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All Journal Media Kesehatan Masyarakat Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Kedokteran Nusantara The Journal Of Medical School Jurnal Kesmas Prima Indonesia Excellent Midwifery Journal International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Buletin Kedokteran dan Kesehatan Prima MEDICINUS Journal of Public Health Science (JoPHS)
Binarwan Halim
Universitas Prima Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Breadfruit leaf extract: A potential hypolipidemic and antioxidant agent in diabetes Tanjaya, Angela; Yunus, Muhammad; Nasution, Ali Napiah; Halim, Binarwan; Hutagalung, Mangatas HP; Sitanggang, Holan Dianju Melva Meinaria
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5462

Abstract

Elevated total cholesterol levels are medically termed as hypercholesterolemia. Breadfruit leaves are recognized for their health benefits owing to the presence of secondary metabolites. This study aimed to investigate the effect of breadfruit leaf extract (Artocarpus altilis) on total cholesterol levels in white rats (Rattus norvegicus) and assess its antioxidant potential. Two control groups were established: negative control (1% Na-CMC) and positive control (simvastatin). The three treatment groups were administered different doses of the breadfruit leaf extract (100, 200, and 400 mg/kg body weight). Each group consisted of five rats. The results indicated that 400 mg/kg body weight of breadfruit leaf extract significantly reduced total cholesterol levels in rats by 29.27% (p<0.05). The antioxidant activity of breadfruit leaf extract was evaluated using the DPPH method at concentrations of 100, 200, 300, 400, and 500 μg/ml. The maximum wavelength used was 516 nm, and the absorbance was measured using a UV-Vis spectrophotometer. The linear regression equation obtained for breadfruit leaf extract was Y = 0.1171x + 35.76, with an IC50 value of 121.605 μg/ml, indicating moderate antioxidant activity. In contrast, the linear regression equation for vitamin C was Y = 0.6378x + 26.083, with an IC50 value of 37.499 μg/ml, indicating a very strong antioxidant activity.
The Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC) on α-Synuclein Levels in Rotenon-Induced Wistar Rats Citra Puan Maulidza; Binarwan Halim; Linda Chiuman; Atika Rimalda Nasution; Yohani Theresia
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10362

Abstract

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopamine and formation of α-synuclein aggregates in the substantia nigra pars compacta (SNpc). This study aims to evaluate α-synuclein levels in the plasma of rotenone-induced Wistar rats as a model of Parkinson's disease and the therapeutic effect of Andaliman fruit extract. The design of this study was experimental with 25 male Wistar rats divided into five groups, negative control group (K-, only given distilled water), positive control (K+, induced rotenone 3 mg/kgBB/day for two weeks), and three treatment groups (P1, P2, P3) induced rotenone and given Andaliman extract orally at a dose of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB respectively for 14 days. Measurement of levels was performed using ELISA on day 14 after induction and day 28 after therapy. The results of one-way ANOVA analysis showed that Andaliman extract significantly reduced α-synuclein levels at all doses compared to the positive control (p=0.000). The decrease in α-synuclein levels indicates the potential of Andaliman fruit extract in reducing Parkinson's disease-related pathology in mouse models.
Differences in nutritional status of exclusively breastfed and non-exclusively breastfed infants aged 0-6 months in Kutambaru Village, Munte Subdistrict Tarigan, Denada Br; Sibagariang, Eva Ellya; Ginting, Rapael; Halim, Binarwan; Kuswani, Lili; Silaen, Mangatas; Hutapea, Johnson; Iskandar, Dalmy; Nasution, Syamsul Arifin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7564

