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All Journal VALENSI BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Biology, Medicine, & Natural Product Chemistry KOVALEN: Jurnal Riset Kimia Jurnal Penelitian Sains Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Chemistry Indonesian Journal of Chemical Research Jambura Journal of Chemistry Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Pharmacoscript SPIN: Jurnal Kimia & Pendidikan Kimia
Boima Ramses Situmeang
Departmen Of Chemistry, Sekolah Tinggi Analis Kimia Cilegon, Banten, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Engineering Environmental Science Mathematics Medicine & Pharmacology Physics Public Health

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POTENSI FRAKSI ETIL ASETAT KULIT BATANG KESAMBI SEBAGAI ANTIBAKTERI TERHADAP Escherichia coli THE POTENTIAL OF ETHYL ACETATE FRACTION OF KESAMBI STEM AS ANTIBACTERIAL AGAINST Escherichia coli Afif Hidayatul Mustafid; Yeyen Maryani; Sri Agustina; Boima Situmeang
Indonesian Journal of Pure and Applied Chemistry Vol 6, No 2 (2023)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v6i2.63497

Abstract

In our previous research, ethyl acetate extract of kesambi stem bark have the highest antibacterial activity against Escherichia coli compared with n-hexane and methanol extract. In our present study, we report the antibacterial activity of fractions from ethyl acetate extract against Escherichia coli. The method of fractionation used coloumn and thin lawyer chromatography. The Antibacterial activity uses Kirby Bauer methods. The characterization of active fractions used spectrometer infrared. The result showed fractions 6 and 7 have the highest antibacterial activity with inhibition zone 11.65 and 7.1 mm. The characterization of fractions 6 and 7 showed fungtional groups C=O, O-H, and C=C. The ethyl acetate fraction has the potential as antibacterial materials.
ETHANOL EXTRACT OF MATOA (Pometia pinnata) AS NATURAL ANTIOXIDANT TO INHIBIT OXIDATION REACTION OF CRUDE PALM OIL: EKSTRAK ETANOL DAUN MATOA (Pometia pinnata) SEBAGAI ANTIOKSIDAN ALAMI UNTUK MENGHAMBAT REAKSI OKSIDASI PADA CRUDE PALM OIL Sriwijayanti; Hidayatullah, Ryan; Musa, Weny JA; Bialangi, Nurhayati; Situmeang, Boima; Widiyanto, Holisha; Lailatussholihah, Isna
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 6 No. 1 (2024): Januari - Juni 2024
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v6i1.9797

Abstract

Indonesia is the 2nd largest country in the world in terms of palm oil production. The demand for Crude Palm Oil increases every year. For this reason, Indonesia is expected to be able to compete at the international industry level in producing palm oil, with the aim of being able to produce good quality palm oil among industries in other countries. The problem that often occurs in CPO factories is a decrease in the quality of CPO caused by an increase in Free Fatty Acid (FFA) levels and Peroxide Numbers. Antioxidants are substances that can delay or prevent the occurrence of free radical anti-oxidation reactions in the oxidation of fats or oils. Natural antioxidants are antioxidants that are obtained directly from nature. Natural antioxidants are antioxidants that are obtained directly from nature. One of them is the leaf of the matoa plant (Pometia pinnata). Based on the results of this study, the antioxidants of the ethanol extract of the matoa plant can reduce levels of FFA and peroxide numbers depending on the length of time the antioxidant mixture is given to CPO. In this study, a decrease in FFA levels and peroxide numbers was obtained from samples on day - 10 with the addition of 5000 ppm antioxidants, namely 2.71%. while the peroxide number is 0.83%.
Triterpene Compound from Ethyl Acetate Fraction of Kesambi Bark (Schleichera oleosa) and Its Activity as Anti-Bacterial Musa, Weny J.A.; Setiyandani, Kurnia Indah; Mustafid, Afif Hidayatul; Bialangi, Nurhayati; Situmeang, Boima
Indonesian Journal of Chemical Research Vol 11 No 3 (2024): Edition for January 2024
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2024.11-wen

