Articles
<![CDATA[Kadar Amoniak Darah Pasien Sirosis Hati dengan Ensefalopati Hepatik Minimal ]]>
<![CDATA[Arnelis Arnelis]]>;
<![CDATA[Andri Kurniawan]]>;
<![CDATA[Nasrul Zubir]]>;
<![CDATA[Saptino Miro]]>;
<![CDATA[Vesri Yoga]]>
<![CDATA[ Majalah Kedokteran Andalas Vol 45, No 2 (2022): Online April 2022 ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Andalas ]]>
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DOI: 10.25077/mka.v45.i2.p167-172.2022
<![CDATA[Ensefalopati Hepatik (EH) merupakan sindrom neuropsikiatri yang dapat terjadi pada penyakit hati akut dan kronik berat. Penelitian ini bertujuan untuk mengetahui kadar amoniak pasien sirosis hati dengan ensefalopati hepatick minimal pasien. Hasil penelitian menunjukkan bahwa dari 43 pasien yang diteliti, didapatkan 3(6,98%) pasien dengan kadar amoniak darah berada dalam nilai normal, sedangkan 40(93,02%) pasien mengalami peningkatan. Nilai amoniak paling tinggi didapatkan 67 µg/dL. Dari penelitian ini dapat ditarik kesimpulan bahwa pada pasien sirosis dengan EHM terjadi peningkatan kadar ammonia darah.]]>
<![CDATA[Pankolitis Akibat Kolitis Ulseratif ]]>
<![CDATA[Afifah Amatullah]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ Health and Medical Journal Vol 3, No 2 (2021): HEME July 2021 ]]>
Publisher : <![CDATA[Universitas Baiturrahmah ]]>
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DOI: 10.33854/heme.v3i2.653
<![CDATA[Introduction: Ulcerative colitis is a chronic disease affecting large intestine, characterized by rectal bleeding, diarrhea, abdominal pain, and could be accompanied by extraintestinal manifestation such as fever, anemia, and weight loss. Ulcerative colitis is causing an inflammation even ulceration of the rectum which can extend to proximal colon. The incidence of this disease is increasing worldwide and its frequency is variable depend on age, race and geographic area. Thorough history and examination are needed in diagnosing ulcerative colitis, since its symptoms are similar to many other gastrointestinal diseases. Definitive diagnosis of ulcerative colitis can be obtained by colonoscopy and histopathology. Case Report: We reported a case of 53 years old man who suffered from diarrhea and weight loss for one month before admission. There were also blood and mucus in his stool. The result of colonoscopy was hyperemia and ulcers along the rectum to the caecum. Histopathology examination showed pieces of intestinal mucosal tissue covered by columnar epithelium, with goblet cell and round-oval core. The lamina propria is densely packed with lymphocyte cells, plasma cells and PMN leukocytes. This result represents chronic colitis with acute exacerbation. Conclusion: Patient was treated with mesalazine 3x1000 mg per oral, methyl prednisolone 3x16 mg per oral, and low fiber diet to achieve remission.]]>
<![CDATA[Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang ]]>
<![CDATA[Husna Yetti]]>;
<![CDATA[Nada Utami Prahastiwi]]>;
<![CDATA[Restu Susanti]]>;
<![CDATA[Eva Decroli]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 21, No 3 (2020): VOLUME 21, NUMBER 3, December 2020 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
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DOI: 10.24871/2132020171-176
<![CDATA[Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients.Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD at Dr. M. Djamil General Hospital from January 2016 – December 2018.Results: Seventy-seven patients were diagnosed with NAFLD. The majority of NAFLD patients were male and female at 36-45 years old and female at 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78% have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin.Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.]]>
<![CDATA[Serum Cystatin C Level in Liver Cirrhosis Patients with MELD-Na > 22 ]]>
<![CDATA[Arnelis Arnelis]]>;
<![CDATA[Vesri Yoga]]>;
<![CDATA[Nasrul Zubir]]>;
<![CDATA[Saptino Miro]]>;
<![CDATA[Andry Kurniawan]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
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DOI: 10.24871/2322022233-236
