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All Journal Jurnal Gizi dan Pangan Jurnal Kesehatan Andalas Paediatrica Indonesiana Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Rismawati Yaswir
Bagian Patologi Klinik Dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Korelasi Kadar Adiponektin dengan Indeks Aterogenik Plasma pada Penyandang Obes Sari, Kartika Aulia; Yaswir, Rismawati; Prihandani, Tuty; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1335

Abstract

Kadar adiponektin dalam plasma secara signifikan menurun pada penyandang obes. Adiponektin telah dilaporkan memiliki efek langsung anti-aterosklerosis. Indeks Aterogenik Plasma (IAP) dihitung sebagai log10(TG/ HDL-C), merupakan biomarker aterosklerosis. IAP dapat menjadi biomarker baru untuk risiko dan prognosis penyakit kardiovaskular. Tujuan: Menentukan korelasi kadar adiponektin dengan indeks aterogenik plasma pada penyandang obes. Metode: Penelitian ini merupakan studi analitik dengan rancangan potong lintang. Subjek penelitian adalah 30 orang penyandang obes dengan Indeks Massa Tubuh (IMT) ≥25 kg/m2 yang memenuhi kriteria inklusi dan eksklusi. Subjek penelitian melakukan pemeriksaan darah di Instalasi Laboratorium Sentral RSUP. Dr. M. Djamil Padang pada bulan Januari 2019 sampai September 2019. Pemeriksaan kadar adiponektin dengan metode enzyme linked immunoassay (ELISA). Pemeriksaan kolesterol high density lipoprotein (HDL) dan trigliserida menggunakan alat kimia klinik otomatis. Data univariat diolah dan disajikan dalam bentuk distribusi frekuensi dan rerata (standar deviasi). Data bivariat dianalisis dengan uji korelasi Pearson, bermakna secara statistik jika p˂0,05. Hasil: Rerata umur adalah 34,5 (6,2) tahun. Rerata kadar adiponektin adalah 2,5 (1,1) μg/mL. Rerata indeks aterogenik plasma (IAP) adalah 0,29 (0,17), termasuk risiko tinggi untuk penyakit kardiovaskular. Uji korelasi Pearson menunjukkan korelasi negatif sangat lemah antara adiponektin dengan IAP dan tidak bermakna secara statistik (r=-0,114, p=0,550). Simpulan: Tidak terdapat korelasi antara kadar adiponektin dengan indeks aterogenik plasma pada penyandang obes.Kata kunci: adiponektin, indeks aterogenik plasma, obes
Korelasi Kadar Adiponektin dengan Kadar Glukosa Puasa pada Penyandang Obes Bakma, Isphandra; Yaswir, Rismawati; Desywar, Desywar; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 9 No. 3 (2020): Online September 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i3.1340

Abstract

Akumulasi lemak tubuh abnormal dan berlebih pada obesitas menyebabkan low grade inflammation sel adiposit yang berkontribusi terhadap penurunan kadar adiponektin. Adiponektin berperan dalam metabolisme glukosa, sehingga kondisi hipoadiponektinemia dapat menyebabkan gangguan metabolisme glukosa. Tujuan: menentukan korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes. Metode: Penelitian ini merupakan studi analitik dengan rancangan potong-lintang terhadap 25 orang penyandang obes yang bekerja di Instalasi Laboratorium Sentral RSUP Dr. M. Djamil Padang yang memenuhi kriteria inklusi dan eksklusi. Penelitian dilakukan mulai bulan September 2018 sampai September 2019. Kadar adiponektin diperiksa dengan metode Elisa two-step sandwich enzyme immunoassay dan kadar glukosa puasa diperiksa dengan metode heksokinase. Data dianalisis dengan uji korelasi Pearson, bermakna jika p<0,05. Hasil: Subjek penelitian terdiri dari laki-laki 8 orang (32,0%) dan perempuan 17 orang (68,0%). Rerata umur adalah 33,5 (6,0) tahun dengan rentang 23-52 tahun. Rerata indeks massa tubuh adalah 34,0 (3,6) kg/m2. Rerata kadar adiponektin adalah 2,8 (1,5) μg/mL dan rerata kadar glukosa puasa adalah 92,8 (11,4) mg/dL. Uji korelasi Pearson menunjukkan korelasi negatif lemah antara log-adiponektin dengan kadar glukosa puasa dan tidak bermakna secara statistik (r= -0,217, p= 0,298). Simpulan: Tidak terdapat korelasi kadar adiponektin dengan kadar glukosa puasa pada penyandang obes.Kata kunci: adiponektin, glukosa puasa, inflamasi adiposit, obesitas
Gambaran Castelli’s Risk Index-1 pada Pasien Sindrom Koroner Akut di RSUP Dr. M. Djamil Padang Sabebegen, Eka Musmita; Yaswir, Rismawati; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1719

