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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Riset Kesehatan Jurnal Surya Medika Jurnal Labora Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis ARTERI : Jurnal Ilmu Kesehatan Borneo Journal of Medical Laboratory Technology Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Abdi Masyarakat Indonesia Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Jurnal Pengabdian Pada Masyarakat Gema Lingkungan Kesehatan Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Dunia Ilmu Kesehatan Jurnal Laboratorium Khatulistiwa Poltekita: Jurnal Ilmu Kesehatan Jurnal Sains dan Kesehatan
Eko Naning Sofyanita
Department Of Medical Laboratory Technology, Poltekkes Kemenkes Semarang, Semarang, Central Java, Indonesia
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Training on Early Detection of Breast Cancer Through Sadari (Breast Self Examination) as Control of Non-Communicable Diseases (NCDs) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Kurniasiwi, Putri
AURELIA: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Vol 3, No 2 (2024): July 2024
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/aurelia.v3i2.2746

Abstract

Breast cancer is the most common type of cancer in women in Indonesia. Early detection through SADARI can help identify changes in the breast that may be early signs of cancer. The aim of this activity is to increase the knowledge and skills of women in carrying out SADARI as an effort to detect breast cancer early. The method used is counseling and practical training on SADARI. The training participants were 40 women of productive age who lived in the Sendang mulyo sub-district. The results of this activity showed an increase in participants' knowledge and skills in carrying out SADARI as measured through pre-test and post-test. Before the training, only 5% of participants understood the correct way to SADARI. After training, this figure increased to 97.5%. The conclusion of this activity is that SADARI training is effective in increasing the knowledge and skills of women in the Sendang mulyo sub-district.
The Effect of Robusta Coffee (Coffea canephora) on the Expression of SOD and Nrf-2 in Diabetes Mellitus condition (Animal Model) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Lestari, Puji; Burhannudin
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3753

Abstract

Hyperglycemia is a condition that occurs when Diabetes Mellitus (DM) is uncontrolled, which causes an increase in free radicals and disruption of cell function and endogenous antioxidants. Coffee, especially robusta coffee, is known to have benefits as an exogenous antioxidant that can increase the activity of endogenous. This study aims to examine the effect of giving robusta coffee on the expression of Nuclear Factor-erythroid-2 Related Factor 2 (Nrf-2) and Superoxide Dismutase (SOD) in DM model mice. The design of this study was experimental with the Post Test Control Group Design method. A total of 24 male Rattus norvegicus mice aged 3 months with a body weight of 230-250 grams were randomly divided into four groups. After undergoing acclimatization for one week, the mice were given robusta coffee once a day for 14 days. On the 15th day, Nrf-2 and SOD expression were examined. The results showed that the average expression of Nrf-2 in each group was: 23.15 ± 1.96 (normal group/KN), 62.14 ± 1.30 (positive DM group/KP), 50.66 ± 2.18 (DM group with low dose coffee/KK1), and 71.13 ± 1.51 (DM group with high dose coffee/KK2). Meanwhile, SOD expression was: 4.95 ± 0.62 (KN), 8.14 ± 0.54 (KP), 6.10 ± 0.79 (KK1), and 9.26 ± 0.31 (KK2). The results of the ANOVA and Post Hoc LSD tests showed a p value <0.05, which indicated a significant difference between groups. In conclusion, administration of robusta coffee (Coffea canephora) was able to increase the activity of the Nrf-2 and SOD enzymes in mice suffering from diabetes mellitus.
Pengetahuan dan Persepsi Masyarakat terhadap Penyakit Tuberkulosis di Pedurungan Tengah Kota Semarang: Knowledge and Perception of Tuberculosis in Pedurungan Sub-district, Semarang City Afriansya, Roni; Hadipranoto, Ichsan; Sofyanita, Eko Naning; Duri, Iin Demiany; Nabila, Jihan
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2285

