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Neutrophil gelatinase-associated lipocalin as a biomarker for acute kidney injury in children after cardiac surgery Meta Herdiana Hanindita; Riskky Vitria Prasetyo; Ninik Asmaningsih Soemyarso; I Ketut Alit Utamayasa; Paul Tahalele
Paediatrica Indonesiana Vol 56 No 4 (2016): July 2016
Publisher : Indonesian Pediatric Society

Background Acute kidney injury (AKI) is still diagnosed by measuring the estimated creatinine clearance (eCCl), despite the fact that it may not change until 50% or more of kidney function has been lost. AKI after cardiac surgery is related to prolonged intensive care, decreased quality of life, and increased long term mortality. Neutrophil gelatinase-associated lipocalin (NGAL) represents an early biomarker of AKI, which may be useful for assessing AKI in cardiac patients.Objective To determine the validity of urinary and plasma NGAL as biomarkers for AKI in children after cardiac surgery.Methods Subjects were children who underwent cardiac surgery in Dr. Soetomo Hospital, Surabaya, Indonesia from August 2013 to January 2014. Serial urine and blood samples were analyzed for NGAL before surgery, as well as at 2h, 4h, 12h, and 24h after surgery. The AKI was established based on pRIFLE criteria. Estimated creatinine clearance (eCCl) was calculated from the estimated glomerular filtration rate (eGFR), according to age by the traditional Schwartz formula. Serum creatinine was assayed by the Jaffe method before surgery, as well as at 12h, 24h, 48h, and 72h after surgery.Results Of 20 subjects, 5 developed AKI. Urinary and plasma NGAL increased markedly at 2h postoperatively, as compared to eGFR which showed a rise at 12-48 h after cardiac surgery. Analysis of 2h post-operative urinary NGAL at a cut off value of 11.270ng/mL yielded an area under the curve (AUC) of 1.00 (95%CI 2.63 to 12.13), with sensitivity and specificity of 100% each for AKI. In addition, 2h post-operative plasma NGAL at a cut off value of 8.385 ng/mL yielded an AUC of 1.00 (95%CI 3.71 to 12.15) with sensitivity and specificity of 100% each for AKI.Conclusion Urinary and plasma NGAL are valid as early biomarkers for AKI in children after cardiac surgery.

Diet dan Sindrom Metabolik pada Remaja Obesitas Rendi Aji Prihaningtyas; Nur Aisiyah Widjaja; Meta Herdiana Hanindita; Roedi Irawan
Amerta Nutrition Vol. 4 No. 3 (2020): AMERTA NUTRITION
Publisher : Universitas Airlangga, Kampus C, Mulyorejo, Surabaya-60115, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v4i3.2020.191-197

