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Effect of High Density Polyethylene on Inflammatory Responses in Wistar Rats (Rattus norvegicus) Talitha Maurilla Zulkarnain; Isa Ma’Rufi; Candra Bumi
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53107

Abstract

Microplastics were a newly emerging type of environmental pollutant composed of plastic particles with a diameter of less than 5 mm. The use of plastic food containers, plastic packaging, and plastic bottles could lead to direct contact and contamination of plastic into food. Microplastics were particles that could not be degraded by phagocytes, allowing inflammation to persist chronically and potentially cause organ dysfunction.The objective of this study was to analyze the effect of oral administration of various doses of HDPE microplastics on neutrophil levels in Wistar rats (Rattus norvegicus). The research method was an experimental study with a post-test only control group design, consisting of one control group and three treatment groups. Neutrophil levels in Wistar rats were measured using an automatic hematology analyzer. The results of neutrophil measurements were analyzed using the Kruskal–Wallis test followed by the Bonferroni post hoc test.The the research results indicate the highest neutrophil levels were observed in the treatment group receiving the highest dose of 0.4 mg/kg/day (X3). The Krus kal–Wallis test yielded a p-value of 0.000 < 0.05, indicating a significant effect among the treatment groups receiving various doses of orally administered HDPE microplastics on the neutrophil levels of Wistar rats.
Relationship between diarrhea history, exclusive breastfeeding, and feeding patterns with stunting incidence in toddlers aged 24-59 months Jamilatul Wahida; Candra Bumi; Citra Anggun Kinanthi
Public Health and Preventive Medicine Archive Vol. 13 No. 1 (2025)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2025.v13.i1.p03

Abstract

Background and purpose: Stunting remains a major public health issue globally, including in Jember District. Despite the significant stunting reduction in the region—from 21.4% in 2020 to 6.6% in 2024—Rambipuji Public Health Center (PHC) reports a comparatively high prevalence of 19.94%, indicating a persistent public health concern. This study aimed to analyze the association between diarrheal history, exclusive breastfeeding, and feeding patterns with the incidence of stunting among children aged 24–59 months. Methods: An analytical observational study with a case–control design was conducted among 114 children aged 24–59 months (57 cases and 57 controls) selected by simple random sampling in the Rambipuji PHC area based on growth monitoring data from May 2025. Data which include stunting status, children characteristics and maternal characteristics were collected through structured interviews and observations, and analyzed using chi-square tests (α=0.05) with SPSS. Results: The results indicated significant associations between maternal education (OR=11.25; 95%CI: 1.354-93.504; p=0.026), exclusive breastfeeding (OR=3.352; 95%CI: 1.377-8.159; p=0.006), and feeding patterns (OR=10.5; 95%CI: 2.336-47.201; p=0.005) with stunting incidence. However, a history of diarrhea was not significantly associated with stunting. Conclusion: Maternal education, exclusive breastfeeding, and feeding patterns are associated with stunting among children. Strengthening maternal nutrition and feeding education, as well as optimizing services at integrated health posts (Posyandu) and public health centers (Puskesmas), are essential to reduce stunting prevalence.
Faktor Risiko Kejadian Mikosis Superfisialis pada Nelayan di TPI Puger Aldi, Muhammad Fauzi; Bumi, Candra; Noveyani, Adistha Eka
Jurnal Epidemiologi Kesehatan Komunitas Vol 11, No 1: Februari 2026
Publisher : Master of Epidemiology, Faculty of Public Health, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v11i1.30692

Abstract

Background: Superficial mycoses are a common global health problem among fishermen, particularly in tropical regions. Factors such as personal hygiene, length of employment, and obesity have been associated with superficial mycoses, while continuous exposure to high-salt seawater in fishermen’s occupational environments has been hypothesized as a potential protective factor. This study aimed to analyze the risk factors for the incidence of superficial mycoses among fishermen at the Puger Fish Auction Place (FAP) in Jember Regency.Methods: This cross‑sectional analytic study included 97 fishermen selected through quota sampling at Puger Primary Healthcare (PHC). Data on personal hygiene and length of employment were collected using validated questionnaires; obesity status was determined by Body Mass Index (BMI); and superficial mycoses were diagnosed by clinical examination. Univariable analysis described the distribution of all variables, and bivariable analysis using the Chi‑square test assessed associations between risk factors and superficial mycoses.Result: The prevalence of superficial mycoses was 10.3% (10/97). There were no statistically significant associations between personal hygiene (prevalence ratio/PR 1.88; 95% CI 0.42–8.33; p=0.494), length of employment (PR 0.88; 95% CI 0.81–0.95; p=0.353), or obesity (PR 0.36; 95% CI 0.10–1.30; p=0.178) and superficial mycoses.Conclusion: In this cross-sectional study, personal hygiene, length of employment, and obesity were not significantly associated with superficial mycoses among fishermen at Puger Primary Health Care. The relatively low prevalence of infection despite high exposure to conventional risk factors suggests that occupational environmental factors may contribute to reduced susceptibility to infection.