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All Journal JURNAL KIMIA SAINS DAN APLIKASI Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Indonesian Journal of Chemistry JURNAL FARMASI GALENIKA Jurnal Farmagazine Narra J Jurnal Kebidanan, Keperawatan dan Kesehatan (J-BIKES) Jurnal Farmasi Galenika
Rika Hartati
Pharmaceutical Biology Research Group, School Of Pharmacy, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, West Java, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Biological activities study of Cinnamon (Cinnamomum burmanni (Nees & T.Nees) Blume) as Cosmetic Ingredients Rizaldy, Defri; Insanu, Muhamad; Hartati, Rika; Fadhilah, Ismah Ibtihal; Putri, Rian Destiyani; Cheong, Min Kyoung
Acta Pharmaceutica Indonesia Vol. 48 No. 2
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v48i2.22472

Abstract

Objectives: The goals of this research were to study the biological activities of cinnamon bark extract related to its use as cosmetic ingredients. The potential use of cinnamon bark as cosmetic preparations was studied by confirming its antioxidative, antimicrobial, and its inhibition towards tyrosinase activity. Methods: Extraction was performed by maceration using 70% ethanol. Antioxidative activity using the DPPH methods, melanin inhibitory effect was determined using in vitro anti tyrosinase assay. MHC and MIC of cinnamon bark extract were determined towards Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes. Results: The standardization result of the crude drugs showed positive result on qualitative analysis of Flavonoid, Tannin, and Quinone groups. Flavonoid content also found on the ethanolic extract. The IC­50 antioxidative activity of cinnamon ethanolic was 7.52 ± 0.13 μg/mL compared to ascorbic acid with 2.54 + 0.02 μg/mL. The Ethanolic extract of cinnamon inhibited tyrosinase with IC­50 of 9.44 ± 0.26 mg/mL. Lowest minimum inhibitory concentration of ethanolic extract was found towards Cutibacterium acne with 1000 μg/mL. Whereas weak antimicrobial activity was showed towards Staphylococcus aureus and Staphylococcus epidermidis with MIC and MBC value started from 2000 μg/mL. Conclusion: Comparable result on antioxidative and anti-tyrosinase analysis shows that cinnamon bark have fair potential to further developed and formulated for topical maintenance product.
Co-Authors . Elfahmi Adi Suwandi Asep Gana Suganda Asep Gana Suganda Benny Permana Cheong, Min Kyoung Choirunnisa, Atina Rizkiya Daryono H. Tjahjono Delta Baharyati Ellis Siti Zahidah Fadhilah, Ismah Ibtihal Fadhilah, Syifa Fitriansyah, Sani Nurlaela Indra Wibowo Irda Fidrianny Komar Ruslan Komar Ruslan Wirasutisna Komar Ruslan Wirasutisna Kurniawan, Fransiska Muhamad Insanu Muslihin, Nisrina Nadiyah Athifah Salim Martak Pramastya, Hegar Putri, Rian Destiyani Regiana, Zhafira Amalia Rizaldy, Defri Roni, Asep Sophi Damayanti Zahidah, Ellis Siti