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Effect of High Density Polyethylene on Inflammatory Responses in Wistar Rats (Rattus norvegicus) Zulkarnain, Talitha Maurilla; Ma’Rufi, Isa; Bumi, Candra
Jurnal Ners Vol. 10 No. 1 (2026)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53107

Abstract

Microplastics were a newly emerging type of environmental pollutant composed of plastic particles with a diameter of less than 5 mm. The use of plastic food containers, plastic packaging, and plastic bottles could lead to direct contact and contamination of plastic into food. Microplastics were particles that could not be degraded by phagocytes, allowing inflammation to persist chronically and potentially cause organ dysfunction.The objective of this study was to analyze the effect of oral administration of various doses of HDPE microplastics on neutrophil levels in Wistar rats (Rattus norvegicus). The research method was an experimental study with a post-test only control group design, consisting of one control group and three treatment groups. Neutrophil levels in Wistar rats were measured using an automatic hematology analyzer. The results of neutrophil measurements were analyzed using the Kruskal–Wallis test followed by the Bonferroni post hoc test.The the research results indicate the highest neutrophil levels were observed in the treatment group receiving the highest dose of 0.4 mg/kg/day (X3). The Krus kal–Wallis test yielded a p-value of 0.000 < 0.05, indicating a significant effect among the treatment groups receiving various doses of orally administered HDPE microplastics on the neutrophil levels of Wistar rats.
Business Sector Engagement in Pentahelix Colaboration for Stunting Reduction: A Qualitative Study in Jember Regency Prasetyowati, Irma; Wahyu Ningtyias, Farida; Ratnawati, Leersia Yusi; Bumi, Candra; Nurika, Globila; Haryanik, Meilinda Alya' Putri
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 14 No. SI1 (2026): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V14.ISI1.2026.106-114

Abstract

Background: Stunting is a persistent public health issue in Indonesia, with long-term effects on children's physical and cognitive development. In 2023, Jember Regency recorded the highest stunting prevalence in East Java at 29.7%. Objective: To examine the role of the business sector in efforts to reduce stunting in Jember within the Pentahelix collaboration model. Methods:  This study employed a qualitative case study design using in-depth interviews and focus group discussions. Data were analyzed using Buse, Mays, and Walt’s policy implementation framework (Buse, Mays, & Walt, 2012), which focuses on context, content, process, and actors. This framework was chosen because it provides a comprehensive approach to understanding how policies are implemented through multi-actor collaboration, making it relevant for analyzing the Pentahelix model in stunting reduction efforts. Results: Findings indicate that businesses contribute significantly through Corporate Social Responsibility (CSR) initiatives, including Posyandu activities, nutrition support, and economic empowerment programs for mothers in areas with high rates of stunting. Coordination with health offices is based on local data, ensuring interventions are targeted and effective. The CSR Forum serves as a platform for aligning business efforts with public health goals. Businesses are also engaged in monitoring and evaluation through regular reporting from health facilities. Conclusion: Active engagement of the business sector through CSR initiatives strengthens stunting reduction efforts by supporting government and community programs. Integrating business participation into health promotion practice enhances sustainability, coordination, and long-term impact on child health and nutrition.