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All Journal AGRIVITA, Journal of Agricultural Science IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia Jurnal Abdi Insani Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat BIOVALENTIA: Biological Research Journal Jurnal Pepadu Bulletin of Chemical Reaction Engineering & Catalysis
Ferlinahayati Ferlinahayati
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, University Of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir, South Sumatera 30622
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Uji Toksisitas Subkronik Ekstrak Etanol Daun Sungkai (Paronema canescens Jack.) Terhadap Tikus Putih Rattus noverticus (Wistar strain) Muharni, Muharni; Ferlinahayati, Ferlinahayati; Fitrya, Fitrya; Eliza, Eliza; Yohandini, Heni; Cenora, Cindy
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.211-217.2023

Abstract

Tumbuhan sungkai (Paronema canescens Jack)  merupakan salah satu tumbuhan obat tradisional yang telah digunakan  untuk pengobatan berbagai penyakit.  Penggunaan suatu tumbuhan obat harus teruji keamanannya, terutama untuk penggunaan jangka panjang.  Pada penelitian ini telah dilakukan uji  toksisitas subkronis ekstrak etanol  daun P. canescens menggunakan  30 ekor tikus  putih jantan Rattus noverticus (Wistar strain), Penelitian ini menggunakan 5 kelompok hewan terdiri dari kelompok kontrol, kelompok perlakuan dosis 100, 200, 400, dan 800 mg/kg berat badan (bb) . Percobaan  dilakukan selama 28 hari. Parameter yang diamati meliputi hematologi darah, biokimia darah, makroskopik organ, berat organ relatif dan histopatologi organ hati dan ginjal. Hasil pengukuran menunjukkan  tidak terdapat perbedaan yang signifikan (p>0.05) antara kelompok kontrol dengan kelompok perlakuan untuk semua parameter hematologi maupun biokimia darah.  Analisa histopatologi juga menunjukkan tidak terdapat gejala kerusakan pada organ hati dan ginjal.  Hal ini mengindikasikan ekstrak daun sungkai tidak memberikan efek toksik pada hewan uji.
PENCEGAHAN HIPERKOLESTEROLEMIA DAN PENURUNAN RESIKO PENYAKIT JANTUNG DENGAN MENGKONSUMSI MINUMAN KESEHATAN Muharni; Yohandini, Heni; Ferlinahayati; Julinar
Jurnal Abdi Insani Vol 11 No 1 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i1.1368

Abstract

Indralaya Mulya is one of the sub-districts in Indralaya District, Ogan Ilir, South Sumatra, about 6 KM from the Sriwijaya Indralaya University campus. In modern life, people's lifestyles tend to be unhealthy due to consuming foods that contain high fat, consuming less vegetables and fruit and relatively lacking sports activities. This will trigger high cholesterol (hypercholesterolemia). Various complications can be caused by high levels of cholesterol in the blood, including heart disease. Considering that the condition of high cholesterol levels is commonly found in society, the public has been introduced to the prevention of hypercholesterolemia and reducing the risk of heart disease by consuming health drinks. In this activity, socialization was carried out on the use of traditional medicinal plants (curcuma, guava leaves, sweet starfruit and green betel leaves) to prevent hypercholesterolemia. Furthermore, activity participants' cholesterol levels were also checked. The results of the activity show that the public has great curiosity about the use of medicinal plants to lower cholesterol, the public is relatively aware of the impact of hypercholesterolemia. The results of checking cholesterol levels showed that the participants (20 people) had cholesterol levels in normal conditions. Based on this activity, it was concluded that the people of Indralaya Mulya were relatively in good health and had a high level of concern about maintaining their health.
Coumarin Derivative from the Unripe Fruit of Mengkudu (Morinda citrifolia Linn) and Cytotoxic Activity Ferlinahayati, Ferlinahayati; Nisa, Sarifatun; Hermansyah, Hermansyah; Basir, Dasril
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 8, No 2 (2023): June 2023
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v8.i2.70

Abstract

A coumarin derivative namely scopoletin (7-hydroxy-6-methoxychromen-2-one) had been isolated from the methanol extract of unripe noni fruits (Morinda citrifolia Linn.). The extraction was conducted by maceration, continuing with separation and purification using several techniques of chromatography. The yellowish isolated compound showed a melting point at 200 – 202 °C. The compound structure was analyzed based on spectral data 1H-NMR, 13C-NMR, and NOE 1D. The inhibition of methanol extract of noni fruits and scopoletin against murine leukemia P388 cells using MTT assay showed IC50 were > 100 μg/mL and 65.69 μg/mL respectively. These showed that scopoletin was more cytotoxic than methanol extract but weaker than artonin E as a positive control IC50 0.48 μg/mL)
Pemberdayaan Masyarakat melalui Pelatihan Pembuatan Salep Herbal Infeksi Kulit dari Ekstrak Daun Kembang bulan di Desa Tanjung Seteko Ferlinahayati, Ferlinahayati; Salni, Salni; Rachmat, Addy; Hermansyah, Hermansyah; Hariani, Poedji Loekitowati
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 6 No. 2 (2026): Maret 2026 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v6i2.1095

