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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya The Southeast Asian Journal of Midwifery Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Indonesian Journal of Cancer
Nila Kurniasari
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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THE RELATIONSHIP BETWEEN BSE KNOWLEDGE AND BREAST TUMOR SIZE DURING SURGICAL CENTER VISIT AT UNAIR HOSPITAL Eva Silvia Yahya; Pungky Mulawardhana; Nila Kurniasari
Indonesian Midwifery and Health Sciences Journal Vol. 6 No. 1 (2022): Indonesian Midwifery and Health Sciences Journal, January 2022
Publisher : UNIVERSITAS AIRLANGGA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/imhsj.v6i1.2022.66-73

Abstract

AbstractBackground: Breast tumor is a group of abnormal cells and continue growing multiply in the breast. In Indonesia, it is known that 8,1% of 38.749 women have tumor in the breast. One way to detect it early is to do the Breast Self Examination (SADARI). The purpose of the research was to know the correlation of SADARI knowledge with the size of the breast tumor at admission to surgery outpatient clinic. Methods: This type of research is observational analytic, cross sectional design. The sample were 36 tumor patients. The sampling technique was a convenient sampling. The independent variable was the knowledge SADARI and the dependent variable was the size of the breast tumor. The secondary data was taken in the form of USG and the primary data was a questionnaire. The data was tested with Spearman Rank. Results: The results of the bivariate analysis showed 0,328 (p>0,05) probability score (p value) and 0,168 R score which meant the correlation was very weak. Conclusion : there is no correlation of SADARI knowledge with the size of breast tumor at admission of surgery outpatient clinic. Keywords: Knowledge, SADARI, The size of breast tumor at admission
Korelasi Ekspresi ezrin dan CD44 dengan Respons Kemoterapi pada Pasien Osteosarkoma CHRISTIAN BAMBANG SULISTIO; SJAHJENNY MUSTOKOWENI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1060.936 KB) | DOI: 10.33371/ijoc.v11i3.513

Abstract

Osteosarcoma is the most common malignant bone tumor in children and young adults. The process of metastasis and recurrence involves several proteins, including ezrin, and CD44 that are shown to be involved in tumor growth,metastasis and recurrence. To analyse the corelation of ezrin and CD44 expression with chemotherapy responsse in osteosarcoma patient. Cross sectional method on paraffin block of Osteosarcoma in Anatomic Pathology Laboratory of RSUD dr Soetomo, (January 1, 2010 - December 31, 2015). There were 17 out of 26 cases of amputated osteosarcoma which are met the inclusion criteria were performed immunohistochemical staining with ezrin and CD44 antibodies. The corellation of ezrin and CD44 expression with chemotherapy responsse was analyzed using Spearman’s rho test. The coeficient correlation in this experiment p<0.05, there was no corellation of ezrin expression with chemotherapy responsse of osteosarcoma. There was no correlation of CD44 expression with chemotherapy responsse in osteosarcoma. There was no correlation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma. There was no corellation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma.ABSTRAKOsteosarkoma merupakan tumor ganas tulang, sering terjadi pada anak-anak dan dewasa muda. Proses metastasis dan rekurensi melibatkan beberapa protein, di antaranya ezrin dan CD44 yang terbukti ikut serta dalam pertumbuhan tumor, metastasis, dan rekurensi. Penelitian ini bertujuan menganalisis hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi. Penelitian ini menggunakan metode cross sectional blok parafin osteosarkoma di Laboratorium Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2010–31 Desember 2015). Sebanyak 17 kasus sesuai kriteria inklusi dari 26 kasus osteosarkoma yang telah diamputasi dilakukan seleksi serta pemeriksaan imunohistokimia dengan antibodi ezrin danCD44. Hubungan ekspresi antara ezrin dan CD44 dengan respons kemoterapi dianalisis menggunakan uji Spearman’srho. Pada penelitian ini, nilai koefisien korelasi p<0,05 sehingga tidak terdapat hubungan antara ekspresi ezrin denganrespons kemoterapi pada osteosarkoma, di mana nilai p=0,868 (p>0,05). Tidak terdapat hubungan antara ekspresi CD44 dengan respons kemoterapi pada osteosarkoma di mana nilai p = 0,740 (p> 0,05).Tidak terdapat korelasi antaraekspresi ezrin dengan CD44 dengan respons kemoterapi osteosarkoma, nilai p=0,113 (p>0,05). Tidak terdapat hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi pada pasien osteosarkoma.
Perbedaan Ekspresi HBME-1 dan E-Cadherin pada Nodular Hiperplasia, Karsinoma Papiler, dan Folikular Tiroid PRIMA ROOSANDRIS; ETTY HARY KUSUMASTUTI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1225.36 KB) | DOI: 10.33371/ijoc.v11i4.530