Abstract

Nutritional status in children under five remains a critical public health issue in Indonesia, characterized by high rates of stunting (21.6%) and wasting (7.9% in North Sumatra). Exclusive breastfeeding (EBF) for the first six months is vital for optimal growth, but compliance is low. This study aimed to analyze the determinants of nutritional status, focusing on the differences between infants aged 0-6 months receiving exclusive breastfeeding and those receiving breastfeeding plus early complementary feeding (MPASI). This research employed a comparative analytical design with a total sampling of 40 mothers and their infants (0-6 months) in Kutambaru Village, Munte Subdistrict. The independent variables were breastfeeding status (exclusive vs. non-exclusive) and complementary feeding status. The dependent variable was infant nutritional status (weight-for-length). Data were analyzed using the Chi-Square test. The results demonstrated a statistically significant association between exclusive breastfeeding and infant nutritional status (p = 0.019). Infants who received EBF were significantly more likely to have an optimal nutritional status. Complementary feeding also showed a significant association (p = 0.033). In conclusion, exclusive breastfeeding is the dominant factor significantly associated with optimal nutritional status in infants 0-6 months. Strengthening interventions to promote EBF is critical to prevent malnutrition.
CORNUAL ECTOPIC PREGNANCIES IN RECURRENT ECTOPIC PREGNANCIES AFTER SALPINECTOMY: CASE REPORTS Dhaniel Theolia Persadanta Ginting; Patricia Riwiris Sry Rezeki Samosir; Kevin Nicholas Rumahorbo; Binarwan Halim
Journal of Public Health Science Vol. 3 No. 2 (2026): Juni
Publisher : Yayasan Nuraini Ibrahim Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70248/jophs.v3i2.3942

Abstract

Ectopic pregnancy remains a major cause of maternal morbidity and mortality in early pregnancy. Recurrent ectopic pregnancy represents a significant clinical challenge, particularly in women with a previous history of ectopic pregnancy and tubal surgery such as salpingectomy. Cornual or interstitial ectopic pregnancy is a rare form of ectopic implantation, accounting for approximately 2–4% of all ectopic pregnancies. Despite its rarity, this condition carries a higher risk of severe hemorrhage due to its location within the highly vascularized uterine cornua. Case Presentasion: A 34-year-old woman with a history of ectopic pregnancy treated with salpingectomy presented with worsening lower abdominal pain in early pregnancy. Physical examination, laboratory evaluation and ultrasonography suggested a suspected ectopic pregnancy. Emergency laparoscopy confirmed a cornual ectopic pregnancy with hematoma and pelvic adhesions. Laparoscopic cornual resection, hematoma evacuation, hystero-raphy, and adhesiolysis were performed successfully without complications. The patient recovered well and was discharged in stable condition. Discussion: Recurrent ectopic pregnancy is a known complication in patients with a prior history of ectopic pregnancy and tubal surgery. Although salpingectomy reduces the likelihood of tubal ectopic pregnancy on the affected side, implantation may still occur in other locations, including the interstitial or cornual region. Cornual ectopic pregnancy can grow longer before rupture due to the surrounding myometrial tissue, which may delay diagnosis but increases the risk of catastrophic bleeding once rupture occurs. Laparoscopic management is preferred in hemodynamically stable patients because it offers less surgical trauma, shorter hospital stay, and faster recovery. Conclusion: Cornual ectopic pregnancy may occur as a recurrent ectopic pregnancy even after salpingectomy. Early recognition and prompt surgical intervention are essential to prevent life-threatening complications. Laparoscopic management provides an effective and minimally invasive treatment option with favorable clinical outcomes.
Co-Authors Abdul Wahab Afina, Lubna Anggraeni, Wenti Atika Rimalda Nasution Chiuman, Linda Citra Puan Maulidza Defacto Firmawati Zega Dhaniel Theolia Persadanta Ginting Eva Ellya Sibagariang Fioni Fioni Fioni, Fioni Girsang, Ermi hafizha, Shalli Holan Dianju Melva Meinaria Sitanggang Hutagalung, Mangatas HP Ichwanul Adenin Ichwanul Adenin Irwin Lamtota Lumbanraja Iskandar, Dalmy Johnson Hutapea Julianto Julianto Kevin Nicholas Rumahorbo Kuswani, Lili Letta Sari Lintang Linda Chiuman M. Fidel Ganis Siregar Meutia, Rena Muhammad Yunus Nardi, Leo Nasution, Ali Napiah Nasution, Chairul Radjab Nasution, Syamsul Arifin Patricia Riwiris Sry Rezeki Samosir Putranto Manalu Rapael Ginting Razoki, Razoki Rizki, Kartika Sari Sarma Nursani Lumbanraja Silaen, Mangatas Sinaga, Suharni Pintamas Singarimbun, Nurbaiti Br Sirait, Reni Aprinawaty Sri Lestari Ramadhani Nasution Tanjaya, Angela Tarigan, Antje Irmella Tarigan, Denada Br Theresia, Yohani Timothy Adiwinata TJ Avicenna Victor Trismanjaya Hulu Yohanna Adelina Pasaribu