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All Journal VALENSI BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Biology, Medicine, & Natural Product Chemistry KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Sains Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Chemistry Indonesian Journal of Chemical Research Jambura Journal of Chemistry Pharmacoscript SPIN: Jurnal Kimia & Pendidikan Kimia
Boima Ramses Situmeang
Departmen Of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Mathematics Medicine & Pharmacology Physics Public Health

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POTENSI FRAKSI ETIL ASETAT KULIT BATANG KESAMBI SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli THE POTENTIAL OF ETHYL ACETATE FRACTION OF KESAMBI STEM AS ANTIBACTERIAL AGAINST Escherichia coli Afif Hidayatul Mustafid; Yeyen Maryani; Sri Agustina; Boima Situmeang
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.63497

Abstract

In our previous research, ethyl acetate extract of kesambi stem bark have the highest antibacterial activity against Escherichia coli compared with n-hexane and methanol extract. In our present study, we report the antibacterial activity of fractions from ethyl acetate extract against Escherichia coli. The method of fractionation used coloumn and thin lawyer chromatography. The Antibacterial activity uses Kirby Bauer methods. The characterization of active fractions used spectrometer infrared. The result showed fractions 6 and 7 have the highest antibacterial activity with inhibition zone 11.65 and 7.1 mm. The characterization of fractions 6 and 7 showed fungtional groups C=O, O-H, and C=C. The ethyl acetate fraction has the potential as antibacterial materials.
ETHANOL EXTRACT OF MATOA (Pometia pinnata) AS NATURAL ANTIOXIDANT TO INHIBIT OXIDATION REACTION OF CRUDE PALM OIL: EKSTRAK ETANOL DAUN MATOA (Pometia pinnata) SEBAGAI ANTIOKSIDAN ALAMI UNTUK MENGHAMBAT REAKSI OKSIDASI PADA CRUDE PALM OIL Sriwijayanti; Hidayatullah, Ryan; Musa, Weny JA; Bialangi, Nurhayati; Situmeang, Boima; Widiyanto, Holisha; Lailatussholihah, Isna
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 6 No. 1 (2024): Januari - Juni 2024
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v6i1.9797

Abstract

Indonesia is the 2nd largest country in the world in terms of palm oil production. The demand for Crude Palm Oil increases every year. For this reason, Indonesia is expected to be able to compete at the international industry level in producing palm oil, with the aim of being able to produce good quality palm oil among industries in other countries. The problem that often occurs in CPO factories is a decrease in the quality of CPO caused by an increase in Free Fatty Acid (FFA) levels and Peroxide Numbers. Antioxidants are substances that can delay or prevent the occurrence of free radical anti-oxidation reactions in the oxidation of fats or oils. Natural antioxidants are antioxidants that are obtained directly from nature. Natural antioxidants are antioxidants that are obtained directly from nature. One of them is the leaf of the matoa plant (Pometia pinnata). Based on the results of this study, the antioxidants of the ethanol extract of the matoa plant can reduce levels of FFA and peroxide numbers depending on the length of time the antioxidant mixture is given to CPO. In this study, a decrease in FFA levels and peroxide numbers was obtained from samples on day - 10 with the addition of 5000 ppm antioxidants, namely 2.71%. while the peroxide number is 0.83%.
Triterpene Compound from Ethyl Acetate Fraction of Kesambi Bark (Schleichera oleosa) and Its Activity as Anti-Bacterial Musa, Weny J.A.; Setiyandani, Kurnia Indah; Mustafid, Afif Hidayatul; Bialangi, Nurhayati; Situmeang, Boima
Indonesian Journal of Chemical Research Vol 11 No 3 (2024): Edition for January 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.11-wen

