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All Journal EKUIVALEN - Pendidikan Matematika Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya The Southeast Asian Journal of Midwifery Majalah Patologi Indonesia Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Stem Cell Research and Tissue Engineering Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Nila Kurniasari
Departemen Patologi Anatomi, Fakultas Kedokteran, Universitas Airlangga
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KESESUAIAN DIAGNOSIS FINE NEEDLE ASPIRATION BIOPSY DENGAN HISTOPATOLOGI POSTOPERATIF PAPILLARY THYROID CARCINOMA DI RUMAH SAKIT RUJUKAN DALAM 3 TAHUN Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo
Majalah Patologi Indonesia Vol. 34 No. 1, Januari 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i1.624

Abstract

Introduction Thyroid carcinoma is the most common malignancy of the endocrine organ, with papillary thyroid carcinoma being the most common variant. Fine needle aspiration biopsy is still one of cost-effective and less invasive preliminary tests for thyroid lesion. The Bethesda System for Reporting Thyroid Cytopathology uses six categories for thyroid reporting. Methods This was an observational descriptive study with retrospective approach. Data of patients with postoperative histopathology diagnosis papillary thyroid carcinoma was obtained. We then retrieved and reviewed all the previous FNAB slides. All was classified based on Bethesda system for reporting thyroid cytopathology. We considered only patients with histopathology proven diagnosis who underwent FNAB in the same institution. Results 56 cases of FNAB with post-operative histopathology diagnosis papillary thyroid carcinoma were obtained, 34 (62%) of them were diagnosed as papillary thyroid carcinoma, 9 (14.8%) cases were non diagnostic, 10 (17.8%) cases were diagnosed as benign, and 3 (5.3%) cases fell into atypia category. Conclusion Pre-operative FNAB had 36% rate of misdiagnosis, with benign criteria being the most common category. Cases with non-diagnostic category should do repeated FNAB with USG guiding to decrease the possibility of misdiagnosis. Nodule with less than 1 cm size cause the most common misdiagnosis in this study. Most malignant FNAB result has more than 6 cm size.
COMPARISON IN CORNEAL COLLAGEN STRUCTURE BETWEEN 20% PLATELET RICH PLASMA AND 20% AUTOLOGOUS SERUM THERAPY POST NATRIUM HIDROKSIDA EXPOSURE (EXPERIMENTAL STUDY ON ORYCTOLAGUS CUNICULUS) Marisca; Kurniasari, Nila; Retnowati, Endang; Purnomo, Windhu
Journal of Stem Cell Research and Tissue Engineering Vol. 7 No. 1 (2023): JOURNAL OF STEM CELL RESEARCH AND TISSUE ENGINEERING
Publisher : Stem Cell Research and Development Center, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jscrte.v7i1.45746

Abstract

Objective to compare therapy response between 20% PRP and AS 20% on cornea post sodium hydroxide exposure on collagen structure. Methods this is a true experimental study with post test only design on 18 New Zealand white rabbits. Sample were divided randomly to two groups, each with 9 rabbits. The right eye of each rabbit were exposed to alkali injury with 1N NaOH under general anesthesia. First group was given 20% PRP eyedrops and 20% AS for the second group. And the end of the 7 day periode, all rabbits were euthanized and enucleated to obtain histopthological data. Collagen density, collagen thickness and keratosit cell were evaluated. The result will be analyzed, ratio scale data will be tested with independent T- test, and ordinal scaled data will be tested with Mann-Whitney test. Result The collagen density in the 20% PRP group shows 88.9% grade 2 and 44.4 % grade 2 for the 20% AS group. The collagen thickness in the 20% PRP group is 55.41 and 67.62 for the 20% AS group. The keratosit cell count in the 20% PRP group are 54.56 and 45.47 in the 20% AS group. There is significant difference in the collagen density between 20% PRP and 20% AS treatment (p= 0.066). There is significant difference in the collagen thickness between 20% PRP and 20% AS treatment (p= 0,224). There is significant difference in the keratosit cell count between 20% PRP and 20% AS treatment (p= 0,227). Conclusion From the statistik analysis shows that there is no significant difference in corneal collagen structure between 20% PRP and 20% AS therapy post natrium hidroksida exposure, from our study there is no significant better corneal healing parameters in post alkali chemical ocular injury with 20% PRP eyedrops compare to 20% AS eyedrops.
Mengungkap Pentingnya Pengenalan Kesehatan Saluran Pernapasan dan Faktor Risiko Kanker Paru; Kegiatan Pengabdian Masyarakat pada Siswa SMAN 1 Gondang, Kabupaten Nganjuk Sari, Aditya Sita; Rahaju, Anny Setijo; Rahniayu, Alphania; Mastutik, Gondo; Kurniasari, Nila; Fauziah, Dyah; Kusumastuti , Etty Hary
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 2 (2025): Bulan November
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i2.562