<![CDATA[Background: Hepatorenal syndrome is a part of the prerenal acute kidney injury (AKI) characterized by kidney dysfunction which is secondary to the decreased renal blood flow that occurs in liver cirrhosis with portal hypertension and is a fatal complication. Hepatorenal syndrome (HRS) occurs in about 20% of liver cirrhosis patients with refractory ascites.Method: This study was conducted on 24 liver cirrhosis patients with ascites who visited Gastroenterohepatology Outpatient Ward and Internal Medicine Inpatient Unit, Dr. M. Djamil Padang. Samples were collected and data analyses were conducted in December 2019 to March 2020.Results: In this study, the model for end-stage liver disease (MELD)-Na score was used to determine the risk of HRS in liver cirrhosis patients with ascites, in which patients with a MELD-Na score 22 belonged to the group at risk of developing HRS. From 24 patients, the mean MELD-Na score was 24.58 ± 3.5. The lowest MELD-Na score was 22 in 8 patients (33.3%), while 1 patient (4.2%) had the highest MELD-Na score of 35. In this study, serum CysC levels were measured in patients with normal creatinine, and the mean serum CysC level was 2.69 ± 0.46 mg/L. The minimum value of CysC was 2.03 mg/L, while the maximum value was 3.9 mg/L. Serum CysC levels in all 24 patients were increased compared to the normal values.Conclusion: Liver cirrhosis patients who were at risk to develop HRS based on the MELD-Na score have increased serum Cystatin C levels, although serum creatinine levels were still normal.]]>
<![CDATA[Gene X Two Triple Mutations Predominance on Chronic Hepatitis B Virus in Padang, West Sumatra Indonesia ]]>
<![CDATA[Afida Razuna Ave]]>;
<![CDATA[Andani Eka Putra]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 2 (2022): VOLUME 23, NUMBER 2, August 2022 ]]>
Publisher : <![CDATA[The Indonesian Society for Digestive Endoscopy ]]>
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DOI: 10.24871/2322022206-211
<![CDATA[Background: Hepatitis B is a health issue that become major problem worldwide with high morbidity. Hepatitis B is a liver infection that caused by Hepatitis B Virus. Chronic hepatitis B is a liver inflammation that lasted more than 6 months and it has the potential to progress to liver cirrhosis and hepatocellular cancer. The disease is influenced by Gene X and viral genotype. Mutations in the Gene X are suspected to having a role in disease progression. The aim of this study was to detect Gene X polymorphism and the phylogeny of HBV from Padang local clinical samples of chronic hepatitis B (CHB), West Sumatera, Indonesia.Method: The entire chronically HBV-infected patients were enrolled in this study: 38 CHB. The research samples were the entire Hepatitis B serum from Indonesian Red Cross Blood Bank than Gene X was amplified using nested PCR, which produced two fragments and aligned with X sequence database continued with mutation analysis. Results: In this study we found all the samples were having nucleotide variation. Of various mutations, we observed the presence of known liver cirrhosis and HCC-related HBx protein mutant i.e double mutations (HBx130 and HBx131) and two triple mutations (HBx5/HBx130/HBx131) and (HBx127/HBx130/HBx131) were high. The analysis also showed that patients were infected mainly by genotype C at 72,2% and followed by B at 27,8%.Conclusion: We conclude that all the samples have nucleotide variation and the mutation implying that molecular progression between the virus and the host at chronically infected patients.]]>
<![CDATA[Lokasi Infark Memengaruhi Kejadian Kardiovaskular Mayor Pasien IMA-EST yang Menjalani Late Intervensi Koroner Perkutan ]]>
<![CDATA[Nandia Rizkita]]>;
<![CDATA[Mefri Yanni]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ Jurnal Ilmu Kesehatan Indonesia Vol 2 No 4 (2021): Desember 2021 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jikesi.v2i4.336
