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<![CDATA[EOSINOFIL PASCA MENGEROK MUKOSA HIDUNG DAN PEMERIKSAAN DARAH RUTIN DI RINITIS ALERGI ]]>
<![CDATA[Rima Yuliati Muin]]>;
<![CDATA[Darwati Muhadi]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v16i1.995
<![CDATA[Diagnostic of rhinitis allergy was based on anamnesis, physical examinations. Examine including anterior rhinoscopy, nasal endoscope, skin test and laboratory assay of nasal cytology, eosinofil count in the blood. Eosinofil mucosal nasal brushing assay andeosinofil routine hematology can be used as other examination to diagnose rhinitis allergy and to evaluate therapy response. The aimof the study was to know the correlation between eosinofil level on mucosal nasal brushing and routine hematology in suspect allergyrhinitis. The study used cross sectional methods, and was done among 37 suspected Rhinitis Allergy patients in the Clinical PathologyLaboratory, and the Clinic of Ears, Nose and Throat at Wahidin Sudirohusodo hospital Makasar, during the period of March - August2008. Eosinofil mucosal nasal brushing assay used Hansel stain and routine hematology assay used automatic blood cell counter Sysmex1800i. The data were analyzed with Pearson Correlation test using SPSS for Windows version 12,0. In the results were found from the37 samples by a correlation test the mean eosinofil level of mucosal nasal brushing. In men was 12.9/HPF and in women was 5/HPF.While eosinofil in routine hematology in men was 1595/µl and in women was 551/µl, with p < 0.000 and r = 0.930. The conclusionso far from this study that the correlation of eosinofil count between mucosal nasal brushing and hematology routine in those patients suspect rhinitis allergy was very strong. So this test can be used as an alternative examination to diagnose rhinitis allergy.]]>
<![CDATA[DAN MYELOPEROxIDASE) DAN DISFUNGSI ENDOTEL (ASIMETRIK DIMETILARGININ) DI KEGEMUKAN (OBESITAS) ]]>
<![CDATA[Joko Widodo]]>;
<![CDATA[Burhanuddin Bahar]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v16i3.1039
<![CDATA[Obesity is a pathological condition in which there is an excess body fat due to imbalance energy expenditure. Its association with oxidative stress could cause other metabolic disorders such as endothelial dysfunction, atherosclerosis, and cardiovascular disease. Theaim of this study was to assess the correlation of oxidative stress (F2-Isoprostane, Superoxide dismutase and Myeloperoxidase) andendothelial dysfunction (Asymmetric dimethylarginine) which happened in central obese men. A cross sectional study was carried outin 62 central obesity male subjects with ages range between 30−60 years. The researcher determined SOD activity, concentration ofMPO as well as ADMA. In this study was found a significant correlation of F2-Isoprostan (r = 0.333, p = 0.008), MPO (r = 0.386; p = 0.008) and ADMA but not with SOD. The elevated concentration of F2-Isoprostane occur 3.5 times (p = 0.02; 95%; CI = 1.19–10.19), elevated MPO occur 3.7 times (p = 0.023; 95%; CI = 1.16–11.56) while combination of elevated F2-Isoprostane-MPO occur6.7 times (p = 0.011; 95%; CI = 1.33-33.24) will increase the risk of endothelial dysfunction. There was a significant correlation of oxidative stress with endothelial dysfunction, and the increase concentration of F2-Isoprostane and MPO indicates the occurrence of endothelial dysfunction in central obesity.]]>
<![CDATA[CARCInoeMBRYonIC AnTIGen (CEA) DI KANKER KOLOREKTAL ]]>
<![CDATA[Nur Rahmi Raehaan]]>;
<![CDATA[Asvin Nurulita]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v20i3.465