Abstract

In our earlier study, we managed to find the antibacterial activity of the ethyl acetate fraction of the kesambi bark stem. In our next study, we isolated secondary metabolite compounds from the ethyl acetate fraction of the kesambi stem bark and tested the antibacterial activity of isolates against the bacteria Escherichia coli and Staphylococcus aureus. Separation is carried out by the method of column chromatography. Analysis of stain patterns and purity was performed with thin-layer chromatography (TLC). The test of antibacterial activity was carried out by the Kirby Bauer method. Characterization of pure isolates was performed with IR, 1H -NMR, 13C -NMR and DEPT 135° spectroscopy. The results of the characterization of pure isolates show that the isolated compound is a triterpenoid compound with the name IUPAC compound lup-20(29)-en-3-ol. The results of antibacterial tests showed that the compound lup-20(29)-en-3-ol has antibacterial activity against E. coli and S. aureus which is relatively moderate.
The potential of methanol extract nanoemulsion from gletang flower (Tridax procumbens) as an antibacterial agent against pathogenic bacteria Sriwijayanti Sriwijayanti; Agrin Febrian Pradana; Fajar Rizki Fauji; Iin Farlina; Boima Situmeang
Jurnal Pendidikan Kimia Vol. 16 No. 3 (2024): J. Pendidik. Kim : December 2024
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i3.65168

Abstract

Gletang plant is a weed that grows wild and is widely distributed in various places such as rice fields, plantations, and roadsides. Phytochemical screening of gletang flower extract using methanol revealed the presence of secondary metabolites such as alkaloids, flavonoids, steroids, phenols, terpenoids, and tannins. This study aims to formulate a nanoemulsion from the methanol extract of gletang flowers. The extraction was performed by maceration with methanol 96%. The nanoemulsion was characterized by testing its pH, % transmittance, stability, viscosity and particle size using a particle size analyzer. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coliusing the Kirby-Bauer method. The results of pH characterization, % transmittance, stability and viscosity tests met the standards. The particle size analyzer showed that the particle size ranged between 300-1000 nm. The antibacterial activity tests indicated that all three formulations showed activity against the pathogenic bacteria E. coli, with formulation 3 showing the highest activity.
Antioxidant and Cytotoxic Potential of Ethyl Acetate Fraction of Gandaria Stem Bark (Bouea macrophylla) Against MCF-7 Cell Line Situmeang, Boima; Primawati, Junia Salsha; Oktafiani, Ismi; Musa, Weny JA; Kilo, Ahmad Kadir
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.345-349

Abstract

The stem bark of Bouea macrophylla (gandaria) represents a promising subject for further scientific investigation. Previous studies have reported that the bark contains high concentrations of total phenolic and flavonoid compounds, associated with potent antioxidant activity. This study evaluates the antioxidant and cytotoxic potential of the ethyl acetate fraction of B. macrophylla stem bark. Antioxidant activity was assessed using the DPPH and ABTS radical scavenging methods, while cytotoxic activity against MCF-7 breast cancer cells was determined using the MTT assay. The ethyl acetate fraction exhibited strong antioxidant activity with IC₅₀ values of 5.837 ± 0.060 ppm (DPPH) and 9.645 ± 0.697 ppm (ABTS). The cytotoxicity assay revealed an IC₅₀ value of 99.55 ppm, indicating moderate cytotoxic potential. These findings suggest that the ethyl acetate fraction of B. macrophylla stem bark possesses significant antioxidant activity and potential anticancer properties, supporting its possible application in natural therapeutic development.
Perbandingan Aktivitas Antioksidan Ekstrak Etil asetat dan Metanol Daun Tumbuhan Matoa (Pometia pinnata) Situmeang, Boima; Musa, Weny JA; Mulyadi, Agus; Ibrahim, Agus Malik; Widiyanto, Holisha; Bialangi, Nurhayati
Jurnal Penelitian Sains Vol 26, No 1 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i1.919

