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All Journal JBIO: jurnal biosains (the journal of biosciences) Prosiding Seminar Biologi Elkawnie Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Buletin Farmatera Indonesian Journal of Medicine IJOEP : International Journal of Ecophysiology Bioscientist : Jurnal Ilmiah Biologi Archives of The Medicine and Case Reports Prosiding Seminar Nasional Biologi, Teknologi dan Kependidikan (Biotik)

Syafruddin Ilyas

Department Of Biology, Faculty Of Mathematics And Natural Sciences, Universitas Sumatera Utara

Author-ID : 285950

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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EFFECTS OF METHANOL EXTRACT AND N-HEXANE EXTRACT OF PAPAYA LEAVES (CARICA PAPAYA L) ON TOTAL AND DIFFERENTIAL WHITE BLOOD CELL COUNTS IN MALE WISTAR RATS AFTER CARRAGEENAN INDUCTION Okto P.E Marpaung; Datten Bangun; Syafruddin Ilyas
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

As one of the countries producing medicinal plants, Indonesia has the potential to develop medicinal plants in the future. The anti-inflammatory effects of methanol and n-hexane extract from papaya leaves were seen in this study using a pretest-posttest control group design using 36 male adult Wistar rats divided into 6 groups. All rats received 1 week acclimatization, then blood specimens were taken from the tail, after which they were treated, and intraplantar injections were carried out with 1% carrageenan solution as much as 0.1 ml. Then retrieval of blood specimens from rats' tails at 3 hours and 6 hours afterwards. Then an examination of the number and type of leukocytes was performed on all blood specimens obtained. It was found that the number of male Wistar rat leukocytes after getting methanol extract of papaya leaves was lower but not significant (p> 0.05) compared to those who did not. The increase in the number of leukocytes cannot be restrained significantly by the administration of n-hexane extract. It was found that changes in leukocyte counts in acute inflammatory conditions with the administration of methanol extract and n-hexane extract of Papaya Leaves. The increase number of neutrophils and monocytes in acute inflammatory conditions can be significantly suppressed by the administration of methanol extract of papaya leaves. Key words: inflammation, carrageenan, papaya, Carica papaya l

PENGUJIAN AKTIVITAS ANTI BAKTERI DAUN Sphagneticola trilobata J.F (L.) Pruski TERHADAP Salmonella typhi DAN Escherichia coli Vivi Mardina; Syafruddin Ilyas; Tisna Hermawan
Prosiding Seminar Nasional Biotik Vol 8, No 1 (2020): PROSIDING SEMINAR NASIONAL BIOTIK VIII 2020
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh, Aceh, Indonesia.

Sphagneticola trilobata (L.) J.F Pruski merupakan tumbuhan semak, dianggap invasive dan mudah tumbuh pada iklim tropis. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak n-heksana dan etil asetat dari daun S. trilobata terhadap bakteri patogen, Salmonella typhi dan Eschericia coli. Metode difusi sumuran diadopsi dengan konsentrasi ekstrak bervariasi dari 0,5-10% (b/v). Hasil uji aktivitas antibakteri memaparkan bahwa ekstrak etil asetat lebih potensial/aktif menghambat pertumbuhan bakteri S. typhi dan E. coli dengan zona inhibisi yang dihasilkan masing-masing pada range 12-17 mm dan 11-19 mm. Adapun ekstrak n-heksana daun S. trilobata dikategorikan lemah aktivitas antibakterinya dengan zona inhibisi yang dihasilkan pada range 3,6-6,8 mm dan 4,3-6 mm masing-masing terhadap S. typhi dan E. coli. Berdasarkan uji aktivitas antibakteri maka penelitian ini menyimpulkan bahwa ekstrak etil asetat daun S. trilobata (L.) J.F Pruski berpotensial untuk dijadikan agen baru antibakteri sehingga purifikasi ekstrak sangat dianjurkan.

