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All Journal VALENSI Jurnal Penelitian Saintek SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Alchemy Jurnal Penelitian Kimia INDONESIAN JOURNAL OF PHARMACY Jurnal Bina Praja Indonesian Journal of Chemistry Mendapo: Journal of Administrative Law Current Research on Biosciences and Biotechnology Jurnal Info Sains : Informatika dan Sains Greensphere: Journal of Environmental Chemistry

Ismiyarto Ismitarto

Department Of Chemistry, Faculty Of Science And Mathematics, Diponegoro University Jl. Prof. H. Soedarto SH Tembalang, Semarang 50275, Indonesia

Author-ID : 289653

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Energy Engineering Environmental Science Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Social Sciences

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Aplikasi Trifenilfosfin dalam Demetilasi Senyawa N-metilpiridinium Iodida Cahyono, Bambang; Ismiyarto, Ismiyarto; Ningsih, Alyxia Stellata Aria
Jurnal Kimia Sains dan Aplikasi Vol 2, No 4 (1999): Volume 2 Issue 4 Year 1999
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Trifenilfosfin (PPh3) adalah nukleofil lunak dengan potensi tinggi dalam reaksi demetilasi garam amonium siklis. Reaksi demetilasi telah dilakukan terhadap garam amonium hetcrosiklik aromatik, N-metilpiridinium iodida dengan menambahkan PPh3. Reaksi berlangsung dalam pelarut asetonitril pada temperatur 82Â°C. Kromatografi lapis tipis (TLC) digunakan untuk mengontrol jalannya reaksi, hasilnya menunjukkan bahwa PPh3 Â berperan dalam reaksi demetilasi. Penentuan waktu reaksi dilakukan dengan optimasi waktu reaksi. Hasil analisis menggunakan spektrofotometer UV-Vis menunjukkan bahwa N-metilpiridinium iodida dapat terdemetilasi setelah reaksi berlangsung selama 6 jam dengan transformasi 98 %.

Katalis Zn/Zeolit Alam dan Pengujian Aktivitasnya pada Konversi Metanol Menjadi Hidrokarbon Ismiyarto, Ismiyarto
Jurnal Kimia Sains dan Aplikasi Vol 3, No 3 (2000): Volume 3 Issue 3 Year 2000
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan sintesis katalis Zn/Zeolit alam dengan metode impregnasi menggunakan larutan [ZN(NH3)4(NO3)2] dan zeolit alam dari Cipatujah, Jawa Barat dengan variasi tempeatur reduksi. Sintesis katalis Zn/Zeolit alam dengan temperatur oksidasi 350oC dan temperatur reduksi 400oC mempunyai karakter katalis yang paling optimal, mempunyai keasaman total 4,07 mmol NH3/g dan kandungan Zn 0,81%. Dibandingkan dengan katalis H+-zeolit alam dengan reaksi thermal, energi aktivasi (Ea) konversi metanol menjadi hidrokarbon menggunakan katalis Zn/zeolit alam mempunyai harga relatif kecil. Analitis konversi metanol menjadi hidrokarbon dilakukan dengan kromatografi gas.

Synthesis of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base Salicylaldehyde and Antibacterial Activity Ismiyarto Ismiyarto; Niken Windi Saputri; Liswinda Zafirah Rahmatia; Purbowatiningrum Ria Sarjono; Ngadiwiyana Ngadiwiyana; Nor Basid Adiwibawa Prasetya; Damar Nurwahyu Bima
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 7, No. 1, May 2021
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v7i1.19866

The development of compounds with a better antibacterial activity is highly needed. One way to achieve this is by modifying the structure of the compound using chitosan as a starting material, because of its abundant natural source in Indonesia, its biodegradable properties, and its structure where free amines are present. This study aims to obtain Mn(II) -Carboxymethyl Chitosan Schiff Base-Salicylaldehyde complex to increase its antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative). Schiff Base carboxymethyl chitosan-salicylaldehyde was synthesized from carboxymethyl chitosan with salicylaldehyde. Next, the Schiff Base Carboxymethyl Chitosan-Salicylaldehyde was complexed with MnCl2.4H2O and then characterized by FTIR, UV-Vis Spectrophotometer, and AAS and tested for antibacterial activity with the disc diffusion method against Staphylococcus aureus and Escherichia coli. The product of Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a brownish yellow solid with a yield of 64% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 11 mm) and Escherichia coli (clear zone diameter 13 mm). The product of Mn(II) Complexes-Carboxymethyl Chitosan Schiff Base-salicylaldehyde is a black solid with a yield of 59% (w/w) and has antibacterial activity against Staphylococcus aureus (clear zone diameter 13 mm) and Escherichia coli (clear zone diameter 17 mm).

