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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication MNJ (Malang Neurology Journal) Journal of Medicine and Health Journal of Indonesian Dental Association Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran Jurnal Neuroanestesi Indonesia OKTAL : Jurnal Ilmu Komputer dan Sains Buletin Ilmiah Ilmu Komputer dan Multimedia (BIIKMA) Neurona Journal of Medicine and Health

Lisda Amalia

Department Of Neurology, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung

Author-ID : 2503958

Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Peran Ferritin pada Stroke Iskemik Akut Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 10, No 2 (2021)
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Stroke merupakan defisit neurologis yang terjadi karena jejas fokal akut pada sistem saraf pusat yang semata-mata terjadi karena gangguan vaskuler, termasuk infark serebri maupun perdarahan. Ferritin adalah protein intraselular dan ekstraselular penyimpan zat besi yang penting bagi homeostasis besi dalam tubuh. Ferritin diekspresikan di mikroglia dan makrofag, namun ada juga di dalam neuron. Pada saat terjadi kerusakan sel akibat stroke iskemik, ferritin akan keluar dari sel dan masuk ke dalam serum. Keadaan hipoksia-iskemia pada stroke menginduksi ekspresi dari ferritin pada oligodendrosit dan mikroglia. Saat terjadi stres oksidatif, pembentukan ferritin akan meningkat. Fungsi ferritin pada saat stres oksidatif terjadi, masih kontroversial. Ferritin dalam kondisi tersebut dapat berperan sebagai pembersih (scavenger) dan sebagai donor untuk ion besi bebas. Pasien stroke iskemik dengan lesi yang lebih besar dan defisit neurologis yang lebih berat menunjukkan peningkatan kadar serum ferritin yang lebih tinggi dan kecenderungan terjadinya komplikasi trasformasi perdarahan akan semakin tinggi pula.Role Of Ferritin in Acute Ischemic Stroke: A Literature ReviewAbstractStroke is a neurological deficit that occurs due to acute focal injury to the central nervous system that occurs solely due to vascular disorders, including cerebral infarction or bleeding. Ferritin is an intracellular and extracellular iron storage protein which is essential for iron homeostasis in the body. Ferritin is expressed in microglia and macrophages, and also in neurons. If there is cell damage due to ischemic stroke, ferritin will leave the cells and enter the serum. The hypoxia-ischemic state in stroke induces the expression of ferritin in oligodendrocytes and microglia. When there is oxidative stress, ferritin formation will increase. The function of ferritin in times of oxidative stress is still controversial. Ferritin in this condition can act as a scavenger and as a donor for free iron ions. Ischemic stroke patients with larger lesions and more severe neurological deficits showed higher serum ferritin levels and a higher likelihood of complications of bleeding transformation.

