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All Journal HAYATI Journal of Biosciences Archive of Community Health Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia Indonesian Journal of Cancer Syntax Literate: Jurnal Ilmiah Indonesia Media Kesehatan Politeknik Kesehatan Makassar ISM (Intisari Sains Medis) : Jurnal Kedokteran Open Access Indonesian Journal of Medical Reviews Indonesian Journal of Cancer Journal of Global Pharma Technology Physical Therapy Journal of Indonesia Kinesiology and Physiotherapy Comprehensive Indonesian Journal of Biomedicine and Clinical Sciences
I Gusti Ayu Artini
Bagian Farmakologi Fakultas Kedokteran, Universitas Udayana
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Journal of Global Pharma Technology

 1 
Role of PPAR-Α Signaling Pathway on the Protection of Antituberculosis-Induced Liver Damage by Purple Sweet Potato Extract i gusti ayu artini
Journal of Global Pharma Technology Volume 12 Issue 08
Publisher : Journal of Global Pharma Technology

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Background: Peroxisome proliferator activated receptor-α (PPAR-α) participates in protecting the liver from many cases of liver damage. It is involved in reducing lipid accumulation, oxidative stress and inflammation. Purple sweet potato extract is one of herbal extract that posses hepatoprotector activity related to its antioxidant and antiinflammatory action. Its hepatoprotective effect on isoniazid and rifampicin induced hepatic injury has not been established yet, as well as its effect on PPAR-α expression and activation in the liver. The aim of this research was to investigate the hepatoprotective effect of purple sweet potato extract on hepatic injury induced by isoniazid and rifampicin, as well as the effect of purple sweet potato on PPAR-α expression and activation in the liver. Methods: The study design was randomized post test only control group design. We included male Wistar rats, age 8-12 weeks, weight 180-220 gram (divided into 3 groups: control, intervention and normal group). The extraction was performed with masseration technique. PPAR-α expression was measured with ELISA; activated PPAR-α was detected using immunohistochemistry; ALT level was measured with spectrophotometry. Data were analyzed using One Way Anova test, continued with Post Hoc test. Results: The result represented that PPAR-α expression in intervention group was significantly higher than control (1.344±0.249 vs. 0.587±0.306; p
Pregnane-X-Receptor Genotype and Hepatotoxic Incidence on Tuberculosis Patients Receiving Antituberculosis in Bali i gusti ayu artini
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Background: Drug-induced liver injury might lead to serious illness. One of the drugs that potentially toxic to the liver is antituberculosis. Many factors could influence antituberculosis-induced liver injury, including genetic variation. One of such genetic variation is polymorphism of pregnane-x-receptor (PXR) gene. PXR plays a crucial role in the regulation of many drug metabolizing enzymes and drug transporters. The association between PXR polymorphism and hepatotoxic incidence in several studies showed the inconsistent result. Therefore, it’s very important to study the PXR genotype pattern and its relation with hepatotoxic incidence among tuberculosis patients who received antituberculosis treatment. This study aimed to investigate the incidence of hepatotoxic according to PXR genotype pattern among tuberculosis patients who received antituberculosis treatment in Bali. Methods: This study was a cross-sectional study. About 65 subjects were enrolled in this study, selected from tuberculosis patients who attended the pulmonary outpatient clinic of Sanglah Hospital, Bali Indonesia and received the antituberculosis drug. Identification of PXR genotype was performed using PCR/RFLP technique with MboI restriction enzyme. Results: The proportion of wild type and mutant genotype of PXR were 72.3% and 27.7%, respectively. There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR. Conclusion: There was no significant difference in the proportion of hepatotoxic between wild type and mutant genotype of PXR on tuberculosis patients who received antituberculosis in Bali.
Developing Animal Model for Analysing Liver Toxicity of Isoniazid and Rifampicin Combination I Gusti Ayu Artini
Journal of Global Pharma Technology Volume 12 Issue 01
Publisher : Journal of Global Pharma Technology

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Background: Liver toxicity often results from drug administration, such as antituberculosis. The prevalence of liver toxicity in tuberculosis patients remained high in the last decade. Liver toxicity induced by isoniazid (INH) and rifampicin (RIF) combination might have different features and mechanisms with liver toxicity induced by other substances or drugs (acetaminophen, carbontetrachloride, d-galactosamine, ethanol or dimethylnitrosamine). The goal of this study was to investigate the toxic dose and duration  of  administration of combined isoniazid and rifampicin that contributed to the hepatic injury in rats. Methods: A combination of INH-RIF contained 100 mg of INH and 100 mg of RIF.  The induction of INH-RIF was given for 28 consecutive days. Twenty rats were divided into five groups: control, group 1 (dose 50 mg), group 2 (dose 100 mg), group 3 (dose 200 mg), group 4 (dose 400 mg),and group 5 (dose 800 mg). At the end of induction, serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured, and liver histopathology was evaluated. Data were analyzed with one-way Anova test.  Results: Serum AST and ALT levels were significantly higher in groups 1 and 2 compared to control (p<0.001). Post-hoc analysis revealed that 50 mg and 100 mg dose significantly increased the serum AST and ALT. Conclusion: There were significant differences in serum AST and ALT, as well as histopathological scores, among rats induced by INH and RIF combination.Keywords: Isoniazid; Rifampicin; Liver; Animal.
Co-Authors Agung Nova Mahendra Agung Wiwiek Indrayani Anak Agung Gede Eka Septian Utama Ari Wibawa Arina Papita Simanungkalit Cokorda Istri Ajeng Prameswari Desak Ketut Ernawati Desak Made Wihandani Dewi, Anak Ayu Nyoman Trisna Narta Dharmajayanti, Ida Ayu Laksmi Diksha, I Gusti Ngurah Ariestha Satya Dinda Paramaningtyas Sudibya Fatimah S, Sitti Febrina, Jessica Gede Denny Wiradarma Gede Parta Kinandana Grudug, Kadek Agastya Widya Sedana I Dewa Gede Alit Kamayoga I Gusti Ayu Agung Anindya Maharani I Gusti Ayu Eka Arirahmayanti I Gusti Made Aman I Gusti Made Gde Surya Chandra Trapika I Kadek Dwi Putra Diatmika I Made Jawi I MADE MULIARTA . I Made Niko Winaya I Nyoman Adi Putra I Wayan Adi Pranata I Wayan Juli Sumadi I.A.A. Widhiartini Ida Ayu Citra Ratnasari Ida Ayu Eka Pradnya Paramita Dewi Paramita Dewi Ida Ayu Ika Wahyuniari Kadek Meitri Ariyantini Kadek Novi Anggreni Kartiga Silvaraju M Widnyana Made Aditya Prawira Arthawan Made Ayu Nadine Indira Surya Made Cindy Widya Murthi Made Hendra Satria Nugraha Made Satria Ambarsika Made Virgo Baharirama Marcella, Marzha Nabila Putri Rachmawati Negara, Anak Agung Gede Angga Puspa Ni Komang Artini Yanti Ni Komang Ayu Juni Antari Ni Luh Nopi Andayani Ni Made Linawati Ni Putu Devi Purnamayanti Ni Wayan Mira Resdiani Ni Wayan Tianing Nila Wahyuni Pande Putu Karina Candra Putu Aditya Mahardika Putu Ayu Sita Saraswati Putu Ayunia Laksmita Putu Diah Saraswati Rahayu Putu Yunita Primasari Rizki Mega Aprilia Saputri, Desi Mevlana Theresia Fitri Hakna Sihombing Trapika, I Gusti Made Gde Surya Chandra Winaya, I Made Nico Wuga, Kristina Supartin Monika