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All Journal Medical Laboratory Technology Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) UMI Medical Journal Ebers Papyrus Journal Of Health Science Community
Mansyur Arif
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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ANALYSIS OF ERYTHROCYTE INDICES IN STORED PACKED RED CELLS AT THE BLOOD BANK OF DR. WAHIDIN SUDIROHUSODO HOSPITAL Fitrie Octavia; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1206

Abstract

Komponen darah Packed Red Cells (PRC) sering ditransfusikan kepada pasien dengan petunjuk untuk memperbaiki danmempertahankan sebaran oksigen ke jaringan. Eritrosit mengalami perubahan metabolik selama masa penyimpanan kantong darah PRCdi Bank Darah yaitu deplesi 2,3-diphosphoglycerate (DPG) dan Adenosine Triphosphat (ATP) yang juga disebut dengan jejas penyimpanandan disebabkan oleh penurunan pH darah, peningkatan kepekatan kalium dan laktat. Tujuan penelitian ini untuk mengetahui pengaruhpenyimpanan terhadap indeks eritrosit pada darah simpan PRC di Bank Darah. Penelitian deskriptif potong lintang dilakukan masawaktu Februari hingga April 2015 dengan menggunakan 35 sampel darah simpan PRC yang disimpan dan batal ditransfusikan laludiperiksa nilai indeks eritrositnya dengan menggunakan alat Hematology Analyzer Sysmex XT-2000i pada hari pertama (hari-1),keempat (hari-4) dan ketujuh (hari-7) penyimpanan di Bank Darah RSUP Dr. Wahidin Sudirohusodo Makassar. Hasil uji statistikFriedman didapatkan perbedaan bermakna di semua tolok ukur indeks eritrosit pada hari pertama, keempat dan ketujuh penyimpanan.Lanjutan dengan Uji Post Hoc Wilcoxon didapatkan perbedaan bermakna tolok ukur MCV antara hari-4 dan hari-7 (p=0,000), hari-1dan hari-7 (p=0,001); MCH antara hari-1 dan hari-7 (p=0,018); MCHC antara hari-1 dan hari-4 (p=0,000), hari-4 dan hari-7(p=0,002), hari-1 dan hari-7 (p=0,000); RDW antara hari-1 dan hari-4 (p=0,011), hari-4 dan hari-7 penyimpanan (p=0,004). HasilPenelitian ini menunjukkan nilai indeks eritrosit darah simpan PRC mengalami perubahan bermakna dari hari pertama hingga ketujuhpenyimpanan di Bank Darah walaupun nilai indeks eritrosit semua tolok ukur masih dalam batas normal.
ASAM HIDROKSIINDOLASETIK 5 (5-HIAA) AIR KEMIH DI KANKER KOLOREKTAL Mansyur Arif; Yosep F. Tallulembang; Burhanuddin Bahar; Ibrahim Abd. Samad; Ibrahim Labeda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.438

Abstract

Colorectal cancer, in fact is one of the three most malignant tumour types found in the world. Early detection is recommended to find out the problem and will affect better life expectancy. Various study have been conducted looking for a test that can be easily, non invasive, inexpensive, no special equipment and skills required such as by detecting 5-hidroxyindolacetic acid that can be found in the urine. The aim of this study was to analyze 5-HIAA in the urine of colorectal cancer patients. The study was conducted at the Clinic and Surgical Ward, and Clinical Pathology Laboratory, at Dr. Wahidin Sudirohusodo Hospital in Makassar during the period May–August 2011. The study was conducted on 42 patients and 45 controls ranging from 35−74 years old and 20−52 years old, respectively. The diagnosis is based on the histopathological and most were in stage III of adenocarcinoma profile. Rated of 5-HIAA colorectal cancer the highest is in the value of 4–6 and all normal control had value of 1–3. There is a significant association between 5-HIAA and colorectal cancer, that shown the highest stadium of colorectal cancer, and the highest value of urine 5-HIAA. The ideal cut-off point for screening is two (2) with its sensitivity and specificity values are 100% and 88. 9%, respectively. 5-HIAA urine test can be used as a tumor marker for colorectal cancer in conjunction with other supporting tests. Further study is needed to determine the cut-off point with a various clinical stage.
PREDIKSI JUMLAH SEL LIMFOSIT T CD4+ MENGGUNAKAN NILAI TLC (TOTAL LYMPHOCYTE COUNT) PADA PENDERITA HIV/AIDS Rostina Rostina; Suci Aprianti; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.902