AKTIVITAS ANTIDIABETES METABOLIT SEKUNDER BAKTERI ENDOFIT ASAL KULIT KAYU MANIS Purbowatiningrum Ria Sarjono; Hendra Dwipa Rifky Mahardika; Nies S. Mulyani; Ngadiwiyana Ngadiwiyana; Nor Basid Adi Prasetyawibowo; Ismiyarto Ismiyarto
Jurnal Penelitian Saintek Vol 25, No 2 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v25i2.32892

Penelitian ini bertujuan untuk mengisolasi bakteri endofit yang bersimbiosis dengan kulit kayu manis, mendapatkan data kemampuan inhibisi enzim α-glukosidase dari metabolit sekunder isolat bakteri endofit yang didapatkan, serta mendapatkan informasi mengenai kandungan kimia dari metabolit sekunder isolat bakteri endofit yang didapat. Bahan yang digunakan pada penelitian ini terdiri atas sampel kulit kayu manis (Cinnamomum burmanii) yang didapatkan dari daerah Kopeng, Kabupaten Semarang. Metode yang digunakan dalam sterilisasi adalah metode klorin. Pengamatan morfologi koloni dilakukan dengan pewarnaan gram sedangkan Uji Inhibisi α-glukosidase dari metabolit menggunakan metode dari Sancheti. Aktivitas antidiabetes diuji menggunakan metode penghambatan enzim α-glukosidase. Hasil yang diperoleh pada penelitian ini adalah lima isolat bakteri memiliki yang bentuk beragam yakni streptobacillus (isolat C1, isolat C4, dan isolat C5), diplobacillus (isolat C2), dan diplococcus (isolat C3). Kemampuan inhibisi α-glukosidase tertinggi dihasilkan oleh metabolit sekunder isolat C5 yakni sebesar 45,634% pada konsentrasi 100 ppm. Penapisan fitokimia pada penelitian ini menunjukkan bahwa metabolit sekunder isolat C5 yang memiliki daya inhibisi tertinggi mengandung senyawa flavonoid, tanin, kuinon dan saponin.ANTIDIABETIC ACTIVITY FROM SECONDARY METABOLIM ENDOPHYTIC BACTERIA BARKThis study was aimed at isolating endophytic bacteria symbiotic with cinnamon bark, obtaining data on the inhibition ability of α-glucosidase enzymes from secondary metabolites of endophytic bacterial isolates obtained, and obtaining information on the chemical content of secondary metabolites of endophytic bacterial isolates obtained. The materials used in this study consisted of the samples of cinnamon bark (Cinnamomum burmanii) obtained from Kopeng, Semarang. The method used in sterilization was the chlorine method. Colony morphological observations were carried out by using gram staining, while the α-glucosidase inhibition test of metabolites used the Sancheti method. The antidiabetic activity was tested using the α-glucosidase enzyme inhibition method. The results show that five bacterial isolates had various forms, namely streptobacillus (isolate C1, isolate C4, and isolate C5), diplobacillus (isolate C2), and diplococcus (isolate C3). The highest α-glucosidase inhibition ability was produced by secondary metabolites of isolate C5, namely 45.634% at a concentration of 100 ppm. Phytochemical screening in this study showed that the secondary metabolites of isolate C5 which had the highest inhibitory power contained flavonoids, tannins, quinones and saponins.

MODIFIKASI KAIN AKTIF ANTIBAKTERI BERBASIS KOMPLEK Mn(II) BASA SCHIFF KITOSAN–SALISILALDEHID Ismiyarto - Ismiyarto; Sesika Novari; Ngadiwiyana Ngadiwiyana; Purbowatiningrum Ria Sarjono; Noor Basid Adiwibawa Prasetya
Jurnal Penelitian Saintek Vol 25, No 1 (2020)
Publisher : Institute of Research and Community Services, Universitas Negeri Yogyakarta

