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All Journal INSPIRASI Mutiara Medika: Jurnal Kedokteran dan Kesehatan Medika Tadulako Journal Health & Science : Gorontalo Journal Health and Science Community Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ners Indian Journal of Forensic Medicine & Toxicology Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Health and Nutrition Research Jurnal Akademika Kimia Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Haerani harun
Universitas Tadulako
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Nanotechnology in Metformin Delivery: Fasting Blood Glucose and Neutrophil-Lymphocyte Ratio of Diabetic Rat Model David Pakaya; Laurents Christovel Iban Demen; Haerani Harun; Sarifuddin Anwar; Gabriella Bamba Ratih Lintin
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13358

Abstract

Diabetes Mellitus (DM) is a chronic inflammatory disease characterized by hyperglycemia and increasing the neutrophil-lymphocyte ratio (NLR). Metformin has been widely used to treat hyperglycemia. Metformin nanoparticles can improve bioavailability and may reduce inflammation. This study aims to analyze the effectiveness of metformin nanoparticles delivery through fasting blood glucose (FGB) level and NLR in the diabetic rat model. This study used 16 white male Wistar rats, 8 weeks of age, and body weight (BW) 250-350 grams. The streptozotocin (STZ) 40 mg/kg BW were injected i.p. Rats were divided into 4 groups; K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/Kg BW; K4: diabetes model treated with nanoparticle metformin 100mg/kg BW. Blood analysis tests were conducted using the Pentra hematology analyzer. Data were analyzed using the Graphpad Prism program with the nonparametric Kruskal Wallis test. The K3 group showed a periodical decrease in FBG level from day 7 to day 28 by 122 ± 11.31 mg/dL, and the mean NLR value was 0.48 ± 0.3 x 103/uL. Group of K4 periodically decreased in FBG level, indicating that it was closer to normal than K3. The result showed that at day 28.79 ± 15.39 mg/dL, the mean NLR value slightly increased compared to the K3 group by 0.54 ± 0.3 x103/uL. The statistical tests showed a significant difference between the level of FBG (p 0.0089) but no significant difference in NLR (p 0.347). Metformin nanoparticles could decrease FBG levels and effectively reduce the NLR in the diabetic rat model.
Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis Haerani Harun1 , Muhammad Nasir2 , Sumarni3, Rosa Dwi Wahyuni1 , Dita aridhatamy4 , Nur Aulia Pratiw
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13561

Abstract

Background: Tuberculosis (TB) is one of the top 10 causes of death in the world and the most commoncause of death with single infectious agent. The neutrophil-lymphocyte ratio is a cheap and fast marker ofinflammation that has been widely studied in TB. The aimed of this study was to investigate Neutrophillymphocyte ratio (NLR) in TB with positive Acid-Fast Bacilli (AFB) and negative AFB. Methods: Thiswas a retrospective study that included TB patients data from the medical records in two hospitals in Palu,Indonesia. A total of 150 TB patients were involved in this study consisting with positive and negative AFBTB suspect. Neutrophil, lymphocyte and NLR data were compared with the Mann-Whitney test. Results:The study shows a significant difference of neutrophils and lymphocytes percentage between positive AFBTB patients (80 subjects, 53.3%) and negative AFB TB patients (70 subjects, 46.7%) with (p < 0.001) as wellas NLR (p < 0.001). The percentage of Neutrophils was significantly higher in positive AFB TB comparedto negative AFB tuberculosis (81.18 ± 8.52 vs. 55.02 ± 9.80), lymphocyte percentage were found to besignificantly lower in positive AFB TB compared with negative AFB TB (12.72 ± 7.51 vs 28.69 ± 12.01).Additionally, NLR were significantly higher in positive AFB TB compared with negative AFB TB (10.20 ±9.53 vs 2.47 ± 1.56). Conclusion: There is a significant increase in the number of neutrophils, a decrease inlymphocytes and an increase in NLR among positive AFB TB compared with negative AFB TB.
PLATELET-LYMPHOCYTE RATIO (PLR) MARKERS IN ACUTE CORONARY SYNDROME (Platelet Lymphocyte Ratio (PLR) sebagai Petanda Sindrom Koroner Akut) Haerani Harun; Uleng Bahrun; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1176