Abstract

AIDS is a severe disease caused by Human Immunodeficiency Virus (HIV) that affects patient’s immune system, especially CD4+ Tcells (CD4). Hence, CD4 count is used as parameter to starting ARV treatment or monitoring the progress of the disease. However, themeasurement of CD4 is expensive and available in big hospitals. In small or remote hospitals there are no means to measure the CD4.Some studies suggest that in an area where CD4 count is unavailable, the total lymphocyte count (TLC) of HIV/AIDS patients can roughlybe used to predict CD4 values. This study is aimed to see whether the TLC values can be used to roughly predict the CD4 count of HIV/AIDS patients and to formulate the correlation form between them. A cross sectional study design was applied to 79 blood samples ofHIV/AIDS patients from Clinical Pathology Laboratory of Wahidin Sudirohusodo Hospital from January to September 2007. The bloodsamples were tested for TLC as well as CD4 values. The correlation of TLC and CD4 values was tested with Pearson Correlation Test andthe correlation formula was derived from curve estimation of Regression Analysis. Sensitivity, specificity, PPV and NPV of various cutpoint of TLC (1000, 1200, 1500, 2000) to predict CD4 < 200/ul were determined using cross tabulation Fisher Exact Test. A positivecorrelation was found between TLC and CD4 count (R = 0.528, p < 0.001) with the regression formula is CD4 = 0.09TLC – 1.42.The WHO standard cut point TLC1200/ul give best result for sensitivity, specificity, PPV and NPV: 80.6%, 91.7%, 98.2% and 45.8%,respectively. The cut point of TLC1200 can be used to roughly predict CD4 < 200/ul of HIV/AIDS patients, so, can be use as a mark forstarting ARV therapy in the place were measurement of CD4 is unavailable
ZAT BESI DI PENDONOR TERATUR DAN YANG TIDAK TERATUR (Iron in Regular and NonRegular Donors) Irna Diyana Kartika; Lince Wijoyo; Syahraswati Syahraswati; Rachmawati Muhiddin; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i3.1277

Abstract

Blood donation is a process of taking blood from someone, either voluntarily or as a replacement donor blood banked for later usein blood transfusions. Regular donors are donors who regularly donate blood between 3−4 times a year. Nonregular donors are thosewho do not routinely donate blood in a year. Each donor donating one bag of blood, suffered a loss of approximately 200 mg of iron.The purpose of this study was to know the differences in the levels of iron profiles in regular and nonregular donors. The study wasconducted cross sectional on 65 samples of blood from the UPTD Transfusi Darah South Sulawesi Provincial Health Office, consisting of34 regular donors and 31 nonregular donors. Serum iron and TIBC levels were examined using ABX Pentra 400 with colorimetric andimmunoturbidimetry method. Ferritin level was examined using Elecsys with ECLIA principle. The data were then analyzed by unpairedT test. In this study, the regular donors showed an average serum iron level of 87.09 μg/dL, TIBC level 255.41 μg/dL and ferritin level121.27 μg/dL. The nonregular donors, showed an average serum iron level of 83.26 μg/dL, TIBC level was 261.80 μg/dL and ferritinlevel was 158.62 μg/dL. The results showed no significant differences between the levels of iron profiles in regular and nonregulardonors. Based on this study, it can be concluded that regular and nonregular blood donation did not affect the levels of iron profiles. Itis recommended to conduct a further cohort research to know the levels of iron profiles in blood donors by comparing before and afterdonating blood.
FACTORS IN ACUTE TRANSFUSION REACTION (Faktor Reaksi Transfusi Darah Akut) Wiwi Payung; Rachmawati A.M; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1245

