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All Journal BALI MEDICAL JOURNAL (BMJ) Buletin Udayana Mengabdi E-Jurnal Medika Udayana The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Essential: Essence of Scientific Medical Journal Makara Journal of Science Hang Tuah Medical Journal Journal of Global Pharma Technology Jurnal Sains dan Kesehatan

I Gusti Kamasan Arijana

Departemen Histologi Fakultas Kedokteran Universitas Udayana

Author-ID : 2936419

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Purple Sweet Potato Reduces Malondialdehyde and TNF-a, Increases p53, and Protects Histopathological Appearance in Formaldehyde-induced Nasopharyngeal Carcinoma Rats Ni Ketut Susilawati; I Wayan Putu Sutirta Yasa; Wayan Suardana; Sri Maliawan; I Made Jawi; Achmad Chusnu Romdhoni; Hamsu Kadriyan; I Wayan Gede Artawan Eka Putra; I Gusti Kamasan Nyoman Arijana
The Indonesian Biomedical Journal Vol 14, No 2 (2022)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v14i2.1906

BACKGROUND:Purple sweet potato tuber ethanol extract (PSPTEE) has been known to have benefits in various disease, including to prevent nasopharyngeal carcinoma (NPC). However, there has been no research on PSPTEE in preventing the proliferation of nasopharyngeal mucosal epithelial cells induced by formaldehyde through the oxidative stress mechanisms and inflammatory process. Studies have proven the effect of PSP on various cancer cells, but the carcinogenesis process of the nasopharyngeal mucosal epithelium is still limited. Hence, this study aimed to demonstrate the mechanism for preventing histopathology changes with PSPTEE due to formaldehyde exposure.METHODS: Thirty-two formaldehyde-induced Wistar rats were treated with or without 1g/kgBW/day PSPTEE for 16 weeks. Malondialdehyde (MDA) level were examined with spectrophotometry method, while tumor necrosis factor (TNF)-α and p53 with enzyme linked immunosorbent assay (ELISA) method. The histopathology appearance of the nasopharyngeal epithelium was observed with hematoxylin-eosin (HE) staining.RESULTS: MDA and TNF-α levels in control and treatment group were 22.89±2.84 μM; 9.83±0.89 μM and 84.18±11.58 ng/L; 73.92±10.59 ng/L, respectively, and they showed significant difference. Meanwhile, the level of p53 showed no significant difference. Histopathology appearance showed a significant difference. Path analysis for MDA, TNF-α and p53 levels contributed 28.7% to histopathology appearance. MDA have an effect on significant direct effect on TNF-α. TNF-α has a significant direct effect to histopathological appearance. Indirect influence MDA on histopatological appearance were smaller than the direct effect. TNF-α has the greatest influence on histopatological appearance.CONCLUSION: Formaldehyde induces the histopathology appearance in nasopharyngeal epithelium. This study also demonstrates the mechanism to prevent the nasopharynx epithelial histopathology appearance by administration of PSPTEE.KEYWORDS: PSP, MDA, TNF-α, p53, nasopharynx epithelial

Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation Dinesh Tanabbal; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.89

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05). Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.

Lipid Peroxidation Inhibition Activity of Sintrong (Crassocephalum crepidioi-des) Leaf Extract in Rats Consuming Arak Jembrana Widayanti, Ni Putu; Laksmita W, Ayu Saka; Apriyanthi, Desak Putu Risky Vidika; Arijana, I G K Nyoman
Makara Journal of Science Vol. 24, No. 4
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The present study was conducted to determine the antioxidant activity of sintrong (Crassocephalum crepidioides) leaf extract to inhibiting lipid peroxidation by decreased malondialdehyde (MDA) level in the blood plasma of rats consuming arak Jembrana. The process of making sintrong leaf extract used 96% ethanol with maceration techniques. In vivo testing used five groups: (1) a control group, (2) treatment with arak, (3) treatment with arak followed by extract at a dose of 37.5 mg/kgBW, (4) treatment with arak followed by extract at a dose of 50 mg/kgBW, and (5) treatment with arak followed by extract at a dose of 75 mg/kgBW. As much as 1 cc/day of arak was provided for seven days. The extract treatment at a dose of 37.5 mg/kgBW decreased the MDA level from 21.24 nmol/L to 16.33 nmol/L. Based on a Tukey’s Honestly Significant Difference (HSDa) test, this treatment was not significantly different from that of the control group (normal condition).