Abstract

The global commitment to end Tuberculosis is outlined in the End TB Strategy, which targets reducing the incidence of Tuberculosis by 80% and deaths from Tuberculosis by up to 90% by 2030. To support the elimination of TBC, Indonesia has created six strategies. One is Optimization effort promotion and prevention, treating tuberculosis prevention and controlling infection. Level of knowledge and perception are essential in the control of TBC disease. Conscious society of the danger of TBC disease will be beneficial to the success of the eradication program TBC disease. Purpose: to determine the level of public knowledge and perception about TBC disease in Pedurungan Sub-district, Semarang City. Methods: This research uses a quantitative descriptive research type with a cross-sectional time approach. The sample in this study were residents of Pedurungan District, Semarang City. Data collection was carried out directly on research subjects using questionnaires and interviews. Result: The knowledge level research results showed that most respondents (62.4%) had sufficient knowledge about TBC disease. The research result category perception gets 88.7% to have a positive perception of TBC disease. Conclusion: the people of Pedurungan Tengah have sufficient knowledge and categories of perception classified as good. Keywords:          Tuberculosis, Knowledge, Perception   Abstrak Komitmen global dalam mengakhiri tuberkulosis dituangkan dalam End TB Strategy yang menargetkan penurunan insidensi tuberkulosis 80% dan kematian akibat tuberkulosis hingga 90% pada tahun 2030. Upaya dalam mendukung eliminasi TBC, Indonesia telah membuat enam strategi. Salah satunya adalah Optimalisasi upaya promosi dan pencegahan, pemberian pengobatan pencegahan tuberculosis serta pengendalian infeksi. Tingkat pengetahuan dan persepsi berperan penting dalam pengendalian penyakit TBC. Masyarakat yang sadar akan bahaya penyakit TB akan sangat membantu dalam keberhasilan program pemberantasan penyakit TBC. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dengan pendekatan waktu cross sectional. Sampel pada penelitian ini adalah warga Kecamatan Pedurungan Kota Semarang. Pengambilan data di lakukan secara langsung pada subjek penelitian dengan menggunakan kuesioner dan wawancara. Hasil penelitian tingkat pengetahuan mendapatkan sebagian besar responden (62,4%) memiliki pengetahuan yang cukup tentang penyakit TBC. Hasil penelitian kategori persepsi mendapatkan 88,7% memiliki persepsi positif terhadap penyakit TBC. Dan dapat disimpulkan bahwa masyarakat kelurahan Pedurungan Tengah memiliki tingkat pengetahuan yang cukup dan kategori persepsi tergo-long baik. Kata Kunci:         Tuberkulosis, Pengetahuan, Persepsi
The Effect of Chlorogenic Acid Content in Coffee Can Reduce Malondialdehyde (MDA) and Increase Testosterone Hormone Levels in DM Conditions Eko Naning Sofyanita; Achmad Zulfa Juniarto; Ari Suwondo; Heri Nugroho
Gema Lingkungan Kesehatan Vol. 23 No. 1 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i1.163

Abstract

Hyperglycemia is an uncontrolled condition of DM in the body, which causes a decrease in cell functions due to an increase in free radicals (ROS). This study explored the effects of Chlorogenic Acid found in coffee on mitigating MDA levels and augmenting testosterone in the context of Diabetes Mellitus (DM). Chlorogenic Acid, recognized for its substantial antioxidative properties, may ameliorate cellular impairments resulting from high glucose concentrations, consequently elevating Testosterone levels. The methodology employed was a Randomized Control Posttest Group Design involving 20 male Rattus norvegicus rats, aged 8-12 weeks, divided equally into four distinct groups. DM was simulated by administering 40mg/KgBB of streptozotocin and verifying the onset of Hyperglycemia through blood glucose evaluations three days post-administration. Following the confirmation of Hyperglycemia, a 14-day intervention with Robusta Coffee was initiated, with subsequent blood sampling on the fifteenth day to measure MDA and Testosterone concentrations. Results indicated that the groups KP, KP1, and KP2 exhibited notable variations in their responses when contrasted with KP, achieving statistical relevance Of ANOVA (p<0.05). However, no marked difference was observed in Testosterone levels between KP1 and KP2 (p>0.05). The investigation corroborated that Chlorogenic Acid in coffee plays a crucial role in reducing MDA and increasing testosterone hormone levels in DM conditions.
Mentoring and Empowerment Diploma Three Student in Blood Bank Technology, Health Polytechnic, Ministry of Health, Semarang, Through Training in Making Soy Milk as an Effort to Prevent Anemia Afrianti, Dina; Hartono, Rodhi; Setyowatiningsih, Lilik; Sofyanita, Eko Naning; Wahyudi
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 1 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i1.169

