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All Journal International Journal of Public Health Science (IJPHS) SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Riset Kesehatan Jurnal Surya Medika Jurnal Labora Medika JURNAL ANALIS LABORATORIUM MEDIK Jaringan Laboratorium Medis ARTERI : Jurnal Ilmu Kesehatan Borneo Journal of Medical Laboratory Technology Abdimasku : Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Abdi Masyarakat Indonesia Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Aurelia: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Jurnal Pengabdian Pada Masyarakat Gema Lingkungan Kesehatan Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan Jurnal Dunia Ilmu Kesehatan Jurnal Laboratorium Khatulistiwa Poltekita: Jurnal Ilmu Kesehatan Jurnal Sains dan Kesehatan
Eko Naning Sofyanita
Department Of Medical Laboratory Technology, Poltekkes Kemenkes Semarang, Semarang, Central Java, Indonesia
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Training on Early Detection of Breast Cancer Through Sadari (Breast Self Examination) as Control of Non-Communicable Diseases (NCDs) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Kurniasiwi, Putri
AURELIA: Jurnal Penelitian dan Pengabdian Masyarakat Indonesia Vol 3, No 2 (2024): July 2024
Publisher : CV. Rayyan Dwi Bharata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57235/aurelia.v3i2.2746

Abstract

Breast cancer is the most common type of cancer in women in Indonesia. Early detection through SADARI can help identify changes in the breast that may be early signs of cancer. The aim of this activity is to increase the knowledge and skills of women in carrying out SADARI as an effort to detect breast cancer early. The method used is counseling and practical training on SADARI. The training participants were 40 women of productive age who lived in the Sendang mulyo sub-district. The results of this activity showed an increase in participants' knowledge and skills in carrying out SADARI as measured through pre-test and post-test. Before the training, only 5% of participants understood the correct way to SADARI. After training, this figure increased to 97.5%. The conclusion of this activity is that SADARI training is effective in increasing the knowledge and skills of women in the Sendang mulyo sub-district.
The Effect of Robusta Coffee (Coffea canephora) on the Expression of SOD and Nrf-2 in Diabetes Mellitus condition (Animal Model) Sofyanita, Eko Naning; Maulana, Mochamad Rizal; Lestari, Puji; Burhannudin
Poltekita: Jurnal Ilmu Kesehatan Vol. 18 No. 3 (2024)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v18i3.3753

Abstract

Hyperglycemia is a condition that occurs when Diabetes Mellitus (DM) is uncontrolled, which causes an increase in free radicals and disruption of cell function and endogenous antioxidants. Coffee, especially robusta coffee, is known to have benefits as an exogenous antioxidant that can increase the activity of endogenous. This study aims to examine the effect of giving robusta coffee on the expression of Nuclear Factor-erythroid-2 Related Factor 2 (Nrf-2) and Superoxide Dismutase (SOD) in DM model mice. The design of this study was experimental with the Post Test Control Group Design method. A total of 24 male Rattus norvegicus mice aged 3 months with a body weight of 230-250 grams were randomly divided into four groups. After undergoing acclimatization for one week, the mice were given robusta coffee once a day for 14 days. On the 15th day, Nrf-2 and SOD expression were examined. The results showed that the average expression of Nrf-2 in each group was: 23.15 ± 1.96 (normal group/KN), 62.14 ± 1.30 (positive DM group/KP), 50.66 ± 2.18 (DM group with low dose coffee/KK1), and 71.13 ± 1.51 (DM group with high dose coffee/KK2). Meanwhile, SOD expression was: 4.95 ± 0.62 (KN), 8.14 ± 0.54 (KP), 6.10 ± 0.79 (KK1), and 9.26 ± 0.31 (KK2). The results of the ANOVA and Post Hoc LSD tests showed a p value <0.05, which indicated a significant difference between groups. In conclusion, administration of robusta coffee (Coffea canephora) was able to increase the activity of the Nrf-2 and SOD enzymes in mice suffering from diabetes mellitus.
Pengetahuan dan Persepsi Masyarakat terhadap Penyakit Tuberkulosis di Pedurungan Tengah Kota Semarang: Knowledge and Perception of Tuberculosis in Pedurungan Sub-district, Semarang City Afriansya, Roni; Hadipranoto, Ichsan; Sofyanita, Eko Naning; Duri, Iin Demiany; Nabila, Jihan
Jurnal Sains dan Kesehatan Vol. 6 No. 6 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i6.2285