Potensi Kulit Jeruk Bali (Citrus Maxima Merr) Sebagai Antibakteri Propionibacterium acne Penyebab Jerawat JOHAN AXEL PARIURY; JUAN PAUL CHRISTIAN HERMAN; TIFFANY REBECCA; ELVINA VERONICA; I GUSTI KAMASAN NYOMAN ARIJANA
HANG TUAH MEDICAL JOURNAL Vol 19 No 1 (2021): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i1.65

Introduction: Acne or known as acne vulgaris is an inflammation of the pilosebaceous layer with blockage of the keratin material due to the Propionibacterium acnes (P.acne) bacteria. The prevalence of acne in Indonesia is 80%-85% in adolescents. Acne appearances can cause insecurity in our look. Acne medication has irritation side effects and already resistant so other alternatives medicines are needed. The production of pomelo (Citrus maxima merr) in Indonesia reaches 511 kg annually with a weight of 208 kg of pomelo peel. About 50% of pomelo peel is removed without reprocessing even though it contains a lot of antioxidants and antibacterial properties. Aims: To know the potential of pomelo peel as an alternative antibacterial P.acne that causes acne. Methods: Literature study using research articles or literature review articles from international and national journals in 10 years. Accessed from Pubmed, Garuda, NCBI, and Google Scholar by typing keywords. Around 30 articles were used in this review article. Results: The antioxidants of pomelo peel interfere with metabolism by inhibiting the performance of the enzyme reversing RNA transcriptase, DNA topoisomerase, transporting active bacteria, disrupting PH regulation, denaturing bacterial proteins, damaging cell membranes thus inhibiting replication and causing the death of P.acne. Conclusion: Pomelo peel is considered to be an antibacterial P.acne that causes acne. Further research is needed, especially in extract concentrations and side effects.

Topical application of purple cabbage (Brassica oleracea L. var. capitata f. rubra) ethanol cream extract of dermic collagen on male Wistar rats (Rattus norvegicus) exposed to ultraviolet B Komang Jegek Triangga Apsari; I Gusti Ayu Dewi Ratnayanti; I Gusti Komang Nyoman Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Purple cabbage or also known as red cabbage (Brassica oleracea L. var. capitata f. rubra) contains polyphenols, especially anthocyanin (cyanidin-3-diglucoside-5-glucoside). Anthocyanin has a protective effect against radical oxidative superoxide (ROS). Thus it can prevent skin damage caused by ultraviolet (UV)-B radiation.Aim: The research aims to prove the effectivity of distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on Wistar rats (Rattus norvegicus) exposed to UV-B rays.Method: This research was arranged with the randomize post-test only control group design. 30 rats were divided into 6 groups containing 5 rats each, there are control group (P1) without distribution of any cream, Treatment Group (P2) with a distribution of base cream (placebo), (P3) sunblock 33 SPF, (P4) 5%, (P5) 10 %, and (P6) 20 % smeared by purple cabbage ethanol cream extract. All groups exposed to UV-B with a total dose of 840 mJ/cm2 for 4 weeks. Then a sampling rats skin was done for examining the level of collagen skin with Sirius red staining. The level of collagen was calculated by the percentage of the area of the pixel of collagen and was compared with the pixels of entire dermal tissues.Result: The result demonstrated that the mean of collagens in The First Group/P1 (57.74%) and P2 (60.84%) decreased more significantly than P3 (82.17%), P4 (68.23%), P5 (76.93%), and P6 (84.54%) following UV-B exposure. The Post Hoc result showed that there was no significant difference in the level of collagen in the control group and placebo group and the sunblock group with the purple cabbageâ€™s ethanol cream extract group of 20% (p>0.05).Conclusion: the distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on male Wistar rats skin exposed to UV-B.

Ethanolic extract cream of red cabbage (Brassica oleracea L. var. capitata f.rubra) on the epidermal thickness in Wistar rats (Rattus norvegicus) after ultraviolet-B exposure Yogarani V.C Rajappan; I Gusti Kamasan Arijana; I Wayan Sugiritama; IGA Dewi Ratnayanti
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: UV exposure is related to oxidative stress and also as an essential factor in skin photoaging. Several antioxidants are widely used in preventing skin photoaging by influencing epidermal skin layer. High concentrations of antioxidant properties in red cabbage are known to have these effects. This study aims to determine the role of ethanolic extract cream of red cabbage on the epidermal thickness in Wistar rats after UV-B exposure.Methods: An experimental study was carried out among 25 Wistar rats which divided into 5 groups as follows: P1 as control (only exposed to UB-B), P2 (placebo and UV-B), P3 (5% ethanolic extract cream and UV-B), P4 (10% ethanolic extract cream and UV-B), and P5 (20% ethanolic extract cream and UVB). The UV-B dosage applied for each group was 65 mJ/cm2. The thickness of epidermis is calculated by direct measurement using Image Raster software from basal membrane to stratum corneum. The statistical analyses were performed using SPSS ver. 20.0.Results: There was a significantly different in the epidermal thickness among groups (P < 0.05). The mean of epidermal thickness in the control group (P1) was 36.00Â±1.08 Âµm, followed by 27.66Â±0.87 Âµm in the treatment group I (P2), 26.76Â±1.02 Âµm in the treatment group II (P3), 24.94Â±1.25 Âµm in the treatment group III (P4), and 20.24Â±1.47 Âµm in the treatment group IV (P5).Conclusion: The ethanolic extract cream of red cabbage (Brassica oleracea L.Var. capitata f. rubra) in different doses have a statistically significant impact on the epidermal thickness in Wistar rats after UV-B exposure.

