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All Journal BALI MEDICAL JOURNAL (BMJ) Buletin Udayana Mengabdi E-Jurnal Medika Udayana The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Essential: Essence of Scientific Medical Journal Makara Journal of Science Hang Tuah Medical Journal Journal of Global Pharma Technology Jurnal Sains dan Kesehatan

I Gusti Kamasan Arijana

Departemen Histologi Fakultas Kedokteran Universitas Udayana

Author-ID : 2936419

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Prevalence of risk factors associated with hypertension at Sanglah General Hospital, Bali Mahen Isaac Pannir Chelvam; I Wayan Sugiritama; I Gusti Nyoman Kamasan Arijana
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: High blood pressure, also called "hypertension," is a serious medical condition. It happens when the force of the blood pumping through the arteries is too strong. The World Health Organization rates hypertension as one of the most important causes of premature death worldwide, and the problem is growing. This study aimed to determine the risk factors affecting Hypertension at Sanglah general hospital.Methods: This study was a descriptive study with a cross-sectional approach. The data used in this study is a secondary data collected from medical record of the patients with Hypertension at Sanglah general hospital, Denpasar, Bali in the year of 2015 until 2016. The data was categorized based on Body Mass Index (BMI), gender, age, alcohol consumption, and history of cardiovascular diseases.Results: There are 73(60.83%) males and 47(39.17%) females, the majority of patients were in the age group of 18 â€“ 70 years of age with the age group of 40 - 50 carrying a rather large quantity of 45.8% among the male gender and for the female gender the age group of 51 â€“ 60 showed the highest percentage of 38.2%, the sample consists of 60.83% of males and 39.17 of females from the total 120 samples taken from Sanglah general hospital. As for Body Mass Index (BMI), 25 â€“ 29.9 has the most significant value of 49 (40.83%) when compared to the other nutritional statuses present. The patients with the cardiovascular disease showed a very substantial amount of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%).Conclusions: This study succeeded in identifying 120 samples of patients with hypertension and their contributing risk factors. The majority of the Samples were with body mass index (BMI) 25 â€“ 29.9 (40.83%). The samples with a history of cardiovascular disease showed a value of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%)

Pengaruh teh kombinasi Euphobia milii dan Propolis terhadap fungsi ginjal tikus Wistar jantan I Dewa Made Agus Paramarta Putra; I Gusti Kamasan Nyoman Arijana; Ni Made Linawati
Intisari Sains Medis Vol. 12 No. 1 (2021): (Available online : 1 April 2021)
Publisher : DiscoverSys Inc.

