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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Universa Medicina Jurnal Surya Medika Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JURNAL EDUCATION AND DEVELOPMENT Amerta Nutrition Jurnal Medika Malahayati Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Jurnal Biomedika dan Kesehatan Jurnal Kedokteran Universitas Palangka Raya JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Inisiasi Jurnal Inovasi Pengabdian dan Pemberdayaan Masyarakat Jurnal Kedokteran Hewan Biomedika Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Miranti Dewi Pramaningtyas
Department Of Physiology, Faculty Of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Universa Medicina

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Honey improves lipid profile of diet-induced hypercholesterolemic rats Nurmasitoh, Titis; Pramaningtyas, Miranti Dewi
Universa Medicina Vol 34, No 3 (2015)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.177-186

Abstract

BackgroundCoronary heart disease (CHD) is a major cause of morbidity and mortality throughout the world, including Indonesia. One of the risk factors for CHD is hypercholesterolemia. One of the natural products that has been developed for the treatment of hypercholesterolemia is honey. Honey contains fructooligosaccharides, various vitamins, minerals, and enzymes which are supposedly able to lower blood cholesterol levels. This research aimed to study the influence of honey on the levels of blood total cholesterol, triglyceride, and low density lipoprotein (LDL) levels in Wistar rats. MethodsThis study was of experimental post test control group design. Twenty-four male Wistar rats (Rattus norvegicus) were randomly divided into 4 groups. K1 was the negative control group (with normal diet), K2 was the positive control group (with high-fat diet), P1 was fed a high-fat diet for 7 days, followed by high-fat diet plus honey for the next 7 days. P2 was fed a high-fat diet for 7 days, followed by regular diet plus honey for the next 7 days. After completion of this treatment, total cholesterol, triglycerides, and LDL levels were measured by the cholesterol oxidase phenol+aminophenazone (CHOD-PAP) method using enzymatic spectrophotometry principles. ResultsThere were significant differences in total cholesterol, triglyceride, and LDL levels between all groups after day 15 (p<0.05). ConclusionHoney supplementation was able to reduce the blood levels of total cholesterol, triglycerides, and LDL. Honey supplementation accompanied by non-cholesterol feeds could more effectively lower total cholesterol, triglycerides, and LDL serum levels in Wistar rats.
Shortening tends to increase aortic foam cell count and wall thickness in male Wistar rats Lusiantari, Rokhima; Pramaningtyas, Miranti Dewi; Nurmasitoh, Titis; Pattimura, Rachmi Hidayati; Dewanti, Anggita
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.13-18

Abstract

BackgroundShortening is widely used as raw material for bread and other foods. Hypercholesterolemia increases aortic arch foam cell formation and abdominal aortic wall thickness. This study aimed to determine the effect of shortening on the number of aortic arch foam cells and abdominal aortic wall thickness in rats.MethodsThis study was of experimental posttest control group design. Twenty four male Wistar rats were randomized into 4 groups. The negative control group (C-) received standard feed, the positive control group (C+) standard high-fat feed, group T1 shortening and standard feed at a ratio of 1:5 and group T2 shortening and standard feed at a ratio of 1:10. The interventions were given for 6 weeks through gavage. The foam cell count in the aortic arch and the thickness of the abdominal aortic wall were measured. One-way ANOVA test was used to analyze the data. ResultsThere was no significant difference in the mean foam cell count of the aortic arch between the four groups C- (7.17 ± 4.17), C + (9.33 ± 7.01), T1 (11.83 ± 4.88) and T2 (9.33 ± 6.80) (p=0.598). The mean thickness of the abdominal aortic wall between the four groups C- (741.98 ± 60.67μm), C + (714.29 ± 90.59μm), T1 (838.90 ± 75.86 μm), and T2 (749.88 ± 99.37μm) also was not significantly different (p=0.110).Conclusion Shortening tends to increase the foam cell count of the aortic arch and the thickness of the abdominal aortic wall of rats.
Co-Authors Adi Nugraha Adnan, Muhammad Luthfi Adyaksa, Dewa Nyoman Murti Al-Ghozi, Yasfi Suryalfihro Al-Ghozi Aprillia, Viola Budiastuti, Ernadita Dewanti, Alfi Brillianti Chrisna Dewanti, Anggita Dini Islamiana Dwi Nur Ahsani Dwi Nurwulan Pravitasari Emi Azmi Choironi Ety Sari Handayani Fadilatul Khusna Amalla Firdaus, Hana Afifah Firdaus, Lidya Sabilla Fitriati, Yasmini Hana Isnaini Al Husna Hasibuan, Diah Hydrawati Sari Hilmi Ardian Sudarto Kaka Citta Prasiddha Kholifa Nur Ardhina Kiasati, Aghnia Lusiantari, Rokhima Mohamad Alif Ramadan Mohamad Alif Ramadan Muhammad Luthfi Muhammad Luthfi Adnan Nurani, Mega Puspa Nurmasitoh, Titis Pamungkas, Katon Pattimura, Rachmi Hidayati Putri, Fara Amalia Putri, Merisa Dinda Rahmawati, Isna Arifah Ratna Wulandari Reza Ishak Estiko RIZKI FAJAR UTAMI Safira, Nazala Safitri, Amalia Adityas Dyah Sukarno, Rizky Triutami Wahdiyati, Siti Wahyana, Eka Budi Wantoputri, Noviani Ima Weningtyas, Vyanda Sri Widyaningsih, Niken Wijaya, Diani Puspa Yanasta Yudo Pratama Zainuri Sabta Nugraha, Zainuri Sabta