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All Journal JBIO: jurnal biosains (the journal of biosciences) Prosiding Seminar Biologi Elkawnie Padjadjaran Journal of Dentistry Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Buletin Farmatera IJOEP : International Journal of Ecophysiology Bioscientist : Jurnal Ilmiah Biologi Archives of The Medicine and Case Reports Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik)
Syafruddin Ilyas
Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Sumatera Utara
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Yield Analysis and Phytochemical Screening of Ethanol Extract of Phaleria macrocarpa Leaves Ira Cinta Lestari; Dharma Lindarto; Syafruddin Ilyas; Tri Widyawati; Suryani Eka Mustika
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.11724

Abstract

Phaleria macrocarpa leaves have the potential to be used as raw materials for medicines derived from natural ingredients, but research is needed to determine the content and efficacy of these plants. This study aims to analyze the yield and screening of the content of phytochemical compounds in the ethanolic extract of the Phaleria macrocarpa leaves. This research is a descriptive study. Extract yield analysis was performed by calculating the weight ratio of the extract divided by the simplicia multiplied by one hundred percent. Screening for the phytochemical content was carried out for compounds belonging to the class of flavonoids, saponins, tannins, alkaloids, steroids, and triterpenoids. The results of the calculation of the yield of the extract obtained were 14.58% and the results of the phytochemical test showed that the extract contained flavonoids, alkaloids, tannins, glycosides, saponins, and steroids.
Utilization of Nanogels Binahong Leaf Extract on Palatal Wound Healing Lestari, Chandra; Ilyas, Syafruddin; Hanafiah, Olivia Avriyanti
Archives of The Medicine and Case Reports Vol. 5 No. 2 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i2.503

Abstract

The palatal wound is challenging to cure due to eating and chewing activities; hence, a medication delivery system is required to expedite the healing process. The leaf of the binahong plant contains saponins, tannins, alkaloids, flavonoids, and vitamin C. Binahong leaves contain important antibacterial, antiviral, anti-inflammatory, analgesic, and antioxidant properties. However, further discussion is necessary regarding the use of nanogels and binahong leaf extract in biomedical and pharmaceutical applications. Analyzing the effectiveness of nanogels binahong leaves in healing palatal mucosa wounds has been examined in previous research. Multiple studies have revealed that using nanogels and binahong leaf extract can accelerate wound healing on the skin and within the oral cavity by boosting fibroblasts, collagen, and other factors. In conclusion, the use of nanogel binahong leaf extracts has the ability to accelerate the healing of palatal mucosa wounds.
Anticancer potency of black sea cucumber (Holothuria atra) from Mentawai Islands, Indonesia Satari, Mieke Hemiawati; Arma, Utmi; Ilyas, Syafruddin; Handayani, Dian
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.217 KB) | DOI: 10.24198/pjd.vol29no1.11654

Abstract

Introduction: The source of bioactive compounds believed to have strong anticancer potency is derived from sea cucumber. Black sea cucumber (Holothuria atra) is a dominant species in Mentawai Islands, West Sumatera, Indonesia. Key factor compound that acts as anticancer in sea cucumber extract is tritepenoid also known as Frondoside A. The purpose of this study was to determine the effectiveness of the active compound taken from black sea cucumber as anticancer. Methods: Methods used was experimental laboratory. Anticancer activity of black sea cucumber was determined by using the MTT assay cytotoxic test to measure the IC50. Cytotoxic test was conducted with Supris clone-1 (SP-C1) derived from cloned lymphadenopathy of patients with oral squamous cell carcinoma on lingual part. Results: It was found that the compounds contained in black sea cucumber has strong anticancer activity (IC50 = 5.25 μL/mL) against SP-C1. Conclusion: Black sea cucumber extract has strong cytotoxic effects against cancer cells SP-C1, therefore black sea cucumber extract potentially developed as a new source of cancer medicine.
In Silico Evaluation of Antioxidant Potential of Adenostemma lavenia Leaf Compounds Against IL-6 in Pulmonary Sepsis Polem, Wardah Sawitri; Ilyas, Syafruddin; Tanjung, Masitta
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 3 (2025): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i3.16396

Abstract

This study aims to evaluate the antioxidant potential of bioactive compounds from Adenostemma lavenia in targeting interleukin-6 (IL-6) associated with pulmonary sepsis. Phytochemicals from Adenostemma lavenia leaves were identified using GC-MS, and ten bioactive compounds with potential antioxidant activity were selected. These compounds underwent further in silico evaluation, including drug-likeness screening, biological activity prediction, pharmacokinetic and toxicity analysis, and molecular docking against interleukin-6 (PDB ID: 8J6F). Among them, stigmasterol showed the highest docking score of –8.1 kcal/mol and a PASS prediction probability (Pa) of 0.867 for antioxidant activity. Half of them fully complied with drug-likeness criteria. Among these, D-Allose, 2,4-Di-tert-butylphenol, and Phytol demonstrated the highest predicted antioxidant activity. Toxicity evaluations revealed a generally safe profile, with minimal nephrotoxicity in two compounds. Notably, Phytol exhibited the closest similarity in binding residues to the native ligand of IL-6, suggesting a strong binding orientation and promising therapeutic value. The in silico findings highlight Phytol and other antioxidant-rich phytoconstituents of A. lavenia as promising agents targeting IL-6, supporting their potential use as adjunct therapies for oxidative stress-related conditions such as pulmonary sepsis. These results contribute to the scientific understanding of natural antioxidants in inflammation control and warrant further validation through in vitro and in vivo studies.
Provision of Oligomer Chitosan from Square Rawan Bonds (Squilla mantis) as Effectanti Microba Agusnar, Harry; Ilyas, Syafruddin
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2022): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (926.722 KB) | DOI: 10.32734/abdimastalenta.v7i1.4195

