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All Journal AGRIVITA, Journal of Agricultural Science IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) JPSriwijaya Science and Technology Indonesia Jurnal Penelitian Sains Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia Jurnal Abdi Insani Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat BIOVALENTIA: Biological Research Journal Jurnal Pepadu Bulletin of Chemical Reaction Engineering & Catalysis
Ferlinahayati Ferlinahayati
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, University Of Sriwijaya, Jl. Raya Palembang Prabumulih Km 32, Ogan Ilir, South Sumatera 30622
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Uji Toksisitas Subkronik Ekstrak Etanol Daun Sungkai (Paronema canescens Jack.) Terhadap Tikus Putih Rattus noverticus (Wistar strain) Muharni Muharni; Ferlinahayati Ferlinahayati; Fitrya Fitrya; Eliza Eliza; Heni Yohandini; Cindy Cenora
Jurnal Sains Farmasi & Klinis Vol 10, No 2 (2023): J Sains Farm Klin 10(2), Agustus 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.2.211-217.2023

Abstract

Tumbuhan sungkai (Paronema canescens Jack)  merupakan salah satu tumbuhan obat tradisional yang telah digunakan  untuk pengobatan berbagai penyakit.  Penggunaan suatu tumbuhan obat harus teruji keamanannya, terutama untuk penggunaan jangka panjang.  Pada penelitian ini telah dilakukan uji  toksisitas subkronis ekstrak etanol  daun P. canescens menggunakan  30 ekor tikus  putih jantan Rattus noverticus (Wistar strain), Penelitian ini menggunakan 5 kelompok hewan terdiri dari kelompok kontrol, kelompok perlakuan dosis 100, 200, 400, dan 800 mg/kg berat badan (bb) . Percobaan  dilakukan selama 28 hari. Parameter yang diamati meliputi hematologi darah, biokimia darah, makroskopik organ, berat organ relatif dan histopatologi organ hati dan ginjal. Hasil pengukuran menunjukkan  tidak terdapat perbedaan yang signifikan (p>0.05) antara kelompok kontrol dengan kelompok perlakuan untuk semua parameter hematologi maupun biokimia darah.  Analisa histopatologi juga menunjukkan tidak terdapat gejala kerusakan pada organ hati dan ginjal.  Hal ini mengindikasikan ekstrak daun sungkai tidak memberikan efek toksik pada hewan uji.
Secondary Metabolite of Endophytic Fungi Daldinia eschscholtzii from The Leaves of Syzygium polyanthum Mia Tirta Sari; Hary Widjajanti; Ferlinahayati; Hermansyah; Rian Oktiansyah; Elfita
Science and Technology Indonesia Vol. 8 No. 4 (2023): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.4.560-569

Abstract

Salam (Syzygium polyanthum) is a plant that is often used by Indonesian people as traditional medicine. The leaves are consumed to treat various diseases. This study reports the endophytic fungi found from S. polyanthum leaves and its secondary metabolites. Endophytic fungi species were determined through morphological and molecular identification. Potato Dextrose Broth medium was used for the cultivation process and ethyl acetate was used as a solvent for the extraction process. Antioxidant tests was carried out by using the DPPH method. Chromatographic techniques were used for the isolation of secondary metabolite and spectroscopic analysis was carried out to identify their chemical structures. The results of morphological and molecular analysis showed that the sample was Daldinia eschscholtzii. The secondary metabolite obtained from this endophytic fungus was idetified as fonsecinone A with good antioxidant activity. The secondary metabolite have the potential to become a source antioxidants through further research.
Removal of Iron(II) Using Intercalated Ca/Al Layered Double Hydroxides with [α-SiW12O40]4- Tarmizi Taher; Mikha Meilinda Christina; Muhammad Said; Nurlisa Hidayati; Ferlinahayati Ferlinahayati; Aldes Lesbani
Bulletin of Chemical Reaction Engineering & Catalysis 2019: BCREC Volume 14 Issue 2 Year 2019 (August 2019)
Publisher : Masyarakat Katalis Indonesia - Indonesian Catalyst Society (MKICS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.9767/bcrec.14.2.2880.260-267

