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Peran Platelet-Selectin sebagai Marker Agregasi Trombosit pada Trombosis Sinus Venosus Serebral Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 11, No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v11i3.407

Abstract

Trombosis sinus venosus serebral (TSVS) merupakan penyakit akibat oklusi struktur vena intrakranial, termasuk sinus serebral, vena korteks, dan bagian proksimal vena jugularis. Keterlambatan diagnosis dan terapi dapat mengakibatkan terjadinya komplikasi seperti infark berdarah bahkan kematian. Trombosis yang menyebabkan TSVS adalah proses pembentukan bekuan darah dalam pembuluh darah. Trombosis terjadi jika keseimbangan antara faktor trombogenik dan mekanisme protektif trombogenesis terganggu. Kelainan fungsi trombosit pada kasus TSVS dapat berupa gangguan fungsi adhesi, gangguan reaksi pelepasan atau sekresi, dan gangguan fungsi agregasi. Disfungsi dan gangguan struktur endotel akibat inflamasi menyebabkan adhesi trombosit sehingga trombosit saling melekat dengan kolagen pada sel endotel. Proses adhesi dan sekresi granul trombosit dapat diprediksi dengan pemeriksaan Platelet-selectin (P-selectin) merupakan protein transmembran tipe 1 pada granul trombosit dan granul megakariosit serta berperan dalam memediasi interaksi antara leukosit dengan ligan yang membantu proses adhesi leukosit dan trombosit sehingga dapat dijadikan prediktor trombosis pada pasien dengan TSVS.
The Relationship of Cortisol Levels and Sleep Quality in Acute Ischemic Stroke Patients: A Literature Review Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 13, No 1 (2024)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i1.533

Abstract

Hormonal factors are one of several elements that contribute to the process by which patients with acute ischemic stroke experience poor sleep quality. The hypothalamic-pituitary-adrenal (HPA) axis is responsible for producing the hormone cortisol. When the hypothalamus is activated, it releases vasopressin and Corticotropin Releasing Hormone (CRH), both of which influence Adrenocorticotropic Hormone (ACTH). This hormone triggers release of cortisol and other glucocorticoids by the adrenal glands. The HPA axis becomes engaged during an acute disease. Cortisol levels will rise as a result of HPA axis activation. Specifically, injury to the frontal or medial temporal lobes of the brain, as well as inflammation, or a lack of regulation of the HPA axis, can lead to this medical condition. Cortisol levels might remain elevated for up to seven days following the start of a stroke. An increase in cortisol levels is connected to an highly risk of stroke severity, length of hospital stay, and mortality in stroke patients. It is also an early warning sign of deteriorating sleep quality in patients with acute ischemic stroke.
Karakteristik Klinis dan Status Nutrisi pada Pasien Stroke Fase Akut Amalia, Lisda; Putri, Arviana Adamantina
Jurnal Neuroanestesi Indonesia Vol 11, No 1 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (11.349 KB) | DOI: 10.24244/jni.v11i1.377

