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All Journal Nexus Pendidikan Kedokteran dan Kesehatan Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Nexus Biomedika Jurnal Gizi dan Kesehatan Journal of Epidemiology and Public Health Indonesian Journal of Medicine Journal of Health Policy and Management Journal of Health Promotion and Behavior Journal of Maternal and Child Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Farmasi
RUBEN DHARMAWAN
Faculty of Medicine, Sebelas Maret University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Nexus Biomedika

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Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar Kolesterol Total Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Tunikasari, Atma Sanggani; Suhanantyo, .; Dharmawan, Ruben
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background : Cardiovascular disease is the leading cause of disability and death in the world. High levels of blood cholesterol becoming a risk factor in atherosclerosis is the leading cause of cardiovascular disease. Yam Bean contains flavonoids, isoflavones, phenols, and saponins which have an effect of antihyperlipidemia. This study aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood total cholesterol level of rats (Rattus norvegicus) with a high fat diet. Methods : This research was an experimental laboratoric research using the post test only with control group design. The research subject were 30 male white rats, Sprague Dawley strain, 2 months old, and their weights were about 130-240 gram. The subjects were arranged into 6 groups. The whole groups were adapted for 7 days. All groups except normal control, were administered high fat diet 2 ml/200 gram BW/day for 21 days. The positive control group was administered 0.18 mg/200 g BW/day of simvastatin and the negative control group was administered 2.00 ml/200 g BW/day of distilled water. While the first, second and third treatment groups were consecutively administered 70 mg, 140mg and 210 mg/200 g BW/day of Yam Bean extracts. On the 22nd day, the blood samples of the subjects were taken from pre-orbital plexus for measurement of cholesterol levels. Then, the data were analyzed using One-way ANOVA test and Least Significance Difference test (LSD). Results : The One-way ANOVA test showed a significant difference in blood total cholesterol level among six groups (p = 0.001). Post Hoc Test showed a significant difference among two groups, except the third treatment group which had the same result and the normal control groups (p = 0.335). Conclusion : Yam Bean (Pachyrhizus erosus) extract had effect to decrease the blood total cholesterol levels of rats. Keywords : Yam Bean (Pachyrhizus erosus) extract, total  cholesterol levels, white rats. 
Pengaruh Ekstrak Daun Lamtoro (Leucaena leucocephala) terhadap Waktu Kematian Cacing Ascaris suum, Goeze In Vitro Ramadhan, Mira Rizki; Dharmawan, Ruben; Mashuri, Yusuf Ari
Nexus Biomedika Vol 3, No 3 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Abstract

Background. Nematodes infection particularly, Ascaris lumbricoides  is cronic infection that make serious health problems. Leucaena leaf (Leucaena lecocephala) contain  leucanin, leucanon, mimosin and tannin that have been known to have athelmintic effect. This study aimed to determine the effect of Leucaena. Leucaena leaf  (Leucocaena leucocephala) extract towards death time of Ascaris suum, Goeze In Vitro.. Methods. This study was a laboratory experimental research using the post-test only controlled group design. The subject were adult worms that have length between 10 -20 cm. The sampling technique was used in purposive sampling. The subject was divides into 6 groups, each group consist of 4 worms, replication performed 4 times. Pirantel Pamoat 5mg/ml was used in Positive Control Group (KKP) and NaCl 0,9% was used in Negative Control Group (KKN). While the handling group was given by leucaena leaf extract in various concentration. 5% b/v was given by first handling group (KP1), 10% b/v was given for KP2, 20% b/v was given for KP3, and  30% b/v was given for KP4. Worms immersed every 60 minutes and counted the number of time. Data were analyzed with regression liner and probit analys. Results. The fastest of death time that given by leucaena leaf is KP4 in the amount of 375 minutest, followed by KP3, KP2 dan KP1. While the death time of  KKP aproximately  at 60 minutes dan 3360 minutes on KKN. The result of Pearson correlation test show close relationship between variation of the concentration and the time of death worms with a correlation coefficient 0,778 marked negative. The result of regression liner show significant p < 0.000,  r square .605 with regression equation is Y = 2704 – 503,464 X. The result of probit analys LC50 in the amount of  10,355%, LT50 is counted at 411,178 minutes LT99 is counted at 571,621 minutes.  While  37,055 minutes is counted for Pirantel Pamoat. Conclution. Based on this study, in can be concluded that the  Leucaena leucocephala leaf extract affect mortality of Ascaris suum in Vitro. The increasing of extract concentration in inversely propotional with the death time of worms. Keywords : Leucaena Leaf extract, death time,  anthelmintic 
Co-Authors -, Muryanti . Soetrisno . Suhanantyo A.A. Ketut Agung Cahyawan W Adi Prayitno Afiono Agung Prasetyo Anggraeni, Fatimah Dewi Argyo Demartoto, Argyo Arinto Hadi, Arinto Aris Sudiyanto Asri Sukawati Putri Atika Puspita Hapsari Atma Sanggani Tunikasari Aviria Ermamilia Bhisma Murti Darukutni, Darukutni Dono Indarto Dyah Kusumawati Dyah Mustikaningtyas Dewanti Endang Sutisna Sulaeman Eti Poncorini Pamungkasari Fajar Alam Putra, Fajar Alam Febrika Devi Nanda Hastuti, Nunik Maya Hervindita Dinda Siswandwika, Hervindita Dinda I Gusti Bagus Wiksuana Icha Dithyana Ike Nurrochmawati Irene Yunita Prihandini JB. Suparyatmo Suparyatmo, JB. Suparyatmo Kharisma Setya Harnani Krisna Rendi Awalludin Kumoro Setya, Adhi Mardiatmi Susilohati Mashuri, Yusuf Ari Mira Rizki Ramadhan, Mira Rizki Murkati, Murkati Narzah, Norma Arista Ningrum, Dhian Nurayni Sulistyo Okid Parama Astirin Pawito -, Pawito Pradana, Riska Chandra Purwanto - Rahardjo, Setyo Sri Rahmah, Anindita Hasniati Rasyiid, Astika Sofi Ariani Sofiyani, Maya Sri Haryati Sugiarto S Supriyadi Hari Respati Syarifah Syarifah, Syarifah Tamaulina Br Sembiring Umi Nadhiroh Wati, Emita Dewi Lilis Angkasa winarni - yoseph Indrayanto