Abstract

Latar belakang: Kanker paru merupakan salah satu penyebab utama kematian akibat kanker di dunia. Pengetahuan dini mengenai kesehatan saluran pernapasan dan faktor risikonya, terutama di kalangan remaja, sangat penting untuk pencegahan. Tujuan: Kegiatan Pengabdian kepada Masyarakat (Pengmas) ini bertujuan untuk meningkatkan pemahaman siswa-siswi SMAN 1 Gondang, Kabupaten Nganjuk, mengenai topik tersebut. Metode yang digunakan adalah penyuluhan kesehatan secara offline dengan media presentasi (PPT), dilengkapi dengan pre-test dan post-test untuk mengukur efektivitas intervensi. Sebanyak 316 siswa berpartisipasi. Hasil menunjukkan peningkatan pemahaman yang signifikan, ditandai dengan kenaikan nilai rata-rata pre-test sebesar 57.29% menjadi 77.69% pada post-test, dengan peningkatan keseluruhan sebesar 20.40%. Peningkatan tertinggi terjadi pada soal tentang bahaya rokok elektrik atau vape (40.02%). Kesimpulan: Kegiatan ini membuktikan bahwa edukasi kesehatan langsung efektif dalam meningkatkan kesadaran remaja akan kesehatan paru dan bahaya faktor risikonya, sehingga dapat menjadi modal untuk perilaku hidup sehat di masa depan.
Optimalisasi Deteksi Dini Kanker Serviks Melalui Peningkatan Kapasitas Tenaga Kesehatan dan Edukasi Komunitas di Puskesmas Ngariboyo, Kabupaten Magetan Sari, Aditya Sita; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Mastutik, Gondo; Fauziah, Dyah; Kusumastuti, Etty Hary; Susilo, Imam; Sandhika, Willy; Mustokoweni, Sjahjenny; Ilmiah, Khafidhotul
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 1 (2025): Bulan September
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i1.549

