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A Comparative Analysis of the Pathogenesis of Plasmodium vivax and Plasmodium falciparum: A Literature Review Anak Agung Ngurah Ardha Dwikananda; Dewa Ayu Agus Sri Laksemi; Putu Ayu Asri Damayanti
The Indonesian Journal of General Medicine Vol. 15 No. 1 (2025): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/7kjc1h37

Abstract

Background: Malaria is one of the significant health problems faced in the world with Plasmodium falciparum and Plasmodium vivax being the major two types of malaria in humans. Humans have long been exposed to plasmodium falciparum, which causes severe disease with dangerous complications, compared to plasmodium vivax, which was identified as causing a less severe, relapsing infection. But recent data casts doubt on this dichotomy since there is the possibility of P. vivax causing severe, and even fatal forms of malaria. Objective: The objective of this review is to compare the pathogenic processes of Plasmodium falciparum and Plasmodium vivax systematically in terms of molecular, cellular interactions, host immunity aspects with the associated clinical presentation and morbidities. Methods: Search of the literature was carried at PubMed, Scopus, and Google Scholar databases with the use of pathogenesis, clinical characteristic and complications of both species to be compared. Results: Literature synthesis indicates that there are unique pathogenic profiles. Major dissimilarities were established in path of erythrocyte invasion, accomplishment of cytoadherence and sequestration, alteration of the host cell, and potential biomass of the parasite. The pathogenesis of the Plasmodium falciparum generally involves microvascular obstruction due to sequestration whereas the pathology of Plasmodium vivax seems more to do with the excessive inflammatory status, severe anaemia and complications of the parasite unique life cycle stages that have evolved as hypnozoites. Conclusion: The causes of infections are different, but both species are serious pathogens that can bring serious illnesses. An in-depth consideration of their specific and symbiotic virulence mechanisms is extremely important in making progress in clinical practice, diagnostics, and creation of new customized therapies and prophylaxis.
Ascorbic Acid Injection Efficacy to Increase Skin Collagen Anggraini, Eny; Damayanti, Putu Ayu Asri
Jurnal Penelitian Pendidikan IPA Vol 10 No 6 (2024): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i6.5282

Abstract

The aging process can be delayed by antioxidant supplement such as ascorbic acid. It is useful for reducing oxidative stress, inflammation, and cellular aging so that older people will be fitter and happier. The methodological approach used in this study is Literature Review (LR). This literature review will investigate the effect of ascorbic acid on inflammaging. Google Scholar, Researchgate, and Mendeley were used as the search engine. The keywords were ascorbic acid & skin collagen. The effect of ascorbic acid on geriatric beta-endorphin were analyzed from 14 articles. Body homeostasis, organ systems, and other changes will reduce the functional capacity in the skin collagen. To delay the   physiological process of aging, ascorbic acid potential to improve the skin collagen. The skin collagen can be improved by the effect of ascorbic acid for a better quality of aging process
Co-Authors Agus Susanta Anak Agung Ayu Mirah Adi Anak Agung Ngurah Ardha Dwikananda Angela, Christine Bisma Krisnanda, I Kadek Damayanti S, Made Rini Dana, I Kadek Desak Made Widyanthari Desak Putu Yuni Sumaryani Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dimas Aji Saputra Dyatmika, I Nyoman Adidana Jaya Eka Diarthini, Ni Luh Putu Eny Anggraini Fitriana Melinda Haritharan Ganesan I Dewa Ayu Inten Dwi Primayanti, I Dewa Ayu Inten Dwi I Gusti Kamasan Arijana I Kadek Swastika I Ketut Tunas I Made Sudarmaja I NYOMAN MANTIK ASTAWA Ida Ayu Dewi Wiryantini Ida Bagus Putra Adyatma Ida Bagus Satriya Wibawa Indah Mei Rahajeng Jody Erlangga Juniantara, I Kadek Ade Kadek Cahya Utami Kanaka Puspita, Ida Ayu Luh Gede Mira Swandewi Luh Putu Ratna Sundari Made Rini Damayanti Ni Kadek Rima Pebrianti Ni Luh Ariwati Ni Luh Ariwati Ni Luh Dian Mirayanti Ni Luh Putu Eka Diarthini Ni Luh Putu Eka Diarthini, Ni Luh Putu Eka Ni Luh Putu Eva Yanti Ni Luh Rustini Ni Made Pitri Susanti Ni Putu Apriliani Ekayanti Ni Putu Emy Darma Yanti Ni Putu Wardani Nurdiyanti, Nurdiyanti Pratisthita Sukadana, I Made Ananda Prajna Purantara, Anak Agung Gede Wiweka Winahya Putra, I Putu Bagus Krisna Pramana Putri, Luh Kadek Meilina Putu Indah Budi Apsari Putu Saras Widar Yuliantari Sanjiwani, Ida Arimurti Semara, I Nyoman Sudha Sri Laksemi, Dewa Ayu Agus Sujaya, I Made Pranawa Yogananda Suputra, I Wayan Bagus Abiyoga Surudarma, I Wayan Swastika, I Nengah Raka Tataraharja, I Putu Langgeng Sugih Tustiani, Ni Ketut Nining Aras William, Kristoforus