<![CDATA[Colorectal cancer is a common gastrointestinal malignancy of the colon and rectum. According to the American Society of Clinical Oncology (ASCO) in 2006, preoperative CEA level is useful in dtermining the tumour stage, plan of action and monitoring therapeutic response during the active treatment. Several factors which influence CEA level in patients with colorectal cancer is the staging and the degree of tumour, liver function, and as well as its location. This retrospective study is aimed to know the preoperative CEA levels in 51 patients with colorectal cancer and to compare the levels of CEA based on tumour stage, degree of tumour based on histopathology and tumour location.. This study was carried out at the Dr.Wahidin Sudirohusodo Hospital (RSWS), Makassar during January 2009−December of 2011. The researchers found a significant difference between the levels of CEA with the tumour stage (p=0.000) and its relation with the degree of the tumour (p=0.002), however, based on the tumour location (p=0.585) there was no significant difference between the levels of CEA. In conclusion, it was found that the higher the tumour stage, the higher the levels of the produced CEA. A well differentiated tumour of colorectal cancer produced a higher level of CEA compared to the moderate or poor-differentiated tumours.]]>
<![CDATA[TALASEMIA BETA HEMOGLOBIN E (Hemoglobin E Beta Thalassemia) ]]>
<![CDATA[Viviyanti Zainuddin]]>;
<![CDATA[Agus Alim Abdullah]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 3 (2015) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v21i3.1286
<![CDATA[Thalassemia is a quantitative abnormality of the hemoglobin marked by inadequate hemoglobin synthesis due to the lack orabsence of synthesis of one or more globin polypeptide chains. Hemoglobin variant is a qualitative abnormality due to the presence ofthe abnormal amino acid sequence of one or more globin polypeptide chains. HbE β thalassemia is a disorder of hemoglobin that resultsfrom the fusion between the gene β-thalassemia allele from one parent with a gene HbE allele from another parent. In this case, HbEβ-Thalassemia patient was a 4.8 year girl diagnosed with hemoglobin E-beta thalassemia based on history and clinical manifestations;pale, the presence of splenomegaly and hepatomegaly. Laboratory tests were Hb: 7.7 g/dL, MCV: 52.9 fl, MCH: 17.7 pg, MCHC: 33.5g/dL and ferritin: 1012 ng/mL. Peripheral blood smear evaluation showed a microcytic hypochromic anemia with hemolytic signs andinfected features of leukocytes. Hb electrophoresis using HPLC showed a Hb F: 37.7% and HbA2 52.4%, indicating that HbA2 was falsehigh due to coeluating with HbE. The patient was treated by blood transfusion and received additional therapy such as folic acid, ironchelation and vitamin E.]]>
<![CDATA[KADAR PENGHAMBAT PENGURAIAN FIBRIN OLEH TROMBIN YANG TERGIATKAN (THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR) DI PASIEN KEGEMUKAN DENGAN DAN TANPA DIABETES MELLITUS ]]>
<![CDATA[Mansyur Arif]]>;
<![CDATA[Ichwani Meinard]]>;
<![CDATA[Winni Agustiani]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 3 (2010) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v16i3.1035
<![CDATA[Obesity will cause the development of insulin resistance and endothelial dysfunction through fat metabolism hormones and cytokines products. The metabolic disorders is hallmarked by the decrease of insulin function and will cause disorders of coagulation andfibrinolysis. Thrombin-activatable fibrinolysis inhibitor (TAFI) is a newly found glycoprotein that has a role in the balance of coagulationand fibrinolytic process. The aim of this study was to analyze the TAFI level in obese subjects with and without diabetes mellitus. A crosssectional study was carried out by collecting data from TAFI level measurements at Prodia Clinical Laboratory Jakarta and Makassarduring January-March 2008. The data was analyzed using t test with SPSS version 12.0. From 80 samples that match with the criteria,was found in four (4) diabetes mellitus patients and 76 subjects without diabetes mellitus. The mean TAFI level in obese subjects withdiabetes mellitus was 7.67 ug/ml and in obese subjects without diabetes mellitus was 8.10 ug/ml. The result of t test showed p = 0.58.There was no significant difference between TAFI level in obese subjects with and without diabetes mellitus.]]>
<![CDATA[KADAR FIBRIN MONOMER DAN UKURAN INFARK DI STROK ISKEMIK AKUT ]]>
<![CDATA[Ani Kartini]]>;
<![CDATA[Mansyur Arif]]>;