ABSTRACTBackground : The prevalence of obesity in adolescents is increasing and causes metabolic syndrome at a young age. Metabolic syndrome results from the interaction of environmental, genetic, and dietary factors. The purpose of this study was to determine the diet profile of obese adolescents suffering from metabolic syndrome.Methods: This study was a cross-sectional study of obese adolescents who visited the Pediatric Nutrition and Metabolic Disease in Dr. Soetomo General Hospital, Surabaya. The anthropometry examination (weight, height and waist circumference), blood pressure, and blood tests (HDL cholesterol, triglycerides and blood glucose levels) were measured. The diagnosis of metabolic syndrome was based on the International Diabetes Federation. Food consumption data was obtained through direct interviews using data collection sheets. Analysis of dietary differences in obese adolescents suffering from metabolic syndrome was performed by chi square using SPSS.Results and Discussions: A total of 59 obese adolescents aged 13-16 years were involved in this study. A total of 27 subjects (45.8%) suffered from metabolic syndrome and 32 subjects (54.2%) did not suffer from metabolic syndrome. The level of the consumption of fish, vegetables, and fruit in obese adolescents were still low. There was no significant difference in the diet profile between obese adolescents who suffer from metabolic syndrome or not.Conclusion: Prevention strategies through food consumption patterns are needed in obese adolescents to control metabolic stress processes and prevent metabolic syndrome in the future. Diet knowledge in obese adolescents needs to be given early to prevent further complications. Increasing foods that contain anti-oxidants, such as fruits and vegetables, is one of the strategies to prevent metabolic syndrome in obese adolescents.ABSTRAKLatar Belakang : Prevalensi obesitas pada remaja semakin meningkat dan menyebabkan sindrom metabolik di usia muda. Sindrom metabolik terjadi akibat interaksi faktor lingkungan, genetik, dan diet. Tujuan dari penelitian ini adalah mengetahui profil diet pada remaja obesitas yang menderita sindrom metabolik.Metode : Penelitian ini merupakan penelitian potong lintang pada remaja obesitas yang berkunjung di Poli Nutrisi dan Penyakit Metabolik Anak di RSUD Dr. Soetomo, Surabaya. Pada subyek dilakukan pemeriksaan antropometri (berat badan, tinggi badan, dan lingkar pinggang), pemeriksaan tekanan darah, dan pemeriksaan darah (kolesterol HDL, trigliserida, dan kadar glukosa darah). Diagnosis sindrom metabolik ditegakkan berdasarkan International Diabetes Federation. Data konsumsi makanan didapatkan melalui wawancara langsung dengan menggunakan lembar pengumpul data. Analisis perbedaan diet pada remaja obesitas yang menderita sindrom metabolik dilakukan dengan chi square menggunakan SPSS.Hasil dan Pembahasan : Sebanyak 59 remaja obesitas yang berusia 13-16 tahun terlibat dalam penelitian ini. Sebanyak 27 subyek (45,8%) menderita sindrom metabolik dan sebanyak 32 subyek (54,2%) tidak menderita sindrom metabolik. Tingkat konsumsi ikan, sayur, dan buah pada remaja obesitas masih rendah. Tidak ada perbedaan yang bermakna pada profil diet antara remaja obesitas yang menderita sindrom metabolik maupun tidak.Kesimpulan : Strategi pencegahan melalui pola konsumsi makanan diperlukan pada remaja obesitas untuk mengontrol proses stres metabolik sehingga dapat mencegah sindrom metabolik di masa datang. Pengetahuan diet pada remaja obesitas perlu diberikan sejak dini untuk mencegah komplikasi lebih lanjut. Memperbanyak makanan yang mengandung anti-oksidan, seperti buah dan sayur merupakan salah satu strategi mencegah sindrom metabolik pada remaja obesitas.

Relationship Between Central Obesity and The Risk of Hypertension in Obesity Adolescents Putri Ardina Maharani; Nur Aisiyah Widjaja; Meity Ardiana; Meta Herdiana Hanindita
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.199

The increasing prevalence of central obesity in adolescents is accompanied by an increase in risk factors for cardiovascular disease. The study aims to analyze the relationship between central obesity and the risk of hypertension in obese adolescents, including both male and female subjects. This study was undertaken to provide opportunities for further exploration of the relationship between central obesity and hypertension in adolescents. The study was a retrospective observational study that utilized medical record data from a previous research project entitled "Polimorfisme Gen Adiponectin ADIPOQ +45 T>G, ADIPOQ – 11377 C>G dengan Kadar Adiponektin Pada Remaja Obesitas dan Resiko Sindrom Metabolik." This data was obtained from research conducted on obese adolescents aged 13-18 years in junior and senior high schools in Surabaya and Sidoarjo who met the criteria. The sample comprised 140 obese adolescents, who were then categorized into two groups: those without central obesity and those with central obesity. Statistical data were analyzed using SPSS with the Chi Square test. There is a very strong and significant relationship between central obesity and the risk of hypertension in obese adolescents (p = 0.000; r = 0.373); central obesity and the risk of hypertension in obese male adolescents (p = 0.001; r = 0.587); and central obesity and the risk of hypertension in obese female adolescents (p = 0.003; r = 0.300). The study found a significant relationship between central obesity and hypertension risk in obese adolescents. Adolescents with central obesity were 3.6 times more likely to develop hypertension than those without. Male adolescents with central obesity were 6.5 times more likely to develop hypertension than those without. Female adolescents with central obesity were 2.9 times more likely to develop hypertension

THE USE OF SOCIAL MEDIA AS A SOURCE OF COMPLEMENTARY FEEDING INFORMATION FOR MOTHERS Hanindita, Meta Herdiana; Widjaja, Nur Aisiyah; Hidayati, Siti Nurul; Irawan, Roedi; Hidayat, Boerhan
The Indonesian Journal of Public Health Vol. 19 No. 2 (2024): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v19i2.2024.316-328

