Article Per Year (5 Year)
p-Index From 2021 - 2026
4.191
P-Index
This Author published in this journals
All Journal EKUIVALEN - Pendidikan Matematika Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya The Southeast Asian Journal of Midwifery Majalah Patologi Indonesia Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Nila Kurniasari
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 38 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 38 Documents
Search

 1   2   3   4 
THE MUTATION STATUS OF KRAS GENE CODON 12 AND 13 IN COLORECTAL ADENOCARCINOMA (Status Mutasi Gen Kras Kodon 12 dan 13 di Adenocarcinoma Kolorektal) Gondo Mastutik; Alphania Rahniayu; Anny Setijo Rahaju; Nila Kurniasari; Reny I’tishom
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1177

Abstract

Kanker kolorektum merupakan salah satu kanker yang tersering di dunia. Target molekuler untuk pengobatan kanker kolorektumyaitu Epidermal Growth Factor Receptor (EGFR) dengan pemberian antibodi monoklonal anti-EGFR. Pemberian pengobatan ini tidakdapat memberikan efek dampak di pasien dengan status gen KRAS bentuk mutan, sehingga perlu dilakukan pemeriksaan status mutasigen KRAS. Telitian berupa deskriptif dengan pendekatan potong lintang yang bertujuan untuk mendapatkan data status mutasi genKRAS kodon 12 dan 13 di pasien adenocarcinoma colorectal. Deteksi mutasi KRAS dilakukan dengan teknik Polymerase Chain ReactionRestriction Fragment Length Polymorphism (PCR RFLP) yang dikonfirmasi dengan sekuensing. Sampel telitian adalah 30 blok parafinyang diperoleh dari Rumah Sakit Dr.Soetomo Surabaya masa waktu Januari-Desember 2013. Setelah dilakukan ekstraksi DNA terdapat21 sampel yang dapat digunakan untuk pemeriksaan lanjutan. Hasil PCR RFLP menunjukkan terdapat 7/21 mutasi pada kodon12 dan tidak terdapat mutasi gen KRAS pada kodon 13. Mutasi pada kodon 12 yaitu GGT>GCT, GGT>GGA dan GGT>GAT yangmenyebabkan perubahan asam amino Gly12Ala, Gly12Gly dan Gly12Asp. Simpulan telitian ini adalah mutasi gen KRAS kodon 12 padaadenocarcinoma colorectal di Rumah Sakit Dr. Soetomo Surabaya sebanyak 33%.
RELATIONSHIP OF RISK FACTORS WITH HISTOPATHOLOGICAL TYPES IN CERVICAL CANCER PATIENTS IN DR SOETOMO HOSPITAL Anggray Puspasari; Pungky Mulawardhana; ,Nila Kurniasari
SEAJOM: The Southeast Asia Journal of Midwifery Vol 7 No 1 (2021): SEAJOM: The Southeast Asia Journal of Midwifery
Publisher : AIPKIND (Asosiasi Pendidikan Kebidanan Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36749/seajom.v7i1.108

Abstract

Cervical cancer is a process of changing into malignancy in the cervix. Based on studies and previous research, cervical cancer is the third female cancer in terms of incidence (527,600 new cases) and mortality (265,700 deaths) in the world. Cervical cancer has histotopathological types in the form of squamous cell carcinoma, adenocarcinoma, and other types. This study aimed to analyze the relationship of risk factors with histopathological types in cervical cancer patients in Dr. Soetomo Hospital. Method: This analytical descriptive study used a cross sectional research design. The number of samples were 300 patients collected by total sampling. Independent variables were risk factors including age, marital age, parity, smoking, oral contraceptives, and education while dependent variables were histopathological types including squamous cell carcinoma, adenocarcinoma, and other types. Instruments used documentation. Data analysis used chi square, fisher and contingency coefficient tests. Results: There was a relationship of cervical cancer risk factors of age to histopathological type (p= 0.000 and contingency coefficient = 0.170) and no relationship of risk factors to number of parity (p= 0.321 and contingency coefficient = 1000 0.064 ), marriage age (p = 0.720 and contingency cofience = 0.038), smoking (p = 0.711 and contingency cofience = 0.036), oral contraceptive (p = 0.655 and contingency comfience = 0.042), education (p = 0.744 and contingency co-efficiency = 0.089) to histopathological type. Conclusion: There is a relationship between risk factors and histopathological types in cervical cancer patients at Oncology Polyclinic at Dr Soetomo Hospital of Surabaya.
EARLY DETECTION OF BREAST AND CERVICAL CANCER OF THE RESIDENTS OF PROPPO PAMEKASAN DISTRICT Dyah Fauziah; Alphania Rahniayu; Nila Kurniasari; Anny Setijo Rahaju; Etty Hary Kusumastuti; Gondo Mastutik; I Ketut Sudiana
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 3 No. 1 (2021): APRIL 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v3i1.21584