Abstract

Thyroid lesion can be neoplastic and non neoplastic, whether benign or malignant. There are some cases in which pathologists have difficulties to differentiated those lesions. Aim: To analyze the expression of HBME-1 and E-cadherin on nodular hyperplasia, papillary carcinomas and follicular carcinomas. Paraffin blocks of nodular hyperplasia, papillary carcinoma and follicular thyroid were collected from Departement of Pathology Dr Soetomo General Hospital from January 1st, 2012 to December 31th, 2014. Immunohistochemical staining for HBME-1 and E-cadherin were performed. The difference of expression HBME-1 and E-cadherin were analyzed by Mann Whitney test, and the correlation between HBME-1 and E-cadherin determined using Spearman test. There were significant difference of HBME-1 expression between Nodular hyperplasia and Thyroid carcinoma(p≤0,05). There were also significant difference of HBME-1 between papillary and follicular carcinoma thyroid(p≤0,05). There were no significant difference of E-cadherin expression between Nodular hyperplasia and Thyroid carcinoma(p≥0,05). Conclusion: HBME-1 can be used as a marker to distinguish benign and malignant lesion of thyroid gland, and also to distinguish papillary carcinoma and follicullar carcinoma thyroid. ABSTRAK Lesi tiroid dapat berupa lesi non-neoplastik dan neoplastik, baik jinak maupun ganas. Membedakan tumor tiroid jinak dan ganas sangat penting untuk penatalaksanaan klinis yang tepat sehingga sering kali patolog menemui kesulitan dalam membedakan lesi tiroid jinak dan ganas. Penelitian ini bertujuann membuktikan adanya perbedaan ekspresi HBME-1 dan E-cadherin antara nodular hiperplasi, karsinoma papiler, dan karsinoma folikular tiroid. Dilakukan pemeriksaan imunohistokimia pada blok parafin dari nodular hiperplasia, karsinoma papiler, dan karsinoma folikular yang tersimpan di Instalasi Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2012 sampai dengan 31 Desember 2014 sebanyak 35 sampel sesuai kriteria inklusi) dengan antibodi HBME-1 dan E-cadherin. Ekspresi HBME-1 dan E-cadherin dianalisis dengan uji Mann Whitney, sedangkan korelasi antara HBME-1 dan E-cadherin diuji dengan Spearman Test. Hasil penelitian menunjukkan terdapat perbedaan ekspresi HBME-1 yang signifikan antara nodular hiperplasia dan karsinoma tiroid( p≤0,05); terdapat perbedaan ekspresi HBME-1 yang signifikan antara karsinoma papiler tiroid dan karsinoma folikular tiroid (p≤0,05). Tidak terdapat perbedaan ekspresi E-cadherin yang signifikan pada nodular hiperplasi dan karsinoma tiroid (p≥0,05). Penelitian ini menyimpulkan bahwa HBME-1 dapat digunakan sebagai marker untuk mebedakan lesi jinak dan ganas kelenjar tiroid, serta dapat digunakan untuk membedakan karsinoma papiler tiroid dan karsinoma folikular tiroid.
PENYULUHAN TENTANG TANDA AWAL DAN DETEKSI DINI TUMOR GANAS PAYUDARA PADA WARGA DI PUSKESMAS SEMEMI KECAMATAN BENOWO KOTA SURABAYA Nila Kurniasari; Gondo Mastutik; Dyah Fauziah; Etty Hary Kusumastuti; Alphania Rahniayu; Anny Setijo Rahaju
Jurnal Layanan Masyarakat Vol. 6 No. 2 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i2.2022.251-258