Penelitian ini bertujuan untuk memperoleh kompleks Mn(II)-basa Schiff kitosan-salisaldehida dan menguji aktivitasnya sebagai bahan aktif kain antibakteri. Metode penelitian dilakukan melalui tiga tahapan. Pada tahap pertama dilakukan sintesis basa Schiff kitosan–salisilaldehid dengan mereaksikan kitosan dengan variasi mol salisilaldehid menggunakan campuran pelarut asam asetat dan etanol, diaduk pada suhu 50oC selama 6 jam. Pada tahap kedua, basa Schiff kitosan–salisilaldehid dijadikan kompleks dengan MnCl2.2H2O menggunakan campuran pelarut asam asetat 2% dan etanol, diaduk pada suhu 60oC selama 12 jam. Pada tahap ketiga dilakukan pelapisan kompleks pada kain katun menggunakan metode spray dan selanjutnya dilakukan uji antibakteri terhadap E. coli (G-) dan S. aureus (G+) menggunakan metode difusi cakram. Hasil penelitian menunjukkan bahwa basa Schiff kitosan–salisilaldehid dengan rasio substitusi paling besar (0,122) diperoleh ketika disintesis menggunakan salisilaldehid 0,00227 mol. Senyawa kompleks Mn(II)-basa Schiff kitosan–salisilaldehid yang terbentuk berupa serbuk berwarna hitam dengan rendemen 66%. Kain katun yang telah dilapisi kompleks Mn(II)-basa Schiff kitosan–salisilaldehid efektif menghambat pertumbuhan bakteri dengan persen daya hambat sebesar 16,02% terhadap bakteri E. coli (G-) dan 14,02% terhadap bakteri S. aureus (G+).MODIFICATION OF ANTIBACTERIAL FABRIC FROM Mn(II) SCHIFF BASE CHITOSAN - SALICYLALDEHYDE COMPLEXThis study was aimed at obtaining the complex of Mn(II)-Schiff base chitosan- salicylaldehyde and evaluating the activity of antibacterial agent on cotton fabric. The study was conducted through three treatment steps. In the first step, chitosan-salicylaldehyde Schiff base was synthesized by reacting chitosan with mole variations of salicylaldehyde and combined with a mixture of acetic acid and ethanol as the solvent which was then stirred at 50oC for 6 hours. In the second step, preparation complexes Mn(II)- Schiff base chitosan-salicylaldehyde was conducted by mixing chitosan-salicylaldehyde Schiff base and MnCl2.2H2O using acetic acid 2% -ethanol as a solvent at 60oC for 12 h. In the third step, the complex was coated onto fabric using spray method and the E. coli (G-) dan S. aureus (G+) antibacterial test was done to the coated fabric using disk diffusion method. The results showed that 0.00227 mole salicylaldehyde lead to the highest substitution ratio of Schiff base chitosan-salicylaldehyde of 0.122. The Mn(II)-Schiff base chitosan-salicylaldehyde complex was obtained as black powder with a yield of 66%. Cotton fabric that has been coated with the complex, effectively inhibits bacterial growth with a percent inhibition against E. coli (G-) and S. aureus (G+) bacteria of 16.02% and 14.02%, respectively.

Potency of cinnamaldehyde of cinnamon oil as an antidiabetic compound Ngadiwiyana .; Ismiyarto .; Nor Basid A. Prasetya; Purbowatiningrum R. S.
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Cafeic and cinnamic compounds have been reported to give an excellent performance as α-glucosidase inhibitor. Inhibition of α-glucosidase in the intestine of mammals are able to lower blood sugar levels of the carbohydrates metabolism so it can reduce postprandial hyperglycemia which can prevent chronic complications of Diabetes Mellitus (DM). Based on cafeic and cinnamic structures in terms of organic chemistry and economic considerations, it can be offered a very promising alternative to provide their derivative compounds of cafeic from cinnamon oil, which is cinnamaldehyde. Cinnamaldehyde can be isolated from cinnamon oil by addition of sodium bisulphite to provide salt compounds which are separated easily from the mixed system. The aldehyde compound can be obtained by acid addition. Structure elucidation of cinnamaldehyde was done by mean of an infra red spectrophotometer and a gas chromatography-mass spectroscopy. Activity test of anti-diabetic compounds was carried through the measurement of the concentration of minimum resistance against α-glucosidase activity. Cinnamaldehyde which is isolated from cinnamon oil was yellowish oil and cinnamaldehyde’s yield was up to 42.67%, and its purity was 99.8723%. Structure elucidation of cinnamaldehyde by mean of infra red spectrophotometer (FTIR) showed carbonyl vibration at 1676 cm-1, -C-H aldehyde at 2813.9 cm-1 and 2742.6 cm-1. From mass spectra, it can be known that cinnamaldehyde had M+ 132 with m/z of main fragmentation were 131, 103, 77, and 51. Inhibition activity of α-glucosidase test showed that inhibitory concentration at 50 ppm of cinnamaldehyde was 93.29%, and IC50 to the α-glucosidase was 27.97 ppm.Key words :cinnamon oil, cinnamaldehyde, anti-diabetic