Yield Analysis and Phytochemical Screening of Ethanol Extract of Phaleria macrocarpa Leaves Ira Cinta Lestari; Dharma Lindarto; Syafruddin Ilyas; Tri Widyawati; Suryani Eka Mustika
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.11724

Phaleria macrocarpa leaves have the potential to be used as raw materials for medicines derived from natural ingredients, but research is needed to determine the content and efficacy of these plants. This study aims to analyze the yield and screening of the content of phytochemical compounds in the ethanolic extract of the Phaleria macrocarpa leaves. This research is a descriptive study. Extract yield analysis was performed by calculating the weight ratio of the extract divided by the simplicia multiplied by one hundred percent. Screening for the phytochemical content was carried out for compounds belonging to the class of flavonoids, saponins, tannins, alkaloids, steroids, and triterpenoids. The results of the calculation of the yield of the extract obtained were 14.58% and the results of the phytochemical test showed that the extract contained flavonoids, alkaloids, tannins, glycosides, saponins, and steroids.

Utilization of Nanogels Binahong Leaf Extract on Palatal Wound Healing Lestari, Chandra; Ilyas, Syafruddin; Hanafiah, Olivia Avriyanti
Archives of The Medicine and Case Reports Vol. 5 No. 2 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i2.503

The palatal wound is challenging to cure due to eating and chewing activities; hence, a medication delivery system is required to expedite the healing process. The leaf of the binahong plant contains saponins, tannins, alkaloids, flavonoids, and vitamin C. Binahong leaves contain important antibacterial, antiviral, anti-inflammatory, analgesic, and antioxidant properties. However, further discussion is necessary regarding the use of nanogels and binahong leaf extract in biomedical and pharmaceutical applications. Analyzing the effectiveness of nanogels binahong leaves in healing palatal mucosa wounds has been examined in previous research. Multiple studies have revealed that using nanogels and binahong leaf extract can accelerate wound healing on the skin and within the oral cavity by boosting fibroblasts, collagen, and other factors. In conclusion, the use of nanogel binahong leaf extracts has the ability to accelerate the healing of palatal mucosa wounds.

Anticancer potency of black sea cucumber (Holothuria atra) from Mentawai Islands, Indonesia Satari, Mieke Hemiawati; Arma, Utmi; Ilyas, Syafruddin; Handayani, Dian
Padjadjaran Journal of Dentistry Vol 29, No 1 (2017): March 2017
Publisher : Universitas Padjadjaran

Introduction: The source of bioactive compounds believed to have strong anticancer potency is derived from sea cucumber. Black sea cucumber (Holothuria atra) is a dominant species in Mentawai Islands, West Sumatera, Indonesia. Key factor compound that acts as anticancer in sea cucumber extract is tritepenoid also known as Frondoside A. The purpose of this study was to determine the effectiveness of the active compound taken from black sea cucumber as anticancer. Methods: Methods used was experimental laboratory. Anticancer activity of black sea cucumber was determined by using the MTT assay cytotoxic test to measure the IC50. Cytotoxic test was conducted with Supris clone-1 (SP-C1) derived from cloned lymphadenopathy of patients with oral squamous cell carcinoma on lingual part. Results: It was found that the compounds contained in black sea cucumber has strong anticancer activity (IC50 = 5.25 μL/mL) against SP-C1. Conclusion: Black sea cucumber extract has strong cytotoxic effects against cancer cells SP-C1, therefore black sea cucumber extract potentially developed as a new source of cancer medicine.