Introduction. Indonesia has abundant natural resources that can be used as traditional medicine. For example, Euphorbia milii and Propolis. Euphorbia milii and Propolis have various benefits such as antioxidants, antibacterials, and immunomodulators. The toxic effects of the combination of Euphorbia milii and Propolis on renal function has not been studied. The purpose of this study was to determine the effects of the combination of Euphorbia milii and Propolis on the kidney function of male Wistar rats.Methods: This study was an experimental analytical study with a randomized post-test only control group design. Twenty-four male rats aged 2-3 months, body weight ± 200 grams were divided into 4 groups, namely; control group (standard feed + aquabidest), P1 (combination of Euphorbia milii and Propolis 40mg/100gram body weight (grbw) for 2 weeks), P2 (combination of Euphorbia milii and Propolis flower 40mg / 100grbw for 4 weeks), and P3 (combination of Euphorbia milii and Propolis flowers 40mg / 100grbw for 6 weeks).Results: Based on data analysis, the mean levels of blood urea nitrogen were not found to be significant between the control group, P2 and P3 from treatment groups, but there was a significant differences between P1 and the other three groups. The serum creatinine does not show significant difference among all the groups.Conclusion. The combination of Euphorbia milii and Propolis does not increase the the blood urea nitrogen and serum creatinine of the Wistar rat. Latar belakang. Indonesia memiliki kekayaan alam yang berlimpah yang dapat dimanfaatkan sebagai pengobatan tradisional. Misalnya tanaman Euphorbia milii dan Propolis. Euphorbia milii dan Propolis mempunyai beragam manfaat seperti antioksidan, antibakteri, dan imunomodulator. Efek toksik dari teh kombinasi Euphorbia milii dan Propolis terhadap fungsi ginjal belum pernah diteliti sebelumnya. Tujuan dari penelitian ini untuk mengetahui efek pemberian teh kombinasi dari bunga Euphorbia milii dan Propolis terhadap fungsi ginjal tikus Wistar jantan.Metode. Penelitian ini adalah penelitian analitik eksperimental dengan rancangan randomized post-test only, control group design. Dua puluh empat tikus wistar jantan berusia 2-3 bulan, berat badan ± 200 gram yang dibagi menjadi 4 kelompok, yaitu; kelompok kontrol (pakan standar + aquabidest), P1 (teh kombinasi bunga Euphorbia milii dan Propolis 40 mg/100 gram berat badan (grbb) selama 2 minggu), P2 (teh kombinasi bunga Euphorbia milii dan Propolis 40mg/100grbb selama 4 minggu), dan P3 (teh kombinasi bunga Euphorbia milii dan Propolis 40mg/100grbb selama 6 minggu).Hasil. Berdasarkan analisis data dari rerata kadar blood urea nitrogen (BUN) tidak ditemukan perbedaan yang signifikan antara kelompok kontrol dengan kelompok perlakuan P2 dan P3. Namun P1 menunjukan rerata yang lebih tinggi daripada kelompok lainnya. Pada kreatinin serum tidak terjadi peningkatan yang signifikan pada keempat kelompok.Simpulan. Pemberian teh kombinasi Euphorbia milii dan Propolis tidak menimbulkan peningkatan yang bermakna terhadap BUN dan kreatinin serum tikus Wistar.

Efek ekstrak sambiloto (Andrographis paniculata) terhadap ekspresi matrix metalloproteinase-1 dan hipertrofi jantung pada mencit yang terpapar asap rokok I Made Agus Endra Permana; I Nyoman Wiryawan; Wayan Aryadana; I Gde Raka Widiana; I Gusti Kamasan Nyoman Arijana; I Made Satria Yudha Dewangga
Intisari Sains Medis Vol. 12 No. 2 (2021): (Available Online: 1 August 2021)
Publisher : DiscoverSys Inc.