Antioxidant activity and cytotoxicity property of extracts from various coastal plants against HepG2 cell lines Leong Kai Vyn; Murni Nur Islamiah Kassim; Desy Fitrya Syamsumir; Hermansyah Amir; Ismiyarto; Yosie Andriani
Current Research on Bioscences and Biotechnology Vol. 1 No. 2 (2020)
Publisher : Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/10.5614/crbb.2019.1.2/ONXN6178

Reports have shown an upward trend for liver cancer in recent years. It is also one of the deadliest cancers globally due to its complexity in detection and treatment. Hence, there is an urgency todevelop the anti-liver cancer agent from natural resources which is highly effective with minimum side effects. This study aimed to evaluate the antioxidant activity and cytotoxicity property of extracts with different polarity solvents (hexane and methanol) obtained from coastal plants collected from Merang, Terengganu. Three species (Melaleuca leucadendra, Terminalia catappa, and Rhodomyrtus tomentosa) were chosen due to their abundance and lacking anticancer studies performed on them. Green leaves were collected directly from the trees and extracted using hexane and methanol successively. Preliminary phytochemical tests (phenolic, flavonoid, terpenoid, saponin, alkaloid and glycoside) were performed on the extracts, followed by an antioxidant test based on 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay. Methanol extracts with high antioxidant property were continued for cytotoxicity study on HepG2 cell lines by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed that all methanol extracts from all plants showed high antioxidant property (IC50: 0.83-1.62 mg/ml) and moderately cytotoxic activity (IC50: 24.7-28 μg/ml) against HepG2 cell lines. In contrast, hexane extracts showed very weak antioxidant activities. The highest activity was obtained by methanol extract of M. leucadendra (MLM), followed by T. catappa (TCM) and R. tomentosa (RTM), respectively. These promising results indicated that MLM could be a potential candidate for further study related to the antioxidant and cytotoxicity on HepG2 cell lines, such as for anti-liver cancer agent.

Synthesis of Chalcone and Flavanone Compound Using Raw Material of Acetophenone and Benzaldehyde Derivative Ismiyarto Ismiyarto; Sabirin Matsjeh; Chairil Anwar
Indonesian Journal of Chemistry Vol 1, No 2 (2001)
Publisher : Universitas Gadjah Mada

Synthesis of flavanoid compounds of chalcone and flavanone groups have been conducted. Flavanoid Is one of the group natural products which is mostly found in plants and have been proved to have physiological activity as drug. In this research, chalcone proup compounds that being synthesized are: chalcone, 3,4-dimethoxychalcone, 2'-hidroxy-3,4-dimethoxychalcone where as compound of flavanone group that being synthesized is 3',4'-dimethoxyflavanone. The synthesis of chalcone group are carried out based on Claisen-Schmidt reaction by using raw material of aromatic aldehydes and aromatic ketones. The synthesis in carried out by stirring at the room temperature using alkali solution as catalyst and ethanol as solvent. The synthesis of 3',4'-dimethoxyflanone is made based on the nucleophilic 1,4 addition of the unsaturated α,β ketone. The synthesis is made by refluxing 2'-hydroxy-3,4-dimethoxychalcone in alkali condition for 12 hours. The identification of flavanoid compound is carried out by using spectroscopic IR, GC-MS and 1H-NMR methods. The result of each synthesis chalcone group are follows: chalcone as yellowish solid with m.p= 50 °C and the yield is 83.39%; 3,4-dimethoxychalcone as yellow solid with m.p= 57°C and the yield is 76.00% ; 2'-hydroxy-3,4-dimethoxychalcone as orange solid with m.p= 90 °C and the yield is 74.29%, for 3',4'-dimethoxyflavanone as pale yellow solid with m.p= 80 °C and the yield is 72.00%.

Total Phenolic and Coumarin Content, Antioxidant Activity of Leaves, Fruits, and Stem Barks of Grey Mangrove (Avicennia marina) Alik Kandhita Febriani; Ismiyarto Ismiyarto; Khairul Anam
Jurnal Kimia Sains dan Aplikasi Vol 23, No 2 (2020): Volume 23 Issue 2 Year 2020
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Avicennia marina is one of the mangrove species used for traditional medicines. The leaves, fruits, and stem barks of A. marina are used for treating skin diseases. The stem barks are used for rheumatism, smallpox, and ulcers. The extract of A. marina was also reported to have antioxidant activity and indicates the presence of alkaloid, saponin, flavonoid, tannin, sterol/triterpenoid, and coumarin. However, the comparison of the antioxidant activity of leaves, fruits, and stem barks is not evaluated yet. The purpose of this study is to compare the antioxidant activity, total phenolic and coumarin content of leaves, fruits, and stem barks of A. marina. The antioxidant activity was determined using DPPH radical scavenging assay and was evaluated by spectrophotometric method at 515 nm. Quercetin was used for comparison. The fruits had the highest antioxidant activity with an IC50 value of 85.246 ppm, followed by stem barks and leaves with IC50 of 205.281 ppm and 307.037 ppm, respectively. Although the antioxidant activity of A. marina fruits was far from quercetin (IC50 of 3.789 ppm), it still categorized as a strong antioxidant. The strong antioxidant activity of fruits was followed by higher total phenolic and coumarin content than the stem barks and leaves part. Total phenolic and coumarin content of fruits were 49.119 mg GAE/ g and 8.894 x 10-3 mg CE/g, respectively. The leaves part had total coumarin content of 8.418 x 10-3 mg CE/g, but it had low IC50. It may be caused by the other secondary metabolite compounds that could reduce the antioxidant activity of coumarin.