Abstract

Data kejadian reaksi transfusi darah akut di Indonesia khususnya di Sulawesi Selatan belum pernah dilaporkan. Pencatatan danpelaporan tentang kejadian reaksi transfusi darah akut di RSUP Dr. Wahidin Sudirohusodo Makassar baru terlaksana mulai bulanJanuari 2014. Begitu pun dengan faktor yang mungkin berpengaruh terhadap kejadian reaksi transfusi darah akut belum pernahditeliti sebelumnya. Penelitian ini bertujuan untuk mengetahui faktor yang berpengaruh terhadap kejadian reaksi transfusi darah akut.Rancangan penelitian adalah kajian potong lintang. Sampel sebanyak 93 subjek, masa waktu antara bulan Januari–Juni 2014 di RSUPDr. Wahidin Sudirohusodo Makassar. Variabel yang diteliti antara lain diagnosis, riwayat transfusi darah sebelumnya, komponen darahyang ditransfusikan dan golongan darah. Metode menghitung yang digunakan adalah diskriptif dan analitik. Metode mendiskriptifkandilakukan dengan perhitungan sebaran kekerapan. Metode menganalitik dilakukan dengan menggunakan uji Chi Kuadrat dan MultipleLogistic Regression. Pasien yang mengalami reaksi transfusi darah akut ada 43 orang. Faktor yang berpengaruh adalah diagnosisp=0,765, riwayat transfusi darah sebelumnya p=0,563, komponen darah yang ditransfusikan p=0,046, golongan darah p=0,018.Berdasarkan kajian ini dapat disimpulkan, bahwa golongan darah merupakan faktor kebahayaan utama reaksi transfusi darah akut.Yaitu golongan darah O berkebahayaan 2,7 kali lebih besar untuk mengalami reaksi transfusi darah akut dibandingkan dengan golongandarah yang bukan.
UJI GLUKOSA DARAH ANTARA METODE HEKSOKINASE DENGAN GLUKOSA OKSIDASE DAN GLUKOSA DEHIDROGENASE DI DIABETES MELITUS Baharuddin Baharuddin; Asvin Nurulita; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1102

Abstract

Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia that occurs because of abnormalities insulinsecretion, insulin or both. Diabetes mellitus diagnosis is established on the basis of examination of blood glucose levels. The recommendedblood glucose test is enzymatic method by hexokinase using venous blood plasma, while for monitoring the outcomes of treatment: bloodglucose test can be done by rapid test using capillary blood. The purpose of this study was to know the test result of blood glucose betweenhexokinase method (ABX Pentra 400), glucose oxidase (StatStrip Xpress, Super Glucocard II) and glucose dehydrogenase methods(Accu-Chek Performa) by comparing them Cross sectional study was conducted on 50 samples of patient hospitalized at Dr. WahidinSudirohusodo Hospital Makassar. The blood glucose test were performed at the Departement of Clinical Pathology from June up to July2012. Each plasma sample was tested using ABX Pentra 400, StatStrip Xpress, Super Glucocard II and Accu-Chek Performa. The datawere analyzed using Kolmogorov Smirnov and Mann Whitney test. Based from this study was showed that there was no difference in bloodthe level using a related (glucose) oxidase (StatStrip Xpress, Super Glucocard II) and its dehydrogenase method (Accu-Chek Performa)compared with hexokinase method (ABX Pentra 400) with p value > 0.05. The result obtained in this study showed that StatStrip Xpress,Super Glucocard II and Accu-Chek Performa can be used as a rapid test for monitoring blood glucose in hospitalized patients.
ANALYSIS OF RHESUS AND KELL GENOTYPE IN PATIENTS WITH TRANSFUSION REACTION Sukmawaty Sukmawaty; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1202