Abstract

Sindrom Koroner Akut (SKA) merupakan puncak manifestasi klinis aterosklerosis di arteri koroner. Inflamasi terjadi dari tahapawal pembentukan ateroma sampai ruptur plak dan trombosis. Trombosis memainkan peran penting dalam perjalanan penyakit SKA.Trombositosis dan limfopenia berhubungan dengan derajat inflamasi sistemik dan Rasio Platelet Limfosit (PLR) menjadi petanda baruyang melibatkan kedua tolok ukur hematologi tersebut. Penelitian ini merupakan penelitian retrospektif di Rumah sakit Dr. WahidinSudirohusodo Makassar dengan mengambil data pasien SKA UAP, STEMI, NSTEMI dan menilai PLR dari pemeriksaan darah rutin saatmasuk Rumah sakit. Data PLR dibandingkan berdasarkan jenis SKA, kemudian dibandingkan dengan kontrol sehat. Hasil penelitiandidapatkan 223 data pasien SKA UAP, STEMI dan NSTEMI masing-masing 89, 68, 66 data dan kontrol normal 198 data. Hasil ujistatistik Kruskal wallis menunjukkan perbedaan bermakna PLR antara pasien UAP, NSTEMI dan STEMI (p=0,011). Hasil uji post hocmenunjukkan perbedaan bermakna antara UAP dan NSTEMI (p=0,023), UAP dan STEMI (p=0,006), tetapi tidak berbeda bermaknaantara NSTEMI dan STEMI (p=0,827). Nilai PLR pasien SKA lebih tinggi dibandingkan dengan pembanding (p=0,037). Berdasarkanhasil penelitian didapatkan nilai PLR meningkat di SKA dibandingkan dengan kontrol normal. Nilai PLR di STEMI dan NSTEMI lebihtinggi dibandingkan UAP, kemungkinan berhubungan dengan pembentukan trombus dan infark miokard.
Comparison of Neutrophile-to-Lymphocyte Ratio Between Dengue Haemorrhagic Fever and Dengue Shock Syndrome in Pediatric Patients at Anutapura Hospital Amri, Imtihanah; Rahma, Rahma; Hutasoit, Gina Andyka; Putri, Ayu Sekarani Damana; Harun, Haerani; Rasyid, Riyadh
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.360

Abstract

Dengue Hemorrhagic Fever (DHF) is an acute viral infectious disease that attacks the body. DHF is divided into 4 grades (I, II, III, IV), in which degrees 3 and 4 are also known as Dengue Shock Syndrome (DSS). When the disease severity is detected too late, it can be fatal. Therefore, a predictor or inflammatory marker is needed to detect and predict this. In this study, the inflammatory marker assessed is the NLR value. This study compares the neutrophil-lymphocyte ratio and the incidence of Dengue Hemorrhagic Fever and Dengue Shock Syndrome in pediatric patients at the Anutapura Regional Hospital, Central Sulawesi Province. This study uses an observational analytical method with a cross-sectional design using secondary data from medical records at the Anutapura Regional Hospital, Palu, in 2021-2023. The sample included is patients with a diagnosis of DHF, totaling 100 samples. The sampling technique used is random sampling. Based on the Mann-Whitney test, a significant difference (p = 0.001) was found in the NLR value between DHF and DSS. The mean NLR in DHF was lower (1.28 (±0.98 SD)) than in DSS (2.07 (±1.59 SD)). There was no significant relationship between age (p=0.217) and gender (p=0.597) in the DHF and DSS groups. It is then concluded that there is a significant difference in NLR values between DHF and DSS, where NLR values are lower in DHF and higher in DSS.
Blood Transfusion in Islam: An Integrative Analysis of Quranic Interpretation, Medical Ethics, and Social Perspectives Talebe, Tamrin; Harun, Haerani; Musyahidah, Sitti; Attamimi, Suraya
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.465

