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Fitriah Fitriah
Malaria Study Group/Laboratory Of Malaria, Institute Of Tropical Disease, Airlangga University
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Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province, Indonesia Fitriah Fitriah; Sriwijayanti Sulistyawati; Sugeng Riyanto; Budiono Budiono; Sukmawati Basuki; Yoes P Dachlan; Haruki Uemura
Journal of Tropical Life Science Vol. 2 No. 3 (2012)
Publisher : Journal of Tropical Life Science

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Abstract

Pregnant women are highly vulnerable to malaria infection in its endemic areas, particularly infection by Plasmodium falciparum that can cause premature, low birth weight, severe anemia in pregnant women, and death. Sulfadoxine-pyrimethamine (SP) for Intermittent Preventive Treatment for pregnant (IPTp) is used for malaria control in pregnancy recommended by the World Health Organization that has already been implemented in Africa. The P. falciparum resistance to SP has been reported in several malarial endemic areas, and mutations in the genes of Plasmodium falciparum Dihydrofolate Reductase (Pfdhfr) and Dihydropteroate Synthase (Pfdhps) are shown to be associated with parasite resistance to SP treatment. Genetic analysis of Pfdhfr and Pfdhps genes in pregnant women infected with P. falciparum has not yet been examined in Indonesia. The cross-sectional study was conducted at two subdistricts, Sungai Pinang and Peramasan, in Banjar district of South Kalimantan Province, where 127 pregnant women were recruited from 2008 to April 2010. Two important mutations in Pfdhfr gene (amino acid positions at N51 and S108) and three in Pfdhps gene (A437, K540 and A581) were analyzed by nested PCR-RFLP method. All of the seven pregnant women samples infected with P. falciparum presented PfDHFR 108N and PfDHPS 437G mutations. One of the samples had the additional mutation at PfDHPS 540, in which Lys is substituted by Glu. These results suggested that P. falciparum might present only some resistance to SP at Sungai Pinang and Peramasan subdistricts, Banjar District, South Kalimantan province, Indonesia. Although there were limited number of samples, this study showed only few mutations of Pfdhfr and Pfdhps genes in P. falciparum at Banjar district, South Kalimantan Province, that suggests SP might be effective for IPTp in this area. Thus, further analysis of the other mutation sites in Pfdhfr and Pfdhps genes and in vivo efficacy study of SP with more sufficient sample numbers will be necessary to confirm this preliminarily result.Keywords: PfDHFR and PfDHPS genes, Pregnant women, Falciparum malaria
Co-Authors Adris Ade Putra Ahmad Syarif Sukri Alce Waromi Alex Sander Enakida Kayame Alfia Yanengga Alkahfi Alkahfi Andi ilham Andi Rosa Andrean Suryadinata Justicia Andreas Afriyanto Moa Aulia Rahmi Azwaruddin, Azwaruddin Baso Mursidi Budiono Budiono Devi Orlanda Dewi Indiastuti Dian Ernaningsih Dika Febrina Safitri Elisabeth Timu Elpisah Entin Monika Febrianti Febrianti Fildzah Luthfia Fitrini Fitrini Gusnawangti Gusnawangti Hartini Hartini Haruki Uemura Imam Ali Khoiri Ismawan Ismawan Jelly Permatasari Kaspul Anwar La Welendo Leni prawitasari M. Syukri Nawir Maelina Putri Maratu Solihah Maliki, Noval Mappiratu Mappiratu Maratus Sholeha Mardiana Mardiana Mariana Sada Marta Ariani Mastikawati Mastikawati Masykur Kimsan Maulana Hakim Al-Fazri Mauren Dwi Vernanda T Mawar Wasela Ayomi Mekina Tabuni mufarika mufarika Muhammad Dzikri Maulana Muhimatul Murtafi'ah Mulia Mayang Sari Mulyawati, Indah Nasrul Nasrul Neneng Prihasti Nia Wandira Nirmala Khoir Nor Huda Nuhun, Ridwan Syah Nur Komariyah Mujib Prismawiryanti Prismawiryanti Putri Amelia Raoda Tul Jannah Maruddani Rindi Kurniawan RM Mediansyah Rudy Kurniawan Safriandi Safriandi Sholihah, Nur Arifatus Siswo Bagaskoro Siti Asmiyah Siti Munirah Rahmatullah Siti Nurjanah Ahmad Siti Sulthonah Hana Mahana Nur Hani'am Mari'a Sri Yunita Suraida Salat Sriwijayanti Sulistyawati Sudirman Sudirman Sugeng Riyanto Sukmawati Basuki Tengku Hartati Theresia Bunga Karlince Wahyu Amni Wahyu Rahman Hakim Wahyudin Wahyudin Yeko Thasya Mobin Kabak Yoes P Dachlan Yohanes Yan Vardus Yuli Mira Syafriati Yuliana Dua Solo