Abstract

Introduction: Breast cancer and cervical cancer are common cancers in females. Both of these cancers can be detected early. Early detect vion can reduce cancer morbidity and mortality. The community outreach activities are required to increase knowledge about breast cancer and cervical cancer, in addition to screening as preventive efforts for these two cancers.Methods: The activity of raising knowledge about the prevention and early detection of breast cancer and cervical cancer was carried out through community counseling to 94 females who were members of the PKK and young females in the Kecamatan Proppo, Kabupaten Pamekasan. Pre and post tests were given before and after the community counseling. After the community counseling, 86 participants were screened for breast cancer by clinical palpation and 46 participants were screened for cervical cancer using the pap smear method.Results: The result of the post test showed a 27.53% increase in knowledge. The results of the pap smear examination on participants showed 96% concluded as Papanicolau Class II, 2% Class I, and 2% Class IV. The patient with class IV results was referred to an obstetrician.Conclusion: Community counseling about breast self examination (BSE) and Pap smear can increase people's knowledge about early detection of breast cancer and cervical cancer.
DETERMINAN PERILAKU DETEKSI DINI KANKER SERVIKS METODE INSPEKSI VISUAL ASAM ASETAT (IVA) Arum Dewi Pusparini; Gatut Hardianto; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 3 No. 1 (2019): Indonesian Midwifery and Health Sciences Journal, January 2019
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v3i1.2019.51-61

Abstract

AbstrakLatar Belakang: Kanker serviks atau kanker leher rahim merupakan kanker pembunuh nomor dua di dunia. Pemerintah telah berupaya untuk mengatasi kanker serviks dengan metode inspeksi visual asam asetat (IVA). Faktor yang dapat mempengaruhi seseorang untuk melakukan IVA antara lain pengetahuan, sikap, budaya dan dukungan petugas kesehatan. Tujuan penelitian ini untuk mengetahui perbedaan faktor yang mempengaruhi wanita usia subur (WUS) yang pernah melakukan pemeriksaan IVA dan belum pernah tes IVA. Metode: mengguanakan analitik  observasional dengan pendekatan cross sectional. Jumlah sampel sebanyak 108 wanita usia subur dengan teknik purposive sampling yang memnuhi kriteria inklusi dan eksklusi. Untuk mengetahui tingkat signifikan, data yang terkumpul akan diuji statistik Chi-Square dan Fisher Exact Test pada tingkat kemaknaan 0,05. Hasil: faktor yang memiliki perbedaan yang bermakna antara wanita usia subur yang pernah melakukan dan belum pernah melakukan pemeriksaan IVA antara lain pengetahuan (p= 0,002), Budaya (p= 0,021), dukungan petugas kesehatan (p= 0,010). Sedangkan sikap (p= 1,000) tidak terdapat perbedaan yang bermakna. Kesimpulan: perbedaan faktor yang mempengaruhi WUS yang pernah dan belum pernah tes IVA di wilayah puskesmas Sidotopo adalah pengetahuan, budaya dan dukungan petugas kesehatan. AbstractBackground: Cervical cancer is the second leading deathly woman disease in the world. The Indonesian government has been trying through visual inspection of the cervix with acetic acid (VIA). There are some factors influencing women to undergo VIA such as knowledge, behaviour, culture and the support of medical workers. Thus, this research was aimed at finding significance differences among reproductive women undergoing and not undergoing. Method: This research employed Observational Analytic using cross sectional approach. The sample of this research was 108 women of reproductive age. Purposive sampling was employed as a technique which met inclusion and eksclusion criteria. To be able to find out the significance, the data collected was tested in the statistical test chi square of 0.05 significance level. Result: Factors like knowledge (p= 0,002), culture (p= 0,021), and support of medical workers (p= 0,010) showed significance difference among reproductive women undergoing and not undergoing VIA while behaviour (p= 1,000) showed no significance difference. Conclusion:the differences among reproductive women undergoing and not undergoingVIA in region of puskesmas Sidotopo was knowledge, culture and the support of medical workers. 
FAKTOR AKSESIBILITAS PELAYANAN KESEHATAN TERHADAP PEMERIKSAAN IVA DI PUSKESMAS BENCULUK KABUPATEN BANYUWANGI Arisca Arisca; Pudji Lestari; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 3 No. 4 (2019): Indonesian Midwifery and Health Sciences Journal, October 2019
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v3i4.2019.305-310