Introduction: Sambiloto (Andrographis paniculata) is a plant that is often used in traditional medicine and is known to have antioxidant, anti-inflammatory and cardiovascular effects. There are many studies of sambiloto on inflammatory markers, but there is no study on the effect of sambiloto on MMP-1 expression. The purpose of this study was to determine the effect of sambiloto on MMP-1 expression and cardiac hypertrophy in mice exposed to cigarette smoke.Methods: This research is an experimental analytic study with a randomized post test only control group design. Thirty-two healthy male Swiss Webster mice aged 8-10 weeks weighing 20-30 grams were divided into 4 groups, namely: control group (standard feed + exposure to cigarette smoke), P1 (standard feed + exposure to cigarette smoke + sambiloto extract 18 mg/ kg BW), P2 (standard feed + exposure to cigarette smoke + sambiloto extract 29 mg/kg BW), P3 (standard feed + exposure to cigarette smoke + sambiloto extract 40 mg/kg BW). All groups were followed for 60 days.Results: There was a significant difference in MMP-1 expression between the control group and all treatment groups. There were significant differences in MMP-1 expression between groups P1 and P2, and between P1 and P3 groups. There was a significant difference in heart weight/weight ratio between the control group and all treatment groups. There was a significant difference in the heart weight/body weight ratio between the P1 and P3 groups.Conclusion: The administration of sambiloto extract decreased the expression of MMP-1 with a tendency for its effect to increase with increasing dose and the optimal dose was found in the sambiloto extract 29 mg/kg BW. The difference in the effect of sambiloto extract on cardiac hypertrophy only appeared after the dose was increased to 40 mg/kg BW Latar Belakang: Sambiloto (Andrographis paniculata) merupakan tanaman yang sering dipakai dalam pengobatan tradisional dan diketahui mempunyai efek antioksidan, anti inflamasi dan efek pada sistem kardiovaskular. Terdapat banyak penelitian sambiloto terhadap marker inflamasi, tetapi belum ada penelitian tentang efek ekstrak sambiloto terhadap ekspresi MMP-1. Tujuan dari penelitian ini untuk mengetahui efek ekstrak sambiloto terhadap ekspresi MMP-1 dan hipertrofi jantung pada mencit yang terpapar asap rokok.Metode: Penelitian ini adalah penelitian analitik eksperimental dengan rancangan randomized post test only control group design. Tiga puluh dua mencit Swiss Webster jantan sehat berumur 8-10 minggu dengan berat 20-30 gram dibagi menjadi 4 kelompok yaitu: kelompok kontrol (pakan standar + paparan asap rokok), P1 (pakan standar + paparan asap rokok + ekstrak sambiloto 18 mg/kg BB), P2 (pakan standar + paparan asap rokok + ekstrak sambiloto 29 mg/kg BB), P3 (pakan standar + paparan asap rokok + ekstrak sambiloto 40 mg/kg BB). Semua kelompok diikuti selama 60 hari.Hasil: Terdapat perbedaan signifikan ekspresi MMP-1 antara kelompok kontrol dengan semua kelompok perlakuan. Terdapat perbedaan signifikan ekspresi MMP-1 antara kelompok P1 dengan P2, dan antara P1 dengan P3. Terdapat perbedaan signifikan rasio berat jantung/berat badan antara kelompok kontrol dengan semua kelompok perlakuan. Terdapat perbedaan signifikan rasio berat jantung/berat badan antara kelompok P1 dengan P3. Simpulan: Pemberian ekstrak sambiloto menurunkan ekspresi MMP-1 dengan kecenderungan efeknya meningkat dengan peningkatan dosis dan dosis optimal terdapat pada ekstrak sambiloto 29 mg/kg BB. Perbedaan efek ekstrak sambiloto terhadap hipertrofi jantung baru muncul setelah dosis ditingkatkan menjadi 40 mg/kg BB.

Efek ekstrak sambiloto (Andrographis paniculata) terhadap ekspresi vascular cell adhesion molecule-1 (VCAM-1) dan intimal media thickness (IMT) pada mencit yang terpapar asap rokok I Made Adi Satria Darma; Wayan Aryadana; I Nyoman Wiryawan; I Gede Raka Widiana; I Gusti Nyoman Kamasan Arijana; Made Satria Yudha Dewangga
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Introduction: Sambiloto (Andrographis paniculata) is a plant that spread almost throughout the Indonesian archipelago and has been used for a long time as traditional medicine. Several previous literatures reported that sambiloto has anti-inflammatory and antioxidant effects, so its use is useful in cardiovascular disease, especially in reducing the process of atherosclerosis. The purpose of this study was to determine the effect of giving sambiloto extract on markers of inflammation and atherosclerosis in the form of VCAM-1 expression and IMT in mice exposed to cigarette smoke.Methods: This study used an experimental analytical method with a post-test-only group design. Using 32 healthy adult male mice weighing 20-30 grams were divided into four treatment groups, namely: control group (P0) only given exposure to cigarette smoke and treatment group 1 (P1), 2 (P2), and 3 (P3) given exposure cigarettes and sambiloto extract with doses of 18, 29, and 40 mg/kg/day. Exposure is given for 60 days, then the VCAM-1 expression and IMT in the aortic arch were examined histologically.Results: There were significant differences in VCAM-1 expression and IMT between the control group and all treatment groups. There was a significant decrease in VCAM-1 expression between P1 and P2 and P2 and P3. There was a significant decrease in IMT between P1 and P2 and P2 and P3.Conclusion: Sambiloto extract has effect in decreasing VCAM-1 expression and IMT. That effect strengthens with increasing dose. The maximum effect is obtained with the use of a dose of 40 mg/kg/day. Latar Belakang: Sambiloto (Andrographis paniculata) merupakan tanaman yang tersebar hampir di seluruh nusantara dan telah digunakan sejak lama oleh masyarakat Indonesia sebagai obat tradisional. Dari beberapa literatur sebelumnya melaporkan sambiloto memiliki efek antiinflamasi dan antioksidan sehingga bermaafaat dalam bidang penyakit kardiovaskular terutama mengurangi proses aterosklerosis. Tujuan dari penelitian ini untuk mengetahui efek pemberian ekstrak sambiloto terhadap petanda inflamasi dan atherosklerosis berupa ekspresi VCAM-1 dan IMT pada mencit yang terpapar asap rokok. Metode: Penelitian ini menggunakan metode analitik eksperimental dengan rancangan post test only group design. Menggunakan 32 ekor mencit jantan dewasa kondisi sehat dengan berat 20-30 gram dibagi menjadi empat kelompok perlakuan yaitu kelompok kontrol (P0) hanya diberikan paparan asap rokok dan kelompok perlakuan 1 (P1), 2 (P2), dan 3 (P3) diberikan paparan rokok sigaret dan ekstrak sambiloto dengan dosis 18, 29, dan 40 mg/kg/hari. Paparan diberikan selama 60 hari, kemudian dilakukan pemeriksaan histologi ekspresi VCAM-1 dan IMT pada arkus aorta mencit.Hasil: Terdapat perbedaan yang bermakna ekspresi VCAM-1 dan IMT antara kelompok kontrol dengan semua kelompok perlakuan. Terdapat penurunan bermakna ekspresi VCAM-1 antara P1 dengan P2 dan P2 dengan P3. Terdapat penurunan bermakna tebal IMT antara P1 dengan P2 dan P2 dengan P3.Simpulan: Ekstrak sambiloto memiliki efek menurunkan ekspresi VCAM-1 dan tebal IMT. Efek tersebut meningkat dengan peningkatan dosis. Efek maksimal diperoleh dengan penggunaan dosis 40 mg/kg/hari.