Abstract

Matoa (Pometia pinnata) is a plant from the Sapindaceae family that is widely distributed throughout the Asia-Pacific region, including Indonesia, Malaysia, Thailand, and Sri Lanka. In Indonesia, the Matoa plant is commonly found in Java, Sumatra, and Papua. Empirically, the leaves of the Matoa plant have been utilized by the community as a traditional remedy for treating hypertension, fever, and diarrhea. The aim of this study was to test the antioxidant activity of ethyl acetate extract and methanol extract of Matoa leaves. Extraction was performed using the maceration method. The antioxidant activity was evaluated using UV-Visible spectroscopy. The free radical used was DPPH at a concentration of 50 ppm. The absorbance was measured at a wavelength of 517 nm. The antioxidant activity of the ethyl acetate extract of Matoa leaves was 38.87 ppm and 37.73 ppm. The antioxidant activity of the methanol extract of Matoa leaves was 27.99 ppm and 33.25 ppm. Based on the antioxidant activity values, both the ethyl acetate and methanol extracts of Matoa leaves have the potential as a source of natural antioxidants. 
Analysis of Total Polyhenolic Content and Antioxidant Activity from n-hexane, Ethyl acetate and Ethanol Extract of Kitolod (Hipobbroma longiflora) Leaf Situmeang, Boima; Faradin, Faradin; Susvira, Dian; Bialangi, Nurhayati; Widiyanto, Holisha; Yulianti, Nani; Jinanti, Nazwa
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1182

Abstract

Isotoma longiflora, commonly known as Kitolod, has been traditionally used as a medicinal plant for treating various ailments. This study aims to extract Kitolod leaves using three different solvents with varying polarities: n-hexane (non-polar), ethyl acetate (semi-polar), and ethanol (polar). The total phenolic content, total flavonoid content, and antioxidant activity were analyzed using a spectrophotometer. The trends observed in both TFC and TPC results indicate that ethyl acetate is the most effective solvent for extracting bioactive compounds from Kitolod leaves. The ethyl acetate extract of Kitolod leaves exhibited the highest antioxidant activity (150.542 ± 3.917 ppm), followed by the ethanol (157.235±0.858 ppm) and n-hexane (217.345 ± 1.749 ppm) extracts. This suggests that ethyl acetate is the most effective solvent for extracting bioactive compounds with antioxidant properties from Kitolod leaves.
THE EFFECT OF GLUCOSE ON Streptococcus mutans ATCC 25175 GROWTH BY VARIATION OF CONCENTRATION AND INCUBATION TIME Widyawati, Widyawati; Boima, Situmeang
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2179

Abstract

Streptococcus mutans is one of the main causative agents of dental caries. Glucose has been reported as one of the factors influencing the growth of S. mutans. This study aims to determine the effect of glucose concentration and incubation time on the growth of S. mutans. The glucose concentrations used in this study were 0, 2, 4, 6, 8, and 10%. The incubation times used were 1, 10, and 15 hours. The result showed that glucose concentration significantly affects the growth of S. mutans. Higher glucose level lead to increase bacterial growth, with the highest absorbance observed at 10% glucose after 10 hours of incubation. Specific growth rate (μ) analysis further supports this finding, showing that S. mutans grows more rapidly during the exponential phase (1–10 hours) with increased glucose concentration, while the growth rate stabilizes or declines during the later phase (10–15 hours). This result indicate that both glucose availability and incubation time are critical factors influencing the growth dynamics of S. mutans.
LC-MS Analysis of Ethyl Acetate Fraction of Gandaria (Bouea macrophylla Griff.) Stem Bark and Molecular Docking Study against HER2 Protein Junia Salsha Primawati; Sriwijayanti Sriwijayanti; Boima Situmeang; Siti Safuroh; Yuke Agustin
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.91-95