Abstract

Ca/Al layered double hydroxide (LDH) was successfully synthesized by co-precipitation method at pH 11 under room temperature condition then followed by calcination at 800 oC. The synthesized Ca/Al LDH was further intercalated with Keggin ion [α-SiW12O40]4- in order to prepare the intercalated form of Ca/Al LDH. The synthesized materials were characterized by X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) and used as an adsorbent for iron(II) removal from the aqueous medium. The adsorption performance was investigated by studying the kinetics and thermodynamic properties of the adsorption process. The results showed that pristine Ca/Al LDH exhibited diffraction peak at 2θ about 20o which corresponds to the layer structure of the LDH material. For the intercalated Ca/Al LDH, the diffraction observed at 2θ around 30-40o indicated that the [α-SiW12O40]4- was successfully intercalated into the interlayer space of Ca/Al LDH. Furthermore, the intercalated Ca/Al LDH showed higher adsorption capacity toward iron(II) than the pristine form of Ca/Al LDH. 
Pelatihan Pembuatan Teh dari Daun Labu Kuning (Cucurbita maxima) dalam Upaya Pencegahan Penyakit Degeneratif Salni, Salni; Juswardi, Juswardi; Junaidi, Endri; Kamal, Mustafa; Marisa, Hanifa; Ferlinahayati, Ferlinahayati
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 3 No. 2 (2023): Maret 2023 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v3i2.377

Abstract

Penyakit degenerative seperti tekanan darah tinggi, jantung koroner, diabetes, maag dan kanker banyak diderita oleh masyarakat Indonesia.  Kegiatan pengabdian masyarakat ini bertujuan memberikan Pelatihan pembuatan teh dari daun labu kuning (Cucurbita maxima Duch.) dalam upaya pencegahan penyakit degeneratif. Kegiatan dilakukan di desa Tanjung seteko, kecamatan Indralaya, Ogan Ilir. Khalayak sasaran adalah ibu-ibu dan remaja putri. Kegiatan dilakukan dalam tiga tahap yaitu (i) Penyuluhan tentang pentingnya menjaga kesehatan khususnya mengenai penyakit degeneratif seperti jantung coroner, tekanan daraah tinggi, kolesterol, diabetes, maag, kanker, (ii) Pelatihan cara membuat teh dari daun labu kuning dan penggunaannya, dan (iii) Evaluasi produk yang dibuat masyarakat dan keberlanjutan kegiatan. Evaluasi kegiatan dilakukan untuk mengetahui tindak lanjut dari keberhasilan iptek yang telah diberikan. Indikator keberhasilan adalah sejauh mana masyarakat memahami dan menggunakan iptek yang diberikan. Hasil kegiatan menunjukkan meningkatnya pengetahuan masyarakat mengenai penyakit degeneratif, pencegahan dan penyembuhannya. Selain itu meningkatnya keterampilan masyarakat dalam membuat teh dari daun labu kuning.
Pelatihan Pembuatan Salep Untuk Infeksi Kulit dari Ekstrak Daun Karamunting (Rhodomyrtus Tomentosa) Di Desa Tanjung Baru, Ogan Ilir Ferlinahayati, Ferlinahayati; Rachmat, Addy; Hermansyah, Hermansyah; Elfita, Elfita; Hariani, Poedji Loekitowati
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 4 No. 1 (2024): Januari 2024 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59395/altifani.v4i1.518