<![CDATA[Hardjoeno Hardjoeno]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v20i3.470
<![CDATA[Coagulation activation and thrombosis frequently exist in ischemic stroke, thrombus formation can be detected early by the presence of fibrin monomer. The purpose of this study was to know the correlation of fibrin monomer level with cerebral infarct size in acute ischemic stroke patients. This was a cross sectional study with a total of 39 samples. The fibrin monomer level was determined by immunoturbidimetry method using STA-Compact and the measurement of the infarct size was done by CT scan of the head using Broderick formula. The results of this study showed that the median level of fibrin monomer in acute ischemic stroke with nonlacunar infarct type and lacunar infarct type were 14.46 μg/mL and 4.29 μg/mL, respectively. Mann-Whitney test showed there was a significant difference of fibrin monomer levels between nonlacunar infarct type and the lacunar type, p=0.000. The cut-off point analysis result of the fibrin monomer level was 5.96 μg/mL with a sensitivity of 88.9% and specificity of 76.4%, respectively. Spearman correlation test showed that fibrin monomer level was positively correlated with cerebral infarct volume in acute ischemic stroke (r=0.56, p=0.000). Based on this study, it can be concluded that fibrin monomer level can be used as a marker to predict the type of cerebral infarct and volume of acute ischemic stroke as well.]]>
<![CDATA[TURNAROUND TIME UJI COCOK SERASI DI PELAYANAN BANK DARAH (Turnaround Time Cross Match in the Blood Bank) ]]>
<![CDATA[Glent Nurtanio]]>;
<![CDATA[Rachmawati Muhiddin]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v22i1.1220
<![CDATA[Turnaround Time (TAT) is the time between the blood request form arriving at the blood bank and when it is issued by the bloodbank. Blood Bank RSWS standard on the TAT of Stat blood service is <45 minutes and is regularly <60 minutes. The aim of this researchwas to know the TAT of blood services at the Blood Bank of the Dr Wahidin Sudirohusodo Hospital, Makassar. The research was carriedout by cross sectional study between August until November 2013. The data were divided into two (2) categories, which were Stat andregular blood service. The blood service was divided into three (3) service times, morning (08:00–14:00), afternoon (14:00–21:00) andevening (21:00–08:00). The statistical method used was Independent Samples T Test. There were 1.366 blood services consisting of 831Stat blood service with average TAT about 37.15 minutes (82.9% complied to standard) and 535 regular blood service with averageTAT about 45.73 minutes (96.1% complied to standard). There were significant differences between morning and afternoon (p=0.000)and between afternoon and evening Stat TAT (p=0.003), but there was no significant difference between morning and evening StatTAT (p=0.196). No significant difference was found in regular TAT between the morning and afternoon session (p=0.915), as well asnoon and evening (p=0.490); and morning and evening session (p=0.428). The TAT blood service at the Dr. Wahidin SudirohusodoHospital Blood Bank which was carried out by gel method should shorten the waiting time of Stat and regular blood service, but not upto 100% yet. Based on this study, the researchers recommended to do some regulation changes in the blood service system especiallyfor the morning and evening Stat sessions.]]>
<![CDATA[MALARIA KONGENITAL ]]>
<![CDATA[Sri Wahyunie S]]>;
<![CDATA[Nurhayana Sennang]]>;
<![CDATA[D. Daud]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v21i2.1109