Abstract

Breast cancer is a disease that has long been a source of concern for the public due to its high mortality rate. Excessive exposure to free radicals has been identified as a potential carcinogen, thus necessitating the utilization of antioxidants to counteract the damaging effects of these molecules. Gandaria (Bouea macrophylla Griff.) is a plant that is commonly found in Java, Sumatra, Maluku, and Kalimantan. B. macrophylla is known to have strong antioxidant activity, which is correlated with anticancer activity. A part of B. macrophylla that has not been extensively researched is its stem bark. The objective of this study was to analyze the potential of the ethyl acetate fraction of B. macrophylla stem bark as an anticancer agent using in silico method. The ethyl acetate fraction of B. macrophylla stem bark was characterized by LC-MS, which revealed four major compounds: 4-hydroxy-3-(3-oxo-1-phenylbutyl)-chromen-2-one, 1-(2,5-dihydroxyphenyl)-propan-1-one, 3-ethoxy-4-hydroxybenzaldehyde, and 2-nitrobenzoic acid. Molecular docking was performed between the compounds against the HER2 protein with PDB ID 3RCD. The four compounds demonstrated binding energy values of -8.29 kcal/mol, -5.04 kcal/mol, -4.66 kcal/mol, and -4.28 kcal/mol, respectively.
The Effect of Methanol Concentrations Against Phenolic Total Content and Antioxidant of Balakacida Leaves (Chromolaena odorata) Sriwijayanti Sriwijayanti; Ahmad Firdaus; Boima Situmeang; Holisha Widiyanto; Dian Susvira
Biology, Medicine, & Natural Product Chemistry Vol 15, No 1 (2026)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2026.151.239-244

Abstract

The balakacida plant with the Latin name Chromolaena odorata is a plant that lives in a tropical climate. The balakacida plant is a plant of the Asteraceae Family. Phytochemical tests on balakacida leaves showed the presence of secondary metabolites of the tannin, phenol, flavonoid, saponin and steroid groups. This study aims to extract balakacida leaves and test the total phenolic and antioxidant content. Sample extraction was carried out by the maceration method using methanol solvent. Testing of total phenolic content using the Folin Ciocalteu method, while testing of antioxidant content using the DPPH method using a UV-Vis spectrophotometer. The results showed that the concentration of methanol solvent significantly affected the acquisition of total phenolics and antioxidants. The highest total phenolic content was obtained at a methanol extract concentration of 80% of 145.64 mg GAE/g. For antioxidant content, a methanol extract concentration of 60% showed the highest activity with an average DPPH % inhibition of 59.77%. It can be concluded that a methanol extract concentration of 60% is the optimal concentration to produce balakacida leaf extract with the best antioxidant activity, although not with the highest total phenolic content.
Co-Authors Achmad Rante Suparman, Achmad Rante Afif Hidayatul Mustafid Afif Hidayatul Mustafid Agrin Febrian Pradana Agus Malik Ibrahim Ahmad Firdaus Ahmad Kadir Kilo Ahmad Rifa’i Apriani Sulu Parubak Apriani sulu parumbak Ari Widiantoro Ari Widiyantoro Dian Susvira Dikdik Kurnia Fajar Rizki Fauji Faradin, Faradin Fauzan Amin Hidayatullah, Ryan Holisha Widiyanto Ibrahim, Agus Malik Ibrahim, Agus Malik Iin Farlina Ika Agustia Umami Indah Permata Yudha Isna Lailatusholihah Jinanti, Nazwa Julinton Sianturi Junia Salsha Primawati Lailatussholihah, Isna Micha Mahardika Mieke H Satari Moh Adam Mustapa Mohamad Adam Mustapa Muhammad Mutfi Amin Shidqi Mulyadi, Agus Murtihapsari . Musa, Weny J.A. Mustafid, Afif Hidayatul Nani Yulianti Nurhayati Bialangi Oktafiani, Ismi Primawati, Junia Salsha Radite Yogaswara Rohmatulloh Saronom Silaban Setiyandani, Kurnia Indah Siti Rohmiyati Siti Safuroh Sri Agustina Sriwijayanti Sriwijayanti Sriwijayanti Sriwijayanti Sriwijayanti Susparini, Ninik Triayu Susvira, Dian Tati Herlina Weny Musa Weny Nuraeni Widiyanto, Holisha Widyawati Widyawati Yasmiwar Susilawati Yeyen Maryani Yuke Agustin Yuszda K Salimi