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All Journal Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner WARTAZOA Indonesian Bulletin of Animal and Veterinary Sciences Jurnal Medik Veteriner ARSHI Veterinary Letters JURNAL KAJIAN VETERINER Jurnal Kedokteran Hewan Jurnal Veteriner dan Biomedis Current Biomedicine Jurnal Veteriner
Sus Derthi Widhyari
Divisi Penyakit Dalam, Departemen Klinik, Reproduksi, Dan Patologi, Fakultas Kedokteran Hewan, Institut Pertanian Bogor Jl Agathis, Kampus IPB Dramaga, Bogor, Jawa Barat, Indonesia 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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PF-4 Immune Response of Dry Holstein Vaccinated by Killed Avian Influenza H5N1 Vaccine Anita Esfandiari; Sri Murtini; Sus Derthi Widhyari; Retno Wulansari; Bayu Febram; Leni Maylina; Arief Purwo Mihardi
Hemera Zoa Proceedings of the 20th FAVA & the 15th KIVNAS PDHI 2018
Publisher : Hemera Zoa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.039 KB)

Abstract

The establishment and spread of highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype in birds and coincident infections in humans since 2003 have raised concerns that we may be facing an influenza pandemic caused by an H5N1 influenza virus [4]. Globally, from January 2003 to 2 March 2017, there were 860 cases of human infection with avian influenza A(H5N1) virus reported from 16 countries worldwide. Of these 860 cases, 454 were fatal (CFR of 53%). The last case was reported from Indonesia on 26 September 2017 [7]. Although the human cases of H5N1 in Indonesia has decreased significantly since 2010, according to WHO until 2017 there have been reported 200 cases H5N1 in  human with 168 cases of deaths. The last case was reported from Indonesia on 26 September 2017. This is indicate Indonesia as the highest fatal case of H5N1 globally. With continued incidence of avian influenza due to existing AI H5N1 viruses in poultry, the avian influenza H5N1 has been believed remain to threaten Indonesia [6].Passive immunization using specific antibody against AI H5N1 from bovine colostrum is one of an alternative to control H5N1 virus infection due to lack of H5N1 vaccine production for human. Bovine colostrums consider an ideal alternative antibody source, as the antibody in the bovine’s blood is transported to mammary gland easily and accumulates in the colostrum in large quantities. As a “biological factory”  and the source of natural antibody, bovine colostrum could be designed to produce the specific antibody against certain disease for animal and human by immunizing the dry cow (with the antigen of interest).Vaccine is an antigenic material used to produce active immunity against diseases. Vaccination is the administration of vaccine to the individual to generate immunity against a disease [2]. According to [1], the exposure of a dry cow against antigen (vaccine) will produce specific antibody in their blood circulation. Therefore, evaluation on the status of antibody against AI H5N1 following the vaccination of dry Holstein cows with killed AI H5N1 vaccine is needed. 
The Role and Deficiency of Zinc Mineral in Immune System Sus Derthi Widhyari
WARTAZOA, Indonesian Bulletin of Animal and Veterinary Sciences Vol 22, No 3 (2012): SEPTEMBER 2012
Publisher : Indonesian Center for Animal Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.953 KB) | DOI: 10.14334/wartazoa.v22i3.848

