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All Journal Jurnal Kesehatan Andalas Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Kesehatan Masyarakat Indonesia (JKMI)
Saptino Miro
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

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Kadar Amoniak Darah Pasien Sirosis Hati dengan Ensefalopati Hepatik Minimal Arnelis Arnelis; Andri Kurniawan; Nasrul Zubir; Saptino Miro; Vesri Yoga
Majalah Kedokteran Andalas Vol 45, No 2 (2022): Online April 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i2.p167-172.2022

Abstract

Ensefalopati Hepatik (EH) merupakan sindrom neuropsikiatri yang dapat terjadi pada penyakit hati akut dan kronik berat. Penelitian ini bertujuan untuk mengetahui kadar amoniak pasien sirosis hati dengan ensefalopati hepatick minimal pasien. Hasil penelitian menunjukkan bahwa dari 43 pasien yang diteliti, didapatkan 3(6,98%) pasien dengan kadar amoniak darah berada dalam nilai normal, sedangkan 40(93,02%) pasien mengalami peningkatan. Nilai amoniak paling tinggi didapatkan 67 µg/dL.  Dari penelitian ini dapat ditarik kesimpulan bahwa pada pasien sirosis dengan EHM terjadi peningkatan kadar ammonia darah.
Pankolitis Akibat Kolitis Ulseratif Afifah Amatullah; Saptino Miro
Health and Medical Journal Vol 3, No 2 (2021): HEME July 2021
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (525.168 KB) | DOI: 10.33854/heme.v3i2.653

Abstract

Introduction: Ulcerative colitis is a chronic disease affecting large intestine, characterized by rectal bleeding, diarrhea, abdominal pain, and could be accompanied by extraintestinal manifestation such as fever, anemia, and weight loss. Ulcerative colitis is causing an inflammation even ulceration of the rectum which can extend to proximal colon. The incidence of this disease is increasing worldwide and its frequency is variable depend on age, race and geographic area. Thorough history and examination are needed in diagnosing ulcerative colitis, since its symptoms are similar to many other gastrointestinal diseases. Definitive diagnosis of ulcerative colitis can be obtained by colonoscopy and histopathology. Case Report: We reported a case of 53 years old man who suffered from diarrhea and weight loss for one month before admission. There were also blood and mucus in his stool. The result of colonoscopy was hyperemia and ulcers along the rectum to the caecum. Histopathology examination showed pieces of intestinal mucosal tissue covered by columnar epithelium, with goblet cell and round-oval core. The lamina propria is densely packed with lymphocyte cells, plasma cells and PMN leukocytes. This result represents chronic colitis with acute exacerbation. Conclusion: Patient was treated with mesalazine 3x1000 mg per oral, methyl prednisolone 3x16 mg per oral, and low fiber diet to achieve remission.
Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang Husna Yetti; Nada Utami Prahastiwi; Restu Susanti; Eva Decroli; Saptino Miro
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 3 (2020): VOLUME 21, NUMBER 3, December 2020
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.035 KB) | DOI: 10.24871/2132020171-176

Abstract

Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients.Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD  at Dr. M. Djamil General Hospital from January 2016 – December 2018.Results: Seventy-seven patients were diagnosed with NAFLD. The majority of  NAFLD patients were male and female at 36-45 years old and female at 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78%  have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin.Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.
Serum Cystatin C Level in Liver Cirrhosis Patients with MELD-Na > 22 Arnelis Arnelis; Vesri Yoga; Nasrul Zubir; Saptino Miro; Andry Kurniawan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.832 KB) | DOI: 10.24871/2322022233-236