Introduction: In the digital age, social media (SM) has undeniably transformed the way parents access information, including complementary feeding (CF) practices. Approximately 57.1% mothers in Indonesia obtained information about CF from the internet, ranging from parenting forums to social media platforms like Instagram. Aims: To explore the use of SM as source of CF information among mothers in Indonesia. Method: Exploratory cross-sectional study was conducted in 1631 mothers of children 0-23 months in May 2023, using an online questionnaire. The analysis of the data was conducted using the statistical software SPSS 21.0 Results: Of all the subjects, the largest group consisted of those aged 26-30 years. A majority had a high level of education, had SM, and spent 30-60 minutes (59.2%) searching for CF information. Full-time mothers were more influenced by SM (p=0.043). A notable distinction existed in the choice of social media based on the level of education. The higher the education, the more Instagram was used, while the lower the education, the more TikTok was used (mothers p=0.000; fathers p=0.002). The higher the education, the more information sources were sorted (mothers p=0.014; fathers p=0.000), and the more the educational background of the informant was considered (mothers p=0.000; fathers p=0.000). Conclusion: Mothers seek CF information from SM because it is faster, easier and convenient. However, it is often not evidence-based, and the amount of conflicting information confuses parents. Health efforts with a promotive approach that are evidence-based, understandable and applicable are needed and can be carried out through SM.

Relationship Between Central Obesity and The Risk of Hypertension in Obesity Adolescents Putri Ardina Maharani; Nur Aisiyah Widjaja; Meity Ardiana; Meta Herdiana Hanindita
Asian Journal of Social and Humanities Vol. 2 No. 03 (2023): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i03.199

The increasing prevalence of central obesity in adolescents is accompanied by an increase in risk factors for cardiovascular disease. The study aims to analyze the relationship between central obesity and the risk of hypertension in obese adolescents, including both male and female subjects. This study was undertaken to provide opportunities for further exploration of the relationship between central obesity and hypertension in adolescents. The study was a retrospective observational study that utilized medical record data from a previous research project entitled "Polimorfisme Gen Adiponectin ADIPOQ +45 T>G, ADIPOQ – 11377 C>G dengan Kadar Adiponektin Pada Remaja Obesitas dan Resiko Sindrom Metabolik." This data was obtained from research conducted on obese adolescents aged 13-18 years in junior and senior high schools in Surabaya and Sidoarjo who met the criteria. The sample comprised 140 obese adolescents, who were then categorized into two groups: those without central obesity and those with central obesity. Statistical data were analyzed using SPSS with the Chi Square test. There is a very strong and significant relationship between central obesity and the risk of hypertension in obese adolescents (p = 0.000; r = 0.373); central obesity and the risk of hypertension in obese male adolescents (p = 0.001; r = 0.587); and central obesity and the risk of hypertension in obese female adolescents (p = 0.003; r = 0.300). The study found a significant relationship between central obesity and hypertension risk in obese adolescents. Adolescents with central obesity were 3.6 times more likely to develop hypertension than those without. Male adolescents with central obesity were 6.5 times more likely to develop hypertension than those without. Female adolescents with central obesity were 2.9 times more likely to develop hypertension

Is the Ketogenic Diet Effective and Safe in Children with Intractable Epilepsy? A Systematic Review Razan, Rafi Alfian; Hanindita, Meta Herdiana; Ramadhani, Ayuning Tetirah; Putri, Melvanda Gisela; Harum, Nabila Annisa; Nurrosyida, Kartika
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 3 No. 4 (2024): APGHN Vol. 3 No. 4 November 2024
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.3.4.2024.1-14

Background: The ketogenic diet (KD) has long been prescribed to children with recurrent epilepsy due to its minimal neurotoxic effects. The side effects caused this diet to be abandoned. New diets are emerging as options such as modified Atkins diet (MAD), low glycemic index therapy (LGIT) and medium-chain triglyceride (MCT). This study compared the safety and effectiveness of the KD and these new methods. Method: Systematic review was conducted by searching databases such as PubMed, ScienceDirect, SpringerOpen, Cochrane, Proquest and Scopus based on the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Result: : A total of 439 pediatric patients aged 0 - 18 years who were intervened with a ketogenic diet compared with other dietary options. A total of five studies reported a higher mean reduction in seizure incidence >90% in children who were intervened with a ketogenic diet compared to other diets, one of which reported KD > MAD (53.3% KD vs. 26.6% MAD). Conclusion: Although KD remains effective, MAD, LGIT, MCT and Polyunsaturated Fatty Acids KD (PUFAKD) diets provide comparable benefits with potential for better adherence. The classic KD group showed a higher morbidity rate; however, it demonstrated significant effectiveness in lowering the incidence of recurrent seizures in children.