Abstract

Abstrak Latar Belakang: Kanker serviks merupakan salah satu penyakit kanker yang menyerang wanita dan menduduki urutan kedua setelah kanker payudara di Indonesia. Salah satu pencegahan yang dapat dilakukan adalah dengan melakukan pemeriksaan deteksi dini kanker serviks metode IVA. Keinginan melakukan pemeriksaan IVA dipengaruhi beberapa faktor, diantaranya pengetahuan, kesadaran, keternagkauan jarak, keterjangkauan biaya, serta persepsi Ibu. Penelitian ini bertujuan untuk menganalisis faktor aksesibilitas pelayanan kesehatan dan persepsi ibu terhadap pemeriksan IVA di Puskesmas Benculuk Kabupaten Banyuwangi. Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan desain cross sectional. Pengambilan sampel menggunakan teknik random sampling sejumlah 60 responden dengan instrument penelitian kuisioner. Variabel penelitian terdiri dari pengetahuan, kesadaran, keterjangkauan jarak, keterjangkauan biaya, dan persepsi Ibu. Hasil: Hasil penelitian didapatkan bahwa 93,3% belum pernah melakukan pemeriksaan IVA, 90% WUS memiliki pengetahuan baik, 70% memiliki keterjangkauan jarak yang jauh dengan tempat pelayanan kesehatan, 100% mampu dalam pembiayaan pemeriksaan IVA, sebagian besar WUS memiliki persepsi yang baik terkait kanker serviks dan pemeriksaan IVA. Kesimpulan: Faktor aksesibilitas pelayanan kesehatan dan persepsi Ibu terhadap pemeriksaan IVA termasuk dalam golongan baik, namun dari 60 responden hanya 4 responden yang sudah pernah melakukan pemeriksaan IVA. Beberapa alasan mengapa WUS belum melakukan pemeriksaan  diantaranya karena rasa malu dan takut kepada petugas kesehatan, rasa takut apabila terdeteksi adanya penyakit kanker serviks, serta merasa belum membutuhkan pemeriksaan IVA karena belum merasakan adanya gejala yang mengarah pada penyakit kanker serviks.Abstract Background: Cervical is a cancer that involves women. Cervical cancer rank’s is the second after breast cancer in Indonesia. Prevention that can be done is by conducting an examination of the early detection of cervical cancer VIA method. The desire to conduct VIA test is influenced by several factors, including knowledge, awareness, distance awareness, cost affordability, and mother's perception. This study aims to analyze the accessibility factors of health services and maternal perceptions of VIA test at the Puskesmas Benculuk Kabupaten Banyuwangi. Methods: This study was a descriptive observational study with a cross sectional design. Sampling used a random sampling technique of 60 respondents with questionnaire research instruments. The research variables consisted of knowledge, awareness, affordability, affordability, and women's perception. Results: The results showed that 93.3% had never done VIA examination, 90% of women of childbearing age had good knowledge, 70% had far-reaching affordability with health care facilities, 100% were able to finance IVA examinations, most women of childbearing age had a good perception of cancer cervix and VIA test. Conclusion: Accessibility factors for health services and maternal perceptions of IVA examination are included in the good category, but from 60 respondents only 4 respondents have already conducted IVA examinations. Some of the reasons why women of childbearing age has not conducted an examination include the feeling of shame and fear of health workers, fear of cervical cancer being detected, and feeling that they have not needed an IVA examination because they have not felt any symptoms that lead to cervical cancer.
RISK FACTORS FOR ESTROGEN EXPOSURE IN VARIOUS GRADES OF ENDOMETRIOID CARINOMA Ma’rifatu Ulfa Hidayati; Pungky Mulawardhana; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 4 No. 1 (2020): Indonesian Midwifery and Health Sciences Journal, January 2020
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v4i1.2020.40-50