Abstract

Kanker payudara merupakan keganasan paling sering dan penyebab kematian tertinggi. Di Indonesia, kanker payudara juga merupakan kanker paling sering dan penyebab kematian kedua setelah kanker paru. Hal ini tejadi karena kanker payudara sering terdiagnosis pada stadium lanjut sehingga menyebabkan kegagalan pengobatan dan kematian. Kejadian kanker payudara stadium lanjut ini dapat dicegah dengan deteksi dini, namun masyarakat masih mempunyai pengetahuan yang rendah tentang tanda awal kanker payudara. Tujuan dari kegiatan ini adalah untuk memberikan penyuluhan tentang tanda awal dan deteksi dini tumor ganas di payudara. Kegiatan dilaksanakan pada 11 November 2020, diikuti oleh 91 orang ibu PKK di wilayah kerja Pusat Kesehatan Masyarakat (Puskesmas) Sememi, Kecamatan Benowo Kota Surabaya. Kegiatan diawali pre-test dan pengisian kuisioner faktor risiko, kemudian dilanjutkan dengan pemberian penyuluhan melalui aplikasi zoom meeting dan diakhiri dengan post-test. Evaluasi dilakukan dengan membandingkan hasil pre-test dan post-test. Hasil kuisioner menunjukkan terdapat peningkatan pemahaman tentang tanda awal dan deteksi dini kanker payudara sebesar 6,96%. Faktor risiko peserta menderita kanker payudara menunjukkan bahwa sebagian besar peserta penyuluhan tidak berisiko menderita kanker payudara karena tidak merokok (100%), tidak mempunyai riwayat benjolan pada payudara (97,14%), menyusui lebih dari 6 bulan (88,57%), tidak terpapar radiasi sinar X (88,57%), mempunyai anak (85,71%), tidak mempunyai riwayat keluarga yang pernah menderita tumor atau kanker (71,43%), rutin berolah raga (60%), namun terdapat 97,14% yang berusia lebih dari 25 tahun sehingga masih mempunyai faktor risiko menderita kanker payudara. Kesimpulan. Terdapat peningkatan pengetahuan masyarakat sebesar 6.96% dan sebagain besar peserta penyuluhan tidak memiliki faktor risiko untuk terjadi kanker payudara.
IMPROVING KNOWLEDGE ABOUT EARLY DETECTION AND SCREENING OF BREAST CANCER AMONG FEMALE RESIDENTS IN GANDUL VILLAGE, PILANGKENCENG DISTRICT, MADIUN REGENCY Alphania Rahniayu; Gondo Mastutik; Anny Setijo Rahaju; Nila Kurniasari; Khafidhotul Ilmiah; Wira Santoso Ongko
Jurnal Pengabdian Masyarakat Dalam Kesehatan Vol. 4 No. 2 (2022): OCTOBER 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpmk.v4i2.34741

Abstract

Introduction: Breast cancer is still a burden by being the most frequent malignancy and the highest cause of cancer death in women. The death rate from breast cancer can be reduced by early case finding and appropriate immediate treatment. Early case finding can be started with a simple periodic examination that can be carried out by each individual independently, namely by breast self-examination. This study aims to determine the effect of education on early detection and screening of breast cancer on the level of knowledge among women in Gandul village, Madiun district. Methods: This study involved 101 participants aged from 25 to 87 years old, including female residents of Gandul village and cadres of public health center.  We conduct health education about breast cancer and early detection of breast cancer, especially regarding breast self-examination. Pre-test and post-test were also conducted to assess the the knowledge of the participants before and after the seminar held. Results: The pre-test score of participants with low scores (<75) was 78.21% (79 people) and decreased in the post-test to 43.56% (44 people), while participants with high scores (>75) were only 21.78% (22 people) in the pre-test and increased to 56.44% (57 people) in the post-test. Conclusion: There is a knowledge improvement about the early detection of breast cancer among participants after the intervention. The knowledge improvement can be seen through the increased score from pre-test to post-test.
EARLY DETECTION OF CERVICAL CANCER AND PAP SMEAR ADEQUACY AT PUSKESMAS PILANGKENCEN, MADIUN DISTRICT Anny Setijo Rahaju; Alphania Rahniayu; Nila Kurniasari; Dyah Fauziah; Etty Hary Kusumastuti; Gondo Mastutik; Dewi Sartika A. W.; Fira Soraya; Khafidhotul Ilmiah
Jurnal Layanan Masyarakat Vol. 7 No. 1 (2023): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v7i1.2023.100-113