<![CDATA[Latar Belakang: Pasien IMA-EST akan mendapat manfaat dari tindakan IKP apabila dilakukan dalam waktu <12 jam setelah onset. Kejadian kardiovaskular mayor (KKM) merupakan gabungan dari hasil akhir gejala klinis yang sering terjadi pada pasien IMA-EST. Terdapat berbagai faktor yang dapat memengaruhi KKM pada pasien IMA-EST. Objektif: Mengetahui faktor-faktor yang memengaruhi KKM pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang. Metode: Penelitian ini merupakan penelitian kohort retrospektif. Data diperoleh dari rekam medik RSUP Dr. M. Djamil Padang dan wawancara via telpon. Analisis data dilakukan dengan analisis kesintasan dengan metode Kaplan-Meier. Hasil: Jenis KKM terbanyak pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang adalah kematian dan tindakan revaskularisasi berulang. Dari delapan faktor yang diteliti, hanya lokasi infark yang memiliki hubungan bermakna dengan KKM adalah (p=0.006). Kesimpulan: Faktor yang memengaruhi KKM pada pasien IMA-EST yang menjalani late IKP di RSUP Dr. M. Djamil Padang adalah lokasi infark.]]>
<![CDATA[Gambaran Kadar Glukosa Darah Puasa dan D-dimer pada Pasien Diabetes Tipe 2 Terkontrol ]]>
<![CDATA[Dwi Yulia]]>;
<![CDATA[Saptino Miro]]>;
<![CDATA[Zaki Ihsan Kamil]]>
<![CDATA[ Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jikesi.v3i1.630
<![CDATA[Latar Belakang: Diabetes Melitus Tipe 2 (DM Tipe 2) adalah suatu kelompok penyakit metabolik yang terjadi karena kelainan kerja insulin, sekresi insulin atau kedua-duanya dengan karakteristik hiperglikemia. Peningkatan kadar glukosa darah puasa (GDP) dan D-dimer dapat ditemukan dalam perjalanan penyakit DM Tipe 2. Objektif: Penelitian bertujuan untuk mengetahui gambaran kadar GDP dan D-dimer pada pasien DM tipe 2 terkontrol. Metode: Penelitian deskriptif kuantitatif dengan pendekatan cross sectional menggunakan data sekunder pasien DM tipe 2 yang dilakukan pemeriksaan kadar GDP dan D-dimer. Sampel penelitian ini adalah pasien DM tipe 2 dengan HbA1c terkontrol (≤ 6.5 %) di Rumah Sakit Umum Daerah (RSUD) Prof. Dr. M Ali Hanafiah Batusangkar, Kabupaten Tanah Datar sebanyak 20 pasien. Waktu penelitian bulan November 2020 – April 2021. Analisis univariat dengan distribusi, persentase dan frekuensi dari masing-masing variabel yang disajikan dalam bentuk tabel. Hasil: Penelitian menunjukkan bahwa kejadian DM tipe 2 banyak terjadi pada perempuan (60%) dan berdasarkan umur pada rentang umur 46 – 55 tahun (35%). Rerata untuk kadar GDP pasien DM Tipe 2 terkontrol sebesar 118.60±33.014 mg/dL dengan 14 pasien mengalami peningkatan. Rerata untuk kadar D-dimer sebesar 432±205.348 ug/dL dengan 9 pasien mengalami peningkatan. Kesimpulan: Pada pasien Diabetes Melitus Tipe 2 terkontrol didapatkan rerata kadar GDP meningkat dan kadar D-dimer dalam batas normal.]]>
<![CDATA[Risiko Perdarahan Saluran Cerna pada Pasien COVID-19 berdasarkan Jenis Obat Antivirus di Rumah Sakit Umum Pusat Dr. M. Djamil Padang ]]>
<![CDATA[Arnelis Arnelis]]>;
<![CDATA[Saptino Miro]]>;
<![CDATA[Nasrul Zubir]]>;
<![CDATA[Vesri Yoga]]>;
<![CDATA[Andry Kurniawan]]>;
<![CDATA[Alexander Kam]]>;
<![CDATA[Abdul Alim Rahimi]]>;
<![CDATA[Jersivindo Ranazeri]]>;
<![CDATA[R. Ifan Arief Fahrurozi]]>
<![CDATA[ Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jka.v11i2.2042
<![CDATA[Coronavirus disease 2019 (COVID-19) has become a global pandemic to date. Some studies reported gastrointestinal tract (GIT) bleeding occurs in several patients hospitalized with COVID-19. Medications known to be associated with an increased risk of GIT bleeding were not associated with GIT bleeding in COVID-19 patients. Objectives: To examined the risk of gastrointestinal tract (GIT) bleeding in COVID-19 patients based on antiviral drugs at Dr. M. Djamil General Hospital Padang. Methods: A nested cohort study was conducted in Dr. M. Djamil General Hospital Padang from May until October 2021. All COVID-19 patients who received antiviral drugs with GIT bleeding with onset days 0 - 7 were included. COVID-19 was confirmed by RT-PCR swab. Data entry and analysis were conducted by computerized. Results: 30 patients were involved in this study. 43,3% COVID-19 Moderate stage and 56,7% Severe stage. 63,3% were treated with remdesivir and 36,7% were treated with favipiravir. Onset on GIT tract bleeding at day 4 (23,3%), day 5 (26.7%), day 6 (30%), and day 7 (20%). The Chi-square test to determine the factors associated with GIT bleeding in COVID-19 patients including COVID-19 severity, type of antiviral drugs, anticoagulant, and corticosteroid revealed that none of all potential factors above related to GI bleeding. Conclusion: The type of antiviral drugs was not related to GIT bleeding in COVID-19 patients.Keywords: antiviral drugs, COVID-19, gastrointestinal tract bleeding]]>