Abstract

We report the provision of chitosan oligomers from pen squid as anti-microbial effect. Chitosan oligomer obtained by adding 10 ml HNO2 in chitosan solution and then incubated for one night at room temperature. Depolymerization of chitosan can be determined by looking at a decrease in its viscosity by using viscometer oswald and molecular weight using the equation Kuhn-Mark-Houwink. Antibacterial test was determined by agar diffusion method. The results showed that the viscosity value of the viscosity standard oligomers with the addition of 10 ml of HNO2 decreased by 76,49% and the molecular weight decreased by 80.94%. Antimicrobial Test uses two microbesstaphylococcus aureus and Escherichia coli with variations in the concentration of 0,5%, 1%, 1.5%, 2% and 2,5% chitosan oligomers, anti-microbial test results obtained the largest clear zone on chitosan oligomers with a concentration of 1% is equal to 13,4 in Escherichia coli and 16,2 in staphylococcus aureus.
The Role of Aspirin in the Prevention of Preeclampsia (A Mini Review) Teguh Firdaus; Ilyas, Syafruddin
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.20227

Abstract

Preeclampsia is a severe pregnancy complication characterized by hypertension and proteinuria after 20 weeks of gestation. It is a leading cause of maternal and neonatal morbidity and mortality worldwide. Low-dose aspirin has been widely studied as a preventive measure for pre-eclampsia in high-risk women. This paper explores the role of aspirin in preventing preeclampsia, its mechanisms of action, and the effectiveness of different dosages and administration times. Studies have shown that aspirin, when taken before 16 weeks of gestation at a dosage of at least 100 mg per day, significantly reduces the risk of severe and early-onset preeclampsia. However, adherence to aspirin therapy remains a challenge, particularly among socioeconomically disadvantaged women. Increased education and healthcare access are crucial to optimizing the benefits of aspirin in preventing preeclampsia.
Anticancer Activity of N-Hexane Extract from Sphagneticola trilobata (L.) J.F Pruski Against MCF-7 Breast Cancer Cell Vivi Mardina; Tisna Harmawan; Halimatussakdiah Halimatussakdiah; Syafruddin Ilyas; Masitta Tanjung
Elkawnie Vol. 6 No. 1 (2020)
Publisher : Faculty of Science and Technology Universitas Islam Negeri Ar-Raniry

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v6i1.6183

Abstract

Abstract : Sphagneticola trilobata (L.) J.F. Pruski is one of the perennial herbs that is widely used by the national and international community to treat various diseases including cancer. The objective of this study was to assessment the anticancer activity of n-hexane extract of S. trilobata leaves for inhibiting the growth of MCF-7 breast cancer cells in vitro by MTT (microculture tetrazolium salt) method. The n-hexane extract of sernai leaves was obtained from the maceration process of samples that were collected from the Langsa city, Aceh. The cytotoxicity test was carried out by incubating MCF-7 cells which had been exposed to several series of sample levels, viz. 1000; 500; 100; 50; 25; 10; 5 and 1 µg/mL. LC50 values are calculated using probit analysis. The results revealed that the n-hexane extract of S. trilobata leaves was cytotoxic against breast cancer cells (MCF-7) with an LC50 value of  0.037 μg /mL.Abstrak : Sphagneticola trilobata (L.) J.F. Pruski merupakan salah satu tanaman herbal yang digunakan secara luas oleh masyarakat nasional dan internasional untuk mengobati berbagai penyakit termasuk kanker. Penelitian ini bertujuan untuk mengetahui aktivitas antikanker ekstrak n-heksana daun S. trilobata dalam menghambat pertumbuhan sel kanker payudara MCF-7 secara in vitro dengan metode MTT (microculture tetrazolium salt). Ekstrak n-heksana daun sernai diperoleh dari proses maserasi sampel yang dikoleksi dari kota Langsa, Aceh. Uji sitotoksisitas dilakukan dengan menginkubasi sel MCF-7 yang telah dipaparkan beberapa seri  kadar sampel yaitu 1000, 500, 100, 50, 25, 10, 5 dan 1 µg/mL. Nilai LC50 dihitung dengan menggunakan analisa probit. Hasil penelitian menunjukkan bahwa ekstrak n-heksana daun S. trilobata bersifat sitotoksik terhadap sel kanker payudara (MCF-7) dengan harga LC50 sebesar 0,037 µg/mL. 
Caspase 3 and Caspase 10 Expression in Rat Muscles Post Gagatan Harimau (Paraboea leuserensis B.L.Burtt) Nanoherbal and Exercise Ashfira; Syafruddin Ilyas; Masitta Tanjung
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8371