Abstract

The global commitment to end Tuberculosis is outlined in the End TB Strategy, which targets reducing the incidence of Tuberculosis by 80% and deaths from Tuberculosis by up to 90% by 2030. To support the elimination of TBC, Indonesia has created six strategies. One is Optimization effort promotion and prevention, treating tuberculosis prevention and controlling infection. Level of knowledge and perception are essential in the control of TBC disease. Conscious society of the danger of TBC disease will be beneficial to the success of the eradication program TBC disease. Purpose: to determine the level of public knowledge and perception about TBC disease in Pedurungan Sub-district, Semarang City. Methods: This research uses a quantitative descriptive research type with a cross-sectional time approach. The sample in this study were residents of Pedurungan District, Semarang City. Data collection was carried out directly on research subjects using questionnaires and interviews. Result: The knowledge level research results showed that most respondents (62.4%) had sufficient knowledge about TBC disease. The research result category perception gets 88.7% to have a positive perception of TBC disease. Conclusion: the people of Pedurungan Tengah have sufficient knowledge and categories of perception classified as good. Keywords:          Tuberculosis, Knowledge, Perception   Abstrak Komitmen global dalam mengakhiri tuberkulosis dituangkan dalam End TB Strategy yang menargetkan penurunan insidensi tuberkulosis 80% dan kematian akibat tuberkulosis hingga 90% pada tahun 2030. Upaya dalam mendukung eliminasi TBC, Indonesia telah membuat enam strategi. Salah satunya adalah Optimalisasi upaya promosi dan pencegahan, pemberian pengobatan pencegahan tuberculosis serta pengendalian infeksi. Tingkat pengetahuan dan persepsi berperan penting dalam pengendalian penyakit TBC. Masyarakat yang sadar akan bahaya penyakit TB akan sangat membantu dalam keberhasilan program pemberantasan penyakit TBC. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif dengan pendekatan waktu cross sectional. Sampel pada penelitian ini adalah warga Kecamatan Pedurungan Kota Semarang. Pengambilan data di lakukan secara langsung pada subjek penelitian dengan menggunakan kuesioner dan wawancara. Hasil penelitian tingkat pengetahuan mendapatkan sebagian besar responden (62,4%) memiliki pengetahuan yang cukup tentang penyakit TBC. Hasil penelitian kategori persepsi mendapatkan 88,7% memiliki persepsi positif terhadap penyakit TBC. Dan dapat disimpulkan bahwa masyarakat kelurahan Pedurungan Tengah memiliki tingkat pengetahuan yang cukup dan kategori persepsi tergo-long baik. Kata Kunci:         Tuberkulosis, Pengetahuan, Persepsi
The Effect of Chlorogenic Acid Content in Coffee Can Reduce Malondialdehyde (MDA) and Increase Testosterone Hormone Levels in DM Conditions Eko Naning Sofyanita; Achmad Zulfa Juniarto; Ari Suwondo; Heri Nugroho
Gema Lingkungan Kesehatan Vol. 23 No. 1 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i1.163