The ethanolic extract of red cabbage (Brassica oleracea l. var,capitata f. rubra) in cream preparation to the dermal-thickness of male Wistar mice (Rattus norvegicus) after Ultraviolet-B exposure Gayathiri Mohana Krishnan; IG Kamasan Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Photoaging effect in dermal layer of skin was commonly caused by Ultraviolet B (UV-B) rays exposure This study aims to assess the histological features of the dermis layer in the male Wistar mice after applied with the ethanolic extract of red cabbage following UV-B exposure.Methods: About 25 male Wistar rats were enrolled in this study by using post-test only control group design during 2 weeks. They were divided into 5 groups as follows: control group (P1), basic cream (P2), 5% ethanolic extract of red cabbage cream (P3), 10% ethanolic extract of red cabbage cream (P4), and 20% ethanolic extract of red cabbage cream (P5). The UV-B dosage used are 325 mJ/cm2 among groups prior to study. The dermis-elastic fiber thickness was assessed by Image Raster software. Statistical analysis was carried out using SPSS version 20 in measuring normality test, mean, and ANOVAResults: There was no statistically significant difference in the thickness of dermal layer among groups (P = 0.3). The mean of dermis thickness was 666.60Â±143.15Âµm in P5 group, followed by 651.19Â±189.18Âµm in P4 group, and 547.43Â±188.41Âµm, 544.76Â±100.67Âµm, and 504.10Â±129.40 Âµm in P3, P2, and P1 group respectively.Conclusion: There was no a significant difference among different dosage of the ethanolic extract cream of red cabbage to the thickness of dermal layer after UV-B exposure.

The effect of red-cabbage (Brassica oleracea L. var. capitata f. rubra) ethanolic extract in cream preparation on dermis-elastic fibre thickness in male Wistar rats after ultraviolet-B rays exposure Intan Syahirah Bt Abdul Rauap; I Wayan Sugiritama; Ni Made Linawati; I Gusti Kamasan Arijana
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Ultraviolet B (UV-B) rays exposure is a leading cause of sunburn, skin dryness and skin aging by influencing the dermal elastic fibers. This photoaging effect was caused by damage of fibrillin-1 as a microfibrillar network. This study aims to evaluate the effect of red-cabbage (Brassica oleracea L. var. capitata f. rubra) ethanolic extract in cream preparation on dermis-elastic fibers thickness in male Wistar rats after UV-B exposure.Methods: A randomized post-test only control group design was conducted among 25 male Wistar rats during 2 weeks. They were divided into 5 groups as follows: control group (P1), basic cream (P2), 5% ethanolic extract of red cabbage cream (P3), 10% ethanolic extract of red cabbage cream (P4), and 20% ethanolic extract of red cabbage cream (P5). The UV-B dosage used are 325 mJ/cm2 among groups prior to study. The dermis-elastic fiber thickness was assessed by Image Raster software. Statistical analysis was carried out using SPSS version 20 in measuring normality test, mean, and ANOVAResults: There was a statistically significant difference of dermal-elastic fibers thickness among groups (P < 0.05). The mean of dermis-elastic fiber thickness was 6.125Â±0.376 Âµm in P5 group, followed by 4.075Â±0.266 Âµm in P4 group, and 3.114Â±0.290 Âµm, 2.109Â±0.420 Âµm, and 1.907Â±0.454 Âµm in P3, P2, and P1 group respectively.Conclusion: Ethanolic extract of red-cabbage in a different dose of cream preparation have a statistically significant difference on the dermis-elastic fibers thickness after UV-B exposure

