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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Research Journal of Life Science MNJ (Malang Neurology Journal) Paediatrica Indonesiana Majalah Kesehatan FKUB Medical Laboratory Technology Journal Jurnal Ilmiah Bidan Indonesian Journal of Medicine International Journal of Community Service Learning Jurnal Riset Kesehatan Poltekkes Depkes Bandung Journal of Issues in Midwifery Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Archives of Biomedical Research (InABR) Journal of Global Pharma Technology Media Penelitian dan Pengembangan Kesehatan
Agustina Tri Endharti
Departemen Parasitologi, Fakultas Kedokteran Universitas Brawijaya Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Journal of Global Pharma Technology

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Cosmos caudatus Leaf Ethanol Extract Inhibit Growth and Viability through Membrane Permeability and Apoptosis in Candida albicans Agustina Tri Endharti
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Candidiasis is the most common fungal gynecological disease in humans. Essentially, the use of antifungal such as Fluconazole has reportedly increased resistance to candidiasis by 7%. The flavonoid has been shown to be used as an antifungal in Candida albicans. Cosmos caudatus contains 51% of Quercetin. To prove the influence of the use of flavonoid antifungal of quercetin group on the growth, viability, membrane permeability, and apoptosis of the C. albicans. Methods: The SV-1148 coded C. albicans isolate was obtained from the Microbiology Laboratory of Brawijaya University, Malang, Indonesia. Initially, the isolate was grown in Sabouraud Dextrose Agar (SDA) medium. The samples were divided into negative and positive control groups of fluconazole (60µg/ml) and difference concentrations (5%, 10%, 20%, and 40%) of leaves ethanol extract of C. caudatus. Results:  Concentration of 40% ethanol extract C. caudatus has Minimum Inhibitory Concentration (MIC) of 30%. This result showed that 40% ethanol extract C. caudatus was able to provide the best growth resistance which was characterized by the absence of colonies from C. albicans. The data of Influx Assay Iodide increased membrane permeability of C. albicans to disrupt cell membranes and induce apoptosis. The percentage of apoptosis increased after treatment of 40% ethanol extract C. caudatus in the culture of C. albicans. Conclusion: C. caudatus has antifungal activity and can be used as an herbal drug in C. albicans infection.
Co-Authors A.A. Santi Dewi Abd. Rasyid Syamsuri Abousouh, Emad Khaleefah Alnawajha, Amin Ambar Dwi Retnoningrum Andre William Tulle Anggie Diniayuningrum Ari Yunanto Arifin, Mochammad Samsul Aris Widodo Bagus Hermansyah Balafif, Farhad Bambang Rahardjo Burhan, Niniek Daniel Happy Putra desy wulandari Dewi Purnama Sari Dewi Santosaningsih Dian Hasanah Didi Candradikusuma Didi Candradikusuma Dinda Oktia Maghfiroh Dwi Yuni Nur Hidayati Elvira Sari Dewi Erma Sulistyaningsih Erryana Martati Ery Olivianto Febriana, Romadhinniar Handono Kalim Hani Susianti Hidayat Sujuti Hittoh Fattory, Hittoh HMS Chandra Kusuma Indriati Dwi Rahayu Irma Hamdayani Pasaribu Josef Sem Berth Tuda Krisni Subandiyah Kusumawati, Shinta Kusworini Handono Loeki Enggar Fitri Maramy, Neyla Vista Muhammad Anshory, Muhammad Muhammad Rivai Nikmatul Ulya, Nikmatul Niniek Burhan Nuning Winaris Nurdiana Nurdiana Nurdiana Nurdiana Perdana Aditya Rahman Prawiro, Sumarno Reto R Setyohadi, R Rahmad Rahmad Rima Zakiyah Samsul Arifin Sanarto Santoso Santosaningsih , Dewi Santoso, Sunarto Sari, Tita Luthfia Satriotomo , Irawan Soeyati Poejiani Solly Aryza Sri Andarini Subandi Subandi Sumarno . Sumarno Reto Prawiro Sumarno Sumarno Sutrisno Sutrisno Taqiyya, Nadia Tatit Nurseta Tri Dewanti Widyaningsih Tuda, Josef Sem Berth Umar Zein Vanji Budi Himawan, Vanji Budi Wahono, Cesarius Singgih Wahyono, Tikto Wardhani, Ratih Kusuma Wening Prastowo Wisnu Barlianto Zahra Ahmed