Pemanjangan Sistem Terkonjugasi Sinamaldehid dan Uji Aktivitas sebagai Bahan Aktif Tabir Surya Ngadiwiyana Ngadiwiyana; Ismiyarto Ismiyarto; Khairul Anam
Jurnal Kimia Sains dan Aplikasi Vol 7, No 1 (2004): Volume 7 Issue 1 Year 2004
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Telah dilakukan pemanjangan sistem terkonjugasi sinamaldehid dengan reaksi aldol kondensasi. Penelitian ini diawali dengan mengisolasi sinamaldehid dari minyak kayu manis menggunakan pelarut natrium bisulfit. Selanjutnya sinamaldehid direaksikan dengan asetofenon melalui reaksi kondensasi. Analisis struktur senyawa hasil menggunakan spektrometer UV-Vis dan spektrometer infra merah, selanjutnya penentuan SPF dari produk yang dihasilkan dilakukan dengan mengukur absorbansinya terhadap sinar UV.Sinamaldehid didapatkan sebagai cairan jernih kekuningan dengan kemurnian 99,87% dan rendemen 82,00%. Senyawa hasil kondensasi didapatkan sebagai padatan berwarna kuning dengan titik lebur 540C, rendemen 72,21%. Analisis dengan spektometer UV-Vis memberikan serapan pada 312 nm dan 224 nm, sedangkan dengan IR mempunyai pita pada 1676,0 cm-1 (-C=O), 1604 cm-1 (–C=C-), 3028 (=C-H), dan 1575 cm- (cincin aromatis). Sinamaldehid mampu memberikan perlindungan SPF maksimum pada konsentrasi 10 g/mL, sedangkan senyawa hasil reaksi mampu memberikan perlindungan maksimum pada konsentrasi 6 g/mL.

Co-Authors A.A. Ketut Agung Cahyawan W Adityo Anggadita Agus Subagio Ahmad Fathoni Alik Kandhita Febriani Anjar Jatika Anshori, Yuli Tirtariandi El Ardhita Niken Destiana Asy'ari, Mukhammad Asy’ari, Mukhammad Ayu Ratri Kartika Iriany Bambang Cahyono Bayu Refindra Fitriadi Chairil Anwar Chairil Anwar Choirunnisa, Nur Fadilla Damar Nurwahyu Bima Desy Fitrya Syamsumir Didik Setiyo Widodo Dimas Syamsudin Ditya Putri Solihati Dzahabiyyah, Hana Putri Enceng Enceng Enny Fachriyah Enny Fachriyah Fannie Kurniasari Fithri Noorikhlas Halim, Siti Anisah Hanum, Rahma Farida Hendra Dwipa Rifky Mahardika Hermansyah Amir Huda, Muhammad Badrul Intan Endah Rachmawati Jaluanto Sunu Punjul Tyoso Jumina Jumina Khairul Anami Laksmitasari, Nuraini Dwi Leong Kai Vyn Liswinda Zafirah Rahmatia Madiyono, Madiyono Marcelinus Christwardana Meiny Suzery Mumtazati, Qonita Murni Nur Islamiah Kassim Ngadiwiyana M.Si. S.Si. Nies S. Mulyani Niken Windi Saputri Ningsih, Alyxia Stellata Aria Noor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nor Basid Adiwibawa Prasetya Nur Amaliyah Nurlina Priastuti Pandelaki, Elmi Christi Julia Pratama Jujur Wibawa Purbowatiningrum Ria Sarjono Purwaningdyah, Purwaningdyah Rani Mustika Ratnawati Dwi Putranti Honorata Rinaryadi, Kemilau Permata Hati Sabirin Matsjeh Salsabila, Salsabila Sesika Novari Suradi, Agus Suyanti Suyanti Triwijayanti, Yunita Wati, Mei Riska Yosie Andriani Yosie Andriani

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