Abstract

This study examines the Islamic bioethical perspective on blood transfusion, a common medical procedure that raises ethical and religious concerns. The research analyzes Quranic verses, hadiths, Islamic jurisprudence, and scholarly interpretations to understand the Islamic stance on blood, its use in medical treatments, and the permissibility of blood transfusion. While blood is generally considered impure in Islam and its consumption is prohibited, exceptions are made for life-saving medical interventions. The study explores the Quranic and hadith-based concepts of blood, its various mentions and contexts in Islamic texts, and how these relate to modern medical practices. It also discusses the medical benefits and risks of blood transfusion, including its life-saving potential and possible complications, within the framework of medical ethics. The research highlights the Islamic principle of preserving life (hifdzu al nafs) and how it applies to blood transfusion. Social aspects, including blood donation as an act of solidarity and charity, are examined through an Islamic lens. The study concludes that blood transfusion is permissible in Islam when medically necessary, aligning with the religion's emphasis on preserving life and helping others. This research contributes to the growing field of Islamic bioethics in contemporary medical practices.
BACTERIAL IDENTIFICATION ON ESCALATOR HANDRAIL IN SHOPPING MALLS IN PALU Harun, Haerani; Sibarani, Deri Ezra; Asrinawaty, Andi Nur; Tulaka, Budi Dharmono
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1215

Abstract

Latar Belakang: Eskalator merupakan konveyer yang banyak digunakan untuk transportasi terutama dalam gedung besar. Kontak eskalator dengan manusia menyebabkan tertinggalnya jejak kuman termasuk bakteri pada pegangan eskalator yang berpotensi berpindah ke orang lain. Identifikasi bakteri pada pegangan eskalator diperlukan untuk menentukan potensi patogen yang dapat menyebabkan penyakit pada manusia. Tujuan: Mengidentifikasi jenis bakteri pada pegangan eskalator di pusat perbelanjaan di kota palu Metode: Penelitian merupakan penelitian observasional deskriptif dengan pengambilan sampel dengan cara total sampling. Sampel diambil dari pegangan eskalator di pusat perbelanjaan yang ada di kota palu. Hasil: Hasil kultur bakteri didapatkan 22% Staphylococcus aureus, 14% Serratia marcescens, 12% Escherichia coli, 12% Serratia sp, 8% Klebsiella sp, 4% Staphylococcus epidermidis, 4% Proteus sp, 4% Proteus penneri.
RASIO MONOSIT LIMFOSIT PADA PASIEN COVID-19 Harun, Haerani; Saptawinata, Aji; Towidjojo, Vera Diana; Anwar, Sarifuddin
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1263

Abstract

Latar belakang : Savere acute respiartory syndrome-corona virus 2 (SARS-CoV2) merupakan virus yang memiliki gejala sama seperti SARS dan MERS yang dapat menyerang manusia dengan melibatkan sistem kekebalan tubuh (Limfosit T, Limfosit B dan Monosit), sehingga perlu dilakukan analisis Rasio Monosit Limfosit yang memiliki nilai prognostik dalam menentukan kasus yang parah. Tujuan : Tujuan penelitian ini adalah untuk membandingkan Rasio Monosit Limfosit pada pasien COVID-19 PCR Positif dan PCR Negatif. Metode : Penelitian ini menggunakan desain penelitian Observasional analitik yang mengambil data sekunder, subjek pada penelitian ialah pasien suspek COVID-19 yang selanjutnya dibagi dalam 2 kelompok (PCR Positif dan PCR Negatif) dengan jumlah responden 30 orang dalam 1 kelompok. Hasil : Hasil penelitian didapatkan hitung jenis monosit lebih rendah pada pada kelompok PCR Positif dibandingkan PCR Negatif (p<0,03) dan terdapat peningkatan bermakna MLR (p=0,005) pada kelompok PCR Positif diabndingkan PCR Negatif. MLR pada kelompok PCR positif lebih tinggi dibandingkan kelompok PCR negatif
PERBANDINGAN LEUKOSIT DAN RASIO NEUTROFIL LIMFOSIT (RNL) PADA APENDISITIS KOMPLIKATA DAN NON KOMPLIKATA Harun, Haerani; Amri, Imtihanah; Tepu, Muhammad Husein; Tulaka, Budi Dharmono
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1273

