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All Journal Jurnal Ilmu Dasar Jurnal Sains dan Teknologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Kesehatan Andalas Jurnal Pendidikan Biologi Panrita Abdi - Jurnal Pengabdian pada Masyarakat Jurnal Ilmiah Universitas Batanghari Jambi Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Jurnal Pengabdian Magister Pendidikan IPA Diseminasi : Jurnal Pengabdian kepada Masyarakat Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Madaniya Bioscientiae, Jurnal ilmu ilmu Biologi Jurnal Pemantik Molekul: Jurnal Ilmiah Kimia BIOTROPIC
Sulistiyawati, Indah
Universitas Nahdlatul Ulama Purwokerto
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Journal : Jurnal Ilmu Dasar

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Efficacy of Ethanol Extract of Sambiloto (Andrographis paniculata) Against Pneumonia-Causing Klebsiella pneumoniae Sulistiyawati, Indah; Falah, Muhammad; Nurasih, Ari Dwi
Jurnal ILMU DASAR Vol 26 No 1 (2025)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v26i1.36846

Abstract

Klebsiella pneumoniae is one of the most common pathogens in nosocomial respiratory infections. Antibiotics are often used for the treatment of K. pneumoniae infections. Increased bacterial resistance to antibiotics is closely related to the success rate of infectious disease therapy. The use of plants as phytopharmacology is currently an alternative treatment. Some medicinal plants that have antibacterial and immunomodulatory activity are Sambiloto (Andrographis paniculata) with an active compound called andrographol. The purpose of this study was to provide a solution to the problem above by developing a phytopharmaceutical using bitter extract to inhibit the growth of K. pneumoniae bacteria. Two sputum samples from the laboratory confirmed Covid-19 patients with pneumonia infection at the Hospital. The sambiloto was extracted by using 96% ethanol. The extract was further analyzed for its antimicrobial activity and phytochemical compounds. There were two K. pneumoniae isolates, namely KpRNG and KpTRI. The active compounds were saponin and steroids. The antimicrobial activity of the ginger extract was measured with different concentrations of 25%, 50%, 75%, and 100%. Its inhibitory zone against K. pneumoniae was ranging from 5.8 to 7 mm or had a moderate inhibition category.
Co-Authors Adityo Nugroho, Adityo Agustiani, Rina Dwi Andika Ristiono Anggraeni, Gita Aniuranti, Asfi Ari Dwi Nurasih Azizah, Teguh Chamid Sutikno Daniel Joko Wahyono Denny Indra Yudhistira Diah Arimbi Diah Harmawati Eko Hendarto Eko Hendarto Eti Wahyuningsih Falah, Muhammad Gita Anggraeni Hendro Pramono Herdian Farisi I Gede Arinton Karseno Khoiriyah, Anna Jarrotul Maditaningtyas Hawwa Zuwanda Mimien Heni Irawati Al Muhdhar, Mimien Heni Irawati Muhammad Falah Nur Laila Rahayu Nura Khabita Nuraini Muhassanah Nurasih, Ari Dwi Oksa Hugi Lestiani Rabbani, Fadhil Rahayu, Nur Laila Rahayu, Nurlaila Rina Dwi Agustiani Rovik, Anwar Sadiah, Hilmi Halimatus Silmi Kafah Siti Fatimah Tien Setyaningtyas Wahyu Maulana Endris Wahyu Siswandari Zain, Nasywa Luthfi Zainul Mustofa, Zainul Zulaikhah, Siti Rahmawati