Abstract

Atherogenic dyslipidemia is one of the risk factors for the acute coronary syndrome (ACS). Castelli's risk index-1 (CRI-1) is one of which risk markers for ACS. Castelli's risk index-1 is the ratio of total cholesterol and HDL cholesterol. The test is cheap and easy to do in the hospital setting. Objectives: To described CRI-1 in ACS patients in Dr. M. Djamil Padang Hospital. Methods: This descriptive study was carried out in the central laboratory and the CardioVascular Care Unit (CVCU) of Dr. M. Djamil Hospital Padang from September 2017 to September 2018. The population was all ACS patients who have been diagnosed by the clinician. The samples were part of the population that meet the inclusion and exclusion criteria. Colorimetric enzymatic method using automated clinical chemistry used to measure total cholesterol and HDL cholesterol. Results: This study used CRI-1> 4. Data were presented descriptively in a frequency distribution table. Seventy ACS patients were consisting of 50 (71.43%) males and 20 (28.57%) females, with a median age of 60.1 (8.93) years old. The median total cholesterol and HDL cholesterol levels were 178.66 (46.84) mg / dL respectively and 35.71 (10.86) mg / dL. CRI-1 mean is 5.43 (2.27). 81.43% CRI-1 subject results were more than four. Conclusion: The low levels of HDL cholesterol and within normal median total cholesterol level made CRI-1 value increased.Keywords: Acute coronary syndrome, Castelli’s risk index-1
Korelasi Glukosa Kapiler Metode Glucose Dehidrogenase-Nicotinamide Adenine Dinucleotide Dengan Glukosa Serum Metode Heksokinase Fitria, Syarifah Tridani; Yaswir, Rismawati; Efrida, Efrida
Jurnal Kesehatan Andalas Vol. 10 No. 3 (2021): Online November 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i3.1827

Abstract

Rapid and accurate measurement of capillary glucose level using point-of-care testing (POCT) is needed to maintain the patient’s normoglycemic status in obtaining adequate management. The glucose POCT method should be evaluated to determine analytical performance by comparing with the hexokinase method as a reference method to provide accurate and reliable results. Objectives: To determined the correlation between capillary glucose using glucose dehydrogenase-nicotinamide adenine dinucleotide (GDH-NAD)  and serum glucose hexokinase methods. Methods:  This analytic cross-sectional study on 42 outpatients who underwent fasting blood glucose examination at Dr. M Djamil Padang General Hospital. This study was conducted from February until September 2020. Capillary fasting blood glucose was measured using glucose POCT GDH-NAD method and serum glucose with hexokinase method. The Spearman correlation test was used to analyze data, significant if p<0.05. Results: The subjects were 28 male (66.7%),14 female (33.3%) with mean age and hematocrit level was 56.12±12.97 years and 40.90±2.42%, respectively. The median capillary glucose GDH-NAD method and serum glucose hexokinase method were 100.00 mg/dL each, with a median difference was 3.00 mg/dL. Spearman correlation test showed very strong positive correlation and statistically significant (r=0,961;p=<0,001). Conclusion: Capillary glucose GDH-NAD method had a very strong positive correlation with serum glucose hexokinase method.Keywords:  hexokinase, fasting glucose level, GDH-NAD, glucose POCT
Monocyte-to-HDL Cholesterol Ratio Predicts 30-Day Mortality in ST-Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention Kurniawan; Yaswir, Rismawati; Deswita Sari; Zelly Dia Rofinda; Dwi Yulia; Syofiati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1279