Abstract

Latar belakang: Apendisitis merupakan salah satu kasus tersering dalam bidang bedah abdomen yang menyebabkan nyeri abdomen akut dan memerlukan tindakan bedah segera. Apendiks dapat menimbulkan berbagai komplikasi apabila penegakkan diagnosis tidak dilakukan dengan segera. Komplikasi yang ditimbulkan seperti perforasi pada apendiks yang dapat membentuk massa atau abses sehingga penanganan dan durasi tindakan operasi akan lebih sulit dan lama. Leukosit merupakan penanda peradangan yang dapat digunakan untuk menilai komplikasi dari apendisitis. Tujuan: Mengetahui perbandingan leukosit dan RNL dengan kejadian apendisitis komplikata dan non-komplikata Metode: Penelitian ini adalah penelitian observasi analitik dengan pendekatan cross-sectional. Data Leukosit dan RNL dari pasien apendisitis diambil dari data rekam medis dan dibagi menjadi kempompok apendisitis komplikata dan apendisitis non komplikata. Leukosit dan RNL kemudian dibandingkan dengan uji Mann-Whitjney Hasil: Hasil yang diperoleh ditemukan perbedaan bermakna jumlah leukosit (p=0,006) dan nilai RNL p=0,000 antara apendisitis komplikata dan non komplikata. Kesimpulan: Jumlah leukosit dan RNL ditemukan lebih tinggi secara bermakna pada apendisitis komplikata dibandingkan dengan apendisitis non-komplikata.
PENGARUH VITAMIN B6 TERHADAP NILAI UJIAN BLOK MAHASISWA Christin Rony Nayoan; Amany, Anisha Inas; Towidjojo, Vera Diana; Andi Alfia Muthmainnah Tanra; Rahma; IPFI White; Haerani Harun
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 7 No 03 (2025): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v7i03.350

Abstract

ABSTRAK Latar Belakang : Vitamin B6 berfungsi sebagai kofaktor dalam lebih dari 100 reaksi enzimatik, dan berperan pada sintesis neurotransmitter seperti gamma-aminobutyric acid (GABA), serotonin, dan dopamine sehingga berpotensi mempengaruhi fungsi otak yang berkaitan dengan konsentrasi, daya ingat, dan performa akademik pada mahasiswa terutama dalam ujian blok. Penelitian ini bertujuan untuk mengetahui pengaruh vitamin B6 terhadap nilai ujian blok mahasiswa Fakultas Kedokteran Universitas Tadulako Angkatan 2023. Metode : Penelitian kuasi-eksperimental dengan Posttest-Only Control Group Design. Pengambilan sampel dilakukan dengan teknik random sampling, kemudian dibagi menjadi dua kelompok dengan perlakuan berbeda. Analisis data dilakukan melalui uji normalitas, uji homogenitas, dan Uji T Sampel Independen. Hasil : Total sampel adalah 36 mahasiswa yang dibagi 2 kelompok yaitu kelompok eksperimen-diberikan vitamin B6 100 mg per hari selama 3 minggu 5 hari dan kelompok kontrol-tidak diberikan vitamin B6. Didapatkan nilai rata-rata ujian blok pada kelompok eksperimen adalah 50,19; kelompok kontrol adalah 42,63; dan nilai signifikansi 0,006 antar kelompok. Kesimpulan: Suplementasi vitamin B6 dapat meningkatkan performa akademik mahasiswa kedokteran. Namun, penelitian ini memiliki keterbatasan, yaitu tidak adanya penilaian awal (pre-test) sehingga kondisi awal sampel tidak diketahui, serta terdapat banyak faktor yang tidak dapat dikendalikan yang mungkin memengaruhi performa akademik sampel penelitian. ABSTRACT Background: Vitamin B6 functions as a cofactor in over 100 enzymatic reactions and plays a role in the synthesis of neurotransmitters such as gamma-aminobutyric acid (GABA), serotonin, and dopamine. These neurotransmitters have the potential to influence brain functions related to concentration, memory, and academic performance, particularly in medical students during block examinations. This study aimed to examine the effect of vitamin B6 supplementation on the block exam scores of medical students at the Faculty of Medicine, Tadulako University, Class of 2023.Methods: This was a quasi-experimental study using a posttest-only control group design. Samples were selected using random sampling and divided into two groups receiving different treatments. Data analysis included normality testing, homogeneity testing, and independent sample t-tests.Results: A total of 36 students participated in the study, divided into two groups: the experimental group received 100 mg of vitamin B6 daily for 3 weeks and 5 days, while the control group received no supplementation. The average block exam score in the experimental group was 50.19, compared to 42.63 in the control group, with a statistically significant difference between groups (p = 0.006).Conclusion: Vitamin B6 supplementation may enhance the academic performance of medical students. However, this study has limitations, including the absence of a baseline (pre-test) assessment, which prevents evaluation of initial conditions, and the presence of various uncontrolled factors that may have influenced the academic performance of the participants.
PERBANDINGAN KADAR GLUKOSA DARAH DUA JAM POSTPRANDIAL SETELAH KONSUMSI KURMA AJWA DAN PISANG AMBON PADA INDIVIDU SEHAT Faaz, Muh Azzam; Harun, Haerani; Rachmat, Nihayatul Khoiriyah; Yanti, Riska; Hermanto, Darent Aditya Nasario; Towidjojo, Vera Diana; Sofyan, Asrawati
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 10, No 2 (2026): APRIL: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMUN
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v10i2.37827