Perbedaan Nilai The Clinic GBS Severity Evaluation Scale (CGSES) dan Skala Disabilitas Sindroma Guillain-Barre (SDSGB) pada Pasien Sindroma Guillian Barre dengan dan tanpa Imunoterapi Sidabutar, Berliana; Ganiem, Ahmad Rizal; Lailiyya, Nushrotul; Kurniani, Nani; Amalia, Lisda; Sobaryati, Sobaryati
Jurnal Neuroanestesi Indonesia Vol 10, No 2 (2021)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Latar Belakang dan Tujuan: The Clinical GBS Severity Evaluation Scale (CGSES) dikembangkan untuk penentuan imunoterapi pasien Sindroma Guillian Barre (SGB) secara lebih obyektif. Skala Disabilitas SGB (SDSGB) menggambarkan tingkat keparahan SGB dan dapat digunakan menilai efektifitas pemberian imunoterapi. Tujuan penelitian untuk mengetahui perbedaan penilaian CGSES dan SDSGB pasien SGB dengan dan tanpa imunoterapi dan membandingkan kesesuaian keputusan subyektif dengan CGSES. Subjek dan Metode: Penelitian observasional analitik potong lintang komparatif secara retrospektif pada pasien rawat SGB periode Januari 2015 Maret 2020 di RSUP Dr Hasan Sadikin Bandung. Hasil: Terdapat 92 subjek (35 dengan dan 57 tanpa imunoterapi). Rerata usia 41,5 tahun, dengan pria:wanita (57,6%:42,4%). Tidak didapatkan perbedaan demografi dan pemeriksaan fisik kedua kelompok, kecuali paresis saraf kranial (62,9% vs. 33,3%; p=0,006). Terdapat perbedaan rerata lama perawatan dengan dan tanpa imunoterapi (29,534,4 vs. 11,44,1 hari, p=0,0001). Hasil penilaian CGSES pasien SGB dengan dan tanpa imunoterapi memiliki perbedaan bermakna (p=0,035). Terdapat perbedaan signifikan SDSGB saat masuk dan pulang pasien dengan imunoterapi (p=0,007) dan tanpa imunoterapi (p=0,025). Terdapat ketidaksesuaian keputusan subyektif dengan nilai CGSES (nilai Kappa 0,117; CI95% 0,021-0,213)Simpulan: Terdapat perbedaan skor CGSES dan SDSGB pada kelompok pasien SGB dengan dan tanpa imunoterapi. Terdapat ketidaksesuaian penilaian subyektif keputusan pemberian imunoterapi dengan skoring CGSESDifferences in Value of The Clinic GBS Severity Evaluation Scale (CGSES) and Guillain-Barre Syndrome Disability Scale (GBSDS) in Guillian Barre Syndrome (GBS) Patients with and without ImmunotherapyAbstractBackground and objective: The Clinical GBS Severity Evaluation Scale (CGSES) was developed to determine immunotherapy of GBS patients more objectively. GBS Disability Scale (SDSGB) describes severity of GBS and assesses effectiveness of immunotherapy. Purpose of this study was to measure difference of CGSES and GBSDS in GBS patients with and without immunotherapy and to compare the suitability of subjective decisions with CGSES. Subject and Methods: This is a comparative cross-sectional analytic observational study retrospectively in GBS patients from January 2015-March 2020 hospitalized at Dr Hasan Sadikin Hospital, Bandung. Results: There were 92 subjects (35 with and 57 without immunotherapy). Mean age was 41.5 years, and male:female ratio was 57.6%:42.4%. There were no differences in demographics and physical examination between two groups, except for cranial nerve paresis (62.9% vs. 33.3%; p=0.006). There was a difference in mean length of stay with and without immunotherapy (29.5 34.4 vs. 11.4 4.1 days, p=0.0001). Results of the CGSES assessment with and without immunotherapy had a significant difference (p=0.035). There were significant differences in GBSDS at admission and discharge with (p=0.007) and without immunotherapy (p=0.025). There was a discrepancy between subjective decisions and CGSES value (Kappa value 0.117; 95% CI 0.021-0.213).Conclusion: There were differences in CGSES and GBSDS in group of GBS patients with and without immunotherapy. There was a discrepancy between subjective assessment of decision to give immunotherapy with CGSES scoring.

Gangguan Tidur pada Pasien Stroke Fase Akut Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 10, No 1 (2021)
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Stroke adalah suatu kondisi ketika seseorang terkena defisit neurologis secara tiba-tiba yang disebabkan oleh adanya gangguan pada pembuluh darah otak. Sekitar 2177% dari pasien stroke memiliki gangguan tidur yang terjadi setelah stroke. Siklus tidur diatur oleh otak dan stroke dapat menyebabkan gangguan tidur karena kelainan yang dapat terjadi pada struktur otak yang mengatur tidur. Post Stroke Sleep Disoder (PSSD) merupakan gejala tersering setelah stroke. Gangguan tidur setelah stroke meliputi Sleep Disordered Breathing (SDB), insomnia, circadian rhythm sleep disturbance, hipersomnia, parasomnia dan sleep-related movement disorder. Tidur memiliki banyak manfaat, salah satunya adalah restorasi fungsi fisik dan mental, konsolidasi memori dan meningkatkan kemampuan belajar dari seseorang baik secara motorik maupun sensorik. Penelitian lain pun menunjukkan adanya korelasi antara waktu tidur elektrografik dan fungsi kognitif dari pasien stroke pada masa pemulihan. Sebuah penelitian percobaan lain pula mengindikasikan bahwa gangguan tidur dapat meningkatkan ekspresi dari neurocan, yaitu gen yang menghambat pertumbuhan saraf. Gangguan tidur pada pasien stroke dapat menurunkan efisiensi dan efektifitas dari rehabilitasi stroke.Sleep Disorders in Acute Phase Stroke PatientsAbstractStroke is a condition when a person has a sudden neurological deficit caused by a disruption in the blood vessels of the brain. About 21-77% of stroke patients have sleep disorders that occur after a stroke. The sleep cycle is regulated by the brain and strokes can cause sleep disturbances due to abnormalities that can occur in the brain structures that regulate sleep. Post Stroke Sleep Disoder (PSSD) is the most common symptom after stroke. Sleep disorders after stroke include Sleep Disordered Breathing (SDB), insomnia, circadian rhythm sleep disturbance, hypersomnia, parasomnia and sleep-related movement disorders. Sleep has many benefits, one of which is the restoration of physical and mental functions, the consolidation of memory and improving the learning ability of a person both motorically and sensitively. Other studies have also shown a correlation between electrographic sleep time and cognitive function of stroke patients during recovery. Another experimental study also indicated that sleep disorders can increase the expression of neurocans, which are genes that inhibit nerve growth. Sleep disorders in stroke patients can reduce the efficiency and effectiveness of stroke rehabilitation