Abstract

Mentoring participants know about anemia and its symptoms. Participants know the equipment and materials needed to make soy milk and know the steps on how to make soy milk and participants are able to give a demonstration of making soy milk to the residents of the target village. Residents of the assisted villages know how to make soy milk. Community service activities with the Entrepreneurship Development Program (PPK) scheme with the theme "Assistance in the Empowerment of Diploma Three Technology Students at the PolkesMar Blood Bank through training in making soy milk (Soymilk) as an effort to prevent anemia" was carried out on Friday 28 July 2023 with a target of 10 people participating. consisting of 8 active students and 2 alumni. The output is in the form of videos and pamphlets on making soy milk that have received IPR certificates as well as the expertise of training participants resulting from a series of training activities on making soy milk (Soymilk) targeting students and alumni. This has also been implemented in community service activities for the target village residents in Pundan Hamlet, Subdistrict. Kebondowo Banyubiru, Semarang district, which will be held on Sunday 15 October 2023. The successful achievement of this activity was that all participants in the training on making soy milk were able to give demonstrations on making soy milk to the residents of the target villages. Residents of the assisted villages were given education about anemia and solutions to preventing anemia, the committee also showed videos of making soy milk, distributed pamphlets and gifts to residents of the assisted villages.
PENGARUH PENGGUNAAN MINYAK KELAPA MURNI SEBAGAI LARUTAN CLEARING PADA SEDIAAN HEPAR MENCIT Sofyanita, Eko Naning; Azahra, Nabila
Jurnal Analis Laboratorium Medik Vol 8 No 1 (2023): JURNAL ANALIS LABORATORIUM MEDIK
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jalm.v8i1.3945

Abstract

Salah satu tahapan dalam pemrosesan jaringan dengan histoteknik adalah clearing yang menggunakan larutan xylol. Xylol sering digunakan sebagai agen clearing karena prosesnya cepat dan harganya tidak terlalu mahal, tetapi penggunaan xylol sudah mulai ditinggalkan karena sifatnya yang karsinogenik. Minyak mempunyai karakter bersifat non polar sehingga dengan sifat non polar dari minyak kelapa ini dapat menghilangkan sisa parafin yang terdapat pada jaringan dan dapat digunakan sebagai alternatif larutan clearing. Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan minyak kelapa murni (virgin coconut oil) sebagai alternatif larutan clearing terhadap gambaran makroskopis jaringan hepar mencit (Mus musculus). Metode penelitian ini menggunakan penelitian eksperimental dengan pendekatan one-shot case study. Hasil penelitian ini dilihat dari parameter transparansi dan tekstur menghasilkan 16 (100%), preparat baik sedangkan parameter kemudahan pemotongan didapat 10 sediaan baik (62,5%). Uji Mann-Whitney didapatkan nilai p-value < 0,05 maka ada perbedaan kualitas sediaan jaringan hepar mencit (Mus musculus) yang dijernihkan menggunakan xylol dan minyak kelapa murni (virgin coconut oil). Kesimpulan pada penelitian ini yaitu minyak kelapa murni (virgin coconut oil) dapat digunakan sebagai alternatif larutan clearing berdasarkan gambaran makroskopis jaringan hepar mencit (Mus musculus) dengan hasil kualitas sediaan jaringan yang baik tetapi kualitasnya masih tidak semaksimal penggunaan larutan xylol.
Perbedaan Hasil Pewarnaan Hematoxylin Eosin (HE) pada Histologi Ginjal Mencit (Mus musculus) Berdasarkan Ketebalan Mikrotom: Differences in Hemtoxylin Eosin Staining Results in Mice Kidney Histology (Mus musculus) Based on Microtome Thickness Sofyanita, Eko Naning; Siwi, Utami Purnama
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.5051