Abstract

AbstractBackground: Incidence endometrial cancer in Southeast Asia it is estimated that 41% of new cases emerge. The incidence of endometrial cancer in Dr. Soetomo General Hospital has increased every year. In 2016 there were 119 new cases of endometrial cancer and in 2017 there were 160 cases. 75%-80% is type I endometrial cancer (endometrioid carcinoma). Risk factors for estrogen exposure (early menarche, parity, obesity) are risk factors for endometrial cancer. The prognosis of endometrial cancer depends on the grade. This study aims to determine differences in risk factors for estrogen exposure in various grades of  type I endometrial cancer (endometrioid carcinoma) in the Poli Onkologi Satu Atap Dr. Soetomo General Hospital Surabaya. Methods: the research method was analytic observational with cross-sectional design. Sample size of 40 medical records was taken by total sampling technique. Research variables include age of menarche, parity, BMI, and grade of endometrial cancer. The instrument used was a data collection sheet and medical records. Data analysis using chi-square test. Results: The results showed 52%  patients were grade 1-2, there were 95% of menarche patients in the age range of 12-14 years,  62.5% patients had parity of 1-2 and 52% patients, BMI was underweight-normal category. Test results based on early menarche did not show significant differences between grades 1-2 and grade 3 in endometrioid carcinoma (p = 0.168). Likewise, parity in various grades of endometrial cancer type I (endometrioid carcinoma) there was no significant difference (p = 0.220) and BMI also no significant difference (p = 0.987). Conclusions: risk factors for estrogen exposure which include menarche, parity, obesity do not make a significant differences to the grades of endometrioid carcinoma.
THE DIFFERENCE OF WEIGHT GAIN IN 5 CONTRACEPTIVE GROUPS IN PUSKESMAS DUPAK SURABAYA AREA Nurul Istiqomah; Nila Kurniasari; Budiono Budiono
Indonesian Midwifery and Health Sciences Journal Vol. 4 No. 3 (2020): Indonesian Midwifery and Health Sciences Journal, July 2020
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v4i3.2020.210-219

Abstract

AbstractBackground: Weight gain is one of the predominantly problem for women who’s in childbearing age. Weight gain that occurs at women in childbearing age is often associated with contraceptive use. One type of contraception that affects weight gain is the hormonal contraception. Lerning the weight gain from each use of contraception is important as a consideration for the family planning program. Methods: This research method was observational analytic with cross-sectional design. Sample size was 136 respondents and the sampling technique used total sampling. The independent variable is the type of contraception includes 1 month injection contraception, 3 month injection contraception, implant contraception, combined pill contraception, and copper T. IUD contraception. The dependent variable is the weight gain. Data was analyzed with Kruskal Wallis test. Results: The results showed that 120 respondents from 5 contraceptive groups experienced weight gain after using contraception. The results of the Kruskal Wallis test were obtained at value of P <0.0001 (p <0.05). that there are differencea in weight gain in 5 groups of contraception. Conclusion: there are difference in weight gain from each contraceptive groups and the contraception that most influences weight gain is 3 months injection contraception. 
THE RELATIONSHIP BETWEEN BSE KNOWLEDGE AND BREAST TUMOR SIZE DURING SURGICAL CENTER VISIT AT UNAIR HOSPITAL Eva Silvia Yahya; Pungky Mulawardhana; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 6 No. 1 (2022): Indonesian Midwifery and Health Sciences Journal, January 2022
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v6i1.2022.66-73

