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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JFIOnline ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Sociality: Journal of Public Health Service
Isriany Ismail
Pharmacy, Faculty of Health Science, Universitas Islam Negeri Alauddin Makassar Jl. Sultan Alauddin No 36 Samata – Gowa SulawesiSelatan
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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PENGARUH KONSENTRASI ETANOL TERHADAP PENJERAPAN NIFEDIPIN PADA FORMULA ETHOSOME Rizal, Rizal; Ismail, Isriany
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i2.584

Abstract

Researched about the influence of ethanol consentration to entrapment of nifedipin in ethosome formula. This research suppose to know about the influence of etanol consentration tonifedipine entrapment, form and size of ethosome, to decide the optimal consentration of etanol forming ethosome with high PDE (Percent Drug Entrapment) in nifedipin, and to know the ethosome characteristic. Ethosome formula  made in by hot method, using variation consentration of ethanol, phosphatidilcholin 1.5% and nefidepin 0,05%. Nifedipin concentration that entrapment in ethosome measured byUV-VIS Spectrophotometer at wavelength 336 nm, form and ethosome size fixed by using microscope.  Ethosome with  high  percent drug entrapment have taken from formula by using ethanol 50% with entrapment 71.440%. The formed ethosome is Multy Lameral Vesicle (MLV) and Multy Vesicular Vesicle (MVV) with the size about 1 μm until 15μm.
PENGARUH KONSENTRASI ETANOL TERHADAP PENJERAPAN NIFEDIPIN PADA FORMULA ETHOSOME Rizal, Rizal; Ismail, Isriany
Jurnal Farmasi Indonesia Vol 10, No 2 (2018)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (963.479 KB) | DOI: 10.35617/jfi.v10i2.584

Abstract

Researched about the influence of ethanol consentration to entrapment of nifedipin in ethosome formula. This research suppose to know about the influence of etanol consentration tonifedipine entrapment, form and size of ethosome, to decide the optimal consentration of etanol forming ethosome with high PDE (Percent Drug Entrapment) in nifedipin, and to know the ethosome characteristic. Ethosome formula  made in by hot method, using variation consentration of ethanol, phosphatidilcholin 1.5% and nefidepin 0,05%. Nifedipin concentration that entrapment in ethosome measured byUV-VIS Spectrophotometer at wavelength 336 nm, form and ethosome size fixed by using microscope.  Ethosome with  high  percent drug entrapment have taken from formula by using ethanol 50% with entrapment 71.440%. The formed ethosome is Multy Lameral Vesicle (MLV) and Multy Vesicular Vesicle (MVV) with the size about 1 μm until 15μm.
Co-Authors Arsul, Muhammad Ikhlas Asriana Sultan Dhuha, Nur Syamsi Doloking, Haeria Elly Wahyudin Jaya, Adrian Khaerani Latifah Rahman Leboe, Dwi Wayuni Maddeppungeng, Nurul Muhlisah Mardan Mardan Nur Ida Pratiwi, Afrianty Rauf, Afrisusnawati Rizal Rizal Syahrana, Nur Azizah Syarif, Alwiyah Nur