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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Research Journal of Life Science MNJ (Malang Neurology Journal) Paediatrica Indonesiana Majalah Kesehatan FKUB Medical Laboratory Technology Journal Jurnal Ilmiah Bidan Indonesian Journal of Medicine International Journal of Community Service Learning Jurnal Riset Kesehatan Poltekkes Depkes Bandung Journal of Issues in Midwifery Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Archives of Biomedical Research (InABR) Journal of Global Pharma Technology Media Penelitian dan Pengembangan Kesehatan
Agustina Tri Endharti
Departemen Parasitologi, Fakultas Kedokteran Universitas Brawijaya Malang, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Research Journal of Life Science

 1 
Nigella sativa Extract Increases Antibacterial Activity by Up-Regulating T-reg and Th2 Levels in Salmonella enterica subsp. enterica serovars Typhimurium-Exposed Balb/c Mice Zahra Ahmed; Sumarno Reto Prawiro; Agustina Tri Endharti
Research Journal of Life Science Vol 5, No 1 (2018)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.27 KB) | DOI: 10.21776/ub.rjls.2018.005.01.2

Abstract

Nigella sativa extract (NSE) is known to be an effective antibacterial and immuno-modulating agent. This study aimed to demonstrate that treatment of Salmonella eterica subsp. eterica serovars typhimurium-infected mice with NSE would cause an increase in T-regulatory (T-reg) and Th2 cells and a decrease in the number of spleen bacterial colonies. Mice were randomly divided into five groups [control (T0), mice infected with S. typhimurium only (T1), and mice infected with S. typhimurium and then treated with NSE 0.52, 5.2, or 52 mg/kg body weight NSE (N1, N2, and N3, respectively)]. Levels of T-reg and Th2 cells were determined via flow cytometry and the number of spleen bacterial colonies was determined by observation. The results showed that treatment with NSE 0.52, 5.2, and 52 mg/kg significantly increased the number of T-reg and Th2 cells (p<0.05) relative to T0. Administration of NSE 5.2 mg/kg increased the number of T-reg cells, while administration of NSE 52 mg/kg caused the greatest increase in the number of Th2 cells in the spleens of S. typhimurium-infected mice. Moreover, no S. typhimurium colonies were found in the spleens of any NSE-treated mice. Our results suggest that NSE has therapeutic potential to ameliorate S. typhimurium infection.
Co-Authors A.A. Santi Dewi Abd. Rasyid Syamsuri Abousouh, Emad Khaleefah Adeodatus Yuda Handaya Ainul Mardiah Alnawajha, Amin Ambar Dwi Retnoningrum Andre William Tulle Anggie Diniayuningrum Ari Yunanto Arifin, Mochammad Samsul Aris Widodo Bagus Hermansyah Balafif, Farhad Bambang Rahardjo Bogi Pratomo Burhan, Niniek Daniel Happy Putra desy wulandari Dewi Santosaningsih Dian Hasanah Didi Candradikusuma Didi Candradikusuma Dinda Oktia Maghfiroh Dwi Yuni Nur Hidayati Elvira Sari Dewi Erma Sulistyaningsih Erryana Martati Ery Olivianto Febriana, Romadhinniar Handono Kalim Hani Susianti Hendra Susanto Hidayat Sujuti Hittoh Fattory, Hittoh HMS Chandra Kusuma Indriati Dwi Rahayu Irma Hamdayani Pasaribu Josef Sem Berth Tuda Krisni Subandiyah Kusumawati, Shinta Kusworini Handono Loeki Enggar Fitri Maramy, Neyla Vista Muhammad Anshory, Muhammad Muhammad Rivai Nikmatul Ulya, Nikmatul Niniek Burhan Nuning Winaris Nurdiana Nurdiana Nurdiana Nurdiana Nurwijayanti Perdana Aditya Rahman Prawiro, Sumarno Reto R Setyohadi, R Rahmad Rahmad Rima Zakiyah Samsul Arifin Sanarto Santoso Santosaningsih , Dewi Santoso, Sunarto Sari, Tita Luthfia Satriotomo , Irawan sholeh, moch Soeyati Poejiani Solly Aryza Sri Andarini Subandi Subandi Sumarno . Sumarno Reto Prawiro Sumarno Sumarno Sutrisno Sutrisno Taqiyya, Nadia Tatit Nurseta Tri Dewanti Widyaningsih Tuda, Josef Sem Berth Umar Zein Vanji Budi Himawan, Vanji Budi Wahono, Cesarius Singgih Wahyono, Tikto Wardhani, Ratih Kusuma Wening Prastowo Wisnu Barlianto Zahra Ahmed