Abstract

Hyperglycemia is an uncontrolled condition of DM in the body, which causes a decrease in cell functions due to an increase in free radicals (ROS). This study explored the effects of Chlorogenic Acid found in coffee on mitigating MDA levels and augmenting testosterone in the context of Diabetes Mellitus (DM). Chlorogenic Acid, recognized for its substantial antioxidative properties, may ameliorate cellular impairments resulting from high glucose concentrations, consequently elevating Testosterone levels. The methodology employed was a Randomized Control Posttest Group Design involving 20 male Rattus norvegicus rats, aged 8-12 weeks, divided equally into four distinct groups. DM was simulated by administering 40mg/KgBB of streptozotocin and verifying the onset of Hyperglycemia through blood glucose evaluations three days post-administration. Following the confirmation of Hyperglycemia, a 14-day intervention with Robusta Coffee was initiated, with subsequent blood sampling on the fifteenth day to measure MDA and Testosterone concentrations. Results indicated that the groups KP, KP1, and KP2 exhibited notable variations in their responses when contrasted with KP, achieving statistical relevance Of ANOVA (p<0.05). However, no marked difference was observed in Testosterone levels between KP1 and KP2 (p>0.05). The investigation corroborated that Chlorogenic Acid in coffee plays a crucial role in reducing MDA and increasing testosterone hormone levels in DM conditions.
Gambaran Ureum dan Kreatinin pada Pasien Penyakit Ginjal Kronik yang Menjalani Hemodialisis Afriansya, Roni Roni; Sofyanita, Eko Naning; Suwarsi, Suwarsi
Jaringan Laboratorium Medis Vol. 2 No. 1 (2020): May 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i1.5813

Abstract

Chronic Kidney Disease is evident if the blood urea level is more than 200 mg/dl. Uremia causes a malfunction in almost all organ systems such as; fluid and electrolyte disorders, metabolic endocrine, neuromuscular, cardiovascular and pulmonary, skin, gastrointestinal, hematological, and immunological. Hemodialysis is an attempt to reduce the symptoms of uremia so that the patient's clinical condition can also improve. The purpose of this study was to determine the description of Ureum and Creatinine in CKD Patients undergoing Hemodialysis. This type of research is observational descriptive. The sample included all CKD patients undergoing hemodialysis at the Ir Sukarno Sukoharjo Regional Hospital in 2019 who met the inclusion criteria, so as many as 83 samples were obtained. The type of data is secondary data obtained from medical records. The results showed that most patients were in the 40-60 years age group of 72% and the majority of the male sex were 51 patients (61%). Urea and creatinine appearance in patients undergoing hemodialysis has increased very high. In 83 patients with CKD increased serum creatinine levels (> 100%) with a mean creatinine level in men of 11.80 mg / dL and women of 9.73 mg / dL and an increase in ureum levels with a mean of 167 men, 09 mg / dL and women of 164.39 mg / dL. This study concludes that all patients with CKD have increased levels of urea and creatinine by more than 100%.
Hubungan Kadar Hemoglobin dan Kadar Kreatinin Darah pada Pasien Gagal Ginjal Kronik Pasca Transfusi Berulang Sofyanita, Eko Naning; Afriansya, Roni; Palupi, Nur Indah
Jaringan Laboratorium Medis Vol. 2 No. 2 (2020): November 2020
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v2i2.7030

Abstract

Kidneys are part of the body that has an important role. One of the functions of the kidney is the production of erythropoietin. Erythropoietin stimulates the production of red blood cells. People or patients who have kidney problems can cause anemia. This study aims to determine the relationship between hemoglobin levels and blood creatinine levels in patients with chronic kidney disease after receiving a transfusion. Blood creatinine levels in this study were used as an index to measure kidney function. The study was conducted at the Wira Tamtama Hospital Semarang by taking data on 20 patients in 2020 with chronic kidney disease and taking data on hemoglobin (cut-off 12 g/dL) and serum creatinine (cut-off 1.5 mg/dL). The relationship between the two was calculated by chi-square test and found 80% of patients with low hemoglobin in patients with high creatinine levels and 0% of patients with low hemoglobin in patients with normal creatinine levels (p=0.040). There is a risk of decreased hemoglobin levels (OR = 3,442) in patients with high creatinine levels. It was concluded that there was a significant relationship between hemoglobin levels and blood creatinine levels and patients with high creatinine levels tended to be at risk of anemia.
Rasio Penutupan Luka pada Tikus Diabetes Diinduksi Streptozotocin dengan Perlakuan Dressing Tipe Pasif dan Interaktif (Penelitian Pendahuluan) Sofyanita, Eko Naning; Iswara, Arya
Jaringan Laboratorium Medis Vol. 3 No. 2 (2021): November 2021
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v3i2.8045