Abstract

This study aims to increase understanding about early detection of cervical cancer and pap smear evaluation among residents, as well as to increase the pap smear sampling skills by health workers in Pilangkenceng District, Madiun Regency. This study was a descriptive observational study using a cross-sectional approach which was conducted on 100 women, from the Pilangkenceng Primary Health Center in Madiun Regency, aged 20 to 70 years. Pretest and post test assessments were carried out before and after the education of cervical cancer. Specimen adequacy assessment was carried out on 100 Pap smear samples taken by the health workers based on the Papaniculaou classification and the Bethesda system. Pap smear results were also compared with the results of the visual inspection of acetic acid (IVA) which was done before. Education of cervical cancer to the community can increase people's understanding of cervical cancer by 8.05% to 82.26%, while training for health workers on the technique of pap smear sampling shows an increase in knowledge of 51.62% to 100%. Adequacy of pap smear samples by health workers in Pilangkenceng District, Madiun Regency showed that 99% were adequate and satisfactory. Ten percent of IVA examinations showed positive results and those cases showed signs of inflammation and infection on pap smear examination. Community service activities of early detection of cervical cancer through the pap smear method can increase the understanding of early detection of cervical cancer in the community and the knowledge and sampling skills of health workers, hence the health workers at the Pilangkenceng Primary Health Center are ready to provide pap smear services for the community.   Keywords: adequacy, early detection, pap smear, IVA, cervical cancer.   Abstrak Kegiatan ini bertujuan untuk mengetahui peningkatan pemahaman tentang deteksi dini kanker serviks dan serta evaluasi pap smear pada warga, serta peningkatan kemampuan dalam melakukan pap smear oleh tenaga kesehatan di Kecamatan Pilangkenceng Kabupaten Madiun. Penelitian observasional deskriptif dilakukan dengan metode pendekatan cross sectional yang dilakukan pada 100 wanita, dari wilayah Puskesmas Pilangkenceng Kabupaten Madiun, dengan usia 20-70 tahun. Penilaian pretest dan post test dilakukan sebelum dan sesudah penyuluhan. Penilaian adekuasi spesimen dilakukan pada 100  sediaan  pap smear  yang diambil oleh para tenaga berdasarkan klasifikasi Papaniculaou dan sistem Bethesda. Hasil pap smear juga dibandingakan dengan hasil pemeriksaan inspeksi visual asam asetat (IVA) yang dilakukan sebelumnya. Penyuluhan terhadap masyarakat dapat meningkatkan pemahaman masyarakat tentang kanker serviks sebesar 8,05% menjadi 82,26%, sedangkan pelatihan pada tenaga kesehatan tentang tehnik pengambilan pap smear menunjukkan peningkatan pengetahuan sebesar 51,62% menjadi 100%. Adekuasi sediaan pap smear oleh tenaga kesehatan Kecamatan Pilangkenceng Kabupaten Madiun menunjukkan bahwa 99% adekuat dan memuaskan. Sepuluh persen pemeriksaan IVA menunjukkan hasil positif  dan setelah dilakukan hapusan  pap smear, kasus IVA positif tersebut menunjukkan gambaran proses keradangan dan infeksi. Kegiatan pengabdian masyarakat dapat meningkatkan pemahaman tentang deteksi dini keganasan serviks pada masyarakat dan pengetahuan para tenaga kesehatan tentang deteksi dini kanker serviks melalui metode pap smear, sehingga diharapkan bahwa tenaga kesehatan di Puskesmas Pilangkenceng siap memberikan pelayanan pap smear bagi warga. Kata kunci: adekuasi, deteksi dini, pap smear, IVA, kanker serviks.
A profile of Gestational Trophoblastic Neoplasia in a tertiary hospital in Surabaya, Indonesia Aisyah Shabrina; Brahmana Askandar Tjokroprawiro; Nila Kurniasari; Hanik Badriyah Hidayati
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.17-22

