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All Journal INSPIRASI Mutiara Medika: Jurnal Kedokteran dan Kesehatan Medika Tadulako Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Indian Journal of Forensic Medicine & Toxicology Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Journal of Health and Nutrition Research Eduvest - Journal of Universal Studies Jurnal Akademika Kimia Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Haerani harun
Universitas Tadulako
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Nanotechnology in Metformin Delivery: Fasting Blood Glucose and Neutrophil-Lymphocyte Ratio of Diabetic Rat Model David Pakaya; Laurents Christovel Iban Demen; Haerani Harun; Sarifuddin Anwar; Gabriella Bamba Ratih Lintin
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 22, No 1 (2022): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v22i1.13358

Abstract

Diabetes Mellitus (DM) is a chronic inflammatory disease characterized by hyperglycemia and increasing the neutrophil-lymphocyte ratio (NLR). Metformin has been widely used to treat hyperglycemia. Metformin nanoparticles can improve bioavailability and may reduce inflammation. This study aims to analyze the effectiveness of metformin nanoparticles delivery through fasting blood glucose (FGB) level and NLR in the diabetic rat model. This study used 16 white male Wistar rats, 8 weeks of age, and body weight (BW) 250-350 grams. The streptozotocin (STZ) 40 mg/kg BW were injected i.p. Rats were divided into 4 groups; K1: normal control; K2: negative control (diabetes model); K3: diabetes model treated with metformin 100mg/Kg BW; K4: diabetes model treated with nanoparticle metformin 100mg/kg BW. Blood analysis tests were conducted using the Pentra hematology analyzer. Data were analyzed using the Graphpad Prism program with the nonparametric Kruskal Wallis test. The K3 group showed a periodical decrease in FBG level from day 7 to day 28 by 122 ± 11.31 mg/dL, and the mean NLR value was 0.48 ± 0.3 x 103/uL. Group of K4 periodically decreased in FBG level, indicating that it was closer to normal than K3. The result showed that at day 28.79 ± 15.39 mg/dL, the mean NLR value slightly increased compared to the K3 group by 0.54 ± 0.3 x103/uL. The statistical tests showed a significant difference between the level of FBG (p 0.0089) but no significant difference in NLR (p 0.347). Metformin nanoparticles could decrease FBG levels and effectively reduce the NLR in the diabetic rat model.
Neutrophil Lymphocyte Ratio and Acid-Fast Bacilli in Tuberculosis Haerani Harun1 , Muhammad Nasir2 , Sumarni3, Rosa Dwi Wahyuni1 , Dita aridhatamy4 , Nur Aulia Pratiw
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13561

Abstract

Background: Tuberculosis (TB) is one of the top 10 causes of death in the world and the most commoncause of death with single infectious agent. The neutrophil-lymphocyte ratio is a cheap and fast marker ofinflammation that has been widely studied in TB. The aimed of this study was to investigate Neutrophillymphocyte ratio (NLR) in TB with positive Acid-Fast Bacilli (AFB) and negative AFB. Methods: Thiswas a retrospective study that included TB patients data from the medical records in two hospitals in Palu,Indonesia. A total of 150 TB patients were involved in this study consisting with positive and negative AFBTB suspect. Neutrophil, lymphocyte and NLR data were compared with the Mann-Whitney test. Results:The study shows a significant difference of neutrophils and lymphocytes percentage between positive AFBTB patients (80 subjects, 53.3%) and negative AFB TB patients (70 subjects, 46.7%) with (p < 0.001) as wellas NLR (p < 0.001). The percentage of Neutrophils was significantly higher in positive AFB TB comparedto negative AFB tuberculosis (81.18 ± 8.52 vs. 55.02 ± 9.80), lymphocyte percentage were found to besignificantly lower in positive AFB TB compared with negative AFB TB (12.72 ± 7.51 vs 28.69 ± 12.01).Additionally, NLR were significantly higher in positive AFB TB compared with negative AFB TB (10.20 ±9.53 vs 2.47 ± 1.56). Conclusion: There is a significant increase in the number of neutrophils, a decrease inlymphocytes and an increase in NLR among positive AFB TB compared with negative AFB TB.
PLATELET-LYMPHOCYTE RATIO (PLR) MARKERS IN ACUTE CORONARY SYNDROME (Platelet Lymphocyte Ratio (PLR) sebagai Petanda Sindrom Koroner Akut) Haerani Harun; Uleng Bahrun; Darmawaty ER
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1176