PROFIL KADAR KREATININ DAN ASAM URAT SEBAGAI PENANDA FUNGSI GINJAL PADA PENDUDUK LANSIA DI DESA KETEWEL I.N. Wande; I.G.A.D. Ratnayanti; I.G.K.N. Arijana; N.M. Linawati; P.P.A.P. Dewi
Buletin Udayana Mengabdi Vol 22 No 2 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i02.p06

Background. Elderly is a group of population aged 46 years and over based on the age category according to the Ministry of Health of the Republic of Indonesia 2009. The function of the body's organs of the elderly population will decrease over time, especially kidney function. Several laboratory tests that can be used to assess kidney function are measuring the glomerular filtration rate or measuring levels of non-protein nitrogen such as creatinine and uric acid. Objectives. To determine kidney health in the elderly population in Ketewel Village by measuring blood creatinine and uric acid levels and providing education to keep the kidneys healthy. Implementation method. Elderly residents were given information about free kidney function tests, namely uric acid and blood creatinine, then directed to the Mantra Medika Clinical Laboratory for blood collection to avoid crowds due to the Covid-19 pandemic situation. Examination of blood creatinine and uric acid with the Erba XL100® device. Results. There were 22 elderly residents of Ketewel Village who did free creatinine and blood uric acid test. A total of 11 elderly men and 11 elderly women who participated in this program. The average age of the elderly who underwent examination was 59.95 ± 9.04 years. The mean systolic blood pressure was 127 ± 15 mmHg. The mean diastolic blood pressure was 76 ± 9.5 mmHg. The mean blood creatinine level was 0.95 ± 0.2 mg/dl. The average blood uric acid level was 5.42 ± 0.92 mg/dl. Conclusion. Free examination Creatinine and blood uric acid levels in the elderly population in Ketewel Village are within normal limits which can indicate kidney function of the elderly population is still within normal limits. Keywords: Creatinine, uric acid, elderly, Ketewel Villag