Perdarahan Gastrointestinal pada Stroke Iskemik Akut: Sebuah Tinjauan Pustaka Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 9, No 3 (2020)
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Perdarahan gastrointestinal pada stroke iskemik akut disebabkan oleh proses neuroinflamasi pada sel otak yang mengalami iskemik. Edema otak yang terjadi pada pasien stroke iskemik akut mempengaruhi hipotalamus dan batang otak. Keterlibatan nukleus vagal pada batang otak menyebabkan peningkatan stimulasi dari vagus serta berkurangnya inhibisi vagus. Proses neuroinflamasi tersebut mempengaruhi sistem saraf parasimpatis menyebabkan hiperaktivitas vagal sehingga terjadi peningkatan pelepasan gastrin yang meningkatkan produksi asam lambung. Perdarahan gastrointestinal pada pasien stroke iskemik akut mengakibatkan penghentian atau penundaan terapi antiplatelet atau antikoagulan sehingga terjadi keadaan prokoagulasi, menyebabkan lebih mudah terjadi trombosis sehingga meningkatkan risiko stroke ulang dan luaran klinis yang buruk. Beberapa penelitian perdarahan gastrointestinal pada pasien stroke iskemik akut mempunyai prognosis yang kurang baik terhadap luaran. Luaran tersebut antara lain perburukan defisit neurologis, kematian di rumah sakit, dan memperpanjang lama perawatan.Gastrointestinal Bleeding in Acute Ischemic Stroke: A Literature ReviewAbstractGastrointestinal bleeding in acute ischemic stroke is caused by the process of neuroinflamation in ischemic brain cells. Brain edema that occurs in acute ischemic stroke patients affects the hypothalamus and brainstem. Involvement of the vagal nucleus in the brainstem results in increased stimulation of the vagus and reduced inhibition of the vagus. The neuroinflamation process affects the parasympathetic nervous system causing vagal hyperactivity resulting in an increase in gastrin release which increases gastric acid production. Gastrointestinal bleeding in patients with acute ischemic stroke results in the cessation or delay of antiplatelet or anticoagulant therapy, resulting in a procoagulatory state, making thrombosis easier, thereby increasing the risk of repeated strokes and poor clinical outcomes. Several studies of gastrointestinal bleeding in patients with acute ischemic stroke have a poor prognosis for outcomes. These outcomes include worsening neurological deficits, hospital deaths, and prolonged treatment.

Karakteristik Klinis Pasien Trombosis Sinus Venosus Serebral (TSVS) di Ruang Rawat Inap Neurologi Rumah Sakit Hasan Sadikin Bandung Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 9, No 2 (2020)
Publisher : https://snacc.org/wp-content/uploads/2019/fall/Intl-news3.html