Abstract

Kulit memiliki fungsi sebagai pertahanan pertama untuk melindungi tubuh dari penyakit. Infeksi kulit dapat disebabkan oleh mikroorganisme, seperti bakteri, virus, jamur, atau parasit. Tanaman karamunting (Rhodomyrtus tomentosa) secara tradisional telah digunakan masyarakat untuk pengobatan termasuk pengobatan luka. Kegiatan pengabdian masyarakat ini bertujuan memberikan pelatihan pembuatan salep untuk pengobatan infeksi kulit dari ekstrak etanol daun karamunting berbasis vaselin.  Kegiatan pengabdian masyarakat dilakukan di desa Tanjung Baru, kecamatan Indralaya Utara, kabupaten Ogan Ilir. Khalayak sasaran adalah ibu-ibu PKK dan remaja putri sebanyak 30 orang. Tahapan kegiatan yaitu (i) penyuluhan tentang penyakit infeksi kulit, penyebab infeksi kulit, penularan dan pengobatan, (ii) pelatihan pembuatan ekstrak etanol dari daun karamunting, pembuatan salep berbasis vaselin dan (iii) evaluasi hasil kegiatan. Hasil evaluasi kegiatan dengan memberikan berbagai pertanyaan setelah kegiatan menunjukkan 97,62 % peserta menjawab tepat dan sangat tepat materi yang diberikan. Hasil uji tingkat kesukaan dan kenyamanan penggunaan salep menunjukkan sebanyak 82,64 % peserta menyatakan sangat suka terhadap aroma, bentuk, warna, kenyamanan dan daya lekat ketika salep digunakan. Hal ini mengindikasikan bahwa salep untuk infeksi kulit ini diterima dengan baik oleh masyarakat sebagai alternatif pengobatan penyakit infeksi kulit.
Adsorption Study on Phenol from Bentonite doped with Zinc oxide: Synthetis, Characterization, Equilibrium, Kinetics, and Thermodynamic Desnelli, Desnelli; Rizkiani, Delisa; Alfarado, Daniel; Ferlinahayati, Ferlinahayati; Yohandini, Heni; Fatma, Fatma; Mara, Ady; Suheryanto, Suheryanto; Nurnawati, Elisa; Hamidah, Afreni; Said, Muhammad
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 9, No 2 (2024): June 2024
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v9.i2.82

Abstract

This study modified current bentonite with zinc oxide (ZnO) and investigated the performance of phenol adsorption. The material bentonite-ZnO was successfully synthesized and characterized with X-ray diffraction (XRD), scanning electron microscopy-energy dispersive X-ray (SEM-EDX), and Fourier transform infrared (FT-IR). The adsorption performance was determined by adsorption equilibrium, kinetics, and thermodynamic parameters. The adsorption, kinetic, and thermodynamic parameters were compared alternatively. The phenol adsorption capacity was obtained from Langmuir and Freundlich adsorption isotherm models, which for bentonite-ZnO was fit with both isotherm models (Langmuir R2 = 0,997 and Freundlich R2 = 0,9515) and was favorable than activated bentonite (n value bentonite-ZnO = 2.389; activated bentonite = 0,898). A kinetic model was tested with pseudo-first-order, pseudo-second-order, and intraparticle diffusion models which bentonite-ZnO and activated bentonite fit in the pseudo-second-order with an excellent agreement (R2 = 0,999). Several thermodynamic parameters such as enthalpy, Gibbs free energy, and bentonite-ZnO have an entropy more than zero (ΔS = 0.008 J/molK), which demonstrated the feasibility and spontaneity (ΔG < 0) and endothermic nature (ΔH = 3,056 kJ/mol) of the phenol adsorption process. Several thermodynamic parameters such as enthalpy, Gibbs free energy, and bentonite-ZnO have an entropy more than zero (ΔS = 0.008 J/molK), which demonstrated the feasibility and spontaneity (ΔG < 0) and endothermic nature (ΔH = 3,056 kJ/mol) of the phenol adsorption process. Based on the result data in this article, modified bentonite with ZnO has increased the ability for phenol adsorption than currently activated bentoniteKeywords: bentonite, adsorption equilibrium, adsorption kinetics, thermodynamics model, phenol, bentonite-ZnO
Study of Potential α-Glucosidase Inhibitor from Tithonia diversifolia: In Vitro, Pharmacokinetics, Toxicology, and Molecular Docking Alfarado, Daniel; Shiyan, Shaum; Ferlinahayati, Ferlinahayati
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103111

