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All Journal Jurnal Gizi dan Pangan MEDIA MEDIKA INDONESIANA Jurnal Kedokteran Brawijaya Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Sari Pediatri Padjadjaran Journal of Dentistry Paediatrica Indonesiana Jurnal Kesehatan Reproduksi Jurnal Ipteks Terapan Journal of Midwifery Majalah Kedokteran Andalas pendidikan, science, teknologi, dan ekonomi Andalas Dental Journal Cakradonya Dental Journal
Fadil Oenzil
Fakultas Kedokteran Universitas Andalas
Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Paediatrica Indonesiana

 1 
Association of resistin level with acanthosis nigricans in obese adolescents Dini Noviarti; Eka Agustia Rini; Fadil Oenzil
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.186 KB) | DOI: 10.14238/pi56.1.2016.32-6

Abstract

Background Childhood obesity is associated with increased risk of cardiovascular diseases and metabolic syndrome, such as insulin resistance. Clinically, insulin resistance may be manifested as acanthosis nigricans. Resistin has a biological activity that is important in glucose and lipid metabolisms and closely related to the incidence of insulin resistance.Objective To find out the association of resistin level with scale of acanthosis nigricans in adolescents obesity.Methods A cross-sectional study was conducted on 53 obese adolescents with acanthosis nigricans in senior high schools in Padang, West Sumatera. Degree of acanthosis nigricans was assessed using scale of Burke and then plasma resistin level was performed with ELISA. Data were analyzed using ANOVA and post-hoc test.Result The mean of resistin level in obese adolescents was 14.21 (SD 7.43) ng/dL. High resistin level was found in scale of acanthosis nigricans 2,3 and 4 (P=0.0001). Obese adolescents with severe degree of acanthosis nigricans has higher resistin level compared to milder acanthosis nigricans.Conclusion In obese adolescents, the higher degree of acanthosis nigricans, the higher level of plasma resistin.
Soluble transferrin receptor levels in obese and non obese adolescents Zul Febrianti; Fadil Oenzil; Firman Arbi; Gustina Lubis
Paediatrica Indonesiana Vol 54 No 2 (2014): March 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.902 KB) | DOI: 10.14238/pi54.2.2014.77-81

Abstract

Background Iron deficiency in children and adolescents maybe dueto an inadequate supply of iron as well as increased iron requirementsfor growth and developmental processes. The incr easing prevalence ofobesity puts children at risk of iron deficiency. Studies on the effectsof obesity on iron deficiency have focused on low grade systemicinflammation as well as examining soluble transferrin receptor levels(sTfR) as an indicator ofiron deficiency.Objective To compare sT fR levels in obese and non-obeseadolescents, assess for correlations between BMI, sTfR and obesity,and determine the risk of iron deficiency in obese adolescents .Method T his cross sectional study was conducted on 20 obeseand 20 non-obese adolescents aged 15-17 in East Aceh District,from September to December 20 11. Subject were chosen throughcluster sampling. The obese subjects had BMI > 95th percentileand the non-obese subjects had BMI s:851h percentile based onthe 2000 National Center for Health Statistics (NCHS). Exclusioncriteria were blood disorders, chronic diseases, and a history ofbleeding. Data were analyzed by Chi-square test and T test witha significance level of P < 0.05, and Pearson's correlation.Results The mean s TfR levels in obese adolescents was higher thanin non-obese adolescents, [2.59 (SD 0.76) vs 2.14 (SD 0.45) μg/mL(P = 0.030)]. Iron deficiency (sTfR> 2.5 μgimL) was more commonin obese than in non-obese adolescents [ (55% vs . 15%, respectively,(P = 0.019) ]. Analysis of the relationship between obesity accordingto BMI andsTfRrevealedan OR of 6.93; 95% CI 1.53 to3 1.38. Ther elationship between the BMI and sTfR levels indicated a positive,moderate strength of association (r = 0.392) .Conclusion The mean sT fR levels in obese adolescents is significantlyhigher than in non-obese individuals. Obese adolescentshave a 6.93 times higher risk of iron deficiency than non-obeseadolescents. Body mass index has a positive and moderate associationwith sTfR.
Co-Authors Akhmad Yogi Pramatirta, Akhmad Yogi Aldian Mulyanto Lokaria Amel Yanis Amirah Zatil Izzah Aria Fransiska Arni Amir Asterina Asterina Basyir, Vaulinne Darma, Azri Darma, Azri Deddy Satriya Putra Delmi Sulastri Denas Symond Desmawati Desmawati Desmiwarti Desmiwarti Detty Iryani Dia Rofinda, Zelly Dia Dian Pertiwi Didin Kustantiningtyastuti Dini Noviarti Dona Mirsa Putri Efrida Efrida Eka Agustia Rini Endrinaldi Eriyati Darwin, Eriyati Erlina Rustam Eryati Darwin Eti Yerizel Eva Chundrayetti Fadma Yuliani Fasli Jalal Feby Ramadhani Fido Arif Firman Arbi Gusti Revilla Gustina Lubis Gustina Lubis Hafni Bachtiar Hannie Qalbina Syaiful Harsa Rusda Havis Dharma Rafke Hidayati Hidayati Hidayati Hidayati Ibrahim Ibrahim Idson Kamal Iskandar Syarif Ismawati Ismawati Johanes C. Mose Johanes C. Mose Julispen Syafruddin Muhi K, Didin Lathiva, Muthia Laura Kosasi Lisbet Rimelfhi Sebataraja Medika Prasetya Meiyestri Dwi Riani Metly, Annesha Mia Puspita Miharti, Sari Ida Minarni Minarni Muhamad Febry Muhammad Ridwan Murniwati . Murniwati Murniwati Muthia Lathiva Nidia Purwadianti Nila Kasuma Novia Susanti Nur Indrawati Lipoeto Nur Indrawaty Liputo Nurul Fadila Pagdya Haninda Nusantri Rusdi Pipit Amelia Burhani Prima Nanda Fauziah Putri Auliya Putri Yuriandini Yulsam Reni Puspita Riani Hafiza Rudy Afriant Sari Ida Miharti Siti Lestari Sumantri, Dedi Syarif, Iskandar Tofrizal Trisna Resti Yanti Usna Maria Harahap Vaulinne Basyir Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelvi Novita Roza Yenita Yenita Yerizal Karani Yusri Dianne Jurnalis Yustini Alioes Zul Febrianti