Abstract

Zinc (Zn) is a micro mineral which is needed by every cell in the body. Adequate Zn mineral is important in maintaining optimal health. Zn functions as a cofactor of various enzymes, structural integrity of cells, DNA synthesis, hormonal storage and release,  immunotransmision  and  immune  system.  Zn  deficiency causes  decreased  appetite,  dermatitis,  growth  retardation, delayed sexual maturation, infertility and imunodeficiency. This is associated with changes in the function of immune system response, such as decreased B and T cell functions, reduced phagocytosis and decreased cytokine production. Severe Zn deficiency is characterized by severely depressed immune function and frequent infections. Zn enhances immune function for specific and non-specific immunity. The role of non-specific immune respone is through the activity of cells phagocytosis by neutrophils and monocytes, while the specific immune response can be humoral and cellular mediated by lymphocytes B and T. Supplementation of Zn can improve the activity of leukocyte cells through stimulating the production of tumor necrosis factor- alpha (TNF-α) by monocytes cells, thereby increasing the ability of phagocytosis. In addition, Zn is also able to increase the production of lymphokines that cause lymphocyte cells able to differentiate and proliferate.   Key words: Zn, deficiency, immunity, leucocyte cells
Suspect feline infectious peritonitis pada kucing Sus Derthi Widhyari; Bayu Firmala Kusuma; Setyo Widodo; Anita Esfandiari; Retno Wulansari; Leni Maylina
ARSHI Veterinary Letters Vol. 2 No. 1 (2018): ARSHI Veterinary Letters - Februari 2018
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.059 KB) | DOI: 10.29244/avl.2.1.15-16

Abstract

Feline infectious peritonitis (FIP) adalah penyakit menular akibat infeksi corona virus dan dapat berakibat kematian. Diagnosa FIP dijumpai pada seekor kucing  dengan gejala anoreksia, lemas, perut membesar dan diare. Hasil pemeriksaan abdomen menunjukkan adanya undulasi positif diduga akibat penimbunan cairan di rongga abdomen. FIP tipe ini dijumpai adanya akumulasi cairan dalam rongga perut dan menyebabkan terjadinya pembesaran daerah abdomen dan disertai kesulitan bernafas. Berdasarkan pemeriksaan klinis dan laboratories, kucing di diagnosa mengalami suspect Feline Infectious Peritonitis (FIP) tipe basah. Perlu dilakukan pemeriksaan penunjang untuk lebih meneguhkan diagnosa, seperti uji serologis, radiografi, dan ultrasonografi.
Suspect cushing’s syndrome pada kucing Hammada Raudlowi; Sus Derthi Widhyari
ARSHI Veterinary Letters Vol. 4 No. 2 (2020): ARSHI Veterinary Letters - Mei 2020
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1060.169 KB) | DOI: 10.29244/avl.4.2.27-28

Abstract

Cushing’s syndrome yaitu sindrom klinis yang disebabkan kelebihan sekresi kortisol oleh kelenjar adrenal. Keluhan pemilik hewan kucing adalah adanya kebotakan dibagian perut kanan dan kiri, sering minum, dan sering urinasi. Temuan klinis adalah pembesaran abdomen seperti ‘pot-bellied’, polidipsia, poliuria dan alopecia bilateral pada bagian abdomen. Diagnosa penunjang melalui pemeriksaan ultrasonografi. Diagnosa banding adalah hipotiroid, pankreatitis dan dermatophytosis. Prognosa fausta sampai dubius. Terapi yang diberikan adalah pemberian mitotane dan ketoconazole
Mastektomi pada kambing peranakan etawa (Capra aegagrus hircus) Gunanti Soeyono; Sus Derthi Widhyari; Selma Laily Nur Afifah; Shavrillia Inovanny Angesti; Intan Khoirunnisa; Irda Khaeriyah; Riana Nurul Maulani; Beata LYL Ayu
ARSHI Veterinary Letters Vol. 4 No. 2 (2020): ARSHI Veterinary Letters - Mei 2020
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (960.378 KB) | DOI: 10.29244/avl.4.2.29-30