Abstract

Transfusi darah dapat memberikan reaksi imunologis. Yang paling sering adalah reaksi transfusi terkait pecahnya sel darah(hemolitik) akibat tidak terdapatnya antibodi. Anti serum (Ab) yang disarankan saat ini untuk mendeteksi keberadaan antigen sel darahmerah yaitu ABO, Rhesus dan Kell. Penelitian ini bertujuan untuk mengetahui genotipe pasien Rhesus dan Kell dengan reaksi transfusi,menggunakan metode potong lintang di 35 subjek yang mengalami reaksi transfusi pada masa waktu antara bulan Juni–Agustus 2015di RS. Dr. Wahidin Sudirohusodo Makassar. Semua sampel diperiksakan antigen Rhesus dan Kell menggunakan sampel darah pasienyang ada di Bank Darah RS. Dr. Wahidin Sudirohusodo. Subjek penelitian rerata berumur 49,91 tahun dan sebagian besar berjeniskelamin perempuan (71,43%). Golongan darah yang paling banyak mengalami reaksi transfusi adalah golongan darah O (54,29%).Semua sampel adalah Rhesus positif (100%). Antigen D (100%), C (62,86%), c (40%), E (57,14%) dan e (91,43%). Antigen Kell diperolehK (8,57%) dan k (91,43%). Dari semua sampel sebagian besar antigen yang didapatkan adalah antigen D dan e, serta k.
HITUNG TROMBOSIT DI SINDROM KORONER AKUT TERKAIT LOW MOLECULAR WEIGHT HEPARIN (LMWH) Cyntia Kornelius; Darwati Muhadi; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 18, No 3 (2012)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v18i3.376

Abstract

Heparin and Low molecular weight heparin (LMWH) had been used widely for prevention and treatment of thrombosis in the patients with acute coronary syndrome (ACS). Actually, the administration of heparin may caused some adverse effect, such as heparin inducedthrombocytopenia (HIT). This study was aimed to reveal thrombocytes count in patients with ACS who underwent LMWH therapy. An observational study with cohort prospective design was performed in 30 patients with ACS. The thrombocytes count was obtained from complete blood count (CBC) by using haematology analyzer (Sysmex XT 2000i) that performed at Clinical Pathology Laboratory, Dr. Wahidin Sudirohusodo Hospital, Makassar. The obtained data was analyzed with Wilcoxon test. The mean thrombocytes count before the administration of LMWH was 236.800/μL, while mean thrombocytes count after the administration of LMWH was 280.270/μL. Suprisingly this data showed that in general thrombocytes count was increased significantly (P=0.004) five day after starting LMWH therapy. In this study only one (3.3%) of 30 patients who received LMWH had trombocytes count less than 150.000/μL. Based on this study an antibody test to PF4-heparin complex was needed to determined occurance of HIT in this patient. The thrombocytes count was increased significantly (P=0.004) in patients with ACS who had given LMWH therapy.
PERBEDAAN GOLONGAN DARAH ABO DI ANEMIA HEMOLITIK AUTOIMUN Hilma Yuniar; Rachmawati Muhiddin; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.473

Abstract

Discrepancy of blood type is the difference result between cell grouping and serum grouping. The technical errors and various conditions are the common cause of their discrepancy, one of the conditions is mentioned as Auto Immune Haemolytic Anaemia (AIHA). Auto immune haemolytic anemia cold type can cause discrepancy due to cold autoantibody reaction. In this study the researchers conducted further testing to determine the actual blood type so the right blood transfusion can be given. A 41 years old woman with weakness and pale since a month before her admission to the present hospital, has been treated in a district hospital with the same condition. On the physical examination, the researchers found hepatomegaly. The complete blood count showed hemoglobin level was 2.1 g/dL and leukocyte count was 21.54×103/uL. The clinical diagnosis made by the emergency department was anemia pro evaluation and planned blood transfusion with 500 cc of PRC. The peripheral blood smear shown hemolytic anemia. The result of the initial blood type test on forward grouping were AB positive agglutination and on reverse grouping O positive, then followed by washing erythrocyte and the researchers found the similar result. Because of the extra antibody found in both examination, the examination was carried out at 37°C of the patient’s temperature. The researchers found that the blood type of AB rhesus positive with cold autoantibody. The indirect coombs test was positive. The patient is had been reported with ABO discrepancy cold type autoantibody (group IV) in autoimmune hemolytic anemia cold type. Further screening antibody tests are needed to confirm the specific antibody.
CHARACTERISTICS OF CROSSMATCH TYPES IN COMPATIBILITY TESTING ON DIAGNOSIS AND BLOOD TYPES USING GEL METHOD (Ciri Inkompatibilitas Uji Cocok Serasi Metode Gel terhadap Diagnosis dan Golongan Darah) Irawaty Irawaty; Rachmawati AM; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1182