Latar Belakang dan Tujuan: Trombosis sinus venosus serebral (TSVS) merupakan penyakit akibat oklusi struktur vena intrakranial, termasuk sinus serebral, vena korteks, dan bagian proksimal vena jugularis. Keterlambatan diagnosis dan terapi dapat mengakibatkan terjadinya komplikasi seperti infark berdarah bahkan kematian.Tujuan penelitian ini adalah untuk mengetahui karakteristik klinis pasien TSVS yang diagnosisnya telah dikonfirmasi melalui pemeriksaan DSA. Metode: Penelitian ini bersifat deskriptif observasional retrospektif. Pada pasien yang telah didiagnosis TSVS di Bagian Neurologi Rumah Sakit Hasan Sadikin Bandung periode Juni 2015 sampai November 2017.Hasil: Terdapat 33 subjek dengan rentang usia 40-49 tahun (24,2%) dan mayoritas adalah perempuan sebanyak 22 orang (66,7%). Faktor resiko terbanyak adalah infeksi 8 orang (24,2%), dan kondisi protrombotik sebanyak 6 orang (18,2%). Gejala klinis terbanyak adalah nyeri kepala yaitu 27 orang (81,8%). Lokasi sinus yang tersering mengalami trombosis adalah sinus transversus pada 28 orang dengan gejala mayoritas nyeri kepala. Kadar D-Dimer ditemukan meningkat dengan rata-rata 1,21 mg/L.Simpulan: Pasien TSVS terjadi pada perempuan dengan rentang usia dekade pertengahan dan faktor resiko terbanyak adalah infeksi. Nyeri kepala merupakan gejala paling sering. Lokasi trombosis mayoritas terjadi pada sinus transversus dan ditemukan peningkatan D-Dimer.Clinical Characteristics of Cerebral Venous Sinus Thrombosis (CVST) Patients in Neurology Ward Hasan Sadikin General Hospital BandungAbstractBackground and Objective: CVST is an entity caused by intracranial vein, including cerebral sinuses, cortical vein and proximal part of the jugular vein. A delay in diagnosing and treating can result in brain infarct with hemorrhagic transformation, even death. The goal of this study is to learn the clinical characteristics of patients with CVST that had been confirmed by DSA.Method: This was a retrospective observational descriptive study and subjects were hospitalized patients which had been diagnosed CVST in Neurology ward Hasan Sadikin General Hospital from June 2015 to November 2017.Results: there was 33 subjects with most (22 patient/66.7%) being women between 40-49 years old. In this study the most frequently found risk factor was infection in 8 subjects (24.2%), prothrombotic conditions in 6 subjects (18.2%). The clinical manifestations were mainly headache in 27 subjects (81,8%). The sinus most often involved was the transverse sinus (28 subjects) with the clinical manifestation being headache. D-dimer levels were also increased with mean 1.21 mg/dl.Conclusion: CVST patients are mostly in women at the midle age of decade, with infection being the most frequent risk. Headache was the most frequent clinical manifestation. Location of thrombosis were more often found on the transverse sinus and D-Dimer level was increased.

Peran Eritropoietin pada Stroke Iskemik Akut Amalia, Lisda; Saputra, Gilang Nispu
Jurnal Neuroanestesi Indonesia Vol 9, No 2 (2020)
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Stroke iskemik merupakan salah satu penyebab stroke tersering, disebabkan oleh oklusi pembuluh darah serebral dan penyebab kematian ketiga. Iskemik otak akan menghasilkan penghasilan mediator inflamasi yang dapat berpartisipasi dalam jejas iskemik di otak. Saat awitan stroke iskemik terjadi, area otak yang diperdarahi oleh pembuluh darah akan kekurangan oksigen dan nutrisi sehingga sel otak terutama neuron berada dalam risiko, neuron ini masih dapat berfungsi yang dikenal sebagai penumbra. Hipoksia jaringan dan iskemik serebral mengaktivasi HIF-1?, yang kemudian mengaktivasi transkripsi gen eritropoietin (EPO) dan Vascular Endothelial Growth Factor (VEGF). Eritropoietin (EPO) merupakan peptida yang juga memiliki efek nonhematopoiesis yaitu berperan mendorong neuroproteksi. Eritropoietin (EPO) dikeluarkan dalam hitungan menit dari proses iskemik dan mencapai puncak dalam 24 jam dari awitan stroke iskemik. Efek neuroproteksi dari EPO yaitu sebagai anti apoptosis, anti oksidan, anti inflamasi, anti eksitoksisitas, neurogenesis, angiogenesis dan neurotropik. Dengan kata lain bahwa EPO dapat mengurangi derajat keparahan akibat oklusi pembuluh darah otak.Role of Eritropoietin in Acute Ischemic StrokeAbstractIschemic stroke is one of the most common causes of stroke, caused by cerebral vascular occlusion and the third cause of death. . Ischemic brain will generate income of inflammatory mediators who can participate in ischemic lesions in the brain. When the recitation of an ischemic stroke occurs, areas of the brain that are obscurated by blood vessels will lack oxygen and nutrients so that brain cells, especially neurons, are at risk, these neurons can still function known as penumbra. Tissue hypoxia and cerebral ischemic activate HIF-1?, which then activates the transcription of the Eritropietin (EPO) and Vascular Endothelial Growth Factor (VEGF) genes. Eritropoietin (EPO) is a peptide that also has the effect of non-hematopoiesis which is responsible for encouraging neuroprotection. Eritropietin (EPO) is issued in minutes of an ischemic process and reaches its peak within 24 hours of the onset ischemic stroke. The neuroprotection effect of EPO is as anti-apoptosis, anti-oxidant, anti-inflammatory, anti-excitation, neurogenesis, angiogenesis and neurotropic. In other words, EPO can reduce the severity due to occlusion of brain blood vessels.