Abstract

Deparaffinization is a stage before the staining process to remove/dissolve paraffin so that the absorption of color in tissue preparations is maximized. Deparaffinization is usually carried out using xylol and toluol. Xylol has toxic effects including acute neurotoxicity, heart and kidney damage, hepatotoxicity, fatal blood dyscrasias, skin erythema, dry skin, peeling skin, and also has a carcinogenic effect. The toxicity effect of olive oil is lower than that of xylol. Oils that have non-polar properties can remove the remaining paraffin contained in the tissue. The purpose of this study was to determine the microscopic appearance of the kidney tissue preparations of mice deparaffinized with olive oil on hematoxylin eosin (HE) staining. The type of research used is experimental research which is analyzed with a descriptive approach. The results of the assessment of preparations deparaffinized with xylol in 80 visual fields obtained 100% good preparations and preparations deparaffinized with olive oil in 80 visual fields obtained 0% poor preparations, 11.3% poor preparations, and 88.7% good preparation. So it can be said that better results are found in the microscopic picture of the kidney preparations of mice (Mus musculus) deparaffinized with xylol.
Tingkat Pengetahuan terhadap Donor Darah pada Masyarakat Pendonor Afrianti, Dina; Susilawati, Elis; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 4 No. 1 (2022): May 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i1.8445

Abstract

Blood donation is an activity to donate blood for transfusion purposes. The number of voluntary blood donors in Indonesia is around 20% of the total production of blood bags per year, the rest is met from replacement donors. People are generally reluctant to donate blood because of fear of pain when blood is drawn using a syringe, fear of running out of blood, resulting in anemia, contracting the disease through blood donors, feeling unwell to donate blood and feeling that it is enough to only donate blood once. This is a factor that causes the limited number of donors due to limited knowledge. Research Objectives: To see an overview of the level of knowledge about blood donors in the community of donors at Pekalongan City. Methods: The type of research used is descriptive quantitative with a cross sectional approach with a questionnaire to determine the level of knowledge of the donor community. Results: Most of the blood donors at the Pekalongan City are Male 73 respondents (73%), the highest percentage aged 17-30 years as many as 54 respondents (54%), high school education, namely as many as 49 respondents (49%). Most of the donor knowledge level is said to be good, namely 88 respondents (88%). Conclusion: Most of the donor community at the Pekalongan City have a good level of knowledge about blood donation.
Minyak Zaitun Sebagai Pengganti Xylene pada Prosesing Jaringan Histologis untuk Pewarnaan Kulit dan Hepar Mencit dengan Hematoxylin Eosin: Sebuah Studi Perbandingan Sofyanita, Eko Naning; Iswara, Arya; Priyatno, Djoko
Jaringan Laboratorium Medis Vol. 4 No. 2 (2022): November 2022
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v4i2.8688