Abstract

Latar Belakang dan Tujuan: Disabilitas yang berat pada stroke meningkatkan risiko terjadinya malnutrisi. Malnutrisi pada pasien stroke dapat disebabkan oleh defisit neurologis dan faktor risiko. Malnutrisi pada stroke meningkatkan morbiditas dan mortalitas. Penelitian ini bertujuan untuk mengetahui karakteristik klinis dan status nutrisi pasien stroke.Subjek dan Metode: Penelitian bersifat deskriptif retrospektif pada pasien stroke yang dirawat di RSUP Hasan Sadikin Bandung pada periode 1 Agustus 2020 hingga 30 September 2020. Status nutrisi dinilai menggunakan Indeks Massa Tubuh (IMT) dan skor Subjective Global Assessment (SGA). IMT dihitung menggunakan kg/m2, dikelompokkan menjadi obesitas (IMT 30), overweight (IMT 25,029,9), normal (IMT 18,524,9) dan underweight (IMT 18,5). Skor SGA 2 termasuk nutrisi baik, dan ?2 tergolong malnutrisi.Hasil: Didapatkan 52 orang pasien stroke yang sebagian besar berjenis kelamin laki-laki (57,7%) dengan rentang usia 3886 tahun (rata-rata 57 tahun), 51,9% mengalami malnutrisi berdasarkan skor SGA, IMT normal dan overweight sebanyak 23 (44,2%) orang, diikuti obesitas (5,7%) dan underweight (5,7%). Ditemukan 71,4% usia ?65 tahun mengalami malnutrisi. Kondisi malnutrisi didominasi pasien stroke infark kardioemboli (63,6%), dengan derajat stroke berat (58,3%), disfagia (59,4%), dengan komorbid infeksi (71,4%) dan stress ulcer (55,6%).Simpulan: Berdasarkan penelitian ini, didapatkan bahwa usia tua , derajat stroke sedang-berat, komorbid infeksi dan stress ulcer akan memiliki kecenderungan malnutrisi sehingga penanganan stroke yang baik dapat menurunkan risiko terjadinya malnutrisi. Kejadian stroke berulang tidak menjadi risiko terjadinya malnutrisi pada penelitian ini.Clinical Characteristics and Nutrition Status in Acute Stroke PatientsAbstractBackground and Objective: Severe disability in stroke increase the risk of malnutrition. Malnutrition in stroke patients can be caused by neurological deficits and risk factors. Malnutrition in stroke increases morbidity and mortality. This study aims to determine the clinical characteristics and nutritional status of stroke patients.Subject and Methods: This study was a retrospective descriptive study of stroke patients who were treated in the Neurology ward of Hasan Sadikin Hospital Bandung from 1 August 2020 to 30 September 2020. Nutritional status was assessed using Body Mass Index (BMI) and Subjective Global Assessment (SGA) scores. BMI was calculated using kg/m2, grouped into obese (BMI 30), overweight (BMI 25.0-29.9), normal (BMI 18.5-24.9) and underweight (BMI 18.5). SGA score 2 is considered as good nutrition, and ?2 is classified as malnutrition.Results: There were 52 stroke patients, most of them were male (57.7%) with an age range of 38-86 years old (mean 57 years), 51.9% were malnourished based on the SGA score, normal BMI and overweight were 23 (44.2%) people, followed by obesity (5.7%) and underweight (5.7%). We also found 71.4% aged ?65 years are malnourished. This condition was dominated by cardioembolic stroke patients (63.6%), with severe stroke (58.3%), dysphagia (59.4%), with comorbid infections (71.4%) and stress ulcers (55.6%).Conclusion: Based on this study, it was found that elderly, moderate-severe stroke, comorbid infections and stress ulcers have a tendency related to malnutrition. Good or better management can/indeed reduce the risk of malnutrition. Stroke history was not a risk for malnutrition in this study.
Faktor-faktor yang Berperan pada Status Epileptikus Non-konvulsivus di RSUP Dr. Hasan Sadikin Bandung Trislawati, Cristina; Gunadharma, Suryani; Gamayani, Uni; Wibisono, Yusuf; Sobaryati, Sobaryati; Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 11, No 3 (2022)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v11i3.423