PHYSICAL BEHAVIOURS IN ADOLESCENTS THAT CONTRIBUTE TO OVERWEIGHT/OBESITY Keya , Rino Tryanto; Widjaja, Nur Aisiyah; Noviyanti, Tausiyah Rohmah; Alexander, Yoppi Yeremia; Iitdrie, Iitdrie; Hermanto, Edi; Ardianah, Eva; Bahmid, Moh; Hanindita, Meta Herdiana; Irawan, Roedi
Media Gizi Indonesia Vol. 20 No. 1 (2025): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v20i1.12-20

Physical behaviours research in adolescents is still limiting in regard of overweight/obesity. Physical behaviour according to World Health Organization Global School Student Health Survey (WHO-GSHS) had four components namely physical activity, active transportation, physical education and sedentary behaviour showed inconsistent results investigating the obesity/overweight epidemic. The objective of this study is to examine the physical behaviour and metabolic components in overweight/obese adolescents. A cross-sectional study was conducted from September to October 2019 involving healthy obese adolescents with overweight/obesity in Sidoarjo and Surabaya. The statistical analysis was test of normality for interval/ratio variables, descriptive, bivariate correlation and binary logistic regression. All the analysis were conducted using SPSS ver. 21 (IBM, US). A total of 109 subjects were recruited in this study, consisting of male (50.46%) and female (49.54%) adolescents. The mean age of the subjects were 15.13 + 1.46 years old. Adolescents with sufficient physical activity, physical transport, physical class and recommended screen time was 93.58%, 23.85%, 14.68% and 36.70% respectively. The overweight subjects were 63 (57.80%) and obesity was 46 (42.20%), and prevalent in male than female (65.22% vs. 34.78%, p=0.012). The prevalent of MetS was 53.21%, no significant difference of MetS distribution among male and female (p=0.506). Subjects with physically transport behaviour had lower risk of abdominal obesity by 0.266-times than subjects with physically immobile. Thus, physical behaviour score did not correlate with anthropometric parameters indicating to overweight/obesity and metabolic factors, but the component of physical behaviour, especially sedentary lifestyle correlated with anthropometric parameters and systolic blood pressure.

NUTRITIONAL INTERVENTION IN STUNTING CHILDREN AGED 1-5 YEARS-OLD USING ORAL NUTRITIONAL SUPPLEMENTS (ONS) IN SURABAYA CITY Alexander, Yoppi Yeremia; Widjaja, Nur Aisiyah; Irawan, Roedi; Hanindita, Meta Herdiana; Noviyanti, Tausyiah Rohmah; Keya, Rino Tryanto; Hermanto, Edi; Bahmid, Moh.; Iitdrie, Iitdrie
Media Gizi Indonesia Vol. 20 No. 2 (2025): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v20i2.168-177

Growth faltering, also known as failure to thrive, in pediatric populations may arise from a combination of insufficient nutritional intake and the presence of chronic infections. When this condition persists over an extended duration, it can culminate in stunting—a form of chronic malnutrition characterized by impaired linear growth—which continues to exhibit a high prevalence rate across various regions of Indonesia. As part of the national effort to mitigate and prevent stunting, oral nutritional supplements (ONS), which are specifically formulated for both therapeutic and dietary management in pediatric patients with specific health conditions, including growth failure, play a critical role. This study aims to examine the impact of ONS intervention, with a caloric density of approximately 1 kilocalorie per milliliter, on stunted children between the ages of one and five years at a private healthcare facility, namely Husada Utama Hospital in Surabaya. This study is an observational analytical study of a quasi- randomized control trial with a pre- and post-test design. The sample of this study was stunting children aged 1-5 years as many as 20 subjects who were willing to follow the ONS intervention research in achieving optimal growth. After being given intervention for 90 days, the number of normal HAZ/LAZ children became 5 (25% increase). There was a decrease from severely stunting by 7 subjects to stunting and a decrease in stunting to normal by 5 subjects

Immune response in IGF-1 and growth parameters among infected children Ardianah, Eva; Widjaja, Nur Aisiyah; Indriani, Diah; Melaniani, Soenarnatalina; Kuntoro; Wibowo, Arief; Notobroto, Hari Basuki; Purnomo, Windhu; Indawati, Rachmah; Saputro, Sigit Ari; Santoso, Febrina Mustika; Puspitasari, Ria; Pebriaini, Prisma Andita; Nurfidaus, Yasmine; Irawan, Roedi; Hidayat, Boerhan; Hidayati, Siti Nurul; Hanindita, Meta Herdiana
BKM Public Health and Community Medicine Vol 41 No 08 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i08.18379