Abstract

Latar belakang: Kanker serviks merupakan masalah kesehatan global dengan angka morbiditas dan mortalitas yang tinggi, termasuk di Indonesia. Deteksi dini melalui pemeriksaan Pap smear masih menjadi metode yang sering dipakai, namun akurasi hasilnya sangat bergantung pada teknik pengambilan sampel yang adekuat. Tujuan: Pengabdian masyarakat ini bertujuan untuk Meningkatkan pengetahuan dan keterampilan tenaga kesehatan di Puskesmas Ngariboyo dalam teknik pengambilan sediaan Pap smear yang memadai, dan Meningkatkan kesadaran dan pengetahuan masyarakat tentang deteksi dini kanker serviks. Metode: Metode kegiatan terdiri dari dua bagian utama. Pertama, pelatihan bagi tenaga kesehatan yang meliputi webinar dan praktikum offline untuk mengukur adekuasi sediaan berdasarkan Sistem Bethesda. Kedua, penyuluhan dan skrining offline bagi 95 warga dan 101 peserta pemeriksaan Pap smear. Hasil Hasil pelatihan menunjukkan peningkatan signifikan pengetahuan tenaga kesehatan (nilai 80-100 meningkat dari 58,82% menjadi 82,35%). Penyuluhan juga berhasil meningkatkan pengetahuan masyarakat (nilai 80-100 meningkat dari 80% menjadi 94,74%). Hasil skrining menunjukkan 100% sediaan adekuat dan 100% hasil Negative for Intraepithelial Lesion or Malignancy (NILM). Kesimpulan: Disimpulkan bahwa program ini efektif dalam meningkatkan kapasitas tenaga kesehatan dan kesadaran masyarakat, sekaligus menghasilkan data dasar skrining kanker serviks yang berkualitas bagi wilayah Ngariboyo.
Distribution of Human Papilloma Virus (HPV) in Cervical Adenocarcinoma and Adenosquamous Carcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Harjanto, Budi
Folia Medica Indonesiana Vol. 57, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Approximately 20-30% of all cervical cancer cases are adenocarcinoma and adenosquamous carcinoma. Around 70% of all of these types of cancer are related to infection of Human Papillomavirus (HPV). This study evaluated the distribution of HPV genotype in cervical adenocarcinoma and adenosquamous carcinoma. A cross-sectional study was conducted at the Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, from January to December 2015. The sample were 22 formalin-fixed paraffin-embedded (FFPE) of cervical adenocarcinoma tissues and adenosquamous carcinoma tissues. FFPE was used for DNA extraction and followed with HPV genotyping to detect 40 genotypes of HPV, including low risk (LR) and high risk (HR) HPV. The histopathological types of adenocarcinomas were adenocarcinoma NOS and mucinous adenocarcinoma, while the adenosquamous carcinoma types were adenosquamous carcinoma and adenosquamous carcinoma glassy. All of the specimens were infected by HPV. In cervical adenocarcinoma, the infection was by HPV 6, 11, 16, 18, 31, 45, 68B, and 72, and in adenosquamous carcinoma by HPV 6, 16, 18, 45, and 59. HPV 18 was predominant, which was found in 13/22 (59.1%) in adenocarcinoma and 19/22 (86.4%) in adenosquamous carcinoma. Single infection and multiple infections in adenocarcinoma were 13/22 (59.1%) and 9/22 (40.9%), while in adenosquamous carcinoma were 21/22 (95.5%) and 1/22 (4.5%) respectively. The most common HR HPVs found in this study were HPV 18, HPV 45, HPV 16 and LR HPV are HPV 11, HPV 6.
The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Alia, Rahmi; Mustokoweni, Sjahjenny
Folia Medica Indonesiana Vol. 55, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Ethanol extract of leaves and petiole of pegagan (Centella asiatica) is potential as antimicrobial and antifertility. This study was to investigate whether ethanol extracts of leaf and petiole of Centella asiatica has potential as an antimicrobial and can decrease sperm quality and spermatogenic cells of mice. This was a randomized controlled study using Centella asiatica plant from which we made ethanol extract. The extract of the leaves and petiole of Centella asiatica was subjected to antimicrobial test using the bacteria S. aureus, S. epidermidis, and A. aerogenes. Then the observation was done after a 24-hour-old bacterial cultures by measuring the diameter of the clear zone in mm. Thereafter, the extract was given to randomly grouped mice that were divided into two groups receiving the leaf extract in one group and the petiole exract in another for 35 days. On day 36 the mice were sacrificed for spermatozoa quality and testicular histology examination. Statistical analyses used in this study were ANOVA and LSD tests. There was inhibition zone difference between leaf and petiole (p=0.000). Inhibition zone between bacteria S. epidermidis, S. aureus and A. aerogenes showed no difference (p=0.198). Inter-dose inhibition zone showed difference (p=0.000). Centella asiatica leaf extract showed inhibition zone better than that of Centella asiatica petiole extract. In spermatozoa quality test, there was effect of Centella asiatica leaf extract on sperm motility (p<0.05), viability (p<0.05), morphology (p<0.05) and concentration (p<0.05). No effect of pegagan petiole extract was found on sperm motility (p<0.05), viability (p<0.05), abnormal morphology (p<0.05) and concentration (p<0.05). Highest degradation of spermatozoa quality was obtained from Centella asiatica petiole extract at a concentration of 150 mg/kg bw. Spermatogenic cell test results showed no effect of Centella asiatica leaf extract in decreasing spermatogonia (p=0.000), spermatocytes (p=0.000), and spermatids (p=0.000) counts. No effect of pegagan petiole extract in decreasing the number of spermatogonia, spermatocytes and spermatids. The highest reduction spermatogenic cells of seminiferous tubules was obtained by Centella asiatica petiole extract in a concentration of 150 mg/kg bw. In conclusion: Centella asiatica leaf and petiole extract has antimicrobial potency as contra-ceptives
Accuracy of Fine Needle Biopsy (FNAB) in Lymph Nodes Tuberculosis Sari, Aditya Sita; Kurniasari, Nila; Rahaju, Anny Setijo; Kusumastuti, Etty Hary; Rahniayu, Alphania
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.1875

