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Journal : Journal of Food and Pharmaceutical Science

Protection Effect of Self-Nanoemulsifying Drug Delivery System (SNEDDS) Piroxicam as Ulcerogenic Agent towards Malondialdehid Level and Protein Expression of Caspase-3, COX-1, COX-2 at Rat Gastric Iis Wahyuningsih; Kurnia Ambarwati; Erninda Ayu Hapsari; Afifah Fauziyyah; Azis Ikhsanudin; Deasy Vanda Pertiwi; Wahyu Widyaningsih
Journal of Food and Pharmaceutical Sciences Vol 8, No 2 (2020): J. Food Pharm. Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.732

Abstract

The aim of this study was to determine the protection effect of SNEDDS piroxicam ulcerogenic agent against malondialdehyde (MDA) level and protein expression of caspase-3, COX-1, COX-2. The research was conducted using the test animals as much as 30 male white Sprague dawley (SD) rats aged 1-2 months with a weight of 100-200 grams divided into 5 groups. Treatment was given for 28 days orally. On the 29th day blood samples were also taken for the determination of MDA (Malondialdehid) levels by Thiobarbituric Acid Reactive Substance (TBARs) method using a visible spectrophotometer. Rats were sacrificed, then gastric organs were taken for immunohistochemical testing of caspase-3 and COX-1 expression, COX-2. The statistical analysis showed that the piroxicam SNEDDS group and the piroxicam suspension group decreased expression of the caspase-3 protein, increased COX-1 expression, decreased COX-2 and significantly decreased MDA levels. The piroxicam-containing SNEDDS (Self-Nanoemulsifying Drug Delivery System) form has protection against ulcogenic piroxicam.
Co-Authors . Lolita Ambar Yunita Nugraheni Danang Yulianto Daniar Dyanas Rais Deasy Vanda Pertiwi Dewi Noor Azizah Dewi Noor Azizah Dhadhang Wahyu Kurniawan Endah Nurlaela Endah Nurlaela Erninda Ayu Hapsari Fasyir, Syaima' Rihan Fasyir, Syaima’ Rihan fatima, fatma fatma fatima Fatma Nuraisyah, Fatma Fauziyyah, Afifah Firdaus, Rizqi Amalia Fitriana Putri Utami Gunanti, Faril Hanisari, Putri Hendra Darmawan Heni Lutfiyati Iis Wahyuningsih Ivong Rusdiyanti Khoirot, Asiilah Fatihatul Kurnia Ambarwati Kurniawati, Lindha Kusrinanti, Nabillah Ainun Larasati, Febrilla Ayu Ligawa, Yuniar Nabilla Lina Widiyastuti Lolita Lolita Lolita Lovita Ningsih Luthfiah Saraswati, Hasna Makwa, Nidaul Muhammad Muhlis Nabila, Nabila Nining Sugihartini Niswara, Anggita Kamalia Noorlina Noorlina Noorlina, Noorlina Noorlina, Noorlina NORMA HAYATI Norma Hayati, Norma Novita, Sisri Novitasari, Putri Rachma Nurjannah Nurjannah Nurlaela, Endah Pertiwi, Deasy Vanda Prasojo Pribadi Puspitasari, Kartini Raharjo, Satriyo Dwi Ramdhani, Merry Ratih Oktri Nanda Ratu Matahari Ratu Matahari Rayi Citra Ayu Pangestuti Rungprai, Daraporn Silvia Mareti Siti Fatmawati Fatimah, Siti Fatmawati Siti Mardhiyah Sudarmanto, B.S. Ari Sukmaningtyas, Rachmawati Sulaiman, Teuku Nanda Saifullah Syarifah, Nur Bidayah Tajjudin, Saiful Nizam Tri Hastuti, Haadiyatul Triandika, Rifaldy Utami, Fitriana Putri Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widiyastuti, Lina Wiwik Indayati Woro Supadmi zai, Khadijah Zayyana Septya Ramadani