Abstract

Tahap pemotongan (sectioning)  menggunakan mikrotom merupakan tahap pembuatan jaringan yang perlu diperhatikan ukuran ketebalannya. Ukuran ketebalan mikrotom yang dapat digunakan yaitu 3-5 μm. Hewan mencit memiliki banyak keunggulan, sedangkan organ ginjal mencit (Mus musculus) merupakan salah satu organ yang sering digunakan dalam penelitian. pewarnaan jaringan yang sering digunakan secara rutin adalah pewarna yang dapat memulas inti dan sitoplasma serta jaringan penyambungnya yaitu pewarnaan Hematoxylin Eosin (HE). Tujuan dari penelitian ini adalah mengetahui perbedaan hasil pewarnaan HE pada histologi ginjal mencit berdasarkan ketebalan mikrotom 3 μm, 6 μm  dan 9 μm. Penelitian ini menggunakan jenis penelitian Eksperimental dengan desain penelitian true experimental post test only control group design. Inti sel tampak berwarna biru keunguan pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 2,97. Sitoplasma tampak jelas dan berwarna merah muda pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 3. Keseragaman warna pada kelompok pemotongan mikrotom 3 μm dengan intensitas warna yang merata pada seluruh lapang pandang dengan rata-rata nilai 3. Hasil uji Kruskal Wallis dan Man Whitney pada ketebalan pemotongan mikrotom 3 μm, 6 μm dan 9 μm menunjukkan adanya perbedaan hasil kualitas pewarnaan sediaan preparat ginjal mencit dengan signifikan p= 0.000. Kesimpulan penelitian ini yaitu pemotongan menggunakan organ ginjal mencit dapat menggunakan ketebalan 3 μm.
Gambaran Ureum dan Kreatinin pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Roni Roni Afriansya; Eko Naning Sofyanita; Suwarsi Suwarsi
Jaringan Laboratorium Medis Vol 2 No 1 (2020): Mei 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i1.5813

Abstract

Chronic Kidney Disease is evident if the blood urea level is more than 200 mg/dl. Uremia causes a malfunction in almost all organ systems such as; fluid and electrolyte disorders, metabolic endocrine, neuromuscular, cardiovascular and pulmonary, skin, gastrointestinal, hematological, and immunological. Hemodialysis is an attempt to reduce the symptoms of uremia so that the patient's clinical condition can also improve. The purpose of this study was to determine the description of Ureum and Creatinine in CKD Patients undergoing Hemodialysis. This type of research is observational descriptive. The sample included all CKD patients undergoing hemodialysis at the Ir Sukarno Sukoharjo Regional Hospital in 2019 who met the inclusion criteria, so as many as 83 samples were obtained. The type of data is secondary data obtained from medical records. The results showed that most patients were in the 40-60 years age group of 72% and the majority of the male sex were 51 patients (61%). Urea and creatinine appearance in patients undergoing hemodialysis has increased very high. In 83 patients with CKD increased serum creatinine levels (> 100%) with a mean creatinine level in men of 11.80 mg / dL and women of 9.73 mg / dL and an increase in ureum levels with a mean of 167 men, 09 mg / dL and women of 164.39 mg / dL. This study concludes that all patients with CKD have increased levels of urea and creatinine by more than 100%.
Hubungan Kadar Hemoglobin dan Kadar Kreatinin Darah pada Pasien Gagal Ginjal Kronik Pasca Transfusi Berulang Eko Naning Sofyanita; Roni Afriansya; Nur Indah Palupi
Jaringan Laboratorium Medis Vol 2 No 2 (2020): November 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i2.7030