Periodontal Health Status and Level of Periodontal Treatment Needs in Stroke Patients at Hasan Sadikin Hospital Bandung Sukmawati, Rani; Sari, Kartika Indah; Susanto, Agus; Amalia, Lisda
Journal of Indonesian Dental Association Vol 3 No 2 (2020): October
Publisher : Indonesian Dental Association

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Introduction: A stroke is any form of brain disorder or central nervous system damage caused by altered blood flow to the brain that impairs motor and cognitive function. Impaired motor and cognitive function restrict oral hygiene, so these patients are vulnerable to dental health problems, such as periodontal disease. They often require help from family members to assist them with oral care. Objectives: The aim of this study was to describe the condition of periodontal tissue and the periodontal treatment needs of stroke patients. Method: This research is a descriptive study using a cross-sectional format. It was conducted at Hasan Sadikin Hospital Bandung with a sample of 30 stroke patients. An examination of periodontal status and periodontal treatment needs was performed using an index from the World Health Organization, the Community Periodontal Index of Treatment Needs (CPITN). Results: None of the patients had healthy periodontal tissue status (score 0), gingival bleeding during or after probing (score 1), or a periodontal pocket ≥ 6 mm (score 4). Nine patients (30%) had supragingival or subgingival calculus (score 2), and 21 patients (70%) had 4–5 mm periodontal pockets (score 3). Conclusion: Most stroke patients at Hasan Sadikin Hospital Bandung had a pocket depth of 4–5 mm, and their periodontal health status indicated a need for scaling, root planing, removal of plaque retentive factors, and oral hygiene instructions.

Gambaran Epidemiologi Pasien Stroke Dewasa Muda yang Dirawat di Bangsal Neurologi RSUP Dr.Hasan Sadikin Bandung Periode 20112016 Syifa, Nadia; Amalia, Lisda; Bisri, Dewi Yulianti
Jurnal Neuroanestesi Indonesia Vol 6, No 3 (2017)
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Latar Belakang dan Tujuan: Kerugian akibat stroke lebih berat pada penderita yang berusia lebih muda dibandingkan usia tua. Insidensi stroke dewasa muda terus meningkat di berbagai negara. Pencegahan yang tepat dapat dilakukan dengan melakukan studi epidemiologi. Penelitian ini bertujuan untuk mengetahui gambaran epidemiologi pasien stroke dewasa muda.Subjek dan Metode: Penelitian ini merupakan studi kuantitatif dengan metode deskriptif. Data yang digunakan adalah resume rekam medis pasien stroke yang dirawat di bangsal neurologi Rumah Sakit Dr.Hasan Sadikin(RSHS) Bandung tahun 20112016. Data kemudian diklasifikasikan berdasarkan kelompok usia, jenis kelamin, tipe stroke, demografi, dan faktor risiko.Hasil: Sampel yang didapatkan sejumlah 450 buah. Jumlah kasus stroke terbanyak berada pada kelompok umur 4245 tahun (45,11%). Kejadian stroke iskemik (50,44%) lebih tinggi dibandingkan kejadian stroke perdarahan (49,56%). Kejadian pada perempuan (56,66%) lebih tinggi dibandingkan laki-laki (43,34%). Pendidikan terakhir penderita paling banyak adalah SMA (32,89%). Kelompok pekerjaan terbanyak adalah kelompok tidak bekerja (56,22%). Faktor risiko terbanyak adalah hipertensi (42,06%). Simpulan: Kejadian stroke dewasa muda di RSHS paling banyak terjadi pada kelompok usia 42-45 tahun, tipe stroke iskemik, jenis kelamin perempuan, pendidikan terakhir SMA, tidak bekerja, dan faktor risiko tertinggi adalah hipertensi.Epidemiological Picture of Young Adult Stroke Patients treated in Neurology Ward of RSUP Dr.Hasan Sadikin Bandung 20112016 PeriodBackground and Objectives: The stroke loss is higher in younger patients compared to the older patients. Stroke incidence is increasing year by year. Epidemiological study can be used as the basis of prevention and reduction of young adult stroke incidence. This study aims to determine the epidemiological picture of young adult stroke patientsSubjects and Method: This study is a quantitative study using descriptive method. The datas were taken from the resume of medical records of patients that are diagnosed as stroke and treated in the neurology ward Dr.Hasan Sadikin Hospital(RSHS) in 2011 - 2016. All samples were taken then classified by its age group, sex, stroke type, demographical characteristic and risk factor. Result: 452 samples were obtained. The highest number of cases are found in the 42-45 year old group (45,11%). Ischemic stroke (50,44%) cases are higher compared to the hemorrhagic stroke (49,56%). Stroke cases in women (56,66%) is higher than in men (43,34%). Most of the patients last education is high school (32,89%). Most of the patients who have stroke are unemployed (56,22%). The most risk factor is hypertension (42,06%). Conclusion: Stroke cases in RSHS happen to be higher in older age group, ischemic stroke type, women, high school as the last education, unemployment and the highest risk factor is hypertension.