Abstract

AbstractBackground: Breast tumor is a group of abnormal cells and continue growing multiply in the breast. In Indonesia, it is known that 8,1% of 38.749 women have tumor in the breast. One way to detect it early is to do the Breast Self Examination (SADARI). The purpose of the research was to know the correlation of SADARI knowledge with the size of the breast tumor at admission to surgery outpatient clinic. Methods: This type of research is observational analytic, cross sectional design. The sample were 36 tumor patients. The sampling technique was a convenient sampling. The independent variable was the knowledge SADARI and the dependent variable was the size of the breast tumor. The secondary data was taken in the form of USG and the primary data was a questionnaire. The data was tested with Spearman Rank. Results: The results of the bivariate analysis showed 0,328 (p>0,05) probability score (p value) and 0,168 R score which meant the correlation was very weak. Conclusion : there is no correlation of SADARI knowledge with the size of breast tumor at admission of surgery outpatient clinic. Keywords: Knowledge, SADARI, The size of breast tumor at admission
Korelasi Ekspresi ezrin dan CD44 dengan Respons Kemoterapi pada Pasien Osteosarkoma CHRISTIAN BAMBANG SULISTIO; SJAHJENNY MUSTOKOWENI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1060.936 KB) | DOI: 10.33371/ijoc.v11i3.513

Abstract

Osteosarcoma is the most common malignant bone tumor in children and young adults. The process of metastasis and recurrence involves several proteins, including ezrin, and CD44 that are shown to be involved in tumor growth,metastasis and recurrence. To analyse the corelation of ezrin and CD44 expression with chemotherapy responsse in osteosarcoma patient. Cross sectional method on paraffin block of Osteosarcoma in Anatomic Pathology Laboratory of RSUD dr Soetomo, (January 1, 2010 - December 31, 2015). There were 17 out of 26 cases of amputated osteosarcoma which are met the inclusion criteria were performed immunohistochemical staining with ezrin and CD44 antibodies. The corellation of ezrin and CD44 expression with chemotherapy responsse was analyzed using Spearman’s rho test. The coeficient correlation in this experiment p<0.05, there was no corellation of ezrin expression with chemotherapy responsse of osteosarcoma. There was no correlation of CD44 expression with chemotherapy responsse in osteosarcoma. There was no correlation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma. There was no corellation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma.ABSTRAKOsteosarkoma merupakan tumor ganas tulang, sering terjadi pada anak-anak dan dewasa muda. Proses metastasis dan rekurensi melibatkan beberapa protein, di antaranya ezrin dan CD44 yang terbukti ikut serta dalam pertumbuhan tumor, metastasis, dan rekurensi. Penelitian ini bertujuan menganalisis hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi. Penelitian ini menggunakan metode cross sectional blok parafin osteosarkoma di Laboratorium Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2010–31 Desember 2015). Sebanyak 17 kasus sesuai kriteria inklusi dari 26 kasus osteosarkoma yang telah diamputasi dilakukan seleksi serta pemeriksaan imunohistokimia dengan antibodi ezrin danCD44. Hubungan ekspresi antara ezrin dan CD44 dengan respons kemoterapi dianalisis menggunakan uji Spearman’srho. Pada penelitian ini, nilai koefisien korelasi p<0,05 sehingga tidak terdapat hubungan antara ekspresi ezrin denganrespons kemoterapi pada osteosarkoma, di mana nilai p=0,868 (p>0,05). Tidak terdapat hubungan antara ekspresi CD44 dengan respons kemoterapi pada osteosarkoma di mana nilai p = 0,740 (p> 0,05).Tidak terdapat korelasi antaraekspresi ezrin dengan CD44 dengan respons kemoterapi osteosarkoma, nilai p=0,113 (p>0,05). Tidak terdapat hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi pada pasien osteosarkoma.
Perbedaan Ekspresi HBME-1 dan E-Cadherin pada Nodular Hiperplasia, Karsinoma Papiler, dan Folikular Tiroid PRIMA ROOSANDRIS; ETTY HARY KUSUMASTUTI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1225.36 KB) | DOI: 10.33371/ijoc.v11i4.530