The effect of purple mangosteen (Garcinia mangostana) peel extract on collagen fiber in male Wistar rats after Ultraviolet-B (UV-B) exposure Tarvin Jit Singh Gill; I Gusti Ayu Dewi Ratnayanti; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Skin aging can be caused by long-term ultraviolet (UV) exposure that usually called as photoaging. Administered antioxidant substances can delay the photoaging process. Purple mangosteen is known to have abundant antioxidant properties such as xanthones and anthocyanins. This study aims to determine the effect of purple mangosteen peel extract on the collagen fiber in male Wistar rats after UV-B exposure.Methods: An experimental study was conducted among 21 male Wistar rats at Histology Laboratorium, Udayana University from a period of March-October 2017. The samples were divided into 3 groups as follows: control, placebo, and mangosteen extract with 7 rats in each group. Collagen fiber was assessed by using a light microscope with 400 times magnification. Statistical analysis was carried out using SPSS ver. 21 software using one way ANOVA.Results: The study found that percentage of collagen area within control group was 61.94%, placebo group 72.90%, and mangosteen peel extract 73.63%. The mean between-group analyzed using one way ANOVA found that there was a statistically significant difference in mangosteen peel extract than control group (p=0.0000), but not statistically significant if compared with placebo group (p=0.640) on the collagen fiber in male Wistar rats.Conclusion: there was a statistically significant difference in mangosteen peel extract than control group on the thickness of collagen fiber in male Wistar rats after UV-B exposure.

The effect of Euphorbia milii tea and its combination with Propolis on number of glomeruli in M.tb-infected mice: a histopathology study Ruthirar Kalaichelvam; Ni Made Linawati; I Gusti Nyoman Sri Wiryawan; Gede Wirata; I Gusti Ayu Dewi Ratnayanti; I Wayan Sugiritama; Ida Ayu Ika Wahyuniari; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The role of both Euphorbia milii and Propolis is to increase the effectiveness in pathological condition of the body part damaged, include renal function in maintaining the homeostasis. That combination into mice which are infected by Mycobacterium tuberculosis will change the total number of glomerulus in the kidney.Aim: The study aims to determine the effect of combination tea from Euphorbia milii and Propolis on the number of the glomerulus in mice infected by M. tb.Method: This study confirmed randomized post-test only control group design consisting of 24 mice divided into six groups (G1-G6). E. milli flowers are obtained from flower plantations, in Ketewel, Gianyar, Bali Province took in fresh and dark red sampling. M. tuberculosis used H37Rv strain (ATCC27294) grown on Middlebrook 7H9 liquid medium for two weeks.Result: It was found that Group 3 and Group 5 from the treatment group has the most significant average number of glomerulus which was 13, followed by Group 2 and Group 6 from the control group has the largest average number of glomerulus which was 12. The differences were not significant between groups with P = 0.463 (P <0.05).Conclusion: The Euphorbia milii tea and its combination with Propolis does not affect histological change on the total number of glomerulus in mice infected with M. tb.

Co-Authors Achmad Chusnu Romdhoni ADNYANA PUTRA, I GEDE AGUS DIVA Agus Dody Pranata Suadi Putra Anak Agung Ngurah Subawa Apolonia Berenika Badu Ayu Gita Bhagawanti Ayu Saka Laksmita W D.A.A.S. Laksmi Desak Putu Citra Udiyani Desak Putu Risky Vidika Apriyanthi Dewa Ayu Agus Sri Laksmi Dinesh Tanabbal ELVINA VERONICA Eugenia Meidy Fedik Abdul Ratam Gayathiri Mohana Krishnan Gede Wirata Hamsu Kadriyan Henky Henky I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Made Agus Paramarta Putra I Gde Raka Widiana I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Kadek Swastika I Ketut Tunas I Made Adi Satria Darma I Made Agus Endra Permana I Made Jawi I Made Sudarmaja I Nyoman Hariyasa Sanjaya I Nyoman Wande I Nyoman Wiryawan I Putu Dema Prasetya I Wayan Gede Artawan Eka Putra I Wayan Putu Sutirta Yasa I Wayan Sugiritama I Wayan Sugiritama I. G. A. D. Ratnayanthi I.G.N.S. Wiryawan I.N. Wande I.W. Sugiritama Ida Ayu Dewi Wiryantini Ida Ayu Ika Wahyuniari Intan Syahirah Bt Abdul Rauap JOHAN AXEL PARIURY Joshua Ezra Ronaldo Bayak JUAN PAUL CHRISTIAN HERMAN Juven Luvianto Komang Jegek Triangga Apsari Made Satria Yudha Dewangga Mahen Isaac Pannir Chelvam N. M. Linawati N.M. Linawati Ni Ketut Susilawati Ni Luh Ariwati Ni Luh Putu Eka Diarthini Ni Made Linawati Ni Made Mertaniasih Ni Made Yuli Lestari Ni Nyoman Mas Utari Rena Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Ni Putu Widayanti Ni Wayan Devi Yulianti Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi P.P.A.P. Dewi Putu Ayu Asri Damayanti Raymond Elbert Budianto Ruthirar Kalaichelvam Sri Maliawan Tarvin Jit Singh Gill TIFFANY REBECCA Tjokorda Gde Agung Suwardewa Wayan Aryadana Wayan Aryadana Wayan Suardana Yogarani V.C Rajappan

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