Abstract

Kambing betina peranakan etawa berumur 3 tahun diperiksa dengan gejala ada pembesaran di kelenjar mamaria. Anamnesis kambing sudah beranak 5 kali, setiap beranak 1-2 ekor dan anaknya selalu mati. Air susu induk tidak keluar walaupun terlihat ada pembesaran kelenjar mamaria. Pemeriksaan klinis menunjukkan ada pembesaran salah satu kelenjar mamaria. Diagnosis kambing tersebut menderita tumor mamaria. Hasil pemeriksaan laboratorium sebelum operasi menunjukkan gambaran hematologi masih dalam keadaan normal meskipun Hb normal rendah dan platelet rendah. Setelah operasi menunjukkan peningkatan neutrophil, monosit, dan kadar hemoglobin. Operasi masektomi berhasil dengan baik dan kondisi hewan setelah operasi memperlihatkan nafsu makan dan minum baik. Terjadi peningkatan gambaran RBC dan Hb sehingga kambing dilanjutkan perawatan sampai pulih kembal
Peran Bone Marrow Mesenchymal Stem cells (BMMSC) dalam Perubahan Seluler Hyperplasia Kelenjar Adrenal Tikus Hipertensi Yanse Yane Rumlaklak; Erni Sulistiawati; Dondin Sajuthi; Sus Derthi Widhyari; Setyo Widi Nugroho
JURNAL KAJIAN VETERINER PROSIDING SEMINAR NASIONAL KE-7
Publisher : FAKULTAS KEDOKTERAN HEWAN UNIVERSITAS NUSA CENDANA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jkv.v0i0.1602

Abstract

Dalam keadaan hipertensi, hyperplasia merupakan salah satu abnormalitas jaringan yang terlihat yang ditunjukkan dengan peningkatan jumlah sel dalam jaringan atau organ sehingga jaringan atau organ menjadi lebih besar ukurannya dari normal. Tujuan penelitian ini adalah untuk mengetahui efektivitas bone marrow mesenchymal stem cells (BMMSC) terhadap perubahan seluler hyperplasia pada organ kelenjar adrenal tikus hipertensi. Penelitian ini menggunakan sepuluh ekor tikus jantan strain Wistar dengan umur ± 10-12 minggu dan berat badan ± 200-250 gram, dan dibagi menjadi 2 kelompok berbeda yaitu hipertensi BMMSC (+) dan hipertensi BMMSC (-). Tikus dikondisikan hipertensi menggunakan Metode Hashinoto. Nefrektomi kanan dan ligase arteri carotid communis dilakukan pada semua tikus. Tikus disuntik dengan deoxycorticosterone acetate (DOCA), kemudian 0,12% aminopropionitrile fumarate (BAPN) ditambahkan ke dalam air minum. Larutan NaCl 1% diberikan sebagai air minum selama penelitian. Evaluasi tekanan darah hipertensi dilakukan, kemudian tikus-tikus di euthanasia untuk koleksi organ kelenjar adrenal. Organ Kelenjar adrenal di fiksasi dengan formalin 10% dan kemudian diwarnai dengan pewarnaan Periodic Acid Shiff (PAS). Data yang diperoleh kemudian dianalisis secara deskriptif kualitatif. Hasil penelitian ini membuktikan terapi hipertensi dengan menggunakan BMMSC menunjukkan perubahan hiperplasia kearah normal.
Konsentrasi Mineral Serum saat Produksi Embrio dan Hubungannya dengan Kualitas dan Kuantitas Embrio pada Sapi Peranakan Ongole Putri Indah Ningtias; Sus Derthi Widhyari; Retno Wulansari
Acta VETERINARIA Indonesiana Vol. 10 No. 2 (2022): Juli 2022
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.10.2.103-110