Abstract

Background: Hepatorenal syndrome is a part of the prerenal acute kidney injury (AKI) characterized by kidney dysfunction which is secondary to the decreased renal blood flow that occurs in liver cirrhosis with portal hypertension and is a fatal complication. Hepatorenal syndrome (HRS) occurs in about 20% of liver cirrhosis patients with refractory ascites.Method: This study was conducted on 24 liver cirrhosis patients with ascites who visited Gastroenterohepatology Outpatient Ward and Internal Medicine Inpatient Unit, Dr. M. Djamil Padang. Samples were collected and data analyses were conducted in December 2019 to March 2020.Results: In this study, the model for end-stage liver disease (MELD)-Na score was used to determine the risk of HRS in liver cirrhosis patients with ascites, in which patients with a MELD-Na score 22 belonged to the group at risk of developing HRS. From 24 patients, the mean MELD-Na score was 24.58 ± 3.5. The lowest MELD-Na score was 22 in 8 patients (33.3%), while 1 patient (4.2%) had the highest MELD-Na score of 35. In this study, serum CysC levels were measured in patients with normal creatinine, and the mean serum CysC level was 2.69 ± 0.46 mg/L. The minimum value of CysC was 2.03 mg/L, while the maximum value was 3.9 mg/L. Serum CysC levels in all 24 patients were increased compared to the normal values.Conclusion: Liver cirrhosis patients who were at risk to develop HRS based on the MELD-Na score have increased serum Cystatin C levels, although serum creatinine levels were still normal.
Gene X Two Triple Mutations Predominance on Chronic Hepatitis B Virus in Padang, West Sumatra Indonesia Afida Razuna Ave; Andani Eka Putra; Saptino Miro
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.082 KB) | DOI: 10.24871/2322022206-211

Abstract

Background: Hepatitis B is a health issue that become major problem worldwide with high morbidity. Hepatitis B is a liver infection that caused by Hepatitis B Virus. Chronic hepatitis B is a liver inflammation that lasted more than 6 months and it has the potential to progress to liver cirrhosis and hepatocellular cancer. The disease is influenced by Gene X and viral genotype. Mutations in the Gene X are suspected to having a role in disease progression. The aim of this study was to detect Gene X polymorphism and the phylogeny of HBV from Padang local clinical samples of chronic hepatitis B (CHB), West Sumatera, Indonesia.Method: The entire chronically HBV-infected patients were enrolled in this study: 38 CHB. The research samples were the entire Hepatitis B serum from Indonesian Red Cross Blood Bank than Gene X was amplified using nested PCR, which produced two fragments and aligned with X sequence database continued with mutation analysis. Results: In this study we found all the samples were having nucleotide variation. Of various mutations, we observed the presence of known liver cirrhosis and HCC-related HBx protein mutant i.e double mutations (HBx130 and HBx131) and two triple mutations (HBx5/HBx130/HBx131) and (HBx127/HBx130/HBx131) were high. The analysis also showed that patients were infected mainly by genotype C at 72,2% and followed by B at 27,8%.Conclusion: We conclude that all the samples have nucleotide variation and the mutation implying that molecular progression between the virus and the host at chronically infected patients.
Diagnosis and Management of Mirizzi Syndrome Related to Gallstones: A Narrative Literature Review Diego Lesgenia; Arnelis; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.703

Abstract

Mirizzi syndrome (MS) is a rare condition caused by compression of the common hepatic duct due to gallstones located in the cystic duct or neck of the gallbladder. Biliary pain, jaundice, and fever are the most common clinical manifestations of MS. Patients usually report a history of biliary pain with jaundice. There are no pathognomonic features in the history and physical examination. Patients may also come with acute cholecystitis, acute cholangitis, or pancreatitis. In cases where MS is suspected, the diagnosis can be made by ultrasonography (US), computed tomography (CT), magnetic resonance cholangiopancreatography (MRCP), and endoscopic retrograde cholangiopancreatography (ERCP). Surgery is the main treatment for cases of MS and is a challenge because preoperative diagnosis is difficult, thus impacting management during surgery. This literature review aimed to describe the features of MS related to gallstones and management options.
Lokasi Infark Memengaruhi Kejadian Kardiovaskular Mayor Pasien IMA-EST yang Menjalani Late Intervensi Koroner Perkutan Nandia Rizkita; Mefri Yanni; Saptino Miro
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 4 (2021): Desember 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v2i4.336