Abstract

Sindrom Koroner Akut (SKA) merupakan puncak manifestasi klinis aterosklerosis di arteri koroner. Inflamasi terjadi dari tahapawal pembentukan ateroma sampai ruptur plak dan trombosis. Trombosis memainkan peran penting dalam perjalanan penyakit SKA.Trombositosis dan limfopenia berhubungan dengan derajat inflamasi sistemik dan Rasio Platelet Limfosit (PLR) menjadi petanda baruyang melibatkan kedua tolok ukur hematologi tersebut. Penelitian ini merupakan penelitian retrospektif di Rumah sakit Dr. WahidinSudirohusodo Makassar dengan mengambil data pasien SKA UAP, STEMI, NSTEMI dan menilai PLR dari pemeriksaan darah rutin saatmasuk Rumah sakit. Data PLR dibandingkan berdasarkan jenis SKA, kemudian dibandingkan dengan kontrol sehat. Hasil penelitiandidapatkan 223 data pasien SKA UAP, STEMI dan NSTEMI masing-masing 89, 68, 66 data dan kontrol normal 198 data. Hasil ujistatistik Kruskal wallis menunjukkan perbedaan bermakna PLR antara pasien UAP, NSTEMI dan STEMI (p=0,011). Hasil uji post hocmenunjukkan perbedaan bermakna antara UAP dan NSTEMI (p=0,023), UAP dan STEMI (p=0,006), tetapi tidak berbeda bermaknaantara NSTEMI dan STEMI (p=0,827). Nilai PLR pasien SKA lebih tinggi dibandingkan dengan pembanding (p=0,037). Berdasarkanhasil penelitian didapatkan nilai PLR meningkat di SKA dibandingkan dengan kontrol normal. Nilai PLR di STEMI dan NSTEMI lebihtinggi dibandingkan UAP, kemungkinan berhubungan dengan pembentukan trombus dan infark miokard.
The The Relationship Between Body Image Satisfaction and Nutritional Status in Female Students of High School Walanda, Ryka M.; Natasya, Lulu; Harun, Haerani; Ramadhan, Muhammad Z.
Jurnal Akademika Kimia Vol. 14 No. 1 (2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2025.v14.i1.pp17-21

Abstract

In the adolescent phase, there is physical, social, and psychological development and growth. These changes will affect the way adolescents view and behave towards their body, known as body image. Appearance is important for adolescent girls, so most adolescent girls try to meet society's beauty standards by fasting, dieting, exercising, taking laxatives, and diet pills. The behavior of restricting diet and living an unhealthy lifestyle can affect adolescent nutrition, such as anemia, malnutrition, and obesity. This study aims to determine the relationship between body image satisfaction and nutritional status in SMA Negeri 5 Palu students. This study uses an observational analysis method with a cross-sectional design. The sample in this study amounted to 92 respondents. The sampling technique used was proportionate stratified random sampling. The bivariate analysis test used the Spearman test. The results of the Spearman test showed a p-value = 0.097 (p>0.05), which means that there is no relationship between body image satisfaction and nutritional status in SMA Negeri 5 Palu students. There is no relationship between body image satisfaction and nutritional status in female students of SMA Negeri 5 Palu.
Comparison of Neutrophile-to-Lymphocyte Ratio Between Dengue Haemorrhagic Fever and Dengue Shock Syndrome in Pediatric Patients at Anutapura Hospital Amri, Imtihanah; Rahma, Rahma; Hutasoit, Gina Andyka; Putri, Ayu Sekarani Damana; Harun, Haerani; Rasyid, Riyadh
Journal of Health and Nutrition Research Vol. 4 No. 1 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i1.360