Abstract

In our earlier study, we managed to find the antibacterial activity of the ethyl acetate fraction of the kesambi bark stem. In our next study, we isolated secondary metabolite compounds from the ethyl acetate fraction of the kesambi stem bark and tested the antibacterial activity of isolates against the bacteria Escherichia coli and Staphylococcus aureus. Separation is carried out by the method of column chromatography. Analysis of stain patterns and purity was performed with thin-layer chromatography (TLC). The test of antibacterial activity was carried out by the Kirby Bauer method. Characterization of pure isolates was performed with IR, 1H -NMR, 13C -NMR and DEPT 135° spectroscopy. The results of the characterization of pure isolates show that the isolated compound is a triterpenoid compound with the name IUPAC compound lup-20(29)-en-3-ol. The results of antibacterial tests showed that the compound lup-20(29)-en-3-ol has antibacterial activity against E. coli and S. aureus which is relatively moderate.
The potential of methanol extract nanoemulsion from gletang flower (Tridax procumbens) as an antibacterial agent against pathogenic bacteria Sriwijayanti Sriwijayanti; Agrin Febrian Pradana; Fajar Rizki Fauji; Iin Farlina; Boima Situmeang
Jurnal Pendidikan Kimia Vol. 16 No. 3 (2024): J. Pendidik. Kim : December 2024
Publisher : Pascasarjana Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jpkim.v16i3.65168

Abstract

Gletang plant is a weed that grows wild and is widely distributed in various places such as rice fields, plantations, and roadsides. Phytochemical screening of gletang flower extract using methanol revealed the presence of secondary metabolites such as alkaloids, flavonoids, steroids, phenols, terpenoids, and tannins. This study aims to formulate a nanoemulsion from the methanol extract of gletang flowers. The extraction was performed by maceration with methanol 96%. The nanoemulsion was characterized by testing its pH, % transmittance, stability, viscosity and particle size using a particle size analyzer. The antibacterial activity was tested against Staphylococcus aureus and Escherichia coliusing the Kirby-Bauer method. The results of pH characterization, % transmittance, stability and viscosity tests met the standards. The particle size analyzer showed that the particle size ranged between 300-1000 nm. The antibacterial activity tests indicated that all three formulations showed activity against the pathogenic bacteria E. coli, with formulation 3 showing the highest activity.
Antioxidant and Cytotoxic Potential of Ethyl Acetate Fraction of Gandaria Stem Bark (Bouea macrophylla) Against MCF-7 Cell Line Situmeang, Boima; Primawati, Junia Salsha; Oktafiani, Ismi; Musa, Weny JA; Kilo, Ahmad Kadir
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.345-349

Abstract

The stem bark of Bouea macrophylla (gandaria) represents a promising subject for further scientific investigation. Previous studies have reported that the bark contains high concentrations of total phenolic and flavonoid compounds, associated with potent antioxidant activity. This study evaluates the antioxidant and cytotoxic potential of the ethyl acetate fraction of B. macrophylla stem bark. Antioxidant activity was assessed using the DPPH and ABTS radical scavenging methods, while cytotoxic activity against MCF-7 breast cancer cells was determined using the MTT assay. The ethyl acetate fraction exhibited strong antioxidant activity with IC₅₀ values of 5.837 ± 0.060 ppm (DPPH) and 9.645 ± 0.697 ppm (ABTS). The cytotoxicity assay revealed an IC₅₀ value of 99.55 ppm, indicating moderate cytotoxic potential. These findings suggest that the ethyl acetate fraction of B. macrophylla stem bark possesses significant antioxidant activity and potential anticancer properties, supporting its possible application in natural therapeutic development.
Perbandingan Aktivitas Antioksidan Ekstrak Etil asetat dan Metanol Daun Tumbuhan Matoa (Pometia pinnata) Situmeang, Boima; Musa, Weny JA; Mulyadi, Agus; Ibrahim, Agus Malik; Widiyanto, Holisha; Bialangi, Nurhayati
Jurnal Penelitian Sains Vol 26, No 1 (2024)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v26i1.919