Abstract

The kipahit plant (Tithonia diversifolia) is commonly used in traditional medicine to treat various diseases, particularly diabetes. Investigating the bioactive compounds of T. diversifolia as α-glucosidase enzyme inhibitors is very promising to be carried out for antidiabetic drug development. A combination of in vitro and in silico studies was conducted to determine the inhibitory interaction of these compounds. In vitro assay was performed using the spectrophotometry method on methanol extracts and revealed that the stems (IC50 = 105.0 ppm) exhibited higher bioactivity than the leaves (IC50 > 500 ppm). Metabolite profiling of the methanol extract of the T. diversifolia stems revealed 94 compounds, which continued for in silico methods (pharmacokinetics and toxicology, followed by molecular docking with flexible-rigid method) for antidiabetic activity and drug-likeness parameters. Among the identified compounds, eight showed promise as drug candidates for inhibiting the α-glucosidase enzyme. The compound 1-(7-hydroxy-2-(hydroxymethyl)-2-methyl-2H-chromen-6-yl)ethanone was the most effective candidate among the eight candidates, based on its high similarity liked positive control, the lowest binding affinity value (−7.739 kcal/mol), and the inhibition constant (97.0 μM). The research findings suggested that the compounds in T. diversifolia had the potential to inhibit the α-glucosidase enzyme and could be developed into antidiabetic drugs.
PEMBUATAN KRIM ANTI KETOMBE EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) Elfita, Elfita; Muharni, Muharni; Ferlinahayati, Ferlinahayati; Maryadi, Maryadi
Jurnal Pepadu Vol 6 No 1 (2025): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v6i1.6274

Abstract

Dandruff and hair loss are conditions that are often experienced by the community, especially mothers and young women. Various products are available on the market to overcome the problem of dandruff and hair loss, but at a relatively expensive. Many traditional medicinal plants are known to be effective as anti-dandruff. One of them is sirsak leaves (Annona muticata L.). For this reason, it is necessary to conduct socialization to the community, especially mothers and young women residents of RW 05 Indralaya Mulya, North Indralaya District, Ogan Ilir Regency, about the use of traditional medicinal plants to overcome dandruff and hair loss and introduce a simple formulation for making anti-dandruff hair cream. The results of the activity showed that the community was very familiar with the A. muricata plant, but did not know that A. muricata leaves could be used as an anti-dandruff ingredient. The community felt that they had gained practical knowledge about how to make anti-dandruff cream from traditional medicinal plants. This activity has increased the insight and knowledge of the community, especially residents of RW 05 Indralaya Mulya about the use of Sirsak leaves and making anti-dandruff cream.
The Effect of Shade, KNO3, Bulbil Conditions on The Shoot Emergence and Porang Growth nurshanti, Dora fatma; Lakitan, Benyamin; Hasmeda, Mery; Ferlinahayati; Zaidan, Zaidan; Susilawati, Susilawati; Rofiqoh, Purnama Ria
BIOVALENTIA: Biological Research Journal Vol. 11 No. 2 (2025)
Publisher : Biology Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24233/biov.11.2.2025.386

Abstract

Porang cultivation can be carried out using three planting materials, namely true seeds, bulbils, and cormel, these three planting materials experience dormancy. Potassium Nitrate Solution (KNO3) is a chemical compound that is effective in breaking the dormancy of some plant seeds.This study aims to the effect of shading, soaking with KNO3 and bulbil conditions on the emergence of shoots and the growth of porang plants. The research was conducted in September 2021 to November 2021. The design used was split split plot using three factors, shading (N) as the main plot, namely N0: without shade, N1: 45%, N2: 55%, N3: 80%, KNO3 concentration (K) as subplots, namely K0: Without immersion KNO3, K1: 1500 ppm, K2: 3000 ppm, K3: 4500 ppm and bulbil conditions (D) as sub-sub plots, namely D0: Dormant and D1: Mentis. The data collected included the percentage of shoots emergence, time of shoot emergence, broken petiole sheath, leaf open fully, shoot height, number of shoots, number of leaves, petiole length, petiole diameter, midrib length, leaf width, leaf area and leaf thickness. The results showed that shading 55% and bulbil mentis accelerated the emergence of shoot at 26 DAP and 26.9 DAP, respectively. Soaking in KNO3 solution did not accelerate the emergence of shoots. The emergence of shoots affects the time of petiole sheath break and the leaves open fully, the faster the emergence of shoot, the faster the petiole sheath breaks, the faster the leaves open fully. Shade 80% increases the growth of porang plants with the longest leaf petiole of 22.6 cm; petiole diameter 5.5 mm; midrib length 10.34 cm; the width of the leaflets is 4.7 cm and the leaf area is 183.2 cm², except for the thickness of the leaves.
PEMBUATAN KRIM ANTI KETOMBE EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) Elfita, Elfita; Maryadi, Maryadi; Muharni, Muharni; Ferlinahayati, Ferlinahayati
Jurnal Pepadu Vol 6 No 1 (2025): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v6i1.6274