Abstract

Introduction: Tuberculosis (TB) is an infection caused by Mycobacterium Tuberculosis (Mtb) that can attack various organs such as peripheral lymph nodes. Fine needle aspiration biopsy (FNAB) is often used as one of the modalities of diagnosis of lymph node tuberculosis to determine the management of patients. Objective: The objective of this study is to evaluate the accuracy, efficiency, and effectiveness of FNAB in diagnosing lymph node tuberculosis. The findings will assess whether FNAB can be adopted as a standard diagnostic and management tool for patients with this condition. Methods: This is an observational analytic cross-sectional study in the population of patients with suspicion of lymph node tuberculosis at the Anatomical Pathology Unit of Dr. Soetomo General Academic Hospital Surabaya in one year period. FNAB examination was performed with Modified Grunwald Giemsa (MGG) and Ziehl Nielsen (ZN) staining to detect AFB (Acid Fast Bacilli) organisms, as well as PCR (Polymerase Chain Reaction) of peripheral blood. The results were analysed using Chi square statistic test. Results: The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) of FNAB examinations were 100%, 33%, 59% and 100%, respectively, meanwhile the sensitivity and specificity of PCR peripheral blood examination were 8% and 70% compared to the ZN examination of the FNA aspiration material. Conclusion: FNAB had a higher sensitivity than PCR of peripheral blood to detect Mycobacterium Tuberculosis infection; on the other hand PCR of peripheral blood had a higher specificity than FNAB to detect Mycobacterium Tuberculosis infection.
PROFIL HISTOPATOLOGIS LIMFOMA EKSTANODAL: PENELITIAN RETROSPEKSTIF SELAMA 5 TAHUN Patikawa, Febria Rizky; Kurniasari, Nila; Fauziah, Dyah
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.659

Abstract

Introduction Extranodal lymphomas account for 30% of all lymphomas. The diverse location and various clinical manifestation of extranodal lymphoma lead to difficulty in diagnosis. The different types of extranodal lymphoma behave and respond differently to therapy. The information regarding the incidence of extranodal lymphoma is still limited, hence further study is needed. Methods Descriptive observational research design with a retrospective approach. This study used data from anatomical pathology examinations at the Dr. Soetomo General Academic Hospital, Surabaya, over a 5-year period, with the diagnosis of lymphoma originating from organs other than lymph nodes and no prior history of lymphoma in the lymph node. Result As many as 379 cases were diagnosed as lymphoma originating from extranodal. The highest age group was 51-60 years old (27.70%), male patient is slightly higher (55.91%) and the highest location is in the head and neck region (48.11%). On anatomical pathology examination, the most common diagnosis were high grade B cell NHL (48.11%). Conclusion This study showed the incidence of extranodal lymphoma, with the majority of cases occurring in the fifth decade of life, with M:F ratio is 1.33:1 and the most common location was in the head and neck area. The most common histological diagnosis was high grade B cell NHL, with DLBCL being the most common subtype. This study provided initial information on the epidemiology of extranodal lymphoma at Dr. Soetomo General Academic Hospital in Surabaya. Further research is needed to determine the relationship between variables and patient survival. 
Co-Authors Agustin, Leonita Aisyah Shabrina Alphania Rahniayu Anggoro, Adhitri Anggray Puspasari Anny Setijo Rahaju, Anny Setijo Ariani, Grace Arisca Arisca Arum Dewi Pusparini Askandar Tjokroprawiro Budi Harjanto Budi Harjanto Budi Utomo Budiono Budiono CHRISTIAN BAMBANG SULISTIO Cinintha Nandini Dewi Sartika A. W. Djuanda, Stephanie N. Dwita Permatasari DYAH FAUZIAH, DYAH Edi Suyanto Endang Retnowati Eva Silvia Yahya Fibriani Dyah Sofiana Fira Soraya Gatot Soegiarto Gatut Hardianto, Gatut Gondo Mastutik Gunawan, Vania A. Hari Basuki Notobroto Heriyawati, Heriyawati I'tishom, Reny Ilmiah, Khafidhotul Imam Susilo Irene Lingkan Parengkuan Khafidhotul Ilmiah Khafidhotul Ilmiah Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lefi, Achmad Lilihata, Jilientasia G. Maharani, Andi RK. Marhana, Isnin A. Marisca Ma’rifatu Ulfa Hidayati Mohammad Hasan Machfoed Muhammad Hafiz Nasrun Bakri Natasya Dyah Ayu Purnamasari Novalia Chumaladewi Guntarno Nugraha, Ricardo A. Nugroho, Gilang MS. Nurul Istiqomah Patikawa, Febria Rizky PRIMA ROOSANDRIS Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Qonitatillah, Ana Rahaju, Anny S. Rahmi Alia Rahmi Alia, Rahmi Ridholia Ridholia Ridholia Ridholia Ridholia Ridholia, Ridholia Rinjani, Lalu GP. ROOSANDRIS, PRIMA Rosyid, Alfian N. S.Pd. M Kes I Ketut Sudiana . Sari, Aditya Sita Semedi, Bambang P. Sjahjenny Mustokoweni, Sjahjenny Soebagjo, Hendrian Dwikoloso SULISTIO, CHRISTIAN BAMBANG Supriadi Supriadi Tulus Panuwun Ummi Maimunah Wahyu, Dwi Willy Sandhika Windhu Purnomo Wira Santoso Ongko Wiratama, Priangga A. Wiratama, Priangga Adi Yandi, I KR. Zuhria, Ismi