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All Journal BALI MEDICAL JOURNAL (BMJ) Buletin Udayana Mengabdi E-Jurnal Medika Udayana The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Essential: Essence of Scientific Medical Journal Makara Journal of Science Hang Tuah Medical Journal Journal of Global Pharma Technology Poltekita: Jurnal Ilmu Kesehatan Jurnal Sains dan Kesehatan
I Gusti Kamasan Arijana
Departemen Histologi Fakultas Kedokteran Universitas Udayana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Effect of Anthocyanins from Purple Sweet Potato Extract In-vitro on IL-6 mRNA Expression in PBMC Cell Cultures Infected With Hepatitis B Virus Made Agus Hendrayana; I Gusti Kamasan Nyoman Arijana
Poltekita: Jurnal Ilmu Kesehatan Vol. 20 No. 2 (2026)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v20i2.4233

Abstract

Background: The immune system is a crucial component of the defense against viral infections.  Some cytokines directly regulate the immune response by suppressing viral replication. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in regulating the biological responses of several target cells to viral infections. Natural compounds, such as anthocyanins, possess antiviral properties that may be beneficial in treating various viral infections. The aims of this study are to analyze the effects of anthocyanins on IL-6 expression in PBMC cultures infected with the Hepatitis B virus. Methods: This study was an in-vitro experimental study. This study used a control group and a treatment group, with 18 PBMC cell culture wells. The treatment involved adding 50 µL of purple sweet potato water extract, with an anthocyanin content of 0.01575 µg/µL, to RPMI1640 culture medium in PBMC culture wells for 24 hours. The effect on the IL-6 cytokine response was assessed by quantifying IL-6 mRNA expression in RNA isolated from PMBC cell culture samples using the quantitative real-time PCR method and interpolating from a standard curve of serial dilutions, based on cycle threshold. Data analysis was performed using statistical analysis. Results: Statistical analysis of the effects of purple sweet potato extract exposure on the treatment and control groups was carried out using a paired t-test, showing that there was an effect of exposure to purple sweet potato extract on IL-6 mRNA expression in the treatment group with a p value of 0.001 (p<0.05), while no significant effect of exposure to purple sweet potato extract was found in the control group with a p value of 0.420 (p>0.05). The results of the independent t-test showed that in the treatment group, the mean difference in IL-6 mRNA expression was -75.87±45.77 fg/µL, whereas in the control group, it was -49.26±173.70 fg/µL. In the treatment and control groups, the mean difference in IL-6 mRNA expression was -26.61 fg/µL, with a p value of 0.66 (p>0.05). Conclusion: This study showed that anthocyanins in purple sweet potato water extract did not significantly increase IL-6 mRNA expression in HBV-infected PBMC cultures compared to controls.
Efek Blueberry (Vaccinium sp.) Terhadap Kelembapan Kulit yang Terpapar Sinar Ultraviolet Akut ADNYANA PUTRA, I GEDE AGUS DIVA; IDA AYU IKA WAHYUNIARI; NI MADE LINAWATI; I GUSTI KAMASAN NYOMAN ARIJANA
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.337

Abstract

Introduction: Maintained skin moisture is an indication of healthy skin. Acute UV exposure can cause sunburn, which is characterized by a loss of moisture in the skin. Polyphenol compounds are one practical approach to protecting the skin from sunburn so that skin moisture is maintained. Blueberries are one of the natural ingredients consists of anthocyanin compounds, which are polyphenols from the flavonoid group. Aims: To determine the effect of blueberries on skin moisture exposed to acute ultraviolet rays. Methods: Literature study using references in the form of research articles and literature reviews from national and international journals and related books published in the last 10 years. In writing this literature review, 42 references were used which were accessed through Google Scholar, NCBI, Crossref, and Pubmed. Results: Blueberries anthocyanins can maintain skin moisture from increased transepidermal water loss (TEWL) due to acute UV ray exposure by reducing the formation of UV stimulated reactive oxygen species (ROS) and lipid peroxidation in keratinocyte cells to maintain the elastic modulus and mechanical properties of keratinocytes as well as can prevent sunburn by reducing the skin's modulation of UV exposure. However, the absorption of anthocyanin compounds in the intestine is so low that taking blueberries orally alone is not enough to achieve good biodistribution. Conclusion: Blueberries affect retaining moisture in skin exposed to acute UV rays, so they have the potential to be used as skincare ingredients. However, further research needs to be done, especially to determine the side effects that can be caused and the required extract concentration.
Co-Authors Achmad Chusnu Romdhoni ADNYANA PUTRA, I GEDE AGUS DIVA Agus Dody Pranata Suadi Putra Anak Agung Ngurah Subawa Apolonia Berenika Badu Ayu Gita Bhagawanti Ayu Saka Laksmita W D.A.A.S. Laksmi Desak Putu Citra Udiyani Desak Putu Risky Vidika Apriyanthi Dewa Ayu Agus Sri Laksmi Dinesh Tanabbal ELVINA VERONICA Eugenia Meidy Fedik Abdul Ratam Gayathiri Mohana Krishnan Gede Wirata Hamsu Kadriyan Henky Henky I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Made Agus Paramarta Putra I Gde Raka Widiana I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Kadek Swastika I Ketut Tunas I Made Adi Satria Darma I Made Agus Endra Permana I Made Jawi I Made Sudarmaja I Nyoman Hariyasa Sanjaya I Nyoman Wande I Nyoman Wiryawan I Putu Dema Prasetya I Wayan Gede Artawan Eka Putra I Wayan Putu Sutirta Yasa I Wayan Sugiritama I Wayan Sugiritama I. G. A. D. Ratnayanthi I.G.N.S. Wiryawan I.N. Wande I.W. Sugiritama Ida Ayu Dewi Wiryantini Ida Ayu Ika Wahyuniari Intan Syahirah Bt Abdul Rauap JOHAN AXEL PARIURY Joshua Ezra Ronaldo Bayak JUAN PAUL CHRISTIAN HERMAN Juven Luvianto Komang Jegek Triangga Apsari Made Agus Hendrayana Made Satria Yudha Dewangga Mahen Isaac Pannir Chelvam N. M. Linawati N.M. Linawati Ni Ketut Susilawati Ni Luh Ariwati Ni Luh Putu Eka Diarthini Ni Made Linawati Ni Made Mertaniasih Ni Made Yuli Lestari Ni Nyoman Mas Utari Rena Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Ni Putu Widayanti Ni Wayan Devi Yulianti Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi P.P.A.P. Dewi Putu Ayu Asri Damayanti Raymond Elbert Budianto Ruthirar Kalaichelvam Sri Maliawan Tarvin Jit Singh Gill TIFFANY REBECCA Tjokorda Gde Agung Suwardewa Wayan Aryadana Wayan Aryadana Wayan Suardana Yogarani V.C Rajappan