In Silico Evaluation of Antioxidant Potential of Adenostemma lavenia Leaf Compounds Against IL-6 in Pulmonary Sepsis Polem, Wardah Sawitri; Ilyas, Syafruddin; Tanjung, Masitta
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 3 (2025): September
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i3.16396

This study aims to evaluate the antioxidant potential of bioactive compounds from Adenostemma lavenia in targeting interleukin-6 (IL-6) associated with pulmonary sepsis. Phytochemicals from Adenostemma lavenia leaves were identified using GC-MS, and ten bioactive compounds with potential antioxidant activity were selected. These compounds underwent further in silico evaluation, including drug-likeness screening, biological activity prediction, pharmacokinetic and toxicity analysis, and molecular docking against interleukin-6 (PDB ID: 8J6F). Among them, stigmasterol showed the highest docking score of –8.1 kcal/mol and a PASS prediction probability (Pa) of 0.867 for antioxidant activity. Half of them fully complied with drug-likeness criteria. Among these, D-Allose, 2,4-Di-tert-butylphenol, and Phytol demonstrated the highest predicted antioxidant activity. Toxicity evaluations revealed a generally safe profile, with minimal nephrotoxicity in two compounds. Notably, Phytol exhibited the closest similarity in binding residues to the native ligand of IL-6, suggesting a strong binding orientation and promising therapeutic value. The in silico findings highlight Phytol and other antioxidant-rich phytoconstituents of A. lavenia as promising agents targeting IL-6, supporting their potential use as adjunct therapies for oxidative stress-related conditions such as pulmonary sepsis. These results contribute to the scientific understanding of natural antioxidants in inflammation control and warrant further validation through in vitro and in vivo studies.

The effect of the ethanolic extract of African leaves (Vernonia amygdalina Delile) on the corrosion rate and microstructure of stainless steel orthodontic wire Bahirrah, Siti; Ilyas, Syafruddin; Narmada , Ida Bagus; Primasari, Ameta; Lestari, Widya; Indra; Sofyanti, Ervina
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 4 (2025): December
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i4.p376-381

Background: Stainless steel orthodontic wire is commonly used in orthodontic treatment but is prone to corrosion; therefore, an inhibitor is required. Purpose: This study aimed to evaluate the effectiveness of the ethanolic extract of African leaves (Vernonia amygdalina Delile) as a corrosion inhibitor for stainless steel wires. Methods: A laboratory experiment with a pre- and post-test control group design was conducted. Samples included one negative control (artificial saliva), one positive control (chlorhexidine), and two treatment groups (ethanolic extract of African leaves at 3.125 mg/mL and 6.25 mg/mL), totaling 28 samples. Immersion lasted 7 days at 37°C. Corrosion rates were measured by weight loss, and microstructural changes were analyzed using a scanning electron microscope. Results: The highest average corrosion rate was observed in the chlorhexidine group (0.98 ± 0.58 mils per year [mpy]), whereas the lowest was in the 6.25 mg/mL extract group (−0.04 ± 0.80 mpy). Scanning electron microscope analysis revealed notable microstructural differences: the artificial saliva group showed long scratches scattered across the surface and localized round porosity; the chlorhexidine group exhibited rough scratches and widespread porosity; in contrast, the African leaves groups displayed minor scratches and a thin layer presumed to be protective. Conclusion: The ethanolic extract of African leaves considerably affects corrosion rates and microstructural changes in stainless steel orthodontic wires.

Provision of Oligomer Chitosan from Square Rawan Bonds (Squilla mantis) as Effectanti Microba Agusnar, Harry; Ilyas, Syafruddin
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 1 (2022): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

We report the provision of chitosan oligomers from pen squid as anti-microbial effect. Chitosan oligomer obtained by adding 10 ml HNO2 in chitosan solution and then incubated for one night at room temperature. Depolymerization of chitosan can be determined by looking at a decrease in its viscosity by using viscometer oswald and molecular weight using the equation Kuhn-Mark-Houwink. Antibacterial test was determined by agar diffusion method. The results showed that the viscosity value of the viscosity standard oligomers with the addition of 10 ml of HNO2 decreased by 76,49% and the molecular weight decreased by 80.94%. Antimicrobial Test uses two microbesstaphylococcus aureus and Escherichia coli with variations in the concentration of 0,5%, 1%, 1.5%, 2% and 2,5% chitosan oligomers, anti-microbial test results obtained the largest clear zone on chitosan oligomers with a concentration of 1% is equal to 13,4 in Escherichia coli and 16,2 in staphylococcus aureus.