Abstract

Matoa (Pometia pinnata) is a plant from the Sapindaceae family that is widely distributed throughout the Asia-Pacific region, including Indonesia, Malaysia, Thailand, and Sri Lanka. In Indonesia, the Matoa plant is commonly found in Java, Sumatra, and Papua. Empirically, the leaves of the Matoa plant have been utilized by the community as a traditional remedy for treating hypertension, fever, and diarrhea. The aim of this study was to test the antioxidant activity of ethyl acetate extract and methanol extract of Matoa leaves. Extraction was performed using the maceration method. The antioxidant activity was evaluated using UV-Visible spectroscopy. The free radical used was DPPH at a concentration of 50 ppm. The absorbance was measured at a wavelength of 517 nm. The antioxidant activity of the ethyl acetate extract of Matoa leaves was 38.87 ppm and 37.73 ppm. The antioxidant activity of the methanol extract of Matoa leaves was 27.99 ppm and 33.25 ppm. Based on the antioxidant activity values, both the ethyl acetate and methanol extracts of Matoa leaves have the potential as a source of natural antioxidants. 
Analysis of Total Polyhenolic Content and Antioxidant Activity from n-hexane, Ethyl acetate and Ethanol Extract of Kitolod (Hipobbroma longiflora) Leaf Situmeang, Boima; Faradin, Faradin; Susvira, Dian; Bialangi, Nurhayati; Widiyanto, Holisha; Yulianti, Nani; Jinanti, Nazwa
Jurnal Penelitian Sains Vol 27, No 2 (2025)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56064/jps.v27i2.1182

Abstract

Isotoma longiflora, commonly known as Kitolod, has been traditionally used as a medicinal plant for treating various ailments. This study aims to extract Kitolod leaves using three different solvents with varying polarities: n-hexane (non-polar), ethyl acetate (semi-polar), and ethanol (polar). The total phenolic content, total flavonoid content, and antioxidant activity were analyzed using a spectrophotometer. The trends observed in both TFC and TPC results indicate that ethyl acetate is the most effective solvent for extracting bioactive compounds from Kitolod leaves. The ethyl acetate extract of Kitolod leaves exhibited the highest antioxidant activity (150.542 ± 3.917 ppm), followed by the ethanol (157.235±0.858 ppm) and n-hexane (217.345 ± 1.749 ppm) extracts. This suggests that ethyl acetate is the most effective solvent for extracting bioactive compounds with antioxidant properties from Kitolod leaves.
THE EFFECT OF GLUCOSE ON Streptococcus mutans ATCC 25175 GROWTH BY VARIATION OF CONCENTRATION AND INCUBATION TIME Widyawati, Widyawati; Boima, Situmeang
Pharmacoscript Vol. 8 No. 2 (2025): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v8i2.2179

Abstract

Streptococcus mutans is one of the main causative agents of dental caries. Glucose has been reported as one of the factors influencing the growth of S. mutans. This study aims to determine the effect of glucose concentration and incubation time on the growth of S. mutans. The glucose concentrations used in this study were 0, 2, 4, 6, 8, and 10%. The incubation times used were 1, 10, and 15 hours. The result showed that glucose concentration significantly affects the growth of S. mutans. Higher glucose level lead to increase bacterial growth, with the highest absorbance observed at 10% glucose after 10 hours of incubation. Specific growth rate (μ) analysis further supports this finding, showing that S. mutans grows more rapidly during the exponential phase (1–10 hours) with increased glucose concentration, while the growth rate stabilizes or declines during the later phase (10–15 hours). This result indicate that both glucose availability and incubation time are critical factors influencing the growth dynamics of S. mutans.
FORMULASI EKSTRAK DAUN KITOLOD (HIPOBROMA LONGIFLORA) DALAM SEDIAAN OBAT KUMUR ALAMI TERHADAP BAKTERI STREPTOCOCCUS MUTANS Situmeang, Boima; Dzulhijar; Juliandoz; Ahmad Fajar Muzakir; Agus Malik Ibrahim; Nani Yulianti; Nurhayati Bialangi; Weny JA Musa
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 7 No. 2 (2025): Literasi Artikel Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v7i2.5802