Abstract

Mineral merupakan salah satu nutrisi yang memiliki peran penting dalam reproduksi. Perubahan konsentrasi mineral akan menyebabkan masalah reproduksi termasuk mempengaruhi produksi embrio. Penelitian bertujuan untuk menganalisis konsentrasi mineral serum selama produksi embrio dan menganalisis hubungan antara konsentrasi mineral serum dengan kualitas dan kuantitas embrio pada sapi donor Peranakan Ongole (PO). Sampel darah dikoleksi dari 10 ekor sapi donor PO sebelum superovulasi dan saat melakukan panen embrio. Darah diambil melalui vena coccygea kemudian disentrifugasi untuk diambil serumnya. Serum dianalisis terhadap parameter kalsium (Ca), fosfor (P), dan magnesium (Mg) dengan prinsip fotometer menggunakan kit komersial. Data diuji secara statistik menggunakan uji nonparametrik Wilcoxon untuk membandingkan konsentrasi mineral serum sebelum superovulasi dan saat panen embrio. Hubungan antara konsentrasi mineral serum dengan kualitas dan kuantitas embrio dianalisis menggunakan uji korelasi nonparametrik Rank Spearman. Hasil penelitian menunjukkan bahwa produksi embrio tidak mempengaruhi konsentrasi mineral serum. Konsentrasi Mg secara signifikan berhubungan dengan embrio morula, tetapi tidak signifikan dengan total embrio (TE), embrio layak transfer (LT), embrio degenerasi (DG), oosit unfertile (UF), dan embrio blastosis. Tidak terdapat hubungan yang signifikan antara konsentrasi Ca dan P dengan TE, embrio LT, DG, oosit UF, embrio morula, dan blastosis.
THE EFFECTS OF AGE ON BIOCHEMISTRY PROFILES OF ACEH CATTLE BLOOD Lia Khairita; Anita Esfandiari; Sus Derthi Widhyari; Wiwin Winarsih
Jurnal Kedokteran Hewan Vol 15, No 3 (2021): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (374.524 KB) | DOI: 10.21157/j.ked.hewan.v15i3.21698

Abstract

The purpose of this study was to analyze the effects of age on the biochemistry profiles of aceh cattle, which  included examinations of: total protein (TP), albumin, globulin, albumin/globulin ratio (A/G), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), creatine kinase (CK), blood urea nitrogen (BUN), calcium (Ca), phosphorus (P) and magnesium (Mg) . Sixteen clinically healthy aceh cattle aged 2-4 years old, and 16 aceh cattle aged 4-6 years old were purposively selected for the study. Blood samples were drawn from the jugular vein and subjected to blood biochemistry measurements using commercial kits. The results showed that serum concentrations of TP, globulin, AST and Ca of aceh cattle were significantly (P0.05) higher in age group 4-6 years old, while ALP activity was significantly (P0.05) higher in age group 2-4 years old. In conclusion, age must be considered as a factor when interpreting the blood biochemistry profiles of aceh cattle.
ELECTROCARDIOGRAM OF PIGS (Sus scrofa) ANESTHETIZED WITH A COMBINATION OF KETAMINE-MEDETOMIDINE AND KETAMINE-ACEPROMAZINE Jessica Anggun Safitri; Gunanti Gunanti; Deni Noviana; Sus Derthi Widhyari
Jurnal Kedokteran Hewan Vol 14, No 4 (2020): December
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.403 KB) | DOI: 10.21157/j.ked.hewan.v14i4.16984

Abstract

This study aims to evaluate and compare the effects of the combination of ketamine-medetomidine and ketamine-acepromazine anesthesia on pig electrocardiogram (ECG) images. The study was conducted to see the ECG Leads II in six pigs which were divided into two groups. Group I (K1) was given a combination of ketamine (10 mg/kg BW) and medetomidine (0.08 mg/kg BW), while Group II (K2) was given a combination of ketamine (22 mg/kg BW) and acepromazine (1.1 mg/kg BW) intramuscularly. ECG recording was performed after the pigs were anesthetized at the surgical stage by attaching the recording electrodes to the front wall of the chest, front left and right ankles, and back right and left back ankles. The ECG recording used 1 voltage (1 cm = 1mV) with a speed of 25 mm/sec. The parameters observed were heart rate frequency, heart rhythm, P duration, P amplitude, PR interval, R amplitude, QRS interval, QT interval, ST segment, T wave, and Mean Electrical Axis (MEA). Data obtained from this study were analyzed by T-test. The results showed that K1 had an average heart rate of 100 x/minute, regular heart rhythm, P duration of 0.07 sec, P amplitude of 0.27 mV, PR interval of 0.17 sec, R amplitude of 0.75 mV, QRS interval of 0.05 sec, QT interval of 0.20 sec, ST segment of 0.17sec, T wave of 0.17 mV, and MEA of 83.60°; meanwhile, K2 had an average heart rate of 122 x/minute, regular heart rhythm, P duration of 0.06 mm/sec, P amplitude of 0.23 mV, PR interval of 0.14 sec, R amplitude of 0.80 mV, QRS interval of 0.04 sec, QT interval of 0.16 sec, ST segment of 0.14 sec, T wave of 0.12 mV, and MEA of 68.60. The ketamine-medetomidine combination produced good quality of anesthetics for the cardiovascular system.
Clinical Signs and Haematology Profiles of Beagle Dogs with Tick Infestation Mihardi, Arief Purwo; Joesoef, Jayusman Arsiyanti; Wolo, Kathirina Beathrik Riwu; Esfandiari, Anita; Widhyari, Sus Derthi; Wulansari, Retno; Wijaya, Agus; Maylina, Leni
Jurnal Medik Veteriner Vol. 5 No. 2 (2022): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol5.iss2.2022.266-269