<![CDATA[Congenital Malaria is an infectious disease caused by the malaria parasite that is transmitted from mother to child through theplacenta during pregnancy or at delivery. Clinical manifestations which may arise due to Plasmodium infection are: the irritability,fever, anaemia, jaundice and hepatosplenomegaly. The incidence of congenital malaria according to the National Basic Health Research2010 is only about 0.3%. Forty two days old male baby with the main complaints fever and pale since he was three (3) weeks old. Fromthe physical examination the reviewer found anaemia, jaundice and splenomegaly. Plasmodium vivax was detected by serologic andmicroscopic examination. From the pregnancy history of mother the reviewer found that at the age of seven (7) months of pregnancyshe suffered from malaria caused by Plasmodium vivax the same as the type of Plasmodium infected the baby. The baby was born innon malaria endemic area which enhanced the diagnosis of congenital malaria of this patient. The patient was fully recovered aftertreated with dehydroartemisin piperaquin and the reviewer reported one case of congenital malaria, forty twodays old male baby. Thediagnosis was made based on the malaria history of mother at seven (7) month of pregnancy, the serologic and microscopic examinationfrom the patient blood and the baby was born in a non malaria endemic area. The prognosis of patient with congenital malaria causedby Plasmodium vivax generally was good. The clinical condition was improved and fully recovered after treated with dehydro-artemisinpiperaquin.]]>
<![CDATA[FLAMING CELLS DI MULTIPLE MYELOMA ]]>
<![CDATA[Nursin Abd. Kadir]]>;
<![CDATA[Hj. Darmawaty E.R,]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v17i1.1091
<![CDATA[Multiple myeloma is a type of cancer on plasma cells which are system of immune cells in bone marrow that produce antibodies. A47 years old man precented with an excruciatingly painfull bone lytic lesion acompanied with compressive fracture in his Thorakal XIIand first Lumbar vertebral body since a week ago. A complete blood count on admission showed anemia normocytic normocrom withhemoglobin content of 5.3 mg/dL. The blood smear revealed clumping of red blood cells to bound "Rouleaux formations". Serum proteinelectrophoresis showed specific evidence of a M-spike. Bence-Jones proteinuria was positive and serum kreatinin arised 2.44 mg/dL.The bone marrow aspiration contained 45% plasma cells, many of which exhibited the morphology of flaming cells with an eccentricnucleus and violaceous cytoplasm. Plasma cells varied in size and shape and included flaming cells and myeloma cells. The patient wasdiagnosed as having flaming cells in multiple myeloma stage IIIB.]]>
<![CDATA[ANALISIS KADAR ASAM URAT PADA PASIEN KARSINOMA MAMMA ]]>
<![CDATA[Susi Sevianty]]>;
<![CDATA[Uleng Bahrun]]>;
<![CDATA[Mansyur Arif]]>
<![CDATA[ INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009) ]]>
Publisher : <![CDATA[Indonesian Association of Clinical Pathologist and Medical laboratory ]]>
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DOI: 10.24293/ijcpml.v16i1.992
<![CDATA[In malignancy cases, an increase of uric acid level is often observed after therapy (Tumor Lysis Syndrome), but some studies also indicated an increase before therapy which is related to a refusal reaction against tumor, and specific only for certain malignancy cases.Carsinoma mammae is the second most common malignancy among women in Indonesia, so that studying the phenomenon occurredin carcinoma mammae including uric acid level are expected to provide insight in management of carcinoma mammae. A longitudinalstudy was conducted by collecting secondary data from medical record of carcinoma mammae patients in Wahidin SudirohusodoHospital for period of July 2007–June 2008. Data were analyzed by using Wilcoxon Signed Rank Test with alpha 0.05. 12 of subjectsare considered eligible for study criteria, with the age ranging from 28–60 years old. In generally, uric acid level determined beforeand after chemotherapy showed a level in normal range, except for 3 samples before therapy and 3 different samples after therapyshowed a level more than 5.7 mg/dL. Statistic result showed mean uric acid level before chemotherapy was 4.508 ± 1.2566 mg/dL andafter chemotherapy was 5.025 ± 1.3240 mg/dL (p = 0.16). Increased of uric acid level is not significant level was found in serum ofcarcinoma mammae before and after chemotherapy.]]>