Purpose: Infections in children can affect weight gain and linear growth by influencing metabolism and nutrition. Chronic inflammation results in growth failure mediated by pro-inflammatory cytokines and poor nutritional intake, which affects the GH/IGF-1 axis. This study aimed to investigate the impact of the inflammatory response on children's anthropometry, particularly HAZ, and the role of IGF-1. Methods: An observational study with a cross-sectional design was conducted from September 2021 to July 2022. The study involved children diagnosed with infections. The subjects had undergone a physical and laboratory investigation, which included a thorax photo, urine culture, Mantoux test, and complete blood test in a hospital setting. A complete medical history was obtained from the pediatrician. Results: The prevalence of undernutrition was 37.33%; the prevalence of underweight/severely underweight, stunted/severely stunted, and wasted/severely wasted was 25.33%, 30.66%, and 14.67% respectively. Stunted/severely stunted was more prevalent in subjects under 2 years old, compared to subjects more than 2 years old (22/41 vs. 7/34, p=0.014). SEM analysis revealed that the inflammatory response affected IGF-1 levels (r=0.850, p=0.000), while IGF-1 affected body composition (r=0.245, p=0.025), and then affected HAZ (r=1.000, p=0.000). The effect of IGF-1 on HAZ appears to be indirect, acting through body composition. Parental height has a weak, albeit significant, effect on body composition (r=0.101, p=0.025) and HAZ (r=0.192, p=0.040). Univariate analysis revealed strong correlations between IL-6 and IL-10 and IGF-1 (r=0.870, p=0.000 and 0.876, p=0.000, respectively). In contrast, parental height showed a correlation with HAZ/LAZ (r=0.319, p=0.000). Maternal height was correlated positively with WAZ (r=0.320, p=0.044). Conclusion: The prevalence of stunting among children under two years of age indicates that early childhood constitutes a critical period for intervention in growth and development. Inflammatory response has been demonstrated to influence IGF-1 levels in children. The role of IGF-1 on HAZ was mediated by body composition.

SLEEP DURATION, ANTHROPOMETRIC MEASUREMENTS AND METABOLIC SYNDROME IN OVERWEIGHT/OBESE ADOLESCENTS Iitdrie; Widjaja, Nur Aisiyah; Hanindita, Meta Herdiana; Irawan, Roedi; Qomaruddin, Mochammad Bagus; Muthmainnah, Muthmainnah; Ardianah, Eva; Noviyanti, Tausyiah Rohmah; Alexander, Yoppi Yeremia; Keya, Rino Tryanto; Hermanto, Edi
Media Gizi Indonesia Vol. 20 No. 3 (2025): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v20i3.356-362

Introduction: Adolescents have sleep problems, as their sleep duration does not meet the recommended sleep duration of 8-10 hours, leading to various sleep-related problems. Sleep duration is suspected to have detrimental effects on health, such as non-communicable diseases including obesity, cardiovascular disease (CVD), and type 2 diabetes mellitus (T2DM). However, the correlation between sleep duration and the prevalence of obesity and metabolic syndrome (MetS) is still conflicting, especially in the adolescent population. This study aimed to examine and analyze the effect of sleep duration on anthropometric measurements and MetS in overweight/obese adolescents. Methods: A cross-sectional study involving healthy overweight/obese adolescents was conducted from September to October 2019 to evaluate the effect of sleep duration on anthropometric measurements, lipid profiles, fasting blood glucose levels, and blood pressure in overweight/obese adolescents. Results and discussion: A total of 197 subjects showed no significant differences in body height, BMI, waist circumference, blood pressure, and lipid profile based on sleep duration categories. Subjects with short sleepers were older than those with sufficient sleep (p<0.05). However, long sleepers were heavier, had larger BMI-for-age z-scores, and larger waist circumferences than sufficient and short sleepers (p<0.05). However, the differences between the short, sufficient, and long sleepers were U-shaped. Sleep duration was not correlated with MetS or MetS components (abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low HDL-c). Conclusion: Long sleepers (>11 h/night) were heavier, had greater BMI-for-age z-scores, and larger waist circumference than (<sufficient sleeper (6-10 h/night), or short sleepers 6 h/night).

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