Abstract

Clearing results in histological processing can be affected due to tissue density and viscosity of the clearing agent. Xylene is the most commonly used aromatic solvent for clearing agents and deparaffinizing agents in histopathology laboratories, but xylene is one of the most dangerous chemicals found in histology laboratories. Based on the dangers posed by xylene, a replacement material is needed. Several xylene substitutes such as reagents derived from limonene, aliphatic hydrocarbons, vegetable oils and mineral oils have been commercially developed, but the available xylene substitutes are still less effective, more expensive, and still as dangerous as xylene itself. Substitutes that are considered safer are from natural oils, one of which is olive oil which has similarities with xylene, namely in hydrocarbon and phenol compounds. This study used two types of tissue, namely skin and liver from mice (Mus musculus) which were cut into two parts; the first part uses xylene as and the other part uses olive oil as a clearing agent. The assessment of hematoxylin eosin staining results were determined based on the category of assessment of cell structure, such as the cell nucleus, cytoplasm, and color uniformity carried out by three readers and five fields of view for each microscopic slide at 40X magnification of the objective lens. Comparison of observations of the xylene group in skin and liver tissue 100% got a good score on the cell nucleus, cytoplasm, and color uniformity. (p=1,000). The olive oil group had a slight difference in color uniformity in liver tissue when compared to skin, but not statistically different (p=0.773). The comparison of the overall readings of the xylene and olive oil groups on skin and liver tissue also showed no statistically different (p=0.262). So it can be concluded that olive oil can be recommended as a substitute for xylene in the clearing process in histological tissue processing.
Deteksi Karsinoma Nasofaring Mengunakan Rapid Test Uji Imunokromatografi pada Petugas SPBU Afriansya, Roni; Rosidah, Umi; Sofyanita, Eko Naning
Jaringan Laboratorium Medis Vol. 5 No. 1 (2023): May 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v5i1.9337

Abstract

Nasopharyngeal cancer (NPC) is the 4th most common malignancy in Indonesia, after breast, cervical and lung cancer. The risk factors for this cancer are Epstein-Barr virus, gender, race, adult age 30-50 years, family history, drinking alcohol and smoking. The prevalence of NPC in Indonesia is 6.2/100,000, with nearly 13,000 new cases, but this is a small proportion that has been documented. Adham et al (2012) reported that NPC is the most common head and neck cancer (28.4%), with a male-female ratio of 2:4 and is endemic to the island of Java. The existence of knowledge about NPC starting from prevention, early detection, appropriate treatment will be able to help overcome problems caused by nasopharyngeal cancer. Early detection is very important. If NPC is found at an early stage, the cure rate is quite high, reaching 90%. The purpose of this study was to find out whether there were gas station workers in Semarang City who experienced NPC. This study used an analytic survey method with a cross-sectional approach. The results of the study of 20 Semarang City Gas Station officers found that the characteristics based on age were the most in the range 31-50, namely 70%. Characteristics based on gender of the 20 gas station attendants are all male (100%). Characteristics based on length of service are 1 - 10 years (35%), 11 - 20 years (35%) and 21 - 30 years (30%) respectively. Characteristics based on smoking history, 55% of respondents smoked and 45% did not smoke. And the NPC examination results of all respondents (100%) were NPC negative.
Co-Authors Achmad Zulfa Juniarto Achmad Zulfa Juniarto Aniesa Izzatun Nafsi Anna Sufi Annisa Anung Sugihartono Ari Suwondo Ari Suwondo Arya Iswara Arya Iswara Auliya, Qurrotu A'yuni Azahra, Nabila Burhannudin Dina Afrianti1 Djoko Priyatno Djoko Priyatno, Djoko Duri, Iin Demiany Elis Susilawati Endang Susilowaty Errina Septiyasari Faiz Shofa Abdillah Hadipranoto, Ichsan Hendra Adistia Bangkit Heri Nugroho Heri Nugroho I Made Wisnu Darma Putra Ichsan Hadipranoto Lilik Setyowatiningsih Maulana, Mochamad Rizal Nabila, Jihan Nanik Aryani Putri Nazhiifah, Tristania Shofi Nur Indah Palupi Nurul Qomariyah Nurul Qomariyah NURUL QOMARIYAH Palupi, Nur Indah PUJI LESTARI Putri Kurniasiwi Qurrotu A’yuni Auliya Raden Mohamad Herdian Bhakti Rihanesa Diana Putri Ririh Jatmi Wikandari Rodhi Hartono Roni Afriansya Rosidah, Umi S.Y. Didik Widiyanto Setyowatiningsih, Lilik Siti Thomas Zulaikhah Siwi, Utami Purnama Susilawati, Elis Swastya Putri, Adita Puspitasari Swastyaputri, Adita Puspitasari Syanubari, Sonnia Pusparindah Taufiqurrachman Nasihun Umi Rosidah WAHYUDI Widiyanto, S.Y. Didik