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Latar Belakang dan Tujuan: Status epileptikus merupakan kasus emergensi neurologis dengan mortalitas 57%, 63% merupakan status epileptikus non-konvulsivus (SENK). Diagnosis SENK tidak mudah karena pasien tidak menunjukkan bangkitan yang jelas sehingga diperlukan pemeriksaan elektroensefalografi (EEG). Penyakit serebrovaskular, infeksi susunan saraf pusat (SSP), tumor otak, penyakit autoimmun, dan gangguan metabolik dapat mengakibatkan SENK selain itu dapat memiliki gambaran klinis menyerupai SENK. Tujuan penelitian untuk melihat faktor-faktor yang berperan pada diagnosis SENK.Subjek dan Metode: Penelitian observasional analitik potong lintang retrospektif pada 132 pasien dengan diagnosis klinis SENK di RSUP dr. Hasan Sadikin Bandung selama periode Juli 2017 Juni 2020. Hasil: Dari 132 subjek dengan diagnosis klinis SENK, hanya 100 pasien yang memenuhi kriteria inklusi. Pemeriksaan EEG dilakukan pada semua pasien, sebagian besar dalam waktu 24 jam (82,4 87,9%), hanya 34 pasien yang terkonfirmasi sebagai SENK. Gangguan metabolik secara signifikan berperan pada SENK sebesar 29,4% (p=0,049). Pada pasien yang tidak terkonfirmasi SENK, penurunan kesadaran diakibatkan gangguan metabolik.Smpulan: Gangguan metabolik berperan pada kejadian SENK. Pasien dengan diagnosis klinis SENK memerlukan pemeriksaan EEG segera untuk menghindari diagnosis berlebihan
Analysis of Mortality Risk in Stroke Patients for Optimizing Stroke Services Amalia, Lisda; Islami, Aditya
Jurnal Neuroanestesi Indonesia Vol 13, No 3 (2024)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v13i3.569

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Introduction: The high mortality rate due to stroke causes a burden on health services, so it is essential to optimize stroke services. Mortality is one of the parameters used to assess stroke services. Hasan Sadikin General Hospital, as a stroke service support hospital, should carry out comprehensive service development, one of which is through continuous evaluation regarding the mortality rate of stroke patients being treated. This study aims to analyze the description of mortality in stroke patients at Hasan Sadikin General Bandung, Indonesia. Subject and Methods: The study used a retrospective analytic method for stroke patients in the Neurology ward from January to April 2023. The patients were divided into two groups: those who died and those who returned home with improvement. Data were taken from medical records regarding age, onset, length of stay, NIHSS, initial leukocytes, NLR, and complications. The data were then analyzed using the Mann-Whitney correlation test. Results: From this study showed that 22 patients died, and 70 patients were discharged with improvement. There were no statistically significant differences (p>0.05) in the variables of age, onset, and length of stay in the two groups. There were statistically significant differences (p
Use of sEMG for Swallowing Muscles Activity Quantification in Acute Phase of Stroke Biben, Vitriana; Tanuwijaya, Andre; Wardhani, Ildzamar Haifa; Amalia, Lisda
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3150

Abstract

Early diagnosis of dysphagia and aspiration risk is very important in minimizing the risk of various medical consequences. This study aimed to establish a scientific database for future sEMG-based dysphagia screening investigations by examining the electrical activity of swallowing muscles in acute stroke cases. A quantitative cross-sectional study was conducted on 61 stroke inpatients admitted to Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to November 2019. The objective of this study was to quantify electrical activities of the suprahyoid (SH) and infrahyoid (IH) muscles during swallowing. Patients participated in both dry swallowing and a 3 mL water swallowing task, with the sEMG used to measure electrical activity parameters (duration, swallowing initiation, time-to-peak, and amplitude) on both paretic and normal sides. The Wilcoxon test was used to compare the electrical activity parameters between the patients paretic and normal sides. Only amplitude showed a significant difference between the paretic and normal side (p=0.023) when performing the 3 mL water swallowing test. Other parameters did not exhibit significant differences in activity between muscle groups during both swallowing tests (p>0.05),  although varying water volumes led to distinct activities in both muscles. Despite the absence of a clear pattern in SH and IH contractions during swallowing, the result showed that the sEMG quantification method might become a promising method for screening dysphagia, complementary to FEES and VFSS. The non-invasive and cost-effective sEMG method can serve as an early screening tool for dysphagia in stroke patients. This study underscores the importance of further investigation on sEMG use, incorporating a larger sample size and diverse cohort results with various swallowing exercises (varying in volume and viscosity) to validate the use of sEMG in dysphagia screening.
SISTEM PENDUKUNG KEPUTUSAN MENGGUNAKAN METODE AHP UNTUK PEMILIHAN SUPPLIER BAHAN BAKU (STUDI KASUS: PT AKRILIK KURNIA KENCANA) Lisda Amalia; Fitri Yanti
OKTAL : Jurnal Ilmu Komputer dan Sains Vol 3 No 12 (2024): OKTAL : Jurnal Ilmu Komputer Dan Sains
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In facing the challenges of globalization, selecting the right raw material supplier is a key factor in supporting the performance of PT Akrilik Kurnia Kencana. Companies face difficulties in choosing reliable suppliers, which risks affecting product quality and production costs. As a solution, a Decision Support System (DSS) was implemented using the Analytical Hierarchy Process (AHP) method, which allows objective evaluation of various criteria. It is hoped that the implementation of this system can increase efficiency and effectiveness in supplier selection, as well as support the company's strategic decisions. Overall, AHP can help companies make more precise decisions, improve performance, and utilize information technology in decision making.
HUBUNGAN ANTARA DERAJAT KEPARAHAN STROKE DENGAN KEJADIAN STROKE-ASSOCIATED PNEUMONIA Wandira, Rega Dwi; Amalia, Lisda; Fuadi, Iwan
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 2 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i2.20