Abstract

Background: ST-elevation myocardial infarction (STEMI) is a leading cause of mortality worldwide. Despite advancements in treatment, especially with primary percutaneous coronary intervention (pPCI), 30-day mortality rates remain significant. The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as a potential predictor of mortality in STEMI patients, reflecting the balance between inflammation and anti-atherosclerotic processes in atherosclerotic plaques. This study aimed to evaluate the association between MHR and 30-day mortality in STEMI patients undergoing pPCI. Methods: This prospective observational study included 55 STEMI patients treated with pPCI at Dr. M. Djamil General Hospital in Padang, Indonesia, between January and July 2024. Patients were included if they were ≥18 years old, undergoing their first pPCI, and had blood tests done within 24 hours of admission. Patients with prior revascularization, acute/chronic infections, malignancies, autoimmune diseases, or on lipid-lowering therapy were excluded. Blood samples were collected within 24 hours of admission. Monocyte counts were measured using flow cytometry, and HDL cholesterol levels were determined using a homogeneous enzymatic colorimetric method. The MHR was calculated by dividing the monocyte count by the HDL cholesterol level. The primary outcome was 30-day mortality, assessed through hospital records and telephone follow-up. Statistical analysis included chi square, t-tests, and Mann-Whitney U tests. Results: The mean age of the study participants was 59.5 (±11.4) years, with 81.8% being male. The mean monocyte count and MHR were 968 (±212)/mm3 and 28.3 (±6.06), respectively. The median HDL cholesterol level was 33.4 (27-49) mg/dL. Both monocyte count and MHR were significantly higher in patients who died within 30 days compared to those who survived (p<0.001). Conclusion: The MHR is an independent predictor of 30-day mortality in STEMI patients undergoing pPCI. This readily available and cost-effective biomarker may aid in risk stratification and guide treatment strategies for this high-risk population.
Nilai ASTO Pasien Tonsilitis Kronis Pre dan Pasca Tonsiloadenoidektomi Dengan Riwayat Endokarditis Infeksi Gunawan, Syahri; Novialdi, Novialdi; Yaswir, Rismawati; Hariyanto, Didik; Rahman, Aulia
Majalah Kedokteran Andalas Vol. 46 No. 4 (2023): Online Oktober
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i6.p1118-1127.2023

Abstract

Tonsilitis merupakan salah satu manifestasi paling sering dari infeksi saluran nafas atas. Pada pasien dengan tonsilitis kronis terdapat kecenderungan peningkatan titer Anti Streptolisin O, sebuah antibodi terhadap antigen Streptolisin O yang dihasilkan oleh bakteri Streptokokus β Hemolitikus grup A. Bakteri yang juga diketahui menjadi agen penyebab pada penyakit jantung infeksi. Tujuan: Mengetahui dan menginterpretasikan nilai ASTO pasien tonsilitis pre dan paska tonsiloadenoidektomi dengan riwayat endokarditis infeksi Laporan Kasus: Seorang anak perempuan 15 tahun dilaporkan dengan tonsilitis kronis dan post infective endocarditis definite. Pada pasien dilakukan pengukuran titer ASTO sebelum dan sesudah tindakan tonsiloadenoidektomi. Setelah dilakukan tonsiloadenoidektomi didapatkan bahwa titer ASTO menjadi negatif. Kesimpulan: Tonsiloadenoidektomi pada pasien dengan tonsilitis kronis dapat menurunkan kadar ASTO dan reaktivasinya sehingga dapat menghindari resiko terjadinya komplikasi yang berhubungan dengan Streptokokus β Hemolitikus grup A
Hubungan Anemia dengan Remisi Komplit Kemoterapi induksi pada Pasien Leukemia Mieloblastik Akut Dewasa di RSUP Dr. M. Djamil Padang Salsabila, Zahra; Afriant, Rudy; Rofinda, Zelly Dia; Elvira, Dwitya; Yaswir, Rismawati; Izzah, Amirah Zatil
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1169