Abstract

Dandruff and hair loss are conditions that are often experienced by the community, especially mothers and young women. Various products are available on the market to overcome the problem of dandruff and hair loss, but at a relatively expensive. Many traditional medicinal plants are known to be effective as anti-dandruff. One of them is sirsak leaves (Annona muticata L.). For this reason, it is necessary to conduct socialization to the community, especially mothers and young women residents of RW 05 Indralaya Mulya, North Indralaya District, Ogan Ilir Regency, about the use of traditional medicinal plants to overcome dandruff and hair loss and introduce a simple formulation for making anti-dandruff hair cream. The results of the activity showed that the community was very familiar with the A. muricata plant, but did not know that A. muricata leaves could be used as an anti-dandruff ingredient. The community felt that they had gained practical knowledge about how to make anti-dandruff cream from traditional medicinal plants. This activity has increased the insight and knowledge of the community, especially residents of RW 05 Indralaya Mulya about the use of Sirsak leaves and making anti-dandruff cream.
Co-Authors Addy Rachmat Ady Mara, Ady Afreni Hamidah Ahmad Fatoni Albertus Aditya Setiawan Aldes Lesbani Alfarado, Daniel Anastasia Wheni Indrianingsih Bambang Yudono Benyamin Lakitan Budi Untari Cenora, Cindy Cindy Cenora Daniel Alfarado Dasril Basir Desnelli Desnelli Dirli Fahmi Rizal Dwi Setyawan Efita Efita Elfita Elfita Elfita Elfita Elisa Nurnawati Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Eliza Emir Fikri Endri Junaidi Endri Junaidi, Endri Euis Holisotan Hakim Euis Holisotan Hakim Euis Holisotan Hakim Fatma Fitrya . Fitrya Fitrya Fitrya Fitrya Galih Satrio Putra Hanifa Marisa Hanifa Marisa Hary Widjajanti Heni Yohandini Herlina Herlina Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Hermansyah Julinar Julinar Julinar Julinar Julinar Jurnal Pepadu Juswardi Juswardi Juswardi Juswardi, Juswardi Lenny Anwar Lia Dewi Juliawaty Maryadi Maryadi Merry Hasmeda Mery Hasmeda Mia Tirta Sari Mikha Meilinda Christina MUHAMMAD SAID Muhammad Said Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Muharni Mustafa Kamal Mustafa Kamal Nadila Pitriani Nelly Erlina Nisa, Sarifatun Nurlisa Hidayati Nurlisa Hidayati Nurshanti, Dora Fatma Nurshanti, Dora Fatma Poedji Loekitowati Hariani Purwitasari, Neny Rian Oktiansyah Ricce Fatsiami Rizdha Apriyaty Rizkiani, Delisa Roby Pahala J Gultom Rofiqoh, Purnama Ria Salni Salni Salni Seow Lay Jing Setiawati Yusuf Shaum Shiyan Suheyanto Suheryanto Sulistyowaty, Melanny Susilawati, Susilawati Tarmizi Taher Tri Widiandani Yana Maolana Syah Zaidan, Zaidan