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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Majalah Farmasetika Jurnal Inovasi Farmasi Indonesia Jurnal Riset Kefarmasian Indonesia JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Indonesian Journal of Pharmaceutical Education Jurnal Abdi Masyarakat Indonesia Jurnal Farmasi Indonesia Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Sciences and Clinical Pharmacy Research Journal Kunir: Jurnal Farmasi Indonesia (KJFI)
Esti Ambar Widyaningrum
Fakultas Farmasi Institut Ilmu Kesehatan Bhakti Wiyata
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Evaluation of Dose Appropriateness in Patients Congestive Heart Failure and Comorbid Chronic Kidney Disease at RSUD Kabupaten Kediri Agustin, Ela; Fajriyah, Shofiatul; Widyaningrum, Esti Ambar; Putri, Adinda Sheisella; Wahyuni, Kumala Sari Poespita Dewi
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9346

Abstract

Congestive heart failure (CHF) is a chronic condition requiring long-term therapy. Patients with heart failure accompanied by comorbid chronic kidney disease (CKD) require dose adjustment to prevent drug toxicity. This study aimed to determine the therapeutic profile and dosing appropriateness among patients with congestive heart failure and comorbid CKD hospitalized at RSUD Kabupaten Kediri during the January–December 2022 period. This study employed a retrospective observational design using medical record data with a total sampling technique, resulting in 72 eligible patients. Dose appropriateness was evaluated based on estimated glomerular filtration rate (eGFR) calculated using the Cockcroft–Gault equation and compared with recommendations from The Renal Drug Handbook. The results indicate that the majority of samples in this study were female (54.17%) and aged 45–54 years (41.67%). Most patients had additional comorbidities (80.56%), with anaemia being the most prevalent concomitant condition. Based on CKD staging, the majority of patients were classified as stage 5 CKD (77.78%). Combination therapy involving two medications was the most common treatment pattern (30.57%), with a diuretic plus ARB combination being the most frequently prescribed regimen. The evaluation of dosing appropriateness demonstrated that 69 patients (95.83%) received doses adjusted appropriately to their renal function, while 3 patients (4.17%) received inappropriate dosing. Inappropriate use was identified in prescriptions of spironolactone and acarbose, which should be avoided in patients with low eGFR values. In conclusion, most patients with congestive heart failure and comorbid CKD received therapy with doses appropriately adjusted to renal function. However, cases of inappropriate dosing were still identified, which may increase the risk of adverse effects.
Co-Authors Admaja, Wika Agustin, Ela Anikasari, Erni Astuti, Lelly Winduhani Astuti, Lely Winduhani Badiaturisa Masyriqoh Dewy Resty Basuki, Dewy Resty Dwi Wahyuni Dwitania Noerhalizah Eka Kartika Sari Evi Kurniawati, Evi Fitriani, Marina Herlinda Mawardika Hidayatunnisa, Shafira Indah Sri Hartini Irawati, Renny Nur Satya Irawati, Reny Nur Satya KRISNA KHARISMA PERTIWI Lailatul M., Nur Lelly Winduhani Astuti Lelly Winduhani Astuti Lestari, Tri Puji Moza Fellya Fadrian Nur Rohmah, Dilla Salwa PDW, Kumala Sari Putri, Adinda Sheisella Rilawati , Fentyana Dwi Rilawati, Fentyana Dwi Rimawati, Rimawati Rizky, Fara Nikhmatul Shofiatul Fajriyah Shoviantari, M.Farm., Apt., Fenita Sony Andika Saputra Sri Agustina Sugiyartono, Sugiyartono Suhartatik, Sri umul farida Wahyuni, Kumala Sari Poespita Dewi Wahyuni, Kumalasari Poespita Dwi Wika Admaja Wika Wika Admaja Wulan, Fitria Wahyuning Yestari, Farah Eka Julia