Gambaran Faktor Risiko Kejadian Stroke di RSHS Bandung Periode Januari 2015 Desember 2016 ; Amalia, Lisda; Suwarman, S
Jurnal Neuroanestesi Indonesia Vol 7, No 3 (2018)
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Latar Belakang dan Tujuan: Stroke merupakan masalah kesehatan di dunia yang menjadi penyebab kematian kedua tertinggi. Epidemiologi pasien stroke berdasarkan faktor risikonya masih sangat bervariasi dan belum ada data yang melaporkan di Jawa Barat. Tujuan penelitian ini adalah untuk mengetahui gambaran faktor risiko kejadian stroke. Subjek dan Metode: Penelitian ini menggunakan studi desain deskriptif dengan rancangan potong lintang. Data diambil secara retrospektif dengan metode total sampling dari rekam medis pasien stroke di bangsal neurologi RSUP Dr. Hasan Sadikin periode Januari 2015Desember 2016 yang memenuhi kriteri inklusi dan eksklusi.Hasil: Didapatkan 1044 subjek terdiri dari 486 laki-laki dan 558 perempuan. Kelompok usia 55-64 tahun (33,3%), pendidikan tamat SD (45,3%), dan tidak bekerja (56,4%) merupakan prevalensi tertinggi dari subjek yang diteliti. Stroke iskemik memiliki prevalensi lebih tinggi dibandingkan stroke perdarahan dengan lokasi sistem karotis lebih tinggi (89,6%) dibandingkan sistem vertebrobasilar (10,4%). Faktor risiko tertinggi yaitu hipertensi. Simpulan: Insidensi pasien stroke lebih tinggi terjadi pada wanita, kelompok usia tua, pendidikan rendah, dan tidak bekerja. Kasus pasien stroke iskemik lebih sering terjadi dibandingkan dengan stroke perdarahan dengan lokasi sistem karotis lebih banyak dibandingkan sistem vertebrobasilar. Hipertensi merupakan faktor risiko paling sering mengakibatkan stroke.Profile of Stroke Risk Factors in Hasan Sadikin General Hospital Bandung During January 2015December 2016Background and Objective: Stroke is an important health issue causing the second most death worldwide. Epidemiology of stroke patients based on risk factors is highly variable without data to report regarding risk factors of stroke in West Java. Aim of this study is to find out profile of stroke risk factor.Subject and Method: This study is a descriptive study with cross section design. Data acquired retrospectively with total sampling method from medical records of stroke patients in Hasan Sadikin General Hospital from January 2015December 2016 that fulfills inclusion criteria and exclusion criteria.Result: Obtained 1044 subjects consisted of 486 males and 558 females. Subjects with age 5564 years old (33.3%), elementary school graduate (45.3%), and no occupation (56.4%) were the highest prevalence of studied subject. Ischaemic stroke had higher prevalence than haemorrhagic stroke with carotid system (89.6%) higher than vertebrobasilar (10.4%). Highest risk factor were hypertension. Conclusion: Incidence of stroke patients are higher in women, older age group, low education, and no occupation. Ischaemic stroke case patients were found more often than haemorrhagic stroke with carotid system more than vertebrobasilar system. Hypertension is the most common risk factor causing stroke.

