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All Journal Medical Journal of Indonesia The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Narra J International Archives of Medical Sciences and Public Health Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Mulyadi M. Djer
Department Of Child Health, Medical School, University Of Indonesia/Cipto Mangunkusumo Hospital, Jakarta
Religion Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Characteristic and Survival Analysis of Infants with Critical Congenital Heart Disease Talib, Suprohaita Rusdi; Siswanto, Johanes Edy; Djer, Mulyadi M; Safanta, Nurzalia; Nurhakiki, Syifa; Taufiqurahman, Khobir Abdul Karim; Adisasmita, Asri
Kesmas Vol. 20, No. 1
Publisher : UI Scholars Hub

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Abstract

Congenital heart disease (CHD) is a major health concern worldwide. This study focused on survival analysis and the factors influencing survival in infants with critical congenital heart disease (CCHD). A total of 79 infants diagnosed with CCHD were identified, with 48.1% (n=38) exhibiting duct-dependent pulmonary circulation, 35.6% (n=28) exhibiting duct-dependent systemic circulation, 6.3% (n=5) exhibiting critical non-duct-dependent, and 10.2% (n=8) exhibiting parallel circulation issues. Of the infants studied, 55.7% (n=44) were male, 78.5% (n=62) had a gestational age of ≥37 weeks, 62% (n=49) had a birth weight of ≥2,500 grams, 59.5% (n=47) exhibited normal fetal growth, 93.7% (n=74) experienced no asphyxia, 91.1% (n=72) had no other congenital disabilities, 87.3% (n=69) had no history of fetal distress, 58.2% (n=46) maintained normal oxygen saturation, and 88.6% (n=70) had an extended stay in the neonatal intensive care unit. The survival analysis indicated that the prognosis of newborns with CCHD was markedly affected by gestational age, birth weight, desaturation, respiratory distress, and hereditary abnormalities. Additional study is required to assess the risk factors influencing the survival of newborns with CCHD.
PRESEPSIN AS A POTENTIAL BIOMARKER OF SEPSIS IN PEDIATRIC PATIENTS UNDERGOING OPEN-HEART SURGERY Fitriany, Julia; Djer, Mulyadi M; Chozie, Novie Amelia; Yanuarso, Piprim Basarah; Putri, Nina Dwi; Yuniar, Irene
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1418

Abstract

Sepsis after pediatric open-heart surgery is rare but highly lethal. Diagnosis is challenging because sepsis symptoms often overlap with post operative inflammatory responses. This study assessed presepsin as a biomarker for postoperative sepsis in children with congenital heart disease. In this prospective diagnostic accuracy study at Cipto Mangunkusumo National Central Hospital, Jakarta, 49 children undergoing open-heart surgery were enrolled. Plasma presepsin and procalcitonin (PCT) levels were measured on postoperative day 1 (T1) and day 3 (T3). Diagnostic performance was evaluated using ROC analysis. Presepsin levels were higher in septic than non-septic patients at T1 (415 vs. 141.5 pg/mL) and T3 (624 vs. 75.9 pg/mL), with a significant difference at T3 (p = 0.001). Presepsin was unrelated to surgical complexity but was associated with 7-day mortality (p = 0.013). At T3, presepsin showed better diagnostic accuracy than PCT (AUC 0.945 vs. 0.895). Optimal cutoffs were 404 pg/mL (T1) and 203.5 pg/mL (T3). PCT levels declined over time in septic patients. Presepsin is a promising biomarker for detecting postoperative sepsis in pediatric open-heart surgery patients, demonstrating diagnostic performance comparable to or superior to PCT, particularly on postoperative day 3. Serial monitoring may facilitate earlier identification of septic complications.
Co-Authors Adhi Teguh Perma Iskandar Agus Firmansyah Amin Subandrio Angelina Angelina Anis Karuniawati Antonius H. Pudjiadi Aria Kekalih Arwin A. P. Akib Aryono Hendarto Asri C. Adisasmita Audrey Audrey Badriul Hegar Bambang Madiyono Bambang Madiyono Bambang Madiyono Bambang Mardiyono Bambang Supriyatno Burhanuddin Iskandar Chozie, Novie A. Damayanti R. Sjarif Damayanti R. Syarif Darmawan B. Setyanto Desy Dewi Saraswati Dilawar, Ismail Djajadiman Gatot Emilda Osmardin Erni Erfan, Erni Fajar Subroto Heri Wibowo Herlina Dimiati Heru Samudro Hikari A. Sjakti Idrus Alwi Ika P Wijaya, Ika P Imral Chair Irawan Mangunatmadja Irene Yuniar, Irene Iskandar, Adhi Teguh Perma Ismet N Oesman Joedo Prihartono Johanes Edy Siswanto, Johanes Edy Julia Fitriany Jusuf Rachmat Jusuf Rachmat Kautsar, Ahmad Laila, Dewi S. Liku Satriani Lily Rundjan Lisnawati Rachmadi Mardjanis Said Maswin Masyhur Mazdar Helmy Mazeni Alwi Melva Louisa Mila Maidarti Mochammading Mochammading Mochammading Mochammading Murni, Indah K. Muzal Kadim Nafrialdi Nafrialdi Najib Advan Najib Advani Najib Advani Najib Advani Najib Advani Nia Kurniati Nikmah S Idris, Nikmah S Nikmah S. Idris Nikmah Salamia Idris Nina Dwi Putri Novie Amelia Chozie NP Veny Kartika Yantie Nurhakiki, Syifa Nusarintowati Ramadhina Perdana, Andri Permatasari, Ruth K. Piprim B Yanuarso Piprim B. Yanuarso, Piprim B. Piprim Basarah Yanuarso Piprim Basarah Yanuarso, Piprim Basarah Pribadi Wiranda Busro Pustika Amalia Putri, Dyanti Prima Rahmadhany, Anisa Rahmat B Kuswiyanto Rahmat B. Kuswiyanto Renno Hidayat Rinawati Rohsiswatmo Risma Kerina Kaban Risma Kerina Kaban Risma Kerina Kaban, Risma Kerina Rizky Adriansyah Rosary Rosary Rubiana Sukardi Rubiana Sukardi Rubiana Sukardi, Rubiana Safanta, Nurzalia Sake Juli Martina Santoso, Dewi Irawati Soeria Setyanto, Darmawan Budi Shirley L. Anggriawan Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sudigdo Sastroasmoro Sudung O Pardede, Sudung O Sudung O. Pardede Suhendro Sukman T Putra Sukman T Putra Sukman T. Putra Sukman T. Putra Sukman T. Putra Sukman Tulus Putra Sukman Tulus Putra, Sukman Tulus Supriatna, Novianti Susanti, Dhama S. Sutjipto, Fiolita Indranita Swanty Chunnaedy Syarif Rohimi Talib, Suprohaita Rusdi Taufiqurahman, Khobir Abdul Karim Tetty Yuniati Wardoyo, Suprayitno