Comparison of the effects of ethanol extract with aqueous extract of purple sweet potato tuber in expression of SOD-2, SOD-3, and eNOS on human vascular endothelial cells exposed by H2O2 in-Vitro I Made Jawi; I G K Arijana; I Wayan Putu Sutirta Yasa; AAN Subawa
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Aqueous extract of purple sweet potato tubers have antioxidant potential in animal and human vascular endothelial, through increased expression of superoxide dismutase. This study aims to prove the comparison between ethanol extract and aqueous extract of purple sweet potato tubers increasing the expression of superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in human vascular endothelium. This study was an experimental study of the vascular endothelial cells which underwent oxidative stress in vitro, which is protected by ethanol extract or aqueous extract of purple sweet potato tuber at various concentrations. Observation of the superoxide dismutase -2, superoxide dismutase -3, and endothelial nitric oxide synthase in endothelial cells is done using the method immunohistochemistry with monoclonal antibodies. The results showed an increase in superoxide dismutase - 2, superoxide dismutase -3, and endothelial nitric oxide synthase was significantly (p < 0.05) in endothelium protected by ethanol extract or water extract of purple sweet potato tubers. The ethanol extract only showed its effect at concentration of 1.5625 µg/ml for superoxide dismutase -2 and superoxide dismutase -3. The effect of aqueous extract were at a concentration of 1.5625–3.125µg/ml. From these results it can be concluded that the ethanol extract or aqueous extract of purple sweet potato tubers can protect endothelial cells from oxidative stress through increased expression of superoxide dismutase -2 and superoxide dismutase -3. The ethanol extract requires much lower concentrations to show its effect compared with aqueous extracts. Keywords: Aqueous extract or ethanol extract of purple sweet potato, Superoxide dismutase, Human umbilical vein endothelial cells.

DISTRIBUSI GOLONGAN DARAH ABO-RH SISWA SDN 3 KETEWEL SUKAWATI GIANYAR N.M. Linawati; I.G.K.N. Arijana; I.N. Wande; I.W. Sugiritama; I.G.N.S. Wiryawan; I.G.A.D. Ratnayanti; I.A.I. Wahyuniari; D.A.A.S. Laksmi
Buletin Udayana Mengabdi Vol 21 No 4 (2022): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2022.v21.i04.p02

Blood group is one of the identification parameters of a person's identity. Blood group is important to know in relation to medical and non-medical problems. However, there are still many blood group data that are not known to students in Ketewel village. This activity aims to determine the ABO-Rhesus blood group in children at SDN 3 Ketewel. The activity was carried out after coordinating with the Village Head, the headmaster of SDN 3 and also Mantra Medika Clinical Laboratory in Ketewel. Implementation of activities in August 2021 by complying with health protocols during the pandemic of Covid-19. The results of the activity were obtained as many as 65 students consisting of 35 male and 30 female which was 100% positive Rhesus. The distribution of ABO blood typing in male students was 14% A, 25% B, 62% O and 3% AB. Meanwhile, distribution of ABO blood type in female students is 13% A, 33% B and 47% O. From the activity, it can be concluded that the distribution of ABO-Rhesus blood group in SDN 3 Ketewel students is mostly O, the least blood group is AB which were all students Rhesus positive. Keywords: Identification, ABO-Rhesus blood group, SDN 3 Ketewel

POTENSI GASTROPROTEKTIF EKSTRAK BUNGA CENGKIH (Syzygium aromaticum): ANTIULKUS LAMBUNG, ANTIOKSIDAN, ANTIINFLAMASI, DAN ANTIMIKROBA Juven Luvianto; Ni Made Linawati; I Gusti Kamasan Nyoman Arijana; I Wayan Sugiritama
Essence of Scientific Medical Journal Vol 21 No 2 (2024): Volume 21 No. 2 (Juli - Desember 2023) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/essential.v21i2.109987