Abstract

Dengue Hemorrhagic Fever (DHF) is an acute viral infectious disease that attacks the body. DHF is divided into 4 grades (I, II, III, IV), in which degrees 3 and 4 are also known as Dengue Shock Syndrome (DSS). When the disease severity is detected too late, it can be fatal. Therefore, a predictor or inflammatory marker is needed to detect and predict this. In this study, the inflammatory marker assessed is the NLR value. This study compares the neutrophil-lymphocyte ratio and the incidence of Dengue Hemorrhagic Fever and Dengue Shock Syndrome in pediatric patients at the Anutapura Regional Hospital, Central Sulawesi Province. This study uses an observational analytical method with a cross-sectional design using secondary data from medical records at the Anutapura Regional Hospital, Palu, in 2021-2023. The sample included is patients with a diagnosis of DHF, totaling 100 samples. The sampling technique used is random sampling. Based on the Mann-Whitney test, a significant difference (p = 0.001) was found in the NLR value between DHF and DSS. The mean NLR in DHF was lower (1.28 (±0.98 SD)) than in DSS (2.07 (±1.59 SD)). There was no significant relationship between age (p=0.217) and gender (p=0.597) in the DHF and DSS groups. It is then concluded that there is a significant difference in NLR values between DHF and DSS, where NLR values are lower in DHF and higher in DSS.
Blood Transfusion in Islam: An Integrative Analysis of Quranic Interpretation, Medical Ethics, and Social Perspectives Talebe, Tamrin; Harun, Haerani; Musyahidah, Sitti; Attamimi, Suraya
Journal of Health and Nutrition Research Vol. 4 No. 2 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i2.465

Abstract

This study examines the Islamic bioethical perspective on blood transfusion, a common medical procedure that raises ethical and religious concerns. The research analyzes Quranic verses, hadiths, Islamic jurisprudence, and scholarly interpretations to understand the Islamic stance on blood, its use in medical treatments, and the permissibility of blood transfusion. While blood is generally considered impure in Islam and its consumption is prohibited, exceptions are made for life-saving medical interventions. The study explores the Quranic and hadith-based concepts of blood, its various mentions and contexts in Islamic texts, and how these relate to modern medical practices. It also discusses the medical benefits and risks of blood transfusion, including its life-saving potential and possible complications, within the framework of medical ethics. The research highlights the Islamic principle of preserving life (hifdzu al nafs) and how it applies to blood transfusion. Social aspects, including blood donation as an act of solidarity and charity, are examined through an Islamic lens. The study concludes that blood transfusion is permissible in Islam when medically necessary, aligning with the religion's emphasis on preserving life and helping others. This research contributes to the growing field of Islamic bioethics in contemporary medical practices.
BACTERIAL IDENTIFICATION ON ESCALATOR HANDRAIL IN SHOPPING MALLS IN PALU Harun, Haerani; Sibarani, Deri Ezra; Asrinawaty, Andi Nur; Tulaka, Budi Dharmono
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1215

Abstract

Latar Belakang: Eskalator merupakan konveyer yang banyak digunakan untuk transportasi terutama dalam gedung besar. Kontak eskalator dengan manusia menyebabkan tertinggalnya jejak kuman termasuk bakteri pada pegangan eskalator yang berpotensi berpindah ke orang lain. Identifikasi bakteri pada pegangan eskalator diperlukan untuk menentukan potensi patogen yang dapat menyebabkan penyakit pada manusia. Tujuan: Mengidentifikasi jenis bakteri pada pegangan eskalator di pusat perbelanjaan di kota palu Metode: Penelitian merupakan penelitian observasional deskriptif dengan pengambilan sampel dengan cara total sampling. Sampel diambil dari pegangan eskalator di pusat perbelanjaan yang ada di kota palu. Hasil: Hasil kultur bakteri didapatkan 22% Staphylococcus aureus, 14% Serratia marcescens, 12% Escherichia coli, 12% Serratia sp, 8% Klebsiella sp, 4% Staphylococcus epidermidis, 4% Proteus sp, 4% Proteus penneri.
RASIO MONOSIT LIMFOSIT PADA PASIEN COVID-19 Harun, Haerani; Saptawinata, Aji; Towidjojo, Vera Diana; Anwar, Sarifuddin
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1263