<![CDATA[Hubungan Lama Penggunaan Obat Antiinflamasi Nonsteroid dengan Kejadian Dispepsia pada Pasien Osteoartritis di Puskesmas Andalas Kota Padang ]]>
<![CDATA[Sherly Febrina]]>;
<![CDATA[Rahmatini Rahmatini]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ Jurnal Ilmu Kesehatan Indonesia Vol 4 No 1 (2023): Maret 2023 ]]>
Publisher : <![CDATA[Fakultas Kedokteran, Universitas Andalas ]]>
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DOI: 10.25077/jikesi.v4i1.929
<![CDATA[Latar Belakang: Obat antiinflamasi nonsteroid (OAINS) adalah obat yang mempunyai efek analgetik, antiinflamasi, dan anti piretik yang penggunaannya sangat umum di masyarakat. Salah satu penggunaan OAINS yang paling sering adalah pada pasien osteoartritis (OA), dimana pengobatan OA berfokus pada pengurangan gejala yaitu nyeri. Penyakit ini merupakan penyakit persendian yang paling umum ditemui secara global. Obat antiinflamasi nonsteroid merupakan faktor agresif eksogen yang dapat merusak mukosa saluran cerna dikenal dengan istilah gastropati yang menimbulkan dispepsia. Sebagian penelitian menunjukkan bahwa risiko kejadian dispepsia berhubungan dengan lama penggunaan OAINS, sedangkan penelitian lain mengatakan tidak. Objektif: Penelitian ini dilakukan untuk mengetahui hubungan antara lama penggunaan OAINS dengan kejadian dispepsia pada pasien OA di Puskesmas Andalas Kota Padang. Metode: Jenis penelitian ini adalah penelitian analitik observasional dengan desain cross sectional yang dilakukan di Puskesmas Andalas Kota Padang dengan jumlah responden sebanyak 74. Instrumen penelitian adalah kuesioner dan rekam medis. Data dianalisis menggunakan uji statstik Chi-square. Hasil: Hasil penelitian menunjukkan mayoritas responden adalah perempuan, usia >60 tahun, telah menggunakan OAINS >3-6 bulan, dan terdapat 50% pasien yang mengalami dispepsia. Analisis bivariat menunjukkan adanya hubungan signifikan antara lama penggunaan OAINS dengan kejadian dispepsia pada pasien OA di Puskesmas Andalas Kota Padang. Kesimpulan: Terdapat hubungan antara lama penggunaan OAINS dengan kejadian dispepsia pada pasien OA di Puskesmas Andalas Kota Padang.]]>
<![CDATA[HB E / Thalassemia Beta ]]>
<![CDATA[Saputra, Hendra]]>;
<![CDATA[Saptino Miro]]>
<![CDATA[ Ranah Research : Journal of Multidisciplinary Research and Development Vol. 7 No. 2 (2025): Ranah Research : Journal Of Multidisciplinary Research and Development ]]>
Publisher : <![CDATA[Dinasti Research ]]>
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DOI: 10.38035/rrj.v7i2.1349
<![CDATA[Thalassemia is a blood disorder which characterized with decreased or absence of globin chain in red blood cell thus disrupted hemoglobin synthesis. Hb E/ β-Thalassemia is a thalassemia syndrome of intermedia severity with a very heterogeneous clinical spectrum. The most presented sign and symptoms in Hb E/ β-Thalassemia are pallor and abdominal mass enlargement. One of the most accurate and fast methods to diagnose thalassemia is High Performance Liquid Chromatography. Hb E/ β-Thalassemia based on clinical severity, can start with blood transfusions, and when serum ferritin level increased, it can also begin with iron chelation therapy to prevent complication from iron overload in the body. We have reported a case of a 28-year-old patient diagnosed with Hb E/ β-Thalassemia, with hemoglobin level is 5,1 g/dL and serum ferritin 1029 ng/mL, started to treat with blood transfusions and iron chelation therapy. Early detection on Hb E/ β-Thalassemia patient will give better outcome to prevent complications caused by the disease it self or treatment given.]]>