Abstract

Thyroid lesion can be neoplastic and non neoplastic, whether benign or malignant. There are some cases in which pathologists have difficulties to differentiated those lesions. Aim: To analyze the expression of HBME-1 and E-cadherin on nodular hyperplasia, papillary carcinomas and follicular carcinomas. Paraffin blocks of nodular hyperplasia, papillary carcinoma and follicular thyroid were collected from Departement of Pathology Dr Soetomo General Hospital from January 1st, 2012 to December 31th, 2014. Immunohistochemical staining for HBME-1 and E-cadherin were performed. The difference of expression HBME-1 and E-cadherin were analyzed by Mann Whitney test, and the correlation between HBME-1 and E-cadherin determined using Spearman test. There were significant difference of HBME-1 expression between Nodular hyperplasia and Thyroid carcinoma(p≤0,05). There were also significant difference of HBME-1 between papillary and follicular carcinoma thyroid(p≤0,05). There were no significant difference of E-cadherin expression between Nodular hyperplasia and Thyroid carcinoma(p≥0,05). Conclusion: HBME-1 can be used as a marker to distinguish benign and malignant lesion of thyroid gland, and also to distinguish papillary carcinoma and follicullar carcinoma thyroid. ABSTRAK Lesi tiroid dapat berupa lesi non-neoplastik dan neoplastik, baik jinak maupun ganas. Membedakan tumor tiroid jinak dan ganas sangat penting untuk penatalaksanaan klinis yang tepat sehingga sering kali patolog menemui kesulitan dalam membedakan lesi tiroid jinak dan ganas. Penelitian ini bertujuann membuktikan adanya perbedaan ekspresi HBME-1 dan E-cadherin antara nodular hiperplasi, karsinoma papiler, dan karsinoma folikular tiroid. Dilakukan pemeriksaan imunohistokimia pada blok parafin dari nodular hiperplasia, karsinoma papiler, dan karsinoma folikular yang tersimpan di Instalasi Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2012 sampai dengan 31 Desember 2014 sebanyak 35 sampel sesuai kriteria inklusi) dengan antibodi HBME-1 dan E-cadherin. Ekspresi HBME-1 dan E-cadherin dianalisis dengan uji Mann Whitney, sedangkan korelasi antara HBME-1 dan E-cadherin diuji dengan Spearman Test. Hasil penelitian menunjukkan terdapat perbedaan ekspresi HBME-1 yang signifikan antara nodular hiperplasia dan karsinoma tiroid( p≤0,05); terdapat perbedaan ekspresi HBME-1 yang signifikan antara karsinoma papiler tiroid dan karsinoma folikular tiroid (p≤0,05). Tidak terdapat perbedaan ekspresi E-cadherin yang signifikan pada nodular hiperplasi dan karsinoma tiroid (p≥0,05). Penelitian ini menyimpulkan bahwa HBME-1 dapat digunakan sebagai marker untuk mebedakan lesi jinak dan ganas kelenjar tiroid, serta dapat digunakan untuk membedakan karsinoma papiler tiroid dan karsinoma folikular tiroid.
Co-Authors Agustin, Leonita Aisyah Shabrina Alphania Rahniayu Anggoro, Adhitri Anggray Puspasari Anny Setijo Rahaju, Anny Setijo Ariani, Grace Arisca Arisca Arum Dewi Pusparini Askandar Tjokroprawiro Budi Harjanto Budi Harjanto Budi Utomo Budiono Budiono CHRISTIAN BAMBANG SULISTIO Cinintha Nandini Dewi Sartika A. W. Djuanda, Stephanie N. Dwita Permatasari DYAH FAUZIAH, DYAH Edi Suyanto Endang Retnowati Eva Silvia Yahya Fibriani Dyah Sofiana Fira Soraya Gatot Soegiarto Gatut Hardianto, Gatut Gondo Mastutik Gunawan, Vania A. Hari Basuki Notobroto Heriyawati, Heriyawati I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Irene Lingkan Parengkuan Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lefi, Achmad Lilihata, Jilientasia G. Maharani, Andi RK. Marhana, Isnin A. Marisca Ma’rifatu Ulfa Hidayati Mohammad Hasan Machfoed Muhammad Hafiz Nasrun Bakri Natasya Dyah Ayu Purnamasari Novalia Chumaladewi Guntarno Nugraha, Ricardo A. Nugroho, Gilang MS. Nurul Istiqomah Patikawa, Febria Rizky PRIMA ROOSANDRIS Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia, Rahmi Ridholia Ridholia Ridholia Ridholia Ridholia Ridholia, Ridholia Rinjani, Lalu GP. ROOSANDRIS, PRIMA Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Semedi, Bambang P. Sjahjenny Mustokoweni, Sjahjenny Soebagjo, Hendrian Dwikoloso SULISTIO, CHRISTIAN BAMBANG Supriadi Supriadi Tulus Panuwun Ummi Maimunah Wahyu, Dwi Willy Sandhika Windhu Purnomo Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Zuhria, Ismi