Abstract

Latar belakang : Savere acute respiartory syndrome-corona virus 2 (SARS-CoV2) merupakan virus yang memiliki gejala sama seperti SARS dan MERS yang dapat menyerang manusia dengan melibatkan sistem kekebalan tubuh (Limfosit T, Limfosit B dan Monosit), sehingga perlu dilakukan analisis Rasio Monosit Limfosit yang memiliki nilai prognostik dalam menentukan kasus yang parah. Tujuan : Tujuan penelitian ini adalah untuk membandingkan Rasio Monosit Limfosit pada pasien COVID-19 PCR Positif dan PCR Negatif. Metode : Penelitian ini menggunakan desain penelitian Observasional analitik yang mengambil data sekunder, subjek pada penelitian ialah pasien suspek COVID-19 yang selanjutnya dibagi dalam 2 kelompok (PCR Positif dan PCR Negatif) dengan jumlah responden 30 orang dalam 1 kelompok. Hasil : Hasil penelitian didapatkan hitung jenis monosit lebih rendah pada pada kelompok PCR Positif dibandingkan PCR Negatif (p<0,03) dan terdapat peningkatan bermakna MLR (p=0,005) pada kelompok PCR Positif diabndingkan PCR Negatif. MLR pada kelompok PCR positif lebih tinggi dibandingkan kelompok PCR negatif
PERBANDINGAN LEUKOSIT DAN RASIO NEUTROFIL LIMFOSIT (RNL) PADA APENDISITIS KOMPLIKATA DAN NON KOMPLIKATA Harun, Haerani; Amri, Imtihanah; Tepu, Muhammad Husein; Tulaka, Budi Dharmono
Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran Vol. 9 No. 1 (2024): Maret
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/mtj.v9i1.1273

Abstract

Latar belakang: Apendisitis merupakan salah satu kasus tersering dalam bidang bedah abdomen yang menyebabkan nyeri abdomen akut dan memerlukan tindakan bedah segera. Apendiks dapat menimbulkan berbagai komplikasi apabila penegakkan diagnosis tidak dilakukan dengan segera. Komplikasi yang ditimbulkan seperti perforasi pada apendiks yang dapat membentuk massa atau abses sehingga penanganan dan durasi tindakan operasi akan lebih sulit dan lama. Leukosit merupakan penanda peradangan yang dapat digunakan untuk menilai komplikasi dari apendisitis. Tujuan: Mengetahui perbandingan leukosit dan RNL dengan kejadian apendisitis komplikata dan non-komplikata Metode: Penelitian ini adalah penelitian observasi analitik dengan pendekatan cross-sectional. Data Leukosit dan RNL dari pasien apendisitis diambil dari data rekam medis dan dibagi menjadi kempompok apendisitis komplikata dan apendisitis non komplikata. Leukosit dan RNL kemudian dibandingkan dengan uji Mann-Whitjney Hasil: Hasil yang diperoleh ditemukan perbedaan bermakna jumlah leukosit (p=0,006) dan nilai RNL p=0,000 antara apendisitis komplikata dan non komplikata. Kesimpulan: Jumlah leukosit dan RNL ditemukan lebih tinggi secara bermakna pada apendisitis komplikata dibandingkan dengan apendisitis non-komplikata.
The Effect of Memorizing The Quran on Improving Students' Academic Achievement Talebe, Tamrin; Sa’diah, Sa’diah; Harun, Haerani
Eduvest - Journal of Universal Studies Vol. 5 No. 1 (2025): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i1.43141

Abstract

In higher education institutions, the academic achievement of students is an important thing. Various activities and maximizing campus facilities are part of students' efforts to realize their best achievements. Against low academic achievement, a teacher is required to innovate learning and the various approaches used. One strategy that is often recommended by experts is through the strategy of memorizing the Qur'an. As the first step in the learning process, appropriate steps and techniques are needed and support the elements that influence it. The Qur'an and Tafsir Study Program at IAIN Palu has implemented a memorization system for its students to improve their academic achievement and the relationship of memorizing the Qur'an for Students of Qur'anic Science and Tafsir IAIN Palu.
Co-Authors Amany, Anisha Inas Andi Alfia Muthmainnah Tanra Anwar, Sarifuddin Asrawati Sofyan Asrinawaty, Andi Nur Benny Rusli, Benny Christin Rony Nayoan CS, Regina Ni Nyoman Darmawaty ER David Pakaya Gabriella Bamba Ratih Lintin Gina Andyka Hutasoit Imtihanah Amri Ipfi White Laurents Christovel Iban Demen Natasya, Lulu Nurhayana Sennang, Nurhayana Putri, Ayu Sekarani Damana Rahma Rahma Rahma Ramadhan, Muhammad Z. Rasyid, Riyadh Saptawinata, Aji Sarifuddin Anwar Sa’diah, Sa’diah Sibarani, Deri Ezra Sitti Musyahidah Suraya Attamimi Syamsul Arifin Tamrin Talebe Tepu, Muhammad Husein Tulaka, Budi Dharmono Uleng Bahrun Vera Diana Towidjojo Walanda, Ryka M.