The Role of Aspirin in the Prevention of Preeclampsia (A Mini Review) Teguh Firdaus; Ilyas, Syafruddin
International Journal of Ecophysiology Vol. 7 No. 1 (2025): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v7i1.20227

Preeclampsia is a severe pregnancy complication characterized by hypertension and proteinuria after 20 weeks of gestation. It is a leading cause of maternal and neonatal morbidity and mortality worldwide. Low-dose aspirin has been widely studied as a preventive measure for pre-eclampsia in high-risk women. This paper explores the role of aspirin in preventing preeclampsia, its mechanisms of action, and the effectiveness of different dosages and administration times. Studies have shown that aspirin, when taken before 16 weeks of gestation at a dosage of at least 100 mg per day, significantly reduces the risk of severe and early-onset preeclampsia. However, adherence to aspirin therapy remains a challenge, particularly among socioeconomically disadvantaged women. Increased education and healthcare access are crucial to optimizing the benefits of aspirin in preventing preeclampsia.

Caspase 3 and Caspase 10 Expression in Rat Muscles Post Gagatan Harimau (Paraboea leuserensis B.L.Burtt) Nanoherbal and Exercise Ashfira; Ilyas, Syafruddin; Tanjung, Masitta
Jurnal Penelitian Pendidikan IPA Vol 10 No 9 (2024): September
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i9.8371

This study aims to analyze the Expression of Caspase 3 and Caspase 10 in Rat Muscles Post Gagatan Harimau (Paraboea leuserensis B.L.Burtt) Nanoherbal and Exercise. Treatment consists of control group, maximum physical exercise, maximum physical exercise + Vitamin C at a dose of 2 mg/Kg Body Weight, maximum physical exercise + Gagatan Harimau nanoherbal with concentration 100, 125 and 150 mg/Kg BW. Data obtained from each observation parameter were recorded and presented in table and figure form. The data were analyzed using SPSS software version 25 with significant differences at 5%. The results of the study showed all treatments (p<0.05) in the expression of caspase 3 and caspase 10 in rat muscle. At dose of 150 mg/Kg BW can reduce the expression of caspase 3 and caspase 10 in rat muscle. Induction of Gagatan Harimau leaf nanoherbal as an antioxidant in male rats given swimming physical exercise showed improvements in muscle histology and morphology. A dose of 150 mg/Kg BW of nanoherbal Gagatan Harimau leaves was the best dose because it showed cell regeneration close to the normal treatment group.

Co-Authors Ameta Primasari Anggraini, Dwi Rita Antika, Maya Anjelir ashfira Asmarinah Asmarinah Budianto Siregar Datten Bangun Dharma Lindarto Dian Handayani Ervina Sofyanti Evi Irianti fatchiyah . Fauzi Yusuf, Fauzi Halimatussakdiah Halimatussakdiah Harry Agusnar Harun Al Rasyid Damanik, Harun Al Rasyid Hery Widijanto Indra Ira Cinta Lestari Kesuma Wardani Lestari, Chandra Marpaung, Okto P.E Masitta Tanjung Mesrawati Purba Mieke Hemiawati Satari Narmada , Ida Bagus Nukman Moeloek Nurjati C. Siregar Nursal Olivia Avriyanti Hanafiah Polem, Wardah Sawitri Ramlan Silaban Ria Lumbantoruan Rina Marintan Sitorus Rosidah, Rosidah Salomo Hutahaean Salomo Hutahaen Sari, Mutiara Indah Silvia W Lestari Sinaga, Ade Putra Fratama Siregar C Siregar, Siregar C Siti Bahirrah Suryani Eka Mustika Teguh Firdaus Ternala Alexander Barus Tisna Harmawan Tisna Hermawan Tri Widyawati Utmi Arma, Utmi Vivi Mardina Vivi Mardina Yasmeini Yazir

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