Abstract

Kegiatan pengabdian masyarakat ini bertujuan memberikan pelatihan kepada masyarakat, khususnya ibu-ibu dan remaja karang taruna di Desa Tanjung Seteko, Kecamatan Indralaya, Kabupaten Ogan Ilir tentang pembuatan salep herbal dari ekstrak daun Kembang bulan sebagai alternatif pengobatan infeksi kulit. Ekstrak daun Kembang bulan diketahui memiliki kandungan bioaktif yang bersifat antibakteri dan antioksidan. Pelaksanaan kegiatan pengabdian dilakukan melalui tiga tahapan, yaitu penyuluhan, pelatihan pembuatan salep, dan pengunaan untuk pengobatan serta evaluasi kegiatan. Khalayak sasaran sebanyak 30 orang. Secara umum, masyarakat telah memahami pentingnya menjaga kesehatan kulit, namun masih belum mengetahui pemanfaatan daun Kembang bulan sebagai bahan pengobatan alami. Setelah kegiatan, tingkat pemahaman peserta mengenai salep herbal dari ekstrak daun Kembang bulan meningkat dari 16,67% sebelum pretes menjadi 90 % setelah postes. Produk salep yang dihasilkan juga mendapatkan tanggapan positif dari peserta. Keberhasilan kegiatan ini turut meningkatkan kesadaran masyarakat akan pentingnya memanfaatkan bahan alami yang aman dan ramah lingkungan sebagai alternatif pengobatan.
Synthesis, In-Vitro Evaluation, and Computational Investigation of Salicylic Hydrazide Derivatives as Potential Tyrosine Kinase–Targeted Anticancer Agents Sulistyowaty, Melanny; Tri Widiandani; Albertus Aditya Setiawan; Seow Lay Jing; Neny Purwitasari; Ferlinahayati; Dwi Setyawan; Galih Satrio Putra; Anastasia Wheni Indrianingsih
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.609-620

Abstract

A series of N2-acyl salicylic hydrazides (S2-S6) and N-(substituted benzylidene) salicylic hydrazides (S7-S9) were synthesized from 2-hydroxybenzohydrazide (S1), using both microwave irradiation and conventional methods, and tested for its in vitro anticancer activity against human lung cancer cell, A549. The salicylic hydrazides were successfully synthesized in good yields (79–98%) and the in-vitro study results indicated that 3,4-dichloro-N'-(2-hydroxybenzoyl)benzohydrazide (S5) was most active among the tested compounds (IC50 value of 68.75 µM). In this work, we applied an integrated approach combining network pharmacology and computational analysis to explore how salicylic hydrazide derivatives affect tyrosine kinase–related pathways. The in-silico findings were in agreement with the in vitro results, indicating that compound S5 produced a docking score of –6.53468 kcal/mol. The findings of this research are expected to support further development toward identifying promising anticancer drug candidates derived from salicylic hydrazide derivatives.
Co-Authors Addy Rachmat Ady Mara, Ady Afreni Hamidah Ahmad Fatoni Albertus Aditya Setiawan Aldes Lesbani Alfarado, Daniel Anastasia Wheni Indrianingsih Bambang Yudono Benyamin Lakitan Budi Untari Cenora, Cindy Cindy Cenora Daniel Alfarado Dasril Basir Desnelli Desnelli Dirli Fahmi Rizal Dwi Setyawan Efita Efita Elfita Elfita Elfita Elfita Elisa Nurnawati Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Emir Fikri Endri Junaidi Endri Junaidi, Endri Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Fatma Fitrya . Fitrya Fitrya Fitrya Fitrya Galih Satrio Putra Hanifa Marisa Hanifa Marisa Hary Widjajanti Heni Yohandini Herlina Herlina Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Julinar Julinar Julinar Julinar Julinar Jurnal Pepadu Juswardi Juswardi Juswardi Juswardi, Juswardi Lenny Anwar Lia Dewi Juliawaty Maryadi Maryadi Merry Hasmeda Mery Hasmeda Mia Tirta Sari Mikha Meilinda Christina MUHAMMAD SAID Muhammad Said Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Mustafa Kamal Mustafa Kamal Nadila Pitriani Nelly Erlina Nisa, Sarifatun Nurlisa Hidayati Nurlisa Hidayati Nurshanti, Dora Fatma Nurshanti, Dora Fatma Poedji Loekitowati Hariani Purwitasari, Neny Rian Oktiansyah Ricce Fatsiami Rizdha Apriyaty Rizkiani, Delisa Roby Pahala J Gultom Rofiqoh, Purnama Ria Salni Salni Salni Seow Lay Jing Setiawati Yusuf Shaum Shiyan Suheyanto Suheryanto Sulistyowaty, Melanny Susilawati, Susilawati Tarmizi Taher Tri Widiandani Yana Maolana Syah Zaidan, Zaidan