Abstract

Latar Belakang: Pasien IMA-EST akan mendapat manfaat dari tindakan IKP apabila dilakukan dalam waktu <12 jam setelah onset. Kejadian kardiovaskular mayor (KKM) merupakan gabungan dari hasil akhir gejala klinis yang sering terjadi pada pasien IMA-EST. Terdapat berbagai faktor yang dapat memengaruhi KKM pada pasien IMA-EST. Objektif: Mengetahui faktor-faktor yang memengaruhi KKM pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian kohort retrospektif. Data diperoleh dari rekam medik RSUP Dr. M. Djamil Padang dan wawancara via telpon. Analisis data dilakukan dengan analisis kesintasan dengan metode Kaplan-Meier. Hasil: Jenis KKM terbanyak pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang adalah kematian dan tindakan revaskularisasi berulang. Dari delapan faktor yang diteliti, hanya lokasi infark yang memiliki hubungan bermakna dengan KKM adalah (p=0.006). Kesimpulan: Faktor yang memengaruhi KKM pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang adalah lokasi infark.
Gambaran Kadar Glukosa Darah Puasa dan D-dimer pada Pasien Diabetes Tipe 2 Terkontrol Dwi Yulia; Saptino Miro; Zaki Ihsan Kamil
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.630

Abstract

Latar Belakang: Diabetes Melitus Tipe 2 (DM Tipe 2) adalah suatu kelompok penyakit metabolik yang terjadi karena kelainan kerja insulin, sekresi insulin atau kedua-duanya dengan karakteristik hiperglikemia. Peningkatan kadar glukosa darah puasa (GDP) dan D-dimer dapat ditemukan dalam perjalanan penyakit DM Tipe 2. Objektif: Penelitian bertujuan untuk mengetahui gambaran kadar GDP dan D-dimer pada pasien DM tipe 2 terkontrol. Metode: Penelitian deskriptif kuantitatif dengan pendekatan cross sectional menggunakan data sekunder pasien DM tipe 2 yang dilakukan pemeriksaan kadar GDP dan D-dimer. Sampel penelitian ini adalah pasien DM tipe 2 dengan HbA1c terkontrol (≤ 6.5 %) di Rumah Sakit Umum Daerah (RSUD) Prof. Dr. M Ali Hanafiah Batusangkar, Kabupaten Tanah Datar sebanyak 20 pasien. Waktu penelitian bulan November 2020 – April 2021. Analisis univariat dengan distribusi, persentase dan frekuensi dari masing-masing variabel yang disajikan dalam bentuk tabel. Hasil: Penelitian menunjukkan bahwa kejadian DM tipe 2 banyak terjadi pada perempuan (60%) dan berdasarkan umur pada rentang umur 46 – 55 tahun (35%). Rerata untuk kadar GDP pasien DM Tipe 2 terkontrol sebesar 118.60±33.014 mg/dL dengan 14 pasien mengalami peningkatan. Rerata untuk kadar D-dimer sebesar 432±205.348 ug/dL dengan 9 pasien mengalami peningkatan. Kesimpulan: Pada pasien Diabetes Melitus Tipe 2 terkontrol didapatkan rerata kadar GDP meningkat dan kadar D-dimer dalam batas normal.
Risiko Perdarahan Saluran Cerna pada Pasien COVID-19 berdasarkan Jenis Obat Antivirus di Rumah Sakit Umum Pusat Dr. M. Djamil Padang Arnelis Arnelis; Saptino Miro; Nasrul Zubir; Vesri Yoga; Andry Kurniawan; Alexander Kam; Abdul Alim Rahimi; Jersivindo Ranazeri; R. Ifan Arief Fahrurozi
Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2042

