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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Riset Kesehatan Jurnal Surya Medika Jurnal Labora Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis ARTERI : Jurnal Ilmu Kesehatan Borneo Journal of Medical Laboratory Technology Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Health Sains Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Jurnal Pengabdian Pada Masyarakat Gema Lingkungan Kesehatan Jurnal Dunia Ilmu Kesehatan Jurnal Laboratorium Khatulistiwa Poltekita: Jurnal Ilmu Kesehatan Jurnal Sains dan Kesehatan
Eko Naning Sofyanita
Department Of Medical Laboratory Technology, Poltekkes Kemenkes Semarang, Semarang, Central Java, Indonesia
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Perbedaan Hasil Pewarnaan Hematoxylin Eosin (HE) pada Histologi Ginjal Mencit (Mus musculus) Berdasarkan Ketebalan Mikrotom: Differences in Hemtoxylin Eosin Staining Results in Mice Kidney Histology (Mus musculus) Based on Microtome Thickness Eko Naning Sofyanita; Utami Purnama Siwi
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.5051

Abstract

Tahap pemotongan (sectioning)  menggunakan mikrotom merupakan tahap pembuatan jaringan yang perlu diperhatikan ukuran ketebalannya. Ukuran ketebalan mikrotom yang dapat digunakan yaitu 3-5 μm. Hewan mencit memiliki banyak keunggulan, sedangkan organ ginjal mencit (Mus musculus) merupakan salah satu organ yang sering digunakan dalam penelitian. pewarnaan jaringan yang sering digunakan secara rutin adalah pewarna yang dapat memulas inti dan sitoplasma serta jaringan penyambungnya yaitu pewarnaan Hematoxylin Eosin (HE). Tujuan dari penelitian ini adalah mengetahui perbedaan hasil pewarnaan HE pada histologi ginjal mencit berdasarkan ketebalan mikrotom 3 μm, 6 μm  dan 9 μm. Penelitian ini menggunakan jenis penelitian Eksperimental dengan desain penelitian true experimental post test only control group design. Inti sel tampak berwarna biru keunguan pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 2,97. Sitoplasma tampak jelas dan berwarna merah muda pada kelompok pemotongan mikrotom 3 μm dengan rata-rata nilai 3. Keseragaman warna pada kelompok pemotongan mikrotom 3 μm dengan intensitas warna yang merata pada seluruh lapang pandang dengan rata-rata nilai 3. Hasil uji Kruskal Wallis dan Man Whitney pada ketebalan pemotongan mikrotom 3 μm, 6 μm dan 9 μm menunjukkan adanya perbedaan hasil kualitas pewarnaan sediaan preparat ginjal mencit dengan signifikan p= 0.000. Kesimpulan penelitian ini yaitu pemotongan menggunakan organ ginjal mencit dapat menggunakan ketebalan 3 μm.
The Effect of Robusta Coffee (Coffea canephora) on the Expression of SOD and Nrf-2 in Diabetes Mellitus condition (Animal Model) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Lestari, Puji; Burhannudin
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3753

Abstract

Hyperglycemia is a condition that occurs when Diabetes Mellitus (DM) is uncontrolled, which causes an increase in free radicals and disruption of cell function and endogenous antioxidants. Coffee, especially robusta coffee, is known to have benefits as an exogenous antioxidant that can increase the activity of endogenous. This study aims to examine the effect of giving robusta coffee on the expression of Nuclear Factor-erythroid-2 Related Factor 2 (Nrf-2) and Superoxide Dismutase (SOD) in DM model mice. The design of this study was experimental with the Post Test Control Group Design method. A total of 24 male Rattus norvegicus mice aged 3 months with a body weight of 230-250 grams were randomly divided into four groups. After undergoing acclimatization for one week, the mice were given robusta coffee once a day for 14 days. On the 15th day, Nrf-2 and SOD expression were examined. The results showed that the average expression of Nrf-2 in each group was: 23.15 ± 1.96 (normal group/KN), 62.14 ± 1.30 (positive DM group/KP), 50.66 ± 2.18 (DM group with low dose coffee/KK1), and 71.13 ± 1.51 (DM group with high dose coffee/KK2). Meanwhile, SOD expression was: 4.95 ± 0.62 (KN), 8.14 ± 0.54 (KP), 6.10 ± 0.79 (KK1), and 9.26 ± 0.31 (KK2). The results of the ANOVA and Post Hoc LSD tests showed a p value <0.05, which indicated a significant difference between groups. In conclusion, administration of robusta coffee (Coffea canephora) was able to increase the activity of the Nrf-2 and SOD enzymes in mice suffering from diabetes mellitus.
Pengetahuan dan Persepsi Masyarakat terhadap Penyakit Tuberkulosis di Pedurungan Tengah Kota Semarang: Knowledge and Perception of Tuberculosis in Pedurungan Sub-district, Semarang City Afriansya, Roni; Hadipranoto, Ichsan; Sofyanita, Eko Naning; Duri, Iin Demiany; Nabila, Jihan
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2285

