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The Outcome of Concurrent Intracameral Fluconazole Injection with Amniotic Membrane Transplantation for Fungal Keratitis in Dr. M. Djamil General Hospital: A Case Series Ferry Indratno; Havriza Vitresia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.795

Abstract

Background: Fungal keratitis is often difficult to eradicate and requires long treatment. Antifungal agents have lower efficacy because of low tissue penetration and the indolent nature of the infection. Fluconazole has effective ocular penetration ability, reaching aqueous concentration as same as plasm concentration. Multilayer amniotic membrane transplantation (MLAMT) has been shown to be a promising surgical procedure to reconstruct the ocular surface by supporting the epithelialization of the cornea and having protective antimicrobial properties. This study aims to report the outcome of concurrent intracameral fluconazole injection with amniotic membrane transplantation for fungal keratitis in Dr. M. Djamil General Hospital. Case presentation: Four inpatients in the ophthalmology ward of Dr. M. Djamil General Hospital with moderate to severe fungal keratitis. All patients were first treated with medications. Because the patients did not show clinical improvement after getting maximum therapy, they underwent intracameral fluconazole injection concurrent with MLAMT. MLAMT was performed with multilayered amniotic membranes to fill and cover the defect. The bandage contact lens was placed to protect and keep the MLAMT in place and for patients’ comfort. Patients were then observed for signs of inflammatory reaction and epithelialization. All patients showed reduced inflammation and improved epithelization after surgery. Conclusion: Concurrent intracameral fluconazole injection with MLAMT can be considered an alternative treatment for refractory fungal keratitis as it decreases the rate of inflammation and improves epithelization.
Clinical Grading of Corneal Ulcer and Its Management in Dr. M. Djamil General Hospital, Padang, Indonesia Amanda Priska Diananti; Havriza Vitresia; Getry Sukmawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.794

Abstract

Background: Infectious corneal ulcer (CU) occurs due to an agent, which may be a bacterial, fungal, or viral microorganism. A detailed examination of the ulcer was needed to determine the severity grading of the ulcer. Based on the size, depth of ulcer, density of infiltrate, and scleral involvement, it's divided into mild, moderate, and severe grades and may be used to objectively monitor the progress of the ulcer and as a parameter for management. Medical management includes topical, systemic antibiotic, and periocular injection, while amniotic membrane transplantation (AMT), conjunctiva flap, fascia lata, and evisceration as surgical. This study aimed to assess the clinical grading associated with the management of CU in Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: Observational analytics based on the medical record of corneal ulcer patients in Dr. M. Djamil General Hospital, Padang, Indonesia, in 2016-2017. A total of 191 research subjects participated in this study. Data analysis was carried out using SPSS univariately. Results: The fungal, bacterial, and viral CU was diagnosed clinically. The severity grading that we found is moderate (60,73%), mild (25,14%), and severe (14,13%). All of the cases used medical treatment. Surgical was performed in moderate (36,59%) and all severe cases. AMT was performed in severe cases with perforation ≤ 4 mm and perforation > 4 mm conjunctival flap (3.7%), fascia lata (3,7%), and evisceration (61,53%), preferably. Conclusion: The clinical grading of corneal ulcers in our hospital is moderate, and it may be associated with our hospital as a referral hospital. Surgery was performed in all severe and moderate cases that don't respond well to medicine.
The Outcome of Concurrent Intracameral Fluconazole Injection with Amniotic Membrane Transplantation for Fungal Keratitis in Dr. M. Djamil General Hospital: A Case Series Ferry Indratno; Havriza Vitresia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 3 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i3.795