Pendahuluan: Cengkih (Syzygium aromaticum) merupakan salah satu tanaman asli yang berasal dari Indonesia. Kandungan utama bunga cengkih adalah eugenol, ?-kariofilen, dan eugenol asetat. Gangguan pada sistem pencernaan atau gastrointestinal merupakan gejala ataupun penyakit yang menyebabkan ketidaknyamanan pada penderitanya, misalnya dispepsia, gastritis, maag, infeksi, konstipasi, perdarahan, ulkus lambung, dan penyakit degeneratif kronis yang dapat disebabkan oleh obat-obatan, minuman beralkolhol, merokok, makanan asam atau lemak tinggi, dan malnutrisi. Pembahasan: Aktivitas antiuklus lambung ekstrak bunga cengkih melalui peningkatan faktor protektif lambung seperti sintesis mukus lambung, bikarbonat, regulasi aliran darah mukosa lambung, serta menghibisi asam lambung. Ekstrak bunga cengkih juga berperan sebagai antioksidan dan antiinflamasi dengan mengurangi sitokin proinflamasi, misalnya IL-1?, IL-6, TNF-?, nitrogen oksida, NF-?B dan meningkatkan antioksidan seluler seperti P450 reduktase, superoksida dismutase, katalase, glutathion peroksida, gluthation, dan thiol non-protein. Aktivitas antimikroba ekstrak bunga cengkih meliputi antibakteri, antivirus, antifungi, dan antiprotozoa. Simpulan: Ekstrak bunga cengkih memiliki berbagai aktivitas biologis, seperti antiulkus lambung, antibakteri, antifungi, antiinflamasi, dan antioksidan. Introduction: Clove (Syzygium aromaticum) is one of Indonesia’s native plant. The main components of clove bud are eugenol, ?-caryophyllene, dan eugenol acetate. Gastrointestinal symptoms or disease can lead to patient feeling uncomfortable. For examples dyspepsia, gastritis, infection, constipation, bleeding, gastric ulcer, and chronic degenerative disease that may be caused by drugs, alcohol, smoking, acidic or fatty foods, and malnutrition. Discussion: Clove bud extract has a lot of biological activities such as, antiulcer, antibacterial, antifungal, antiinflammation, and antioxidant. The methods used for this literature review are from 41 journals and electronic databases search. The antiulcer component of clove bud extract works by increasing the gastric protective factor, such as synthetizing gastric mucous, bicarbonate, regulating gastric mucosal blood flow, and inhibiting gastric acid. Clove bud extract also plays a role as antioxidant and antiinflammation by reducing cytokines proinflammation like IL-1?, IL-6, TNF-?, nitrite oxide, NF-?B and enhancing cellular antioxidant, for example P450 reductase, superoxide dismutase, catalase, glutathione peroxidase, glutathione, thiol non-protein. The microbial activity of clove bud extract includes antibacterial, antiviral, antifungal, and antiprotozoal. Conclusion: Clove bud extract has several biological activity, such as antiulcer, antimicrobial, antibacterial, antifungal, antiinflammation, and antioxidant.

Efek Blueberry (Vaccinium sp.) Terhadap Kelembapan Kulit yang Terpapar Sinar Ultraviolet Akut ADNYANA PUTRA, I GEDE AGUS DIVA; IDA AYU IKA WAHYUNIARI; NI MADE LINAWATI; I GUSTI KAMASAN NYOMAN ARIJANA
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.337

Introduction: Maintained skin moisture is an indication of healthy skin. Acute UV exposure can cause sunburn, which is characterized by a loss of moisture in the skin. Polyphenol compounds are one practical approach to protecting the skin from sunburn so that skin moisture is maintained. Blueberries are one of the natural ingredients consists of anthocyanin compounds, which are polyphenols from the flavonoid group. Aims: To determine the effect of blueberries on skin moisture exposed to acute ultraviolet rays. Methods: Literature study using references in the form of research articles and literature reviews from national and international journals and related books published in the last 10 years. In writing this literature review, 42 references were used which were accessed through Google Scholar, NCBI, Crossref, and Pubmed. Results: Blueberries anthocyanins can maintain skin moisture from increased transepidermal water loss (TEWL) due to acute UV ray exposure by reducing the formation of UV stimulated reactive oxygen species (ROS) and lipid peroxidation in keratinocyte cells to maintain the elastic modulus and mechanical properties of keratinocytes as well as can prevent sunburn by reducing the skin's modulation of UV exposure. However, the absorption of anthocyanin compounds in the intestine is so low that taking blueberries orally alone is not enough to achieve good biodistribution. Conclusion: Blueberries affect retaining moisture in skin exposed to acute UV rays, so they have the potential to be used as skincare ingredients. However, further research needs to be done, especially to determine the side effects that can be caused and the required extract concentration.