Abstract

Coronavirus disease 2019 (COVID-19) has become a global pandemic to date. Some studies reported gastrointestinal tract (GIT) bleeding occurs in several patients hospitalized with COVID-19. Medications known to be associated with an increased risk of GIT bleeding were not associated with GIT bleeding in COVID-19 patients. Objectives: To examined the risk of gastrointestinal tract (GIT) bleeding in COVID-19 patients based on antiviral drugs at Dr. M. Djamil General Hospital Padang. Methods: A nested cohort study was conducted in Dr. M. Djamil General Hospital Padang from May until October 2021. All COVID-19 patients who received antiviral drugs with GIT bleeding with onset days 0 - 7 were included. COVID-19 was confirmed by RT-PCR swab. Data entry and analysis were conducted by computerized. Results: 30 patients were involved in this study. 43,3% COVID-19 Moderate stage and 56,7% Severe stage. 63,3% were treated with remdesivir and 36,7% were treated with favipiravir. Onset on GIT tract bleeding at day 4 (23,3%), day 5 (26.7%), day 6 (30%), and day 7 (20%). The Chi-square test to determine the factors associated with GIT bleeding in COVID-19 patients including COVID-19 severity, type of antiviral drugs, anticoagulant, and corticosteroid revealed that none of all potential factors above related to GI bleeding. Conclusion: The type of antiviral drugs was not related to GIT bleeding in COVID-19 patients.Keywords: antiviral drugs,  COVID-19, gastrointestinal tract bleeding
Relationship between Albumin Levels and the Incidence of Ascites in Patients with Liver Cirrhosis Vesri Yoga; Arnelis; Nasrul Zubir; Saptino Miro; Andry Kurniawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.739

Abstract

Background: Patients with cirrhosis often develop hypoalbuminemia. In conditions of hepatic dysfunction, albumin synthesis is decreased due to hepatic dysfunction and abnormal distribution of portal blood flow. Ascites is a major complication and an important sign in the course of cirrhosis and is associated with 50% mortality after two years. 75% of patients' ascites etiology is liver cirrhosis, 10% malignancy, 3% heart failure, 2% tuberculosis, 1% pancreatitis, and others. Methods: This cross-sectional study was conducted from the medical records of patients with liver cirrhosis who were treated at the internal medicine section of Dr. M Djamil General Hospital, Padang, in 2015-2020. Patients with heart defects, malignancy, tuberculosis, pancreatitis, kidney failure, and incomplete medical record data were excluded from the study. Patients were grouped according to the presence or absence of ascites and albumin levels. Analysis using the chi-square test in 2020. Results: From 225 cases, 103 cases were analyzed. 77 were men (74.8%), and 26 were women (25.2%). The age of the patient was in the range of 40-60 years. No ascites were found in 30 people (29.1%), and 73 people (70.9%) had ascites. From normal albumin levels, five were without ascites, and four were with ascites. On mild hypoalbumin, 13 had no ascites, and 38 people had ascites. On severe hypoalbumin, 12 people were without ascites and 31 with ascites. A chi-square test was analyzed, and it was found that there was no relationship between the incidence of ascites and albumin levels (p 0.182). Conclusion: The incidence of ascites is not related to blood albumin levels.
Co-Authors Abd. Rasyid Syamsuri Abdul Alim Rahimi Ade Asyari Afida Razuna Ave Afifah Amatullah Alexander Kam Alexander Kam Alika Ristama Nigandiva Almurdi Almurdi Andani Eka Putra Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Angela Lovena Annisa Ul Husni Arina Widya Murni Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Asrining Tyas Asterina Asterina Bayu Gemilang Daan Khambr Deka Viotra Delmi Sulastri Detty Iryani Dia Rofinda, Zelly Dia Dian Pertiwi Diego Lesgenia Dina Arfiani Rusjdi Dinda Aprillia Dinda Aprillia Dwi Yulia Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Eka Kurniawan Elmatris Sy Emil Prasetyo Muhammad Endrinaldi Eti Yerizel Eva Decroli Fadhil Alfino Azmi Fauzar Fauzar Fauzar Fauzar Fisca Syofi Arrasyi Hendra Saputra Husna Yetti Jersivindo Ranazeri Mefri Yanni Nada Utami Prahastiwi Najirman Najirman Nandia Rizkita Nasrul Zubir Nasrul Zubir Nasrul Zubir Nasrul Zubir Novita Ariani Putri Reno Indrisia Putri Wahyuni Putri, Septia Harma R. Ifan Arief Fahrurozi Rahmatini . Raveinal Raveinal RAVEINAL RAVEINAL Restu Susanti Rikarni Rikarni Rivani Sintia Suratman Rivo Armanda Satria Rony Rustam Roza Kurniati Roza Kurniati Roza Mulyana Rudy Afriant Sherly Febrina Suri Hanifa Efendi Vella Paraditha Vesri Yoga Vesri Yoga Yanwirasti Yanwirasti Yustini Alioes Zaki Ihsan Kamil