Abstract

The global commitment to end Tuberculosis is outlined in the End TB Strategy, which targets reducing the incidence of Tuberculosis by 80% and deaths from Tuberculosis by up to 90% by 2030. To support the elimination of TBC, Indonesia has created six strategies. One is Optimization effort promotion and prevention, treating tuberculosis prevention and controlling infection. Level of knowledge and perception are essential in the control of TBC disease. Conscious society of the danger of TBC disease will be beneficial to the success of the eradication program TBC disease. Purpose: to determine the level of public knowledge and perception about TBC disease in Pedurungan Sub-district, Semarang City. Methods: This research uses a quantitative descriptive research type with a cross-sectional time approach. The sample in this study were residents of Pedurungan District, Semarang City. Data collection was carried out directly on research subjects using questionnaires and interviews. Result: The knowledge level research results showed that most respondents (62.4%) had sufficient knowledge about TBC disease. The research result category perception gets 88.7% to have a positive perception of TBC disease. Conclusion: the people of Pedurungan Tengah have sufficient knowledge and categories of perception classified as good. Keywords:          Tuberculosis, Knowledge, Perception   Abstrak Komitmen global dalam mengakhiri tuberkulosis dituangkan dalam End TB Strategy yang menargetkan penurunan insidensi tuberkulosis 80% dan kematian akibat tuberkulosis hingga 90% pada tahun 2030. Upaya dalam mendukung eliminasi TBC, Indonesia telah membuat enam strategi. Salah satunya adalah Optimalisasi upaya promosi dan pencegahan, pemberian pengobatan pencegahan tuberculosis serta pengendalian infeksi. Tingkat pengetahuan dan persepsi berperan penting dalam pengendalian penyakit TBC. Masyarakat yang sadar akan bahaya penyakit TB akan sangat membantu dalam keberhasilan program pemberantasan penyakit TBC. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dengan pendekatan waktu cross sectional. Sampel pada penelitian ini adalah warga Kecamatan Pedurungan Kota Semarang. Pengambilan data di lakukan secara langsung pada subjek penelitian dengan menggunakan kuesioner dan wawancara. Hasil penelitian tingkat pengetahuan mendapatkan sebagian besar responden (62,4%) memiliki pengetahuan yang cukup tentang penyakit TBC. Hasil penelitian kategori persepsi mendapatkan 88,7% memiliki persepsi positif terhadap penyakit TBC. Dan dapat disimpulkan bahwa masyarakat kelurahan Pedurungan Tengah memiliki tingkat pengetahuan yang cukup dan kategori persepsi tergo-long baik. Kata Kunci:         Tuberkulosis, Pengetahuan, Persepsi
The Effect of Chlorogenic Acid Content in Coffee Can Reduce Malondialdehyde (MDA) and Increase Testosterone Hormone Levels in DM Conditions Eko Naning Sofyanita; Achmad Zulfa Juniarto; Ari Suwondo; Heri Nugroho
Gema Lingkungan Kesehatan Vol. 23 No. 1 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i1.163

Abstract

Hyperglycemia is an uncontrolled condition of DM in the body, which causes a decrease in cell functions due to an increase in free radicals (ROS). This study explored the effects of Chlorogenic Acid found in coffee on mitigating MDA levels and augmenting testosterone in the context of Diabetes Mellitus (DM). Chlorogenic Acid, recognized for its substantial antioxidative properties, may ameliorate cellular impairments resulting from high glucose concentrations, consequently elevating Testosterone levels. The methodology employed was a Randomized Control Posttest Group Design involving 20 male Rattus norvegicus rats, aged 8-12 weeks, divided equally into four distinct groups. DM was simulated by administering 40mg/KgBB of streptozotocin and verifying the onset of Hyperglycemia through blood glucose evaluations three days post-administration. Following the confirmation of Hyperglycemia, a 14-day intervention with Robusta Coffee was initiated, with subsequent blood sampling on the fifteenth day to measure MDA and Testosterone concentrations. Results indicated that the groups KP, KP1, and KP2 exhibited notable variations in their responses when contrasted with KP, achieving statistical relevance Of ANOVA (p<0.05). However, no marked difference was observed in Testosterone levels between KP1 and KP2 (p>0.05). The investigation corroborated that Chlorogenic Acid in coffee plays a crucial role in reducing MDA and increasing testosterone hormone levels in DM conditions.
Co-Authors Achmad Zulfa Juniarto Aniesa Izzatun Nafsi Anna Sufi Annisa Anung Sugihartono Ari Suwondo Arya Iswara Auliya, Qurrotu A'yuni Burhannudin Dina Afrianti1 Djoko Priyatno Duri, Iin Demiany Elis Susilawati Endang Susilowaty Errina Septiyasari Faiz Shofa Abdillah Hadipranoto, Ichsan Hendra Adistia Bangkit Heri Nugroho I Made Wisnu Darma Putra Kurniasiwi, Putri Lilik Setyowatiningsih Maulana, Mochamad Rizal Nabila Azahra Nabila, Jihan Nanik Aryani Putri Nazhiifah, Tristania Shofi Nur Indah Palupi NURUL QOMARIYAH Nurul Qomariyah PUJI LESTARI Qurrotu A’yuni Auliya Rihanesa Diana Putri Ririh Jatmi Wikandari Roni Afriansya S.Y. Didik Widiyanto Setyowatiningsih, Lilik Siti Thomas Zulaikhah Suwarsi Suwarsi Swastya Putri, Adita Puspitasari Swastyaputri, Adita Puspitasari Syanubari, Sonnia Pusparindah Taufiqurrachman Nasihun Umi Rosidah Utami Purnama Siwi