Abstract

Kidneys are part of the body that has an important role. One of the functions of the kidney is the production of erythropoietin. Erythropoietin stimulates the production of red blood cells. People or patients who have kidney problems can cause anemia. This study aims to determine the relationship between hemoglobin levels and blood creatinine levels in patients with chronic kidney disease after receiving a transfusion. Blood creatinine levels in this study were used as an index to measure kidney function. The study was conducted at the Wira Tamtama Hospital Semarang by taking data on 20 patients in 2020 with chronic kidney disease and taking data on hemoglobin (cut-off 12 g/dL) and serum creatinine (cut-off 1.5 mg/dL). The relationship between the two was calculated by chi-square test and found 80% of patients with low hemoglobin in patients with high creatinine levels and 0% of patients with low hemoglobin in patients with normal creatinine levels (p=0.040). There is a risk of decreased hemoglobin levels (OR = 3,442) in patients with high creatinine levels. It was concluded that there was a significant relationship between hemoglobin levels and blood creatinine levels and patients with high creatinine levels tended to be at risk of anemia.
Rasio Penutupan Luka pada Tikus Diabetes Diinduksi Streptozotocin dengan Perlakuan Dressing Tipe Pasif dan Interaktif (Penelitian Pendahuluan) Eko Naning Sofyanita; Arya Iswara
Jaringan Laboratorium Medis Vol 3 No 2 (2021): November 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v3i2.8045

Abstract

Deparaffinization is a stage before the staining process to remove/dissolve paraffin so that the absorption of color in tissue preparations is maximized. Deparaffinization is usually carried out using xylol and toluol. Xylol has toxic effects including acute neurotoxicity, heart and kidney damage, hepatotoxicity, fatal blood dyscrasias, skin erythema, dry skin, peeling skin, and also has a carcinogenic effect. The toxicity effect of olive oil is lower than that of xylol. Oils that have non-polar properties can remove the remaining paraffin contained in the tissue. The purpose of this study was to determine the microscopic appearance of the kidney tissue preparations of mice deparaffinized with olive oil on hematoxylin eosin (HE) staining. The type of research used is experimental research which is analyzed with a descriptive approach. The results of the assessment of preparations deparaffinized with xylol in 80 visual fields obtained 100% good preparations and preparations deparaffinized with olive oil in 80 visual fields obtained 0% poor preparations, 11.3% poor preparations, and 88.7% good preparation. So it can be said that better results are found in the microscopic picture of the kidney preparations of mice (Mus musculus) deparaffinized with xylol.
Co-Authors Achmad Zulfa Juniarto Aniesa Izzatun Nafsi Anna Sufi Annisa Anung Sugihartono Ari Suwondo Arya Iswara Arya Iswara Auliya, Qurrotu A'yuni Azahra, Nabila Burhannudin Dina Afrianti Dina Afrianti1 Djoko Priyatno Djoko Priyatno Duri, Iin Demiany Elis Susilawati Endang Susilowaty Errina Septiyasari Faiz Shofa Abdillah Hadipranoto, Ichsan Hendra Adistia Bangkit I Made Wisnu Darma Putra Ichsan Hadipranoto K. Heri Nugroho HS, K. Heri Lilik Setyowatiningsih Maulana, Mochamad Rizal Nabila, Jihan Nanik Aryani Putri Nazhiifah, Tristania Shofi Nur Indah Palupi Nurul Qomariyah NURUL QOMARIYAH PUJI LESTARI Putri Kurniasiwi Qurrotu A’yuni Auliya Raden Mohamad Herdian Bhakti Rihanesa Diana Putri Ririh Jatmi Wikandari Rodhi Hartono Roni Afriansya S.Y. Didik Widiyanto S.Y. Didik Widiyanto Siti Thomas Zulaikhah Siwi, Utami Purnama Suwarsi, Suwarsi Swastya Putri, Adita Puspitasari Swastyaputri, Adita Puspitasari Syanubari, Sonnia Pusparindah Taufiqurrachman Nasihun Umi Rosidah Umi Rosidah WAHYUDI