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Journal : Medula

Formulasi dan Uji Antijerawat Gel Ekstrak Etanol 70% Buah Belimbing Wuluh (Averrhoa Bilimbi Linn.) terhadap Bakteri Propionibacterium acnes Azis Ikhsanudin; Siti Mardhiyah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.024 KB) | DOI: 10.46496/medula.v5i1.3890

Abstract

ABSTRACT Belimbing wuluh fruit known have flavonoids that has a function as natural anti bacterial for acne treatmeant. To easer in  using it, so it formulated in the form of gel. The aims of research was to know the influence of variation concentration ethanol extract 70% belimbing wuluh fruit to physical characteristic of gel and antibacterial activity of Propionibacterium acnes which a bacteria causes acne. Belimbing wuluh fruit extract was obtained by maceration. Extract formulated in the form of gel with variation concentration 4,17%w/v, 8,33% w/v, 12,5%w/v, 16,67%w/v, and 20,83%w/v. Antibacterial activity test was conducted by cup plate technique difusion methode and physical characteristic test covered organoleptic test, spreadibility test, and adhesivity test. The result of antibacterial test and physical characteristic test were analyzed statistically using Kruskall Wallis test and Mann Whitney test with 95% level confidence. The result of research showed that with an increasing concentration of extract could affect physical characteristic of gel and will increase antibacterial activity. The higher concentration extract, the color of gel obtained more concentrated, pH of gel be acid, decreasing adhesive power, spread power obtained smaller and inhibition diameter obtained bigger. The result of research obtained that formula 2 was a good formula with pH value 5, average adhesive power was 4,63 seconds ± 0,57, average spread power was 11,34 cm2 ± 0,44 and average diameter obstruent was 5 mm ±1,41. Based on the research could be concluded that gel extract ethanol 70% belimbing wuluh (Averrhoa bilimbi Linn) fruit had antibacteria activity against Propionibacterium acnes. Minimal concentration which could inhibit growth that bacteria found at concentration 5% and formula which had a good physical characteristic at formula 2.Keywords : Gel, Etanolic extract 70%; Averrhoa Bilimbi Linn, Propionibacterium acnes.
Co-Authors . Lolita Ambar Yunita Nugraheni Danang Yulianto Daniar Dyanas Rais Deasy Vanda Pertiwi Dewi Noor Azizah Dewi Noor Azizah Dhadhang Wahyu Kurniawan Endah Nurlaela Endah Nurlaela Erninda Ayu Hapsari Fasyir, Syaima' Rihan Fasyir, Syaima’ Rihan fatima, fatma fatma fatima Fatma Nuraisyah, Fatma Fauziyyah, Afifah Firdaus, Rizqi Amalia Fitriana Putri Utami Gunanti, Faril Hanisari, Putri Hendra Darmawan Heni Lutfiyati Iis Wahyuningsih Ivong Rusdiyanti Khoirot, Asiilah Fatihatul Kurnia Ambarwati Kurniawati, Lindha Kusrinanti, Nabillah Ainun Larasati, Febrilla Ayu Ligawa, Yuniar Nabilla Lina Widiyastuti Lolita Lolita Lolita Lovita Ningsih Luthfiah Saraswati, Hasna Makwa, Nidaul Muhammad Muhlis Nabila, Nabila Nining Sugihartini Niswara, Anggita Kamalia Noorlina Noorlina Noorlina, Noorlina Noorlina, Noorlina NORMA HAYATI Norma Hayati, Norma Novita, Sisri Novitasari, Putri Rachma Nurjannah Nurjannah Nurlaela, Endah Pertiwi, Deasy Vanda Prasojo Pribadi Puspitasari, Kartini Raharjo, Satriyo Dwi Ramdhani, Merry Ratih Oktri Nanda Ratu Matahari Ratu Matahari Rayi Citra Ayu Pangestuti Rungprai, Daraporn Silvia Mareti Siti Fatmawati Fatimah, Siti Fatmawati Siti Mardhiyah Sudarmanto, B.S. Ari Sukmaningtyas, Rachmawati Sulaiman, Teuku Nanda Saifullah Syarifah, Nur Bidayah Tajjudin, Saiful Nizam Tri Hastuti, Haadiyatul Triandika, Rifaldy Utami, Fitriana Putri Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Widiyastuti, Lina Wiwik Indayati Woro Supadmi zai, Khadijah Zayyana Septya Ramadani