merupakan salah satu penyakit saraf yang menjadi permasalahan kesehatan masyarakat global. Prevalensi epilepsi di Indoesia berdasarkan data dari Departemen Kesehatan tahun 2018 sebesar 1.8 juta. Insidensi epilepsi berkisar 50.4 per 100.000 populasi pertahun dengan 80% pasien epilepsi di dunia terjadi di negara berkembang. Penderita epilepsi sering mendapatkan stigma negatif di masyarakat. Pentingnya penyuluhan mengenai informasi terkait epilepsi pada masyarakat khususnya pada kader PMR diharapkan dapat memberikan informasi secara lebih lengkap terkait epilepsi sekaligus sebagai pemutus stigma. Penelitian ini dibuat untuk mengetahui efektivitas penyuluhan epilepsi terhadap tingkat pengetahuan kader PMR SMA/SMK Surakarta mengenai penyakit epilepsi dan penanganan kedaruratan pada kasus kejang. Penyelenggaraan penyuluhan diikuti oleh 159 responden yang berasal dari 70 SMA/SMK se-karesidenan Surakarta dengan masing-masing mengirimkan minimal 2 perwakilan PMR. Sebelum dan sesudah penyuluhan dilakukan evaluasi terkait pengetahuan peserta mengenai epilepsi melalui pretest dan posttest. Data hasil evaluasi menunjukkan adanya perbaikan pengetahuan peserta dari skor rata rata awal  74.12 menjadi 82.5. Kata kunci : epilepsi, penyuluhan, anggota PMR 
Efektifitas Promosi Kesehatan Menggunakan Video Senam Rehabilitasi Vestibuler untuk Mengurangi Keluhan Vertigo di Masa Pandemik Mirawati, Diah Kurnia; Tedjo, Raden Andi Ario; Budianto, Pepi; Prabaningtyas, Hanindia Riani; Ristinawati, Ira; Subandi, Subandi; Danuaji, Rivan; Hafizhan, Muhammad; Putra, Stefanus Erdana
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 12, No 2 (2023): November
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v12i2.68328

Abstract

Vertigo merupakan sensasi gerakan atau rasa gerak dari tubuh seperti sensasi berputar namun tanpa adanya sensasi berputar yang sebenarnya. Vertigo paling sering disebabkan oleh disfungsi pada sistem vestibular dari lesi perifer maupun sentral. pada masa pandemi COVID-19 sebagian besar pasien vertigo mengalami kesulitan untuk rutin memeriksakan diri di rumah sakit. Oleh karena itu, dicari alternatif berupa perawatan non farmakologis agar pasien bisa tetap mengontrol keluhan penyakitnya di masa pandemi ini. Senam rehabilitasi vestibular melatih otak melalui petunjuk visual dan proprioseptif alternatif untuk menjaga keseimbangan. Penelitian ini dibuat untuk mengetahui efektifitas promosi kesehatan menggunakan video senam rehabilitasi vestibuler untuk mengurangi keluhan vertigo. Penyelenggaran penyuluhan pada anggota posyandu lansia ANTHURIUM, Kelurahan Tegalrejo yang diikuti sebanyak 47 orang. Sebelum dan sesudah penyuluhan dilakukan evaluasi terkait pengetahuan peserta mengenai vertigo melalui pretest dan posttest. Data hasil evaluasi menunjukkan adanya perbaikan pengetahuan peserta dari skor rata rata awal 62.4 menjadi 83.7.
Efektivitas Promosi Kesehatan Menggunakan Leaflet Nyeri Punggung Bawah untuk Mengurangi Keluhan Nyeri Punggung di Masa Pandemik Mirawati, Diah Kurnia; Prabaningtyas, Hanindia Riani; Budianto, Pepi; Subandi, Subandi; Danuaji, Rivan; Hamidi, Baarid Luqman
SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Vol 11, No 2 (2022): November
Publisher : LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/semar.v11i2.56217

Abstract

Nyeri punggung  bawah  (NPB) adalah  suatu keadaan  tidak  nyaman  atau  rasa  nyeri  yang  akut  pada  di  daerah  ruas lumbalis  kelima  dan  sakralis pertama (L5-S1). Kebijakan social distancing pada masa pandemi COVID-19 diberlakukan untuk menurunkan angka infeksi COVID-19, namun hal ini memunculkan masalah baru seperti nyeri musculoskeletal yang terjadi karena kurangnya aktivitas fisik individu. Pandemi COVID-19 juga secara signifikan mengurangi akses pasien untuk mendapatkan pengobatan di fasilitas kesehatan untuk mengatasi nyeri punggung yang dialami. Hal ini mendorong peneliti untuk mengembangkan media edukasi untuk tatalaksana mandiri untuk pasien dengan NPB. Pada pengabdian masyarakat ini, peneliti menyusun materi edukasi mengenai rehabilitasi NPB yang dapat dilakukan di rumah. Kami mengukur skala nyeri dan kualitas hidup pasien sebelum dan sesudah edukasi. Skala nyeri pasien diukur dengan Numeric Rating Scale (NRS), sedangkan kualitas hidup pasien dinilai dengan The World Health Organization Quality of Life – BREF (WHOQOL-BREF). Uji T-test dependen menunjukkan terdapat penurunan intensitas nyeri (p=0.000) dan perbaikan kualitas hidup peserta (p=0.000) setelah edukasi. Kata kunci: nyeri punggung bawah; pengabdian masyarakat; pendidikan
Co-Authors Adhiputri, Artrien Annisa Susilowati Apriyanto, Arif Arifin Arifin Ario Tedjo, Raden Andi Bambang Purwanto Bhisma Murti Budianto, Pepi Damar Dyah Mentari Damayanti, Elok Desyandri Desyandri Dewi, Endang Kusuma Dhiandra Dwi Hapsari Dhoni Akbar Ghozali Diah Kurnia Mirawati Dono Indarto Fairuzya, Azmi Farah Ginong Pratidina Wijnaputri Ginting, Suska Lara Hafizhan, Muhammad Hambarsari, Yetty Hamidi, Baarid Lukman Hamidi, Baarid Luqman Hapsari, Maria Yosita Ayu Hutabarat, Ervina Arta Jayanti Immanuel Billy Brilliandi Jatu Aphridasari Joko, Agus Laqif, Abdurahman Martha Oktavia Dewi Savitri Marwanta, Sri Mochammad Imron Awalludin Muhammad Agus Muljanto Muhammad, Faizal Novian Anindito Santosa Permana, Septian Adi Prabaningtyas, Hanindia Riani Prabaningtyas, Hanindya Prabaningtyas, Hanindya Riani Pretikasari, Zefania Yonisa Rakha Zidane Muhammad Rakhma, Titian Rieva Ermawan Ristinawati, Ira Saraswati, Kunti Sidharta, Rina Soetjahjo, Bintang Soetrisno Sri Mulatsih Sri Sutarni Stefanus Erdana Putra Subandi Subandi Sudarman, Befrie Mahaztra Sulistyani Sulistyani SUROTO Suroto Suroto Susilo, Wahyu Agung Tedjo, Raden Andi Ario Tejomukti, Teddy Vitri Widyaningsih Widhianingsih, Nella Lusti Yetty Hambarsari