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All Journal Jurnal Kesehatan Andalas Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Kesehatan Masyarakat Indonesia (JKMI)
Saptino Miro
Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary Other

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EDUKASI DAN PEMERIKSAAN KESEHATAN MASYARAKAT DI KAMPUNG BATU BUSUK KECAMATAN PAUH KOTA PADANG Saptino Miro; Najirman Najirman; Dinda Aprillia; Fauzar Fauzar; Andry Kurniawan; Zelly Dia Rofinda
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 5 No. 1 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i1.391

Abstract

Non-contagious diseases have continued to increase over the years. In 2016, about 71 percent of the world's causes of death were non-contagious diseases (NCD) that kill 36 million people annually. Major risk factors of the non-contagious disease are metabolic factors, behavioral factors, and environmental factors. Riskesdas 2018 shows the prevalence of non-contagious diseases increasing compared with Riskesdas 2013, including cancer, stroke, chronic kidney disease, diabetes mellitus, and hypertension. The purpose of this activity is to increase promotive and preventive effort and education in the community, as well as improved screening and early detection through health education, blood pressure, blood sugar, cholesterol levels, and the abdominal ultrasound of society in Kampung Batu Busuk, Kelurahan Limau Manis, Kecamatan Pauh, Padang on Saturday, November 13th, 2021. Such activities include medical examinations of blood pressure, cholesterol, blood sugar, and abdominal ultrasound. From the activity of the examination of the health of 41 persons, 13 were hypertensive, 2 (32%) were hyperglycemia, 24 (58.5 percent) were dyslipidemia, and 6 were fatty liver. To counter the problem of non-contagious diseases, comprehensive and holistic intervention efforts must be made, that is, promotive, preventive, curative, and rehabilitative, as a unified continum of care. Disorders that are not treatable during an activity are recommended for treatment at a nearby health care center.
EDUKASI COVID-19 DAN VAKSINASI BAGI MASYARAKAT DI KAMPUNG BATU BUSUAK KECAMATAN PAUH KOTA PADANG Saptino Miro; Roza Kurniati; Dwitya Elvira; Arina Widya Murni; Raveinal Raveinal; Alexander Kam
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 5 No. 1 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i1.398

Abstract

Infectious diseases are still a major health issue that requires serious treatment. The covid-19 is now one of the significant infectious diseases worldwide marked by rapid contagion and global spread. The world health organization (who) has defined covid-19 as a global pandemic and the government has set public health emergencies in Indonesia, obliging countermeasures. The covid-19 countermeasures should continue massively with several strategies. In addition to promotive strategies and the application of health protocols, another effective strategy is needed to break off the chain of disease transmission through vaccination efforts. The purpose of the activity is to do the education about covid-19 and the covid-19 vaccination of the people in Kampung Batu Busuak, Kelurahan Limau Manis, Kecamatan Pauh, Padang. The implementation of this activity includes the counseling of covid-19 and the covid-19 vaccination on Saturday, November 13th, 2021. Before counseling, the Questionnaire was issued to assess a public knowledge level on covid-19 and a covid-19 vaccination. From a questionnaire on covid-19 and covid-19 vaccination, the total of people who have already been vaccinated twice is 22 people and 4 with the covid-19 vaccine once. Therefore, still needed counseling about covid-19 and covid-19 vaccination to enhance awareness of the society towards the importance of covid-19 vaccination.
Giant Gastric GIST Manifesting as Profound Iron Deficiency Anemia: A Case Report of a Diagnostic Pitfall Suri Hanifa Efendi; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1366

Abstract

Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract, yet they remain rare, particularly in patients under 40. Their clinical presentation is highly variable, often posing a diagnostic challenge. Severe anemia as the initial manifestation is common, but diagnostic confusion with benign lesions on initial biopsy is a significant clinical pitfall. Case presentation: A 39-year-old male presented with a three-month history of epigastric pain, early satiety, significant weight loss, and profound fatigue. His initial hemoglobin was a life-threatening 3.8 g/dL, consistent with profound iron deficiency anemia. Esophagogastroduodenoscopy (EGD) revealed a large, partially obstructing mass in the gastric corpus. However, initial endoscopic biopsies were paradoxically reported as a benign hyperplastic polyp. In contrast, contrast-enhanced computed tomography (CT) of the abdomen characterized a massive, 9.9 x 7.3 x 13.5 cm heterogeneously enhancing mass suggestive of malignancy. Given the stark discrepancy between imaging and histology, a decision was made for surgical intervention. The patient underwent a total gastrectomy. Final histopathological analysis of the resected specimen, supported by immunohistochemistry, confirmed a high-risk gastrointestinal stromal tumor with a high mitotic rate. Conclusion: This case underscores the critical importance of maintaining a high index of suspicion for GIST in patients with unexplained iron deficiency anemia, even in younger age groups. It highlights the potential for sampling error with endoscopic biopsies of large submucosal tumors, which can lead to dangerously misleading diagnoses. Clinicians must integrate clinical, radiological, and endoscopic findings to guide management, especially when histopathological results are incongruent with the overall clinical picture.
Demographic, Clinical, and Treatment Factors That Affect the Five Years Survival of Thyroid Cancer Patients Alika Ristama Nigandiva; Daan Khambr; Saptino Miro; Novita Ariani; Rony Rustam; Dina Arfiani Rusjdi
Jurnal Kesehatan Masyarakat Indonesia (JKMI) Vol. 1 No. 3 (2024): April
Publisher : Publikasi Inspirasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62017/jkmi.v1i3.1018

Abstract

Thyroid cancer is the most common malignancy of the endocrine glands, the incidence of thyroid cancer in Indonesia ranks ninth after other types of cancer, it is known that the survival rate of thyroid cancer is better when compared to other types of cancer because thyroid cancer has a slow growth rate. Several demographic factors such as age and gender, clinical factors and treatments factors can affect the survival rate of thyroid cancer patients. This study was conducted to analyze the influence of demographic, clinical, and management factors on thyroid cancer survival rates at Dr. M. Djamil Padang Hospital. This study is an observational analytic study with a retrospective cross-sectional design. Sampling was done by total sampling technique. Data collection is done through patient medical record data. The results showed a five-year survival rate for thyroid cancer of 86.7%. Age, histopathological type, metastases, tumor extension, and management were significantly related to survival (p=0.013) (p=0.000), (p=0.001), (p=0.000) and (p=0.001).  Factors that have a significant relationship with survival rate are age, histopathological type, tumor extension, treatment, and metastases, and those that most influence survival rate are non-operative management and regional extension
Diagnosis and Current Management of Hepatocellular Carcinoma Satria, Rivo Armanda; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.945

Abstract

Hepatocellular carcinoma (HCC) is a primary malignant liver tumor originating from hepatocytes which has a very poor prognosis and is ranked the sixth most common cancer disease in the world and is ranked third in deaths caused by cancer worldwide. Symptoms of underlying liver diseases such as hepatitis and cirrhosis often disguise the diagnosis of HCC so that most cases are discovered at an advanced stage. The examination modalities commonly used in surveillance are liver ultrasound (USG) examination and measurement of alpha levels fetoprotein (AFP) with sensitivity diagnostic up to 90%. Non-invasive imaging plays an important role in objective recognition and staging enforcement diagnosis as early as possible so that the patient's prognosis is better. Treatment for early-stage HCC can be given through curative therapy such as resection, liver transplantation, and local ablation, but disease at an advanced stage causes limited options in management where governance The current focus is on systemic therapy with a focus on a combination strategy of immunotherapy or a combination of targeted therapy with immunotherapy as the first line.
Management of Thrombocytopenia with Partial Splenic Embolization in Liver Cirrhosis Putri, Septia Harma; Arnelis; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1015

Abstract

Thrombocytopenia is a frequent complication in patients with cirrhosis. Thrombocytopenia is generally divided into mild, moderate, and severe thrombocytopenia. Thrombocytopenia in liver cirrhosis not only increases the risk of bleeding during surgery but can also have an impact on patient management, such as liver biopsy, administration of antiviral therapy, and postponement of elective surgery. The pathophysiology of thrombocytopenia in chronic liver disease can be caused by decreased platelet production, sequestration in the spleen, and increased platelet destruction. Partial splenic embolization (PSE) is one option for treating thrombocytopenia in chronic liver disease. PSE is an effective procedure in treating complications associated with hypersplenism and portal hypertension, such as esophageal varices, pancytopenia, portal hypertensive gastropathy and ascites.
Argon Plasma Coagulation for Proctitis: A Meta-Analysis Fisca Syofi Arrasyi; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1156

Abstract

Background: Proctitis, encompassing various etiologies, significantly diminishes patient quality of life. Argon plasma coagulation (APC) has emerged as a potential therapeutic modality, yet its efficacy and safety profile remain to be fully elucidated. This meta-analysis aimed to rigorously evaluate the effectiveness and safety of APC across diverse proctitis subtypes. Methods: A comprehensive search of PubMed, Embase, and the Cochrane Library databases was conducted, spanning 2013 to 2023, to identify pertinent studies. Randomized controlled trials (RCTs) and observational studies comparing APC with alternative treatments or placebo in proctitis management were included. The primary outcome was clinical improvement, defined as symptom reduction or amelioration of endoscopic findings. Secondary outcomes encompassed adverse events and quality of life metrics. Results: A total of 15 studies (5 RCTs and 10 observational studies) encompassing 2042 patients met the inclusion criteria. APC demonstrated a significant association with clinical response improvement compared to other treatments or placebo (OR 2.58, 95% CI 2.14-3.12, p<0.001). Subgroup analysis revealed APC's efficacy in both radiation-induced and non-radiation-induced proctitis. Adverse event incidence was comparable between APC and other treatments, with no significant differences in severe complications. Conclusion: APC appears to be an effective and safe therapeutic option for various proctitis subtypes, warranting consideration in clinical practice.
Pharmacological and Interventional Approaches to Ascites Management in Cirrhosis: A Meta-Analysis Annisa Ul Husni; Saptino Miro
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1231

Abstract

Background: Ascites, a common complication of cirrhosis, significantly impacts patient morbidity and mortality. This meta-analysis evaluated the efficacy and safety of various pharmacological and interventional approaches for ascites management in patients with cirrhosis. Methods: A systematic search of PubMed, Embase, and Cochrane Library databases was conducted from January 2013 to December 2024, identifying randomized controlled trials (RCTs) comparing different pharmacological agents (diuretics, albumin, vasopressin receptor antagonists) and interventional procedures (large-volume paracentesis, transjugular intrahepatic portosystemic shunt [TIPS]) in cirrhotic patients with ascites. The primary outcome was complete ascites resolution. Secondary outcomes included time to ascites recurrence, adverse events, and mortality. A random-effects model was used to pool data, and heterogeneity was assessed using the I² statistic. Results: Twelve RCTs (n=2848 patients) met the inclusion criteria. Diuretics plus albumin was superior to diuretics alone in achieving complete ascites resolution (OR 2.18, 95% CI 1.65-2.88, p<0.001; I²=38%). Vasopressin receptor antagonists were comparable to diuretics plus albumin in terms of ascites resolution (OR 1.09, 95% CI 0.88-1.35, p=0.42; I²=12%) but associated with a lower incidence of hyponatremia (OR 0.52, 95% CI 0.35-0.78, p=0.002; I²=23%). Large-volume paracentesis was more effective than repeated small-volume paracentesis for ascites control (OR 1.75, 95% CI 1.31-2.34, p<0.001; I²=41%). TIPS was associated with a higher rate of complete ascites resolution compared to large-volume paracentesis (OR 2.45, 95% CI 1.78-3.38, p<0001; I²=35%) but a higher risk of hepatic encephalopathy (OR 2.21, 95% CI 1.48-3.30, p<0.001; I²=15%). Albumin reduced mortality in patients undergoing large-volume paracentesis (OR 0.68, 95% CI 0.49-0.94, p=0.02; I²=0%). Conclusion: This meta-analysis supports the use of diuretics plus albumin, vasopressin receptor antagonists, large-volume paracentesis, and TIPS for ascites management in cirrhosis, with the choice of therapy individualized based on patient characteristics, ascites severity, and the risk of complications.
Peran Reflux Symptom Index dalam diagnostik terapi pasien Laryngopharyngeal Reflux sebelum dan sesudah diberikan Lansoprazole di Poliklinik THT-KL RSUP Dr. M. Djamil Padang.: Indonesia Febrina Monica; Ade Asyari; Saptino Miro; Al Hafiz; Rozi Abdullah; Abdiana Abdiana
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 3 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v3i1.58

Abstract

Pendahuluan : Laryngopharyngeal Reflux(LPR) adalah pergerakan retrograde dari isi lambung ke daerah laring, faring, trakea, dan bronkus yang berkontak dengan jaringan pada traktus aerodigestif atas yang dapat menimbulkan jejas. Diagnosis dari LPR dapat ditegakkan dengan tindakan non-invasif yaitu dengan Reflux Symptom Index(RSI) dan Reflux Finding Score(RFS), RSI dapat digunakan dalam membantu dokter untuk menilai tingkat keparahan gejala penderita LPR saat pemeriksaan maupun setelah pengobatan. Metode : Jenis penelitian ini adalah analitik observasional dengan pendekatan studi kohort prospektif melalui observasi pasien yang didiagonosis LPR dari nilai RSI yang didapatkan. Jumlah sampel minimal dari hasil perhitungan uji hipotesis beda rata-rata pada 2 kelompok dependen adalah 18 orang. Hasil : Nilai rata-rata sebelum dan sesudah diberikan terapi PPI 21,50±5,969 dan 15,90±9,008 (me=13,5;min=5;maks=36). Hasil uji Wilcoxon Signed Rank Test didapatkan analisis nilai rata-rata RSI sebelum dan sesudah adalah p=0,002. Kesimpulan : didapatkan perubahan bermakna nilai rata-rata RSI sebelum dan sesudah diberikan PPI pada pasien LPR.Kata kunci: Laryngopharyngeal Reflux, Reflux Symptom Index,Proton Pump Inhibitor
The Role of Immunotherapy in Hepatocellular Carcinoma (HCC) Nurhayani Fatimah; Vesri Yoga; Arnelis -; Saptino Miro
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 27, No 1 (2026): VOLUME 27, NUMBER 1, April, 2026
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/271202670-79

Abstract

Hepatocellular carcinoma (HCC) is an aggressive primary liver malignancy with a historically poor prognosis and limited treatment options. It accounts for approximately 75–85% of all liver cancer cases worldwide, with an estimated global incidence of about 9.5 per 100,000 person-years. According to GLOBOCAN 2022, the liver cancer mortality-to-incidence ratio in Indonesia is 0.99, indicating that nearly all patients diagnosed with HCC die from the disease. Systemic therapy, primarily sorafenib, a targeted therapy approved since 2007, has long been the mainstay for advanced cases, but it offers limited clinical benefit. In recent years, immunotherapy, particularly immune checkpoint inhibitors (ICIs), has significantly altered the therapeutic approach to HCC. These agents function by inhibiting regulatory pathways such as PD-1/PD-L1 and CTLA-4, thereby enhancing immune-mediated tumor clearance. Clinical trials, such as IMbrave150, have shown that combining atezolizumab and bevacizumab leads to notable improvements in both overall and progression-free survival compared to sorafenib, resulting in its approval as a first-line treatment. Similarly, combinations like durvalumab with tremelimumab have shown encouraging efficacy. Nonetheless, therapeutic resistance remains a challenge, often driven by the immunosuppressive tumor microenvironment. Emerging strategies, such as next-generation checkpoint blockades, adoptive cell therapy, therapeutic cancer vaccines, and oncolytic virotherapy, are under investigation to improve response rates. This review discusses current progress in immunotherapy for HCC, addresses clinical limitations, and explores potential future directions to enhance treatment success.
Co-Authors Abd. Rasyid Syamsuri Abdiana Abdiana, Abdiana Abdul Alim Rahimi Ade Asyari Afida Razuna Ave Al Hafiz Alexander Kam Alexander Kam Alika Ristama Nigandiva Almurdi Almurdi Amatullah, Afifah Andani Eka Putra Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Angela Lovena Annisa Ul Husni Arina Widya Murni Arnelis Arnelis Arnelis Arnelis - Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Asrining Tyas Asterina Asterina Bayu Gemilang Daan Khambr Deka Viotra Delmi Sulastri Detty Iryani Dia Rofinda, Zelly Dia Dian Pertiwi Diego Lesgenia Dina Arfiani Rusjdi Dinda Aprillia Dinda Aprillia Dwi Yulia Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Eka Kurniawan Elmatris Sy Emil Prasetyo Muhammad Endrinaldi Eti Yerizel Eva Decroli Fadhil Alfino Azmi Fadrian Fauzar Fauzar Fauzar Fauzar Febrina Monica Fisca Syofi Arrasyi Gestina Aliska Hendra Saputra Husna Yetti Jersivindo Ranazeri Malinda Meinapuri Miftahuz Zahrah Nada Utami Prahastiwi Najirman Najirman Nandia Rizkita Nasrul Zubir Nasrul Zubir Nasrul Zubir Nasrul Zubir Novita Ariani Nurhayani Fatimah Putri Reno Indrisia Putri Wahyuni Putri, Septia Harma R. Ifan Arief Fahrurozi Rahmatini . RAVEINAL RAVEINAL Raveinal Raveinal Restu Susanti Rikarni Rikarni Rivani Sintia Suratman Rivo Armanda Satria Rony Rustam Roza Kurniati Roza Kurniati Roza Mulyana Rozi Abdullah Rudy Afriant Sherly Febrina Suri Hanifa Efendi Vella Paraditha Vesri Yoga Yanni, Mefri Yanwirasti Yanwirasti Yusticia Katar Yustini Alioes Zaki Ihsan Kamil