Abstract

HIGHLIGHTS This study aimed to identify the characteristics of Gestational Trophoblastic Neoplasia (GTN). GTN is chemosensitive, but without appropriate therapy and follow-up, GTN will develop into complications and fatalities.   ABSTRACT Objective: Gestational Trophoblastic Neoplasia (GTN) is a pregnancy-related malignancy due to abnormal proliferation of trophoblastic tissue. This study aimed to identify the characteristics of patients with GTN to help diagnose cases of GTN earlier and provide better treatment. Materials and Methods: This was a descriptive retrospective study on medical records of patients with GTN in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, during the period of January 2018 to December 2020 with a total sampling technique. There were 41 patients with GTN included as study subjects.  Results: Forty-one cases of GTN met the inclusion criteria out of the fifty medical records collected. The majority of patients aged 21 – 30 years old (34%) and had parity status without data (42%). Regarding the clinical profile based on prognostic factors, the predominant patients (71%) also had no data about the time interval between the end of the last pregnancy and the first time diagnosed by GTN, Those with more than 100,000 mIU/ml of beta-hCG levels were 32%, and those without metastases were 41.5%. Most patients belonged to the low-risk group (49%) and received chemotherapy (71%) with the MTX LD regimen (69%).  Conclusion: GTN occurred predominantly in reproductive women that belonged to the low-risk group. Furthermore, chemotherapy is one of the chosen therapy for those patients.
Clinical profile of geriatric cervical cancer patients in a tertiary hospital in Surabaya, Indonesia Natasya Dyah Ayu Purnamasari; Brahmana Askandar Tjokroprawiro; Budi Utomo; Nila Kurniasari
Majalah Obstetri & Ginekologi Vol. 31 No. 1 (2023): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V31I12023.36-44

Abstract

HIGHLIGHTS Squamous cell carcinoma majorly covered in histopathologic of the records, while adenosquamous followed second. Most of the subjects were referral patients to Dr. Soetomo General Academic Hospital. They were mostly originated from Java outside Surabaya.   ABSTRACT Objective: To identify the distribution of age, histopathology type, clinical stage, treatment type, parity, first complaint, and referral origin of geriatric cervical cancer patients at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. Materials and Methods: This study was a retrospective study observing data from medical records and presented the data descriptively. The medical records were taken from Oncology Outpatient Clinic in Dr. Soetomo Hospital, from 2020-2021, covering geriatric patients aged more than 55 years old. The data were screened and processed. Results: At Dr. Soetomo Hospital, in 2020-2021 there were 228 cervical cancer patients. From 176 patient data that met the inclusion criteria, the average age was 65.38 ± 4.86 years, with 4 types of histopathology dominated by squamous cell carcinoma (82.39%), adenocarcinoma (11.93%), adenoquamous (3.41%) and others (4%), divided into 8 clinical stages and dominated by stages IIIB (77.27%), IIB (15.9%), IVB (2.84%), IIIA and IB had same number (1.14%), 1A (0.57%) and no cases of IIA were found. The treatments were dominated by chemotherapy (86.36%), radiation therapy (7.38%), no treatment (3.41%), hysterectomy (1.7%), while for conization and palliative therapy each in 1 case (0.57%). Most experienced 3 parity (29.5%), followed by 4 parity (17.61%), >5 (13.07%), 5 (10.23%), 1 (6.82%) and no parity (2.27%). The three first complaints were. vaginal bleeding (82.38%), vaginal discharge (46.02%), and pain (82.38%), and the patients were dominated by referrals from Java Island other than Surabaya City (78.40%), outside Surabaya in Java Island as many as 36 referrals (20.45%) and outside Java Island 2 referrals (1.14%). Conclusion: There were 176 geriatric patients with cervical cancer at Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in the 2020-2021 period, dominated by age 56-65 years, the histopathology type of squamous cell carcinoma, stage IIIB patients, most received therapy was chemotherapy, most were multiparous with 3 parities, the majority experienced complaints of vaginal bleeding when diagnosed with cervical cancer, and were dominated by referrals from Java Island outside Surabaya.
Co-Authors Aisyah Shabrina Alphania Rahniayu Anggray Puspasari Anny Setijo Rahaju, Anny Setijo Arisca Arisca Arum Dewi Pusparini Askandar Tjokroprawiro Budi Harjanto Budi Utomo Budiono Budiono CHRISTIAN BAMBANG SULISTIO Cinintha Nandini Dewi Sartika A. W. Dwita Permatasari DYAH FAUZIAH, DYAH Eva Silvia Yahya Fira Soraya Gatut Hardianto, Gatut Gondo Mastutik Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Hari Basuki Notobroto Irene Lingkan Parengkuan Khafidhotul Ilmiah Khafidhotul Ilmiah KUSUMASTUTI, ETTY HARY Ma’rifatu Ulfa Hidayati Muhammad Hafiz Natasya Dyah Ayu Purnamasari Novalia Chumaladewi Guntarno Nurul Istiqomah PRIMA ROOSANDRIS Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Rahmi Alia Ridholia Ridholia S.Pd. M Kes I Ketut Sudiana . Sjahjenny Mustokoweni, Sjahjenny Soebagjo, Hendrian Dwikoloso Wira Santoso Ongko Zuhria, Ismi