Abstract

Pemeriksaan uji cocok serasi adalah pemeriksaan kesesuaian darah pasien dan donor. Pemeriksaan ini untuk mengetahui apakahantigen eritrosit donor sesuai dengan antibodi di serum pasien (uji mayor) dan antigen eritrosit pasien terhadap antibodi di serum donor(uji minor). Pemeriksaan uji cocok serasi dapat dilakukan dengan metode tabung (metode konvensional) dan Gel. Penelitian ini bertujuanuntuk mengetahui ciri golongan darah dan diagnosis di inkompatibilitas uji cocok serasi dengan menggunakan metode Gel. Rancanganpenelitian berupa observasional retrospektif di Bank Darah Rumah Sakit (BDRS) RSUP Dr.Wahidin Sudirohusodo Makassar denganmengambil data Sistem Informasi Rumah Sakit (SIRS) dan data rekam medis masa waktu Juni 2013-Juni 2014. Jumlah keseluruhan 213sampel dengan jumlah laki-laki 105 orang (49,3%) dan perempuan 108 orang (50,7%). Rentang umur terbanyak >17 tahun (83,6%).Kelompok di inkompatibilitas terbanyak di penyakit infeksi (36,2%) dengan golongan darah B (32,9%), rhesus positif (100%) dan tipeinkompatibilitas minor (81,2%). Pasien tanpa riwayat transfusi lebih banyak (97,7%) dibandingkan dengan riwayat transfusi (2,3%).Perlu diteliti lebih lanjut dengan anamnesis langsung di pasien untuk menghindari bias sehingga diperoleh hasil yang lebih sahih. Selainitu diperlukan penelitian lebih lanjut pemeriksaan penyaringan dan identifikasi antibodi di setiap ketidaksesuaian uji cocok serasi.
Co-Authors Abd Muis Agus Alim Abdullah Ani Kartini Arie Yanti Asvin Nurulita Baharuddin Baharuddin Burhanuddin Bahar Cyntia Kornelius D. Daud Darmawaty Darmawaty Rauf Darwati Muhadi Dewi Sri Kartini Fitrie Octavia Glent Nurtanio HAM Akil Hardjoeno Hardjoeno Hendra Rasubala herlinah herlinah Hilma Yuniar Hilma Yuniar Thamrin Hj. Darmawaty E.R, I Hutagalung I. Hutagalung Ibrahim Abd. Samad Ibrahim Abdul Samad Ibrahim Labeda Ichwan Meinardi Ichwani Meinard Idham Jaya Ganda Ilhamjaya Patellongi Irawaty Irawaty Irfan Idris Irna Diyana Kartika Iwan Joseph Joko Widodo Juranah . Kusriny A.P. Lince Wijoyo Liong Boy Kurniawan, Liong Boy Muh Taufiq Muh Taufiq Mutmainnah . Nur Rahmi Raehaan Nurhayana Sennang Nursin Abd. Kadir Nyoman Trisna Yustiani Rachmawati A.M Rachmawati AM Rachmawati Muhiddin Rachmawati Muhiddin Raehana Samad Reini Meilani Isbach Riesti Ekasanti Rifai Amirudin Rima Yuliati Muin Rostina Rostina Ruland Pakasi Sri Wahyunie S Suci Aprianti Sukmawaty Sukmawaty Sulina Yanti Wibawa Suriyanti Suryani Jamal Susi Sevianty Syahraswati Syahraswati Theosobia Grace Orno Uleng Bahrun Viviyanti Zainuddin Waode Rusdiah Winni Agustiani Wiwi Payung Yedid Lebang Yosep F. Tallulembang ZK Abdurahman Baizal