Potensi Senyawa Fitokimia pada Tumbuhan dalam Menurunkan Kadar Glukosa Darah pada Diabetes Melitus: Potential of Phytochemical Compounds in Plants in Lowering Blood Glucose Levels in Diabetes Raymond Elbert Budianto; Ni Made Linawati; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari; I Gusti Nyoman Sri Wiryawan
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1259

Diabetes melitus adalah gangguan metabolik kronis yang ditandai dengan hiperglikemia atau tingginya glukosa dalam darah karena gangguan dalam sekresi maupun respons terhadap hormon insulin. Menurut data dari International Diabetes Federation, prevalensi diabetes melitus di seluruh dunia sudah sangat tinggi, yaitu 537 juta pada tahun 2021. Akan tetapi, sudah ada berbagai obat alternatif alami yang dapat digunakan untuk menangani penyakit tersebut. Dalam beberapa penelitian, banyak tanaman yang sudah teruji khasiatnya sebagai obat antidiabetes alami karena kandungan fitokimianya. Studi literature review ini dilakukan dengan pencarian data melalui Google Scholar dan Science Direct dalam kurun waktu 10 tahun terakhir (2013-2022). Dari 29 artikel yang sesuai diperoleh hasil bahwa beberapa kandungan fitokimia pada tumbuhan seperti alkaloid dengan kemampuannya memperbaiki sel beta pankreas, flavonoid sebagai astringen, saponin dengan kemampuannya menstimulasi sekresi insulin dari sel beta pankreas, dan tanin sebagai antioksidan alami berpotensi menurunkan glukosa darah pada diabetes melitus tipe 1 dan 2.

Co-Authors Achmad Chusnu Romdhoni ADNYANA PUTRA, I GEDE AGUS DIVA Agus Dody Pranata Suadi Putra Anak Agung Ngurah Subawa Apolonia Berenika Badu Ayu Gita Bhagawanti Ayu Saka Laksmita W D.A.A.S. Laksmi Desak Putu Citra Udiyani Desak Putu Risky Vidika Apriyanthi Dewa Ayu Agus Sri Laksmi Dinesh Tanabbal ELVINA VERONICA Eugenia Meidy Fedik Abdul Ratam Gayathiri Mohana Krishnan Gede Wirata Hamsu Kadriyan Henky Henky I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Made Agus Paramarta Putra I Gde Raka Widiana I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Kadek Swastika I Ketut Tunas I Made Adi Satria Darma I Made Agus Endra Permana I Made Jawi I Made Sudarmaja I Nyoman Hariyasa Sanjaya I Nyoman Wande I Nyoman Wiryawan I Putu Dema Prasetya I Wayan Gede Artawan Eka Putra I Wayan Putu Sutirta Yasa I Wayan Sugiritama I Wayan Sugiritama I. G. A. D. Ratnayanthi I.G.N.S. Wiryawan I.N. Wande I.W. Sugiritama Ida Ayu Dewi Wiryantini Ida Ayu Ika Wahyuniari Intan Syahirah Bt Abdul Rauap JOHAN AXEL PARIURY Joshua Ezra Ronaldo Bayak JUAN PAUL CHRISTIAN HERMAN Juven Luvianto Komang Jegek Triangga Apsari Made Satria Yudha Dewangga Mahen Isaac Pannir Chelvam N. M. Linawati N.M. Linawati Ni Ketut Susilawati Ni Luh Ariwati Ni Luh Putu Eka Diarthini Ni Made Linawati Ni Made Mertaniasih Ni Made Yuli Lestari Ni Nyoman Mas Utari Rena Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Ni Putu Widayanti Ni Wayan Devi Yulianti Nyoman Intan Cahaya Pertiwi Nyoman Pratiwi Hapsari Dewi P.P.A.P. Dewi Putu Ayu Asri Damayanti Raymond Elbert Budianto Ruthirar Kalaichelvam Sri Maliawan Tarvin Jit Singh Gill TIFFANY REBECCA Tjokorda Gde Agung Suwardewa Wayan Aryadana Wayan Aryadana Wayan Suardana Yogarani V.C Rajappan

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