Abstract

This study aims to analyze the Expression of Caspase 3 and Caspase 10 in Rat Muscles Post Gagatan Harimau (Paraboea leuserensis B.L.Burtt) Nanoherbal and Exercise. Treatment consists of control group, maximum physical exercise, maximum physical exercise + Vitamin C at a dose of 2 mg/Kg Body Weight, maximum physical exercise + Gagatan Harimau nanoherbal with concentration 100, 125 and 150 mg/Kg BW. Data obtained from each observation parameter were recorded and presented in table and figure form. The data were analyzed using SPSS software version 25 with significant differences at 5%. The results of the study showed all treatments (p<0.05) in the expression of caspase 3 and caspase 10 in rat muscle. At dose of 150 mg/Kg BW can reduce the expression of caspase 3 and caspase 10 in rat muscle. Induction of Gagatan Harimau leaf nanoherbal as an antioxidant in male rats given swimming physical exercise showed improvements in muscle histology and morphology. A dose of 150 mg/Kg BW of nanoherbal Gagatan Harimau leaves was the best dose because it showed cell regeneration close to the normal treatment group.
ANTI-MELANOGENIC PROPERTIES OF CELERY LEAF EXTRACT IN HYPERPIGMENTATION INDUCED BY AZIDOTHYMIDINE Dearni Damanik; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas; Hadyanto L
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.20682914

Abstract

The purpose of this study is to examine the impact of ethanolic extract form Celery leaves (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
THE EFFECT OF CELERY LEAF EXTRACT (APIUM GRAVEOLENS L.) ON TNF-Α, IL-6 AND MDA LEVELS IN HYPERPIGMENTED WISTAR RATS (RATTUS NOVERGIUS SP.) Dina R. Purba; Jekson M. Siahaan; Endy Juli Anto; Syafruddin Ilyas; Hadyanto L
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 3 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.20747569

Abstract

The objective of this study was to evaluate the anti-inflammatory effects of Celery leaf extract (Apium graveolens L.) on hyperpigmented Wistar rats (Rattus norvegicus sp.) induced by Azidothymidine (AZT). Celery leaves are known to contain bioactive compounds which may serve as potent anti-inflammatory and antioxidant agents. About 30 male Wistar rats were divided into five groups, including a positive control, a negative control, and groups treated with various doses (1%, 3% and 5%) of celery leaf extract. The study examined inflammation indicators such as MDA, TNF-α, and IL-6. Celery leaf extract significantly (P<0.001) reduced MDA, TNF-α, and IL-6 levels in rats, demonstrating its capacity to attenuate inflammation and oxidative stress produced by AZT. With the increase in celery leaf extract concentration from 1% to 5%, MDA, IL-6 and TNF-α levels decreased from 42.083 ± 3.49 to 28.277 ± 10.27 nmol/ml, 14.588 ± 3.38 to 4.539 ± 1.40 nmol/ml and 667.614 ± 143.41 to 326.920 ± 62.72 nmol/ml respectively. Histopathological examinations demonstrated improvements in skin tissues damaged by inflammation. The results indicate that an ethanol extract of celery leaves has the potential to be an efficient anti-inflammatory drug, notably in lowering AZT-induced inflammation and hyperpigmentation. Further research is required to explore its clinical applicability in controlling inflammatory diseases in human.
Co-Authors Anggraini, Dwi Rita Antika, Maya Anjelir Ashfira Asmarinah Asmarinah Budianto Siregar Datten Bangun Dearni Damanik Dharma Lindarto Dian Handayani Dina R. Purba Endy Juli Anto Evi Irianti fatchiyah . Fauzi Yusuf, Fauzi Hadyanto L Halimatussakdiah Halimatussakdiah Harry Agusnar Harun Al Rasyid Ira Cinta Lestari Jekson M. Siahaan Kesuma Wardani Lestari, Chandra Marpaung, Okto P.E Masitta Tanjung Mesrawati Purba Mieke Hemiawati Satari Nukman Moeloek Nurjati C. Siregar Nursal Olivia Avriyanti Hanafiah Polem, Wardah Sawitri Ramlan Silaban Ria Lumbantoruan Rina Marintan Sitorus Rosidah, Rosidah Salomo Hutahaean Salomo Hutahaen Sari, Mutiara Indah Silvia W Lestari Sinaga, Ade Putra Fratama Siregar C Siregar, Siregar C Suryani Eka Mustika Teguh Firdaus Ternala Alexander Barus Tisna Harmawan Tisna Hermawan Tri Widyawati Utmi Arma, Utmi Vivi Mardina Vivi Mardina Yasmeini Yazir