Abstract

Latar Belakang: leukemia mieloblastik akut merupakan salah satu keganasan darah yang terjadi akibat gangguan proses pertumbuhan sel mieloid, yang menyebabkan terjadinya penumpukan sel blast di sumsum tulang, dan menekan pembentukan sel darah lain yang menyebabkan anemia. Pengobatan yang diberikan pada penderita LMA adalah kemoterapi. Kondisi anemia dapat menyebabkan hipoksia di jaringan, yang dapat mengakibatkan berkurang nya efektivitas kemoterapi. Objektif: Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara derajat anemia dengan tercapainya remisi komplit pada pasien LMA yang di kemoterapi induksi. Metode: Penelitian ini dilakukan dengan menggunakan desain cross sectional dengan pendekatan observasional analitik retrospektif. Sampel pada penelitian ini berjumlah 15 sampel yang diambil dari data rekam medik. Analisis univariate dilakukan untuk mendeskripsi frekuensi variable dan analisis bivariate dengan uji statistic fisher exact test. Hasil: Hasil yang didapat dari penelitian ini adalah pasien LMA banyak yang berusia >40 tahun, berjenis kelamin perempuan, dengan klasifikasi LMA M4, keluhan utama lemah letih, derajat anemia ringan dan berhasil remisi komplit yang lebih banyak. Hasil uji statistik memperlihatkan tidak adanya hubungan derajat anemia dengan tercapainya remisi komplit pada pasien. Hasil analisi LMA dengan nilai p=1,000. Kesimpulan: kesimpulan yang didapatkan adalah tidak adanya hubungan antara derajat anemia dengan tercapainya remisi komplit pada pasien leukemia mieloblastik akut dewasa yang menjalani kemoterapi induksi di RSUP Dr. M Djamil Padang.
The Role of NT-proBNP in the Diagnosis of Peripartum Cardiomyopathy with Multiple Left Ventricular Thrombus: A Case Report Yashinta Octavian Gita Setyanda; Yaswir, Rismawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1090

Abstract

Background: Peripartum cardiomyopathy (PPCM) is a rare but serious condition characterized by left ventricular dysfunction in late pregnancy or early postpartum. Early diagnosis is essential to prevent complications such as thromboembolism. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a promising biomarker for the diagnosis of PPCM. Case presentation: An 18-year-old female presented with progressive shortness of breath and generalized edema. Physical examination and echocardiography revealed acute heart failure with multiple left ventricular thrombus. Very high levels of NT-proBNP (1,796 pg/mL) supported the diagnosis of PPCM. The patient was successfully treated with standard heart failure therapy and anticoagulants. Conclusion: This case report highlights the importance of NT-proBNP in the early diagnosis of PPCM and detecting of thromboembolic complications. Significant increases in NT-proBNP levels, even without obvious symptoms, should be promptly evaluated for PPCM, especially in high-risk populations.
The Role of NT-proBNP in the Diagnosis of Peripartum Cardiomyopathy with Multiple Left Ventricular Thrombus: A Case Report Yashinta Octavian Gita Setyanda; Yaswir, Rismawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1090

Abstract

Background: Peripartum cardiomyopathy (PPCM) is a rare but serious condition characterized by left ventricular dysfunction in late pregnancy or early postpartum. Early diagnosis is essential to prevent complications such as thromboembolism. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a promising biomarker for the diagnosis of PPCM. Case presentation: An 18-year-old female presented with progressive shortness of breath and generalized edema. Physical examination and echocardiography revealed acute heart failure with multiple left ventricular thrombus. Very high levels of NT-proBNP (1,796 pg/mL) supported the diagnosis of PPCM. The patient was successfully treated with standard heart failure therapy and anticoagulants. Conclusion: This case report highlights the importance of NT-proBNP in the early diagnosis of PPCM and detecting of thromboembolic complications. Significant increases in NT-proBNP levels, even without obvious symptoms, should be promptly evaluated for PPCM, especially in high-risk populations.
Association of Vitamin D with Insulin Resistance and Pancreatic β-Cell Function in Non-Diabetic Obese Staff: A Cross-Sectional Study Efrida, Efrida; Putri, Dian Eka; Yaswir, Rismawati; Lipoeto, Nur Indrawati; Zhuhra, Rahma Tsania; Almurdi, Almurdi
Jurnal Gizi dan Pangan Vol. 20 No. 3 (2025)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2025.20.3.209-218