Pola Pengobatan Stroke Iskemik Pada Pasien Lansia di Rumah Sakit Hasan Sadikin Bandung Togu, Glenn Mark; Amalia, Lisda; Sitorus, Trully Deti Rose
Majalah Kedokteran Indonesia Vol 71 No 2 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.71.2-2021-387

Background: Ischemic stroke in Indonesia is one of the main causes of disability and mortality in elderly. Aging is related with the increase of comorbidities. The comorbidities in elderly increase the potential for polypharmacy prescribing which increases the incidence of drug side effects. This study’s purpose is to know the demographic characteristic, treatment pattern, and side effect of the treatment in elderly patients with ischemic stroke. Methods: This study is a descriptive study with a cross-sectional design which was conducted throughout September–October 2020. This study used secondary data from ischemic stroke patients’ medical records admitted in Dr. Hasan Sadikin Central General Hospital’s in 2015–2019, with simple random sampling.Result: Result of this study shows that most elderly patients with ischemic stroke were young elderly aged 60-69 years, male, with hypertension as the major risk factor. Polytherapy (2-4 drugs) was found in 79 patients and polypharmacy (greater than 5 drugs) was found in 21 patients. Six patients with polytherapy and four patients with polypharmacy experienced drug side effects. Drug side effects of treatment observed were stress ulcer, upper gastrointestinal bleeding, and anemia.Conclusions: The treatment patterns were dominated by polytherapy (2-4 drugs). The percentage of elderly patients with polypharmacy (greater than 5 drugs) experiencing side effects was more than those with polytherapy. Drug side effects were dominated by stress ulcer.

Co-Authors Adriana Damayanti Afdi Arahim Putra Agnes Rengga Indrati Agus Susanto Ahmad Rizal ahmad rizal Ahmad Rizal Ganiem, Ahmad Rizal Aih Cahyani Al Rasyid Amanda Diannisa Azzahra Amany Khansa Amaylia Oehadian Anam Ong Andi Basuki Prima Birawa Andi Basuki Prima Birawa Andi Basuki Prima Birawa Andre Tanuwijaya, Andre Ardiana Arviana Adamantina Putri Asep Nugraha Hermawan Asep Nugraha Hermawan Ayu, Auliya Putri Badriyah, Nur’aini Jamilatul Berliana, Sobaryati Biben, Vitriana Calista, Chandra Cep Juli Chandra Calista Dewi Yulianti Bisri Eppy Buchori Fifi Veronica Fitri Yanti Gaga Irawan Nugraha Gloria Kartika Gunadharma, Suryani Guntur Darmawan Hanna Goenawan Hermawan, Asep Nugraha Hidayat, Faqih Hidayat, Shaffana Hilman Hilman Ida Parwati Islami, Aditya Iwan Fuadi Kartika, Gloria Khairunnisa, Shafa Ayu Lailiyya, Nushrotul Laniyati Hamijoyo, Laniyati Lee Shok Chen Lee Shok Chen, Lee Shok Leni Lismayanti Liunardo Bintang Pratama Lulu Eva Rakhmilla Marina A. Moeliono Marina A. Moeliono, Marina A. Millata Azma Basmala Muhammad Mustofa Ramadhan Nandina Oktavia Nani Kurniani Nesyia Tara Restikasari Nur Atiik Nurmin, Rahmawati Nushrotul Lailiyya Ong, Paulus Anam Pandji Irani Fianza Paulus Anam Ong Paulus Anam Ong Ramdan Panigoro Reza W. Sudjud Ria Bandiara Rita Arsika Fauziah Rizkia, Fildza Intan Rizky Gimnastiar Saputra, Gilang Nispu Sari, Kartika Indah Shenny Dianathasari Santoso Sidabutar, Berliana Siti Aminah Siti Aminah Sobana Siti Nur Fatimah Sitorus, Trully Deti Rose Siuliyanty, Siuliyanty Sobaryati, Sobaryati Sofiati Dian Sukmawati, Rani Suryani Gunadharma Suwarman, S Suwarman, S Syifa, Nadia Syifa, Nadia Tiara Pramaesya Tiene Rostini, Tiene Togu, Glenn Mark Trislawati, Cristina Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani, Uni Wandira, Rega Dwi Wardhani, Ildzamar Haifa Wardoyo, Chandra Calista Yusuf Wibisono Yusuf Wibisono

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