Abstract

Rhipicephalus sanguineus is one of the vectors that could induce diseases in dogs. A physical examination and haematology test could examine the dog's condition with tick infestation. Five dogs, beagle breeds from Veterinary Teaching Hospital, School of Veterinary Medicine and Biosciences, IPB University, have been examined for physical examination and CBC test. A haematology test was performed using a haematology analyzer and made the blood smear. Physical examination showed that 60% of dogs have a tick infestation, 80% have pallor, 60% have pruritus, 40% have crusted skin, and 100% have wounds in extremities. However, the body temperature and heart rate were relatively normal. Complete blood count test showed that red blood cells (RBC), peak cells volume, and haemoglobin (Hb) decreased (80%), MCHC increased (40%), thrombocytopenia (100%), leukopenia (40%), lymphocytopenia (60%), neutropenia (10%) and monositopenia (80%). The blood smear result showed all dogs have positive blood parasites, with the highest percentage being the third dog (0.056%). From the physical examination, CBC, and blood smear, it can be concluded that dogs with tick infestation would experience anaemia that showed by RBC, PCV, decreasing number of platelet and positive blood parasite.
Co-Authors . Herlina A.S. Satyaningtijas Aditia Dwi Cahyono Agus Wijaya Agus Wijaya Ali Hujarat Amani, Aqila Zata Anita Esfandiari April Hari Wardhana Aulia Andi Mustika Azzahrah, Putri Bayu Febram Bayu Firmala Kusuma Beata LYL Ayu Chusnul Choliq Deni Noviana Deny Setyo Wibowo Dewi, Fitriya Nur Annisa Dodi Darmakusuma Dondin Sajuthi Effendi, Siti Aisyah Rahmalia Erni Sulistiawati Esti Dhamayanti Fitri, Arni Diana Gunanti . Hammada Raudlowi I Ketut Sutama I Putu Kompiang I wayan Teguh Wibawan IETJE WIENTARSIH Intan Khoirunnisa Irda Khaeriyah Jessica Anggun Safitri Joesoef, Jayusman Arsiyanti Kartjito, Nicolas Edward Christanto Khairita, Lia Laksamana , Vincentius Bryan Leni Maylina Lia Khairita Lina Noviyanti Sutardi Muhammad Bintang Nabila Latifa Hafizsha Nadelia, Nurul Ningtias, Putri Indah Novitasari , Dina Nuraliyu , Roro Iyaka Pradianto, Bagus Ilham Prastiwi, Nurul Anjar Putri Indah Ningtias Putri Indah Ningtias Putri, Tiara Annisa Rahma, Kinanti Dwi Rahmawati Januar Retno Wulansari Riana Nurul Maulani Rizal Rahadian Ramdhany Rumlaklak, Yanse Yane Satriawan, Ivan Selma Laily Nur Afifah Setyo Widi Nugroho Setyo Widodo Setyo Widodo Shavrillia Inovanny Angesti Soesatyoratih, Roro Solinda, Gamelita Rizkawandi sri murtini . Supriyono Supriyono Suryono Susi Soviana Tika Aryanti Upik Kusumawati Hadi, Upik Kusumawati Wiwin Winarsih Wolo, Kathirina Beathrik Riwu Yanse Yanne Rumlaklak