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All Journal Jurnal Kesehatan Andalas Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Health and Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Kesehatan Masyarakat Indonesia (JKMI)
Saptino Miro
Fakultas Kedokteran Universitas Andalas
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Perbedaan Nilai Fibrosis Hati Sebelum dan Setelah Terapi Antivirus Tenofovir pada Pasien Hepatitis B Kronik di RSUP M.Djamil Padang Miftahuz Zahrah; Saptino Miro; Yusticia Katar; Fadrian; Gestina Aliska; Malinda Meinapuri
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 2 (2026): Juni 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i2.1529

Abstract

Hepatitis B virus infection is a global health problem. Long-term exposure to hepatitis B virus can cause inflammation in hepatocytes leading to liver fibrosis. Liver fibrosis is a predictor of serious complications such as liver cirrhosis and hepatocellular carcinoma. One of the targets of antiviral therapy is to reduce the degree of liver fibrosis which is associated with clinical improvement in patients with chronic hepatitis B. The aim of this study is knowing the difference in liver fibrosis values before and after tenofovir antiviral therapy in chronic hepatitis B patients at M.Djamil Padang Hospital. This study was an observational analytic study using medical record data of 43 chronic hepatitis B patients who had received tenofovir antiviral therapy for 1 year. Data were analyzed with Wilcoxon test. 93% of chronic hepatitis B patients experienced a decrease in liver fibrosis values after tenofovir antiviral therapy for one year with the difference in median values before and after tenofovir antiviral therapy was 10.8 vs 6.4 kPa. There was a significant difference between liver fibrosis values before and after tenofovir antiviral therapy.
Co-Authors Abd. Rasyid Syamsuri Abdiana Abdiana, Abdiana Abdul Alim Rahimi Ade Asyari Afida Razuna Ave Al Hafiz Alexander Kam Alexander Kam Alika Ristama Nigandiva Almurdi Almurdi Amatullah, Afifah Andani Eka Putra Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Andry Kurniawan Angela Lovena Annisa Ul Husni Arina Widya Murni Arnelis Arnelis Arnelis Arnelis - Arnelis Arnelis Arnelis Arnelis Arnelis Arnelis Asrining Tyas Asterina Asterina Bayu Gemilang Daan Khambr Deka Viotra Delmi Sulastri Detty Iryani Dia Rofinda, Zelly Dia Dian Pertiwi Diego Lesgenia Dina Arfiani Rusjdi Dinda Aprillia Dinda Aprillia Dwi Yulia Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Eka Kurniawan Elmatris Sy Emil Prasetyo Muhammad Endrinaldi Eti Yerizel Eva Decroli Fadhil Alfino Azmi Fadrian Fauzar Fauzar Fauzar Fauzar Febrina Monica Fisca Syofi Arrasyi Gestina Aliska Hendra Saputra Husna Yetti Jersivindo Ranazeri Malinda Meinapuri Miftahuz Zahrah Nada Utami Prahastiwi Najirman Najirman Nandia Rizkita Nasrul Zubir Nasrul Zubir Nasrul Zubir Nasrul Zubir Novita Ariani Nurhayani Fatimah Putri Reno Indrisia Putri Wahyuni Putri, Septia Harma R. Ifan Arief Fahrurozi Rahmatini . RAVEINAL RAVEINAL Raveinal Raveinal Restu Susanti Rikarni Rikarni Rivani Sintia Suratman Rivo Armanda Satria Rony Rustam Roza Kurniati Roza Kurniati Roza Mulyana Rozi Abdullah Rudy Afriant Sherly Febrina Suri Hanifa Efendi Vella Paraditha Vesri Yoga Yanni, Mefri Yanwirasti Yanwirasti Yusticia Katar Yustini Alioes Zaki Ihsan Kamil