Abstract

This research explored whether vitamin D status is related to Insulin Resistance (IR) and pancreatic β-cell performance among non-diabetic obese employees at Dr. M. Djamil Padang Hospital, West Sumatra, Indonesia. Insulin resistance and β-cell activity were assessed using the Homeostatic Model Assessment—specifically Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) as an indicator of insulin resistance and Homeostasis Model Assessment of Beta-Cell Function (HOMA-B) to evaluate β-cell function. The study applied a cross-sectional design conducted from January to July 2020 and involved 81 obese hospital staff without diabetes. Measurements included Fasting Blood Glucose (FBG), Fasting Insulin (FI), and Serum 25-Hydroxyvitamin D [25(OH)D], all analyzed with automated instruments. HOMA-IR and HOMA-B indices were derived from FBG and FI using standard formulas. Statistical analysis used the Spearman correlation test with a significance threshold of p<0.05, followed by multivariate linear regression. The participants were predominantly female (58%), aged 18–58 years, with a mean Body Mass Index (BMI) of 31.46±3.99 kg/m². Average vitamin D levels were 14.84±5.48 ng/mL, while median values for HOMA-IR and HOMA-B were 2.30 and 193.09%, respectively. The results indicated that vitamin D concentrations did not show a meaningful correlation with either HOMA-IR (r=0.071; p=0.530) or HOMA-B (r=−0.106; p=0.347). BMI demonstrated the strongest association with HOMA-IR (β=0.165), and HOMA-IR was the variable most strongly related to HOMA-B (β=21.83). Overall, this study concludes that baseline vitamin D levels are not significantly linked to insulin resistance or pancreatic β-cell function, as reflected by HOMA-IR and HOMA-B measurements, among non-diabetic obese staff at Dr. M. Djamil Padang Hospital.
Co-Authors Adelin, Prima Afrida Maiyesi Akmal M Hanif Almurdi Almurdi Amirah Zatil Izzah Ardho Mahamada Arina Widya Murni Atika Indah Sari Aulia Rahman Aulia Rahman Bahana Sasmita Bakma, Isphandra Bayu Rahmadin Chicamy, Yhosie Anto Cici Julia Sri Dewi Debie Anggraini Deswita Sari Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar Desywar, Desywar Dewi Oktavia Dia Rofinda, Zelly Dia Dian Eka Putri Dian Eka Putri, Dian Eka Dian Pertiwi Didik Hariyanto Didik Hariyanto Donaliazarti Donaliazarti Dwi Yulia Dwitya Elvira, Dwitya Efrida Efrida Efrida Eka Agustia Rini Eka Musmita Sabebegen Ellyza Nasrul Ellyza Nasrul Elsi Kelana Eugeny Alia Fadhillah Al Hijjah Farida Isroani Fitria, Syarifah Tridani Gunawan, Syahri Hanifah Maani Helma Helma Huriyah Fauzani Husna Yetti Husni Husni Husni Husni Husni Husni Ilhamifithri Ilhamifithri Ima Septia Indra Ihsan Ira Ferawati Irza Wahid Isphandra Bakma Kartika Aulia Sari Kurniawan Lillah Lillah Lillah Lillah Lillah Lillah Lillah Lillah M. Ikhlasul Amal Eel Taslim Meiti Frida Mira Purwinanty Muthia Rendra Nafiandi Nafiandi Nora Harminarti Novialdi . Nur Afrianin Syah Nur Indrawati Lipoeto Oktavia, Nanda Prihandani, Tuty Putri Mira Magistri Raisa Putri Secioria Reni Lenggogeni Ridha Amaliah Rikarni Rikarni Rizanda Machmud Rosfita Rasyid Rudy Afriant Sabebegen, Eka Musmita Sari, Deswita Sari, Kartika Aulia Sri Vanny Suhirman Syahri Gunawan Syarifah Tridani Fitria Syofiati Syofiati Syofiati Syofiati, Syofiati Tuti Asryani Tuty Prihandani Tuty Prihandani Tuty Prihandani Wardhy Arief Hidayat Yashinta Octavian Gita Setyanda Yayie Dwina Putri Yerizal Karani Yessi Yestiani Yoshie Anto Chicamy Yulia, Dwi Yusri, Elfira Yustini Alioes zahra salsabila Zelly Dia Rofinda Zhuhra, Rahma Tsania