Abstract

The kitolod plant (Hippobroma longiflora) has been demonstrated to possess antibacterial activity against Streptococcus mutans, the bacterium responsible for the development of dental caries. The objective of this study was to formulate a mouthwash preparation using kitolod leaf extract. The extract was formulated into three distinct formulations. The mouthwash was evaluated for its pH, viscosity, stability, and antibacterial activity. The antibacterial evaluation was executed in accordance with the Kirby-Bauer method. The positive control utilized in this study was 0.2% chlorhexidine. The pH test results indicated that all three formulations had a pH of 6. The viscosity test demonstrated that all formulations had a viscosity of 0.99, which is close to that of water. The antibacterial evaluation against S. mutans indicated that formulation 2 demonstrated the most pronounced antibacterial activity, exhibiting an inhibition zone measuring 3.81 mm. All three formulations exhibited stability at ambient temperature. In light of the findings from this study, it can be posited that formulation 2 possesses the potential to serve as a natural mouthwash.
Antioxidant and Antibacterial Properties of Methanol Extract of Gletang Flower (Tridax procumbens) Situmeang, Boima; Musa, Weny JA; Bialangi, Nurhayati; Sriwijayanti, Sriwijayanti; Widiyanto, Holisha; Susvira, Dian
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1085-1090

Abstract

In a previous study, the methanol extract of Tridax procumbens flowers (commonly known as gletang) at high concentrations was reported to exhibit strong antibacterial activity against Streptococcus mutans and Enterococcus faecalis. This study aimed to examine the secondary metabolite content, antioxidant activity, and antibacterial activity of the methanol extract of gletang flowers. The antioxidant activity was evaluated using two methods, namely DPPH and ABTS assays. The antibacterial activity was assessed using the Kirby-Bauer method at concentrations of 1000, 5000, and 10000 ppm against Staphylococcus aureus, Escherichia coli, Streptococcus mutans, and Enterococcus faecalis. Phytochemical screening revealed that the methanol extract of gletang flowers contains phenolic compounds, flavonoids, alkaloids, and triterpenoids. The antioxidant activity tests showed very strong activity in both DPPH and ABTS assays, with IC50 values of 6.8478 ± 1.335 and 12.8608 ± 0.579 ppm, respectively. The antibacterial activity tests showed that the methanol extract of gletang flowers exhibited strong activity against E. faecalis at concentrations of 5000 and 10000 ppm, with inhibition zone diameters of 3.00 ± 0.14 and 3.20 ± 0.14 mm, respectively.
Co-Authors Achmad Rante Suparman, Achmad Rante Afif Hidayatul Mustafid Afif Hidayatul Mustafid Agrin Febrian Pradana Agus Malik Ibrahim Agus Malik Ibrahim Ahmad Fajar Muzakir Ahmad Kadir Kilo Ahmad Rifa’i Apriani Sulu Parubak Apriani sulu parumbak Ari Widiantoro Ari Widiyantoro Dikdik Kurnia Dzulhijar Fajar Rizki Fauji Faradin, Faradin Fauzan Amin Hidayatullah, Ryan Ibrahim, Agus Malik Ibrahim, Agus Malik Iin Farlina Ika Agustia Umami Indah Permata Yudha Isna Lailatusholihah Jinanti, Nazwa Juliandoz Julinton Sianturi Lailatussholihah, Isna Micha Mahardika Mieke H Satari Moh Adam Mustapa Mohamad Adam Mustapa Muhammad Mutfi Amin Shidqi Mulyadi, Agus Murtihapsari . Musa, Weny J.A. Mustafid, Afif Hidayatul Nani Yulianti Nurhayati Bialangi Oktafiani, Ismi Primawati, Junia Salsha Radite Yogaswara Rohmatulloh Saronom Silaban Setiyandani, Kurnia Indah Siti Rohmiyati Sri Agustina Sriwijayanti Sriwijayanti Sriwijayanti Sriwijayanti, Sriwijayanti Susparini, Ninik Triayu Susvira, Dian Tati Herlina Tati Herlina Weny JA Musa Weny Musa Weny Nuraeni Widiyanto, Holisha Widyawati Widyawati Yasmiwar Susilawati Yeyen Maryani Yuszda K Salimi