Abstract

Pemilihan jenis buah memengaruhi respons glikemik postprandial yang esensial dalam pencegahan gangguan metabolisme glukosa. Kebaruan penelitian ini terletak pada perbandingan langsung respons glikemik dua jam postprandial antara konsumsi porsi lazim kurma Ajwa dan pisang Ambon pada individu sehat menggunakan desain quasi-eksperimental. Penelitian ini bertujuan untuk membandingkan pengaruh konsumsi porsi lazim kurma Ajwa (tiga butir) dan pisang Ambon (satu buah) terhadap kadar glukosa darah dua jam postprandial (GD2PP) pada individu sehat. Penelitian ini merupakan penelitian analitik komparatif berdesain quasi-eksperimental (two-group pretest-posttest) ini melibatkan 92 responden sehat (52 kelompok kurma; 40 kelompok pisang) melalui consecutive sampling. Setelah berpuasa 8–10 jam, glukosa darah puasa (GDP) diukur menggunakan glucometer POCT. Subjek kemudian diberikan intervensi buah dan diukur kembali GD2PP-nya tepat dua jam pascakonsumsi. Data dianalisis menggunakan uji Paired t-test dan Independent t-test. Kelompok pisang menunjukkan rerata GDP 89,03±6,98 mg/dL dan GD2PP 88,68±8,06 mg/dL tanpa perbedaan bermakna (P-value=0,673). Kelompok kurma menunjukkan penurunan signifikan dari GDP 92,67±8,67 mg/dL menjadi GD2PP 89,25±9,60 mg/dL (p=0,010). Terdapat perbedaan perubahan kadar glukosa (ΔGD2PP) yang signifikan secara statistik antara kelompok pisang (-0,35±5,20 mg/dL) dan kurma (-3,42±9,28 mg/dL) dengan nilai p=0,048. Konsumsi kurma Ajwa memberikan respons glikemik yang secara statistik lebih rendah dibandingkan pisang Ambon. Kedua jenis buah ini terbukti aman dan tidak memicu hiperglikemia postprandial, sehingga dapat direkomendasikan untuk menjaga stabilitas glukosa darah pada individu sehat.
Co-Authors Amany, Anisha Inas Amus, Dzaki Ahmad Fahrezi Andi Alfia Muthmainnah Tanra Andi Nur Asrinawaty Anggara, Ary Anwar, Sarifuddin Asrawati Sofyan Ayu Sekarani Damana Putri Benny Rusli, Benny Christin Rony Nayoan CS, Regina Ni Nyoman Darent Aditya Nasario Hermanto Darmawaty ER David Pakaya Faaz, Muh Azzam Faaz, Muhammad Azzam Gabriella Bamba Ratih Lintin Gina Andyka Hutasoit Hasannudin, Hasannudin Hermanto, Darent Aditya Nasario Imtihanah Amri Imtihanah Amri Ipfi White Junjun Fitriani Laurents Christovel Iban Demen Liwang, Muhammad Nur Ikhsan Lulu Natasya M. Sabir Muh Azzam Faaz Muhammad Z. Ramadhan Nihayatul Khoiriyah Rachmat Nurhayana Sennang, Nurhayana Rachmat, Nihayatul Khoiriyah Rahma Rahma Rahma Rasyid, Riyadh Ressy Dwiyanti Riska Yanti RISKA YANTI, RISKA Ryka M. Walanda Saptawinata, Aji Sarifuddin Anwar Sekarani Damana Putri, Ayu Sibarani, Deri Ezra Sitti Musyahidah Sulistiana, Ria Suraya Attamimi Syamsul Arifin Tamrin Talebe Tanan, Jeremy Tanra, Andi Alfia Muthmainah Tepu, Muhammad Husein Tulaka, Budi Dharmono Uleng Bahrun Undayanti, Meri Gita Vera Diana Towidjojo