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ASSOCIATION BETWEEN STROKE SEVERITY AND STROKE-ASSOCIATED PNEUMONIAABSTRACTIntroduction: Stroke-associated pneumonia (SAP) occurs in 5-26% and decreases the quality of life and clinical outcomes of stroke patients. One of the factors that affect the incidence of SAP is the stroke severity.Aims: To determine the association between the stroke severity and the incidence of stroke-associated pneumonia in the neurological ward of Dr. Hasan Sadikin Hospital, Bandung.Methods: This is an analytic retrospective (historical) cohort design study. The study population was stroke patients who were treated in the neurological ward of Dr. Hasan Sadikin Hospital, Bandung between 2014-2016. Exclusion criteria were patient with pneumonia other than SAP and using mechanical ventilation. Stroke severity was assessed using NIHSS (National Institute of Health Stroke Scale). Chi-square was used to determine inter-variable association.Results: Among 81 subjects, 24 were assessed as SAP (29.6%). The SAP prevalence were mostly male (58.3%), age group between 65-74 year old (41.7%) with hypertension risk (87.5%), stroke onset <48 hours, lesion location on left hemisphere, onset of SAP≥48 hours, and those with consciousness impairment. Those with high stroke severity tend to have higher risk of pneumonia 3.063 times compare to patients with low stroke severity.Discussion: There was a significant association between the severity of stroke and the incidence of SAP in the neu- rological ward of Dr. Hasan Sadikin Hospital, Bandung.Keywords: NIHSS, stroke-associated pneumonia, stroke severityABSTRAKPendahuluan: Stroke-associated pneumonia (SAP) cukup sering terjadi (5-26%) pada pasien stroke, sehingga menurunkan angka kualitas hidup dan luaran klinis. Salah satu faktor yang memengaruhi kejadian SAP adalah derajat keparahan stroke.Tujuan: Mengetahui hubungan antara derajat keparahan stroke dengan kejadian SAP di Ruang Rawat NeurologiRSUP Dr. Hasan Sadikin, Bandung.Metode: Penelitian analitik dengan desain kohort retrospektif (historikal) terhadap pasien stroke iskemik yang di rawat di Ruang Rawat Neurologi RSUP Dr. Hasan Sadikin, Bandung pada tahun 2014-2016. Kriteria eksklusi adalah pasien dengan pneumonia selain SAP dan menggunakan alat ventilasi mekanik. Derajat keparahan stroke dinilai menggu- nakan skor NIHSS (National Institutes of Health Stroke Scale). Uji korelasi Chi-square digunakan untuk melihat hubungan antar-variabel.Hasil: Didapatkan 81 subjek yang 24 orang di antaranya  mengalami SAP (29,6%). Prevalensi SAP tertinggi pada laki-laki (58,3%) kelompok usia 65-74 tahun (41,7%) dengan faktor risiko hipertensi (87,5%), onset stroke<48 jam, lokasi lesi di hemisfer kiri, onset SAP≥48 jam, serta pada subjek dengan penurunan kesadaran. Subjek dengan derajat keparahan stroke berat memiliki risiko terjadinya pneumonia 3,063 lebih tinggi dibandingkan dengan derajat keparahan ringan.Diskusi: Terdapat hubungan yang bermakna antara derajat keparahan stroke dengan kejadian SAP di Ruang Rawat Neurologi RSUP Dr. Hasan Sadikin, Bandung.Kata kunci: Derajat keparahan stroke, NIHSS, stroke-associated pneumonia
Inactivated SARSCoV2 Vaccine Inducing Acute Transverse Myelitis and Hypercoagulable State: A Case Report Amalia, Lisda
Jurnal Neuroanestesi Indonesia Vol 14, No 1 (2025)
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Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24244/jni.v14i1.631

Abstract

Introduction: Global pandemic of Coronavirus disease 2019 (COVID-19) have been developed with a respiratory infection as main symptom and vaccines had been proven against SARS-CoV-2 infection. We would like to present acute transverse myelitis with hypercoagulable condition case, after receiving the inactive SARS-CoV-2 vaccine (SinoVac). Case Presentation: This is a case from a 20-year-old male with acute onset of flaccid paraplegia, hyporeflexia, loss of sensation below 5th thoracic level, loss of autonomic function, and a positive Babinski sign bilaterally on 7 days after receiving SARS-CoV-2 vaccine. From lumbar puncture examination, we found elevated liquor cerebrospinal protein with mononuclear cell predominantly and elevated d-dimer and also decreased fibrinogen levels from laboratory examination. From Magnetic Resonance Imaging (MRI) showed hyperintensity at the 5th until 9th thoracal level. He improved motoric strength of the lower limb (walking without assistance), numbness and pain, urine and fecal retention after receiving methylprednisolone for 3 days. Conclusion: Acute transverse myelitis with hypercoagulable state was a rare case associated with COVID-19 vaccination, but clinician should be aware for early detection and giving proper treatment.
Characteristics of Cardioembolic Stroke Patient in Neurologic Ward Dr. Hasan Sadikin General Hospital Bandung Adriana Damayanti; Lisda Amalia; Reza W. Sudjud
Journal of Medicine and Health Vol 2 No 1 (2018)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i1.740

Abstract

Stroke is the second most common cause of death worldwide after heart disease. About80% stroke cases are ischemic stroke. One of 4 people with ischemic stroke had cardioembolicstroke. Ninety percent of cardiac emboli obstruct cerebral blood vessels and causedneurological deficit. Cardioembolic stroke may be due to abnormalities in cardiac walls,rhythm, valve, or function. Stroke patients with cardiac abnormalities have poor prognosis. Thisretrospective descriptive study was done in May-June 2017. We collected 103 medical recordsof stroke patients from Department of Neurology, Dr. Hasan Sadikin General Hospital duringJanuary 2015- March 2016. Data regarding sex, age, education level, economic status, andcardiac abnormalities were recorded. Majority of subjects were female (53.4%). The mostfrequent age group was 45-65 years old (49.51%). Most subjects had low educational level(76.7%) and low economic status (77.67%). Among subjects, 41.75% had cardiac rhythmabnormalities, 29.13% had cardiac wall abnormalities, 14.56% had cardiac valveabnormalities, and 14.56% had cardiac function abnormalities. The most common cause ofcardioembolic stroke was atrial fibrillation.Keywords: cardioembolic stroke epidemiology, patient characteristics, cardiac disease
Co-Authors Adnin Nugroho Adriana Damayanti Afdi Arahim Putra Agnes Rengga Indrati Agus Susanto Agusti Setiabudi Pramata Ahmad Doni ahmad doni Ahmad Rizal Ahmad Rizal Ahmad Rizal ahmad rizal Ahmad Rizal Ganiem Ahmad Rizal Ganiem, Ahmad Rizal Aih Cahyani Al Rasyid Amanda Diannisa Azzahra Amany Khansa Amaylia Oehadian Anam Ong Anam Ong Ananda Pratama Kesumaningtyas Gunawan Andi Basuki Prima Birawa Andi Basuki Prima Birawa Andi Basuki Prima Birawa Andre Tanuwijaya, Andre Anindyta Murfia Khairunnisa Ardiana Aries Saifudin Arviana Adamantina Putri Asep Nugraha Hermawan Asep Nugraha Hermawan Asep Nugraha Hermawan Ayu, Auliya Putri Badriyah, Nur’aini Jamilatul Berliana, Sobaryati Biben, Vitriana Calista, Chandra Cep Juli Chandra Calista Dewi Yulianti Bisri Eppy Buchori Eppy Buchori Aristiady Fadila Arsanti Fauzan Musyaffa Fifi Veronica Fitri Yanti Gaga Irawan Nugraha Galuh Saputri Ginna Megawati Glenn Mark Togu Gloria Kartika Gunadharma, Suryani Guntur Darmawan Hanna Goenawan Hanna Goenawan Haqun Baitika Harry Galuh Nugraha Hermawan, Asep Nugraha Hidayat, Faqih Hidayat, Shaffana Hilman Hilman Ida Parwati Islami, Aditya Iwan Fuadi Jonathan Jeremi Siagian Kartika, Gloria Khairunnisa, Shafa Ayu Khofifah Nurfaisah Lailiyya, Nushrotul Laniyati Hamijoyo, Laniyati Lee Shok Chen Lee Shok Chen, Lee Shok Leni Lismayanti Liunardo Bintang Pratama Lulu Eva Rakhmilla Marina A. Moeliono Marina A. Moeliono, Marina A. Millata Azma Basmala Muhammad Mustofa Ramadhan Nandina Oktavia Nani Kurniani Nesyia Tara Restikasari Nur Atiik Nurmin, Rahmawati Nurohman Nushrotul Lailiyya Nushrotul Lailiyya Nushrotul Lailiyya Dahlan Ong, Paulus Anam Pandji Irani Fianza Paranita Utama Paulus Anam Ong Paulus Anam Ong Paulus Anam Ong Ramdan Panigoro Reihan Achmad Reza Reza W. Sudjud Ria Bandiara Rico Defryantho,* Lisda Amalia,* Ahmad Rizal,** Suryani Gunadharma,* Siti Aminah,* Nushrotul Lailiyya* Rita Arsika Fauziah Rizkia, Fildza Intan Rizky Gimnastiar Saprudin Saprudin Saputra, Gilang Nispu Sari, Kartika Indah Shenny Dianathasari Santoso Sidabutar, Berliana Siti Aminah Siti Aminah Siti Aminah Siti Aminah Siti Aminah Siti Aminah Sobana Siti Nur Fatimah Siuliyanty, Siuliyanty Sobaryati Sobaryati Sobaryati Sobaryati Sobaryati, Sobaryati Sofiati Dian Sukmawati, Rani Suryani Gunadharma Suryani Gunadharma Suryani Gunadharma Suwarman, S Suwarman, S Syifa, Nadia Syifa, Nadia Tiara Pramaesya Tiene Rostini, Tiene Trislawati, Cristina Trully Deti Rose Sitorus Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani Uni Gamayani, Uni Vania Angeline Bachtiar Verolia Yunita Putri Wandira, Rega Dwi Wardhani, Ildzamar Haifa Wardoyo, Chandra Calista Wirayuga Rizkia Suwahyo Yovita Stevina Yusuf Wibisono Yusuf Wibisono