Abstract

Background: Fungal keratitis is often difficult to eradicate and requires long treatment. Antifungal agents have lower efficacy because of low tissue penetration and the indolent nature of the infection. Fluconazole has effective ocular penetration ability, reaching aqueous concentration as same as plasm concentration. Multilayer amniotic membrane transplantation (MLAMT) has been shown to be a promising surgical procedure to reconstruct the ocular surface by supporting the epithelialization of the cornea and having protective antimicrobial properties. This study aims to report the outcome of concurrent intracameral fluconazole injection with amniotic membrane transplantation for fungal keratitis in Dr. M. Djamil General Hospital. Case presentation: Four inpatients in the ophthalmology ward of Dr. M. Djamil General Hospital with moderate to severe fungal keratitis. All patients were first treated with medications. Because the patients did not show clinical improvement after getting maximum therapy, they underwent intracameral fluconazole injection concurrent with MLAMT. MLAMT was performed with multilayered amniotic membranes to fill and cover the defect. The bandage contact lens was placed to protect and keep the MLAMT in place and for patients’ comfort. Patients were then observed for signs of inflammatory reaction and epithelialization. All patients showed reduced inflammation and improved epithelization after surgery. Conclusion: Concurrent intracameral fluconazole injection with MLAMT can be considered an alternative treatment for refractory fungal keratitis as it decreases the rate of inflammation and improves epithelization.
Surgical Outcome of Amniotic Membrane Transplantation (AMT) in Patients with Corneal Ulcer in Dr. M. Djamil General Hospital, Padang, Indonesia Rahmi Fatma Sari; Havriza Vitresia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.830

Abstract

Background: Amniotic Membrane Transplantation or AMT Graft has been known to successfully manage ocular surface diseases, especially corneal ulcers. The amniotic membrane promotes epithelialization and inhibits proteinase activity that is required for wound healing. A corneal ulcer is a potentially sight-threatening condition resulting in permanent corneal opacity. Methods: This is a retrospective descriptive study. Subjects were patients diagnosed with corneal ulcers and have been treated with AMT grafts. The data were grouped according to age, gender, severity, cause, visual acuity before and after AMT, and time required for complete epithelialization. Results: Fifty-two patients were included in this study, aged 41-50, with a mean age of 43,17. Men were more common than women by 88,5% vs 11,5%. AMT graft was performed for moderate and severe corneal ulcers in this study, and most of them were caused by infection. The visual acuity before AMT was mostly in the second WHO category of blindness and visual impairment. Four weeks after surgery, 34.6% of patients had improved visual acuity. Complete epithelialization was most frequently (59,6%) achieved in 15-28 days. AMT graft was repeated in 3 patients, and other surgical interventions were required for 2 patients. Conclusion: The AMT graft has successfully managed corneal ulcer patients, especially in moderate to severe cases, in Dr. M. Djamil General Hospital, Padang, Indonesia.
Surgical Outcome of Amniotic Membrane Transplantation (AMT) in Patients with Corneal Ulcer in Dr. M. Djamil General Hospital, Padang, Indonesia Rahmi Fatma Sari; Havriza Vitresia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 6 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i6.830

Abstract

Background: Amniotic Membrane Transplantation or AMT Graft has been known to successfully manage ocular surface diseases, especially corneal ulcers. The amniotic membrane promotes epithelialization and inhibits proteinase activity that is required for wound healing. A corneal ulcer is a potentially sight-threatening condition resulting in permanent corneal opacity. Methods: This is a retrospective descriptive study. Subjects were patients diagnosed with corneal ulcers and have been treated with AMT grafts. The data were grouped according to age, gender, severity, cause, visual acuity before and after AMT, and time required for complete epithelialization. Results: Fifty-two patients were included in this study, aged 41-50, with a mean age of 43,17. Men were more common than women by 88,5% vs 11,5%. AMT graft was performed for moderate and severe corneal ulcers in this study, and most of them were caused by infection. The visual acuity before AMT was mostly in the second WHO category of blindness and visual impairment. Four weeks after surgery, 34.6% of patients had improved visual acuity. Complete epithelialization was most frequently (59,6%) achieved in 15-28 days. AMT graft was repeated in 3 patients, and other surgical interventions were required for 2 patients. Conclusion: The AMT graft has successfully managed corneal ulcer patients, especially in moderate to severe cases, in Dr. M. Djamil General Hospital, Padang, Indonesia.
Hubungan Tingkat Stres dan Sleep Hygiene dengan Kualitas Tidur pada Mahasiswa Kedokteran Raisa Hussein; Eldi Sauma; Endrinaldi Endrinaldi; Afriwardi Afriwardi; Havriza Vitresia
Jurnal Ilmu Kesehatan Indonesia Vol 4 No 3 (2023): September 2023
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v4i3.1045

Abstract

Latar Belakang: Mahasiswa kedokteran merupakan kelompok yang rentan terhadap kualitas tidur yang buruk dan dianggap memiliki tingkat stres yang tinggi dibandingkan dengan mahasiswa jurusan lain. Untuk meningkatkan kuantitas dan kualitas tidur seseorang maka perlu penerapan praktik sleep hygiene secara rutin dalam kehidupan sehari-hari. Sleep hygiene merupakan serangkaian perilaku dan lingkungan untuk menciptakan kualitas tidur yang optimal. Objektif: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara tingkat stres dan sleep hygiene dengan kualitas tidur pada mahasiswa program studi pendidikan dokter Fakultas Kedokteran Universitas Andalas angkatan 2019-2021. Metode: Penelitian ini merupakan penelitian analitik dengan menggunakan metode cross sectional, menggunakan teknik proportionate stratified random sampling dengan jumlah sampel sebanyak 160 responden. Data responden didapatkan dari kuesioner dan dianalisis menggunakan uji chi square. Hasil: Hasil penelitian ini didapatkan responden perempuan lebih banyak dibandingkan dengan responden laki-laki, dengan usia terbanyak adalah 21 tahun (32,5%). Lebih dari setengah mahasiswa memiliki tingkat stres normal (61,9%) dan sleep hygiene kategori tidak baik (63,8%). Mayoritas mahasiswa memiliki kualitas tidur yang buruk (90,6%). Kesimpulan: Tidak terdapat hubungan antara tingkat stres dengan kualitas tidur (p = 0,215) dan tidak terdapat hubungan antara sleep hygiene dengan kualitas tidur (p = 1,000). Kata kunci: Tingkat stres, sleep hygiene, Kualitas Tidur
Management for Perforated Mooren’s Ulcer Linda Wira Putri; Havriza Vitresia; Getry Sukmawati
Majalah Oftalmologi Indonesia Vol 41 No 2 (2015): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v41i2.23

Abstract

Background: To report the surgical management for perforated Mooren's ulcer by performing conjunctival resection with situational corneal suture and Amniotic Membrane Transplantation. Case Illustration: There were six patients diagnosed with Mooren's ulcer between 2011-2013. Three of them were perforated Mooren's ulcer with iris prolaps, and the size of perforation was 2-4 mm. The sex distribution of the patient were 3 male and 3 female patients. The age of presentation of were varied from 11-48 yo. Three patients underwent surgery, one patient refused. The other 2 patients only got medical therapy. For perforated cases with iris prolaps, we performed conjunctival resection with situational corneal suture, overlying the perforation. The suture were made like a net or bridge, depend on cases, and then amniotic membrane were put over the suture. The corneal suture should not be tight because it can disrupt the corneal contour. Amniotic membrane were put on the net layer by layer, and then fixed by interrupted suture to the episclera and cornea, at least in 8 position. The eyes were patching about 4 days and give topical and systemic antibiotic, and corticosteroid systemic. All of patient have complete epithelization after surgery between day 7-10 and have visual acuity improvement. Some of the patient still followed up until now. Conclusion: Conjunctival Resection with situational corneal suture and Amniotic Membrane Transplantation appeared to be an effective procedure for perforated Mooren's ulcer and iris prolaps, even more than 2 mm size of perforation.
Sympathetic ophthalmia following corneal patch graft for corneal perforation: Poster Presentation - Case Report - Ophthalmologist RENI ANGRAINI; Havriza Vitresia
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/vgy9vv80

Abstract

Introduction : Sympathetic ophthalmia (SO) is a rare, bilateral, diffuse granulomatous uveitis that usually occurs after open globe injury or intraocular surgery. We report a rare case of SO after the closure of corneal perforation using a corneal patch graft. Case Illustration : A 12 year old boy diagnosed as corneal perforation in the right eye, with visual acuity (VA) 20/100, underwent a corneal patch graft. He presented with redness and decreased vision in both eyes 2 weeks after surgery. The patient had VA of hand movements in the RE and 20/200 in the LE. Anterior segment examination showed a corneal patch graft with iris adherent to the graft posteriorly in RE, endothelial dusting, 2+ cells in both eye. Fundus examination showed optic disc oedema in both eye and inferior retinal detachment with macular involvement in RE. The patient was managed with pulse steroids for three days followed by oral steroids in tapering doses along with continued topical steroids. Three months follow-up showed improvement of VA to 20/60 in RE and 20/25 in LE Discussion : SO is thought to be an autoimmune response to uveal injury. The incarceration of uveal tissue in the wound is a major risk factor. SO has been reported 5 days to 66 years after penetrating insult to the eye. In this case, incarceration of uvea in corneal pacth resulted in SO 2 weeks after surgery. Conclusion : In a case of a perforated cornea, the possibility of iris incarceration in the wound is high and hence SO can develop
Performing Ocular Examinations as A Component of Self-Care For Individuals with Leprosy with The Aim of Eradicating Social Stigma and Prejudice Hendriati Hendriati; Tutty Ariani; Havriza Vitresia; Kemala Sayuti; Andrini Ariesti; Julita Julita; Qaira Anum; Satya Wydya Yenny; Rina Gustia; Gardenia Akhyar; Ennesta Asri; Indah Indria Sari; Astria Rima Rara Yuswir; Novian Novian; Rizki Dwayana; Agustin Vira; Rika Desviorita; Rendra Darma Satria
Warta Pengabdian Andalas Vol 31 No 3 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.3.537-546.2024

Abstract

Leprosy is still a health problem in several countries, including Indonesia. Disability due to leprosy is a health threat for sufferers and causes quality-of-life problems that can disrupt the productivity of leprosy patients. Ocular involvement in leprosy is joint, but little data has been reported. Apart from multi-drug treatment (MDT), leprosy sufferers must also be able to carry out continuous self-care to prevent further disability. This is a collaborative activity between the Department of Ophthalmology and Dermatology Venereology of the Faculty of Medicine, the University of Andalas in Puskesmas Pauh Kamba district of Padang Pariaman. This is an advocacy activity on self-care (3M: Seeing, Examining, and Protecting) and eye examination. The activity was followed by interactive discussions and continued with a direct examination for skin abnormalities and disabilities, eye examination, and fundoscope. The activity results were obtained from 24 respondents, 11 men and 13 women. The age range is 16-59 years (67%), with the highest level of education being Elementry School graduates, which is 11 people (46%). In the self-care questionnaire of patients, 40% behaved well, and the results of eye examinations almost suffered from dry eye complaints without disabilities.
KEJADIAN KARDIOVASKULAR MAYOR PASCA INTERVENSI KORONER PERKUTAN PRIMER PADA PASIEN INFARK MIOKARD AKUT ELEVASI SEGMEN ST DI RSUP DR. MDJAMIL PADANG Nabila, Salsya; Rasyid, Hauda El; Vitresia, Havriza
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 1 No. 4 (2024): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Desember 2024
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/r0556q27

Abstract

Abstract: Infark miokardial akut (IMA) adalah suatu kondisi nekrosis otot jantung yang diakibatkan oleh ketidakadekuatan pasokan darah karena adanya sumbatan secara tiba-tiba pada arteri koroner. Kejadian kardiovaskular mayor (KKM) merupakan gabungan dari hasil akhir gejala klinis yang sering terjadi pada pasien IMA-EST antara lain gagal jantung atau syok kardiogenik, rehospitalisasi akibat SKA, aritmia, komplikasi mekanik, perikarditis, stroke bahkan kematian. Tujuan dari penelitian ini adalah untuk mengetahui gambaran KKM pada pasien IMA-EST yang menjalani IKPP di RSUP Dr. M. Djamil Padang. Metode : Penelitian ini merupakan penelitian deskriptif dengan menggunakan data rekam medis di RSUP Dr. M. Djamil Padang periode Juli 2018 – Juni 2019 dan wawancara via telpon. Variabel yang diteliti adalah usia, jenis kelamin, lama perawatan, faktor risiko mayor dan KKM (periode 1 bulan, 6 bulan dan 12 bulan) Hasil : Hasil penelitian ini menunjukkan Pasien IMA-EST yang menjalani IKPP sebagian besar laki-laki (84.2%) yang berumur < 65 tahun (85.3%). Faktor risiko mayor yang paling banyak dimiliki adalah faktor merokok (77.9%). Pasien IMA-EST yang mengalami KKM kematian dalam waktu rawatan di rumah sakit adalah 6 orang (6.3%), gagal jantung 8 orang (8.4%). Sedangkan KKM kematian periode 1 bulan adalah 1 orang (1.1%). KKM kematian periode 6 bulan adalah 3 orang (3.2%). KKM kematian periode 12 bulan adalah 2 orang (2.1%), gagal jantung 3 orang (3.2%) dan stroke sebanyak 1 orang (1.1%) Kesimpulan : Faktor risiko mayor yang paling banyak dimiliki pasien adalah merokok dan kejadian KKM yang paling banyak terjadi yaitu gagal jantung pada waktu rawatan.