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All Journal Medula The Indonesian Biomedical Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Acta Biochimica Indonesiana Poltekita : Jurnal Ilmu Kesehatan Jurnal Gema Ngabdi NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Borneo Journal of Pharmacy
Tien Tien
Departemen Biokimia, Fakultas Kedokteran, Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Tentative Identification of Compounds, Antioxidant, and Antimicrobial Activity of the Edible Part of Benincasa hispida L. fruit (Cucurbitaceae) Carla Wulandari Sabandar; Harni Sartika Kamaruddin; Reskiya Nur Insani; Rana Triana Amin; Zulkifli Zulkifli; Tien Tien
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4350

Abstract

The edible part of Benicasa hispida (Thunb.) Cogn. fruit is traditionally used in Southeast Sulawesi to treat high blood pressure, typhoid fever, and body cooling. The present study evaluated the chemical compounds present in the 80% ethanol of the edible part of the plant using phytochemical screening and an LC-MS analysis, antioxidant activity based on assays on total phenolics content (TPC), total flavonoids content (TFC), and DPPH, and antimicrobial activity towards Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Candida albicans. Phytochemical screening revealed the presence of tannins, flavonoids, terpenoids, steroids, and saponins in the extract. As many as eighteen compounds (1-18) were tentatively identified in the extract, including sugars, a simple phenolic, a tricarboxylic acid, a peptide, flavonoids, quinic acid derivatives, phytosterols, triterpenoids, and saponins. The extract exhibited remarkable antioxidant activity with an SC50 value of 23.4 µg/mL, although its TPC (1.1±0.1 mg GAE/g extract) and TFC (1.0±0.1 mg QE/g extract) values were considered in low amounts. The extract was found inactive to inhibit the microbial growths of all tested microbes. However, raffinose (3) present in the extract might be beneficial as a prebiotic to promote a healthy human gut. The study concludes that the 80% ethanol extract of the edible part of B. hispida fruit could be used to develop natural antioxidant agents and nutraceuticals.
Co-Authors A Kadir La Ode Adellya Febriyani Hadini Adry Leonardy Tendean Agus Chahyadi Agussalim Ali Ardiansyah Ardiansyah Arimaswti Arimaswati Carla Wulandari Sabandar Dionisius Excelsis Deo Sombolinggi Gustavita Maria Bandong Hartati Hartati Haryati Haryati I Putu Sudayasa Juminten Saimin Kamaruddin, Harni Sartika Laode Kardin Laode Kardin Laode Kardin Mulyawati, Sufiah Asri Nina Indriyani Nina Indriyani Nasruddin Nur Rahmi Pranita Aritrina Pranita Aritrina Pranita Aritrina Pranita Aritrina Pranita Ayitrina Raja Al fath Widya Iswara Rana Triana Amin Reskiya Nur Insani Ririn Afrianto Sapto Raharjo Sukurni Syarifin, Andi Noor Kholidha Tety Yuniarty Sudiro Tomy Nurtamin